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- Antibody Data
- Antigen structure
- References [3]
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- Validations
- Other assay [1]
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- Product number
- MA5-15176 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Phospho-c-Raf (Ser338) Monoclonal Antibody (E.838.4)
- Antibody type
- Monoclonal
- Antigen
- Synthetic peptide
- Description
- It is not recommended to aliquot this antibody.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Antibody clone number
- E.838.4
- Vial size
- 100 µL
- Concentration
- 108 µg/mL
- Storage
- -20°C
Submitted references Aberrant cytoplasmic localization of ARID1B activates ERK signaling and promotes oncogenesis.
Escitalopram Ameliorates Cognitive Impairment in D-Galactose-Injected Ovariectomized Rats: Modulation of JNK, GSK-3β, and ERK Signalling Pathways.
Bipartite Role of Heat Shock Protein 90 (Hsp90) Keeps CRAF Kinase Poised for Activation.
Animireddy S, Kavadipula P, Kotapalli V, Gowrishankar S, Rao S, Bashyam MD
Journal of cell science 2021 Feb 26;134(4)
Journal of cell science 2021 Feb 26;134(4)
Escitalopram Ameliorates Cognitive Impairment in D-Galactose-Injected Ovariectomized Rats: Modulation of JNK, GSK-3β, and ERK Signalling Pathways.
Ibrahim WW, Abdelkader NF, Ismail HM, Khattab MM
Scientific reports 2019 Jul 11;9(1):10056
Scientific reports 2019 Jul 11;9(1):10056
Bipartite Role of Heat Shock Protein 90 (Hsp90) Keeps CRAF Kinase Poised for Activation.
Mitra S, Ghosh B, Gayen N, Roy J, Mandal AK
The Journal of biological chemistry 2016 Nov 18;291(47):24579-24593
The Journal of biological chemistry 2016 Nov 18;291(47):24579-24593
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Supportive validation
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- Invitrogen Antibodies (provider)
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- Experimental details
- Figure 4 Escitalopram mitigated D-galactose/ovariectomy-induced alterations in the hippocampal protein expression of (a) p-PI3K, (b) p-Akt, (c) p-GSK-3beta, (d) p-Raf-1, (e) p-MEK1/2, and (f) p-ERK1/2 in rats. The cropped blots for these proteins were presented relative to that of beta-actin, and the uncropped images are available in the Supplementary File. Each bar with a vertical line represents mean +- SD (n= 5). * vs SO group, # vs D-gal/OVX group, using one-way ANOVA followed by Tukey's multiple comparisons test; p < 0.05. SO sham operation, D-gal D-galactose, OVX ovariectomy, Esc escitalopram, PI3K phosphoinositide 3-kinase, Akt protein kinase B, GSK-3beta glycogen synthase kinase-3beta, ERK extracellular signal-regulated kinase.
