Antibody data
- Antibody Data
- Antigen structure
- References [24]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 10858-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10858-1-AP, RRID:AB_2204973
- Product name
- Timp-3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Timp-3 antibody (Cat. #10858-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Long non-coding RNA LINC01554 overexpression suppresses viability, migration, and invasion of liver cancer cells through regulating miR-148b-3p/EIF4E3.
WNTA5-mediated miR-374a-5p regulates vascular smooth muscle cell phenotype transformation and M1 macrophage polarization impacting intracranial aneurysm progression.
FERMT2 upregulation in CAFs enhances EMT of OSCC and M2 macrophage polarization.
Pacenta polypeptide injection alleviates the fibrosis and inflammation in cigarette smoke extracts-induced BEAS-2B cells by modulating MMP-9/TIMP-1 signaling.
Sublytic C5b-9 induces TIMP3 expression by glomerular mesangial cells via TRAF6-dependent KLF5 K63-linked ubiquitination in rat Thy-1 nephritis.
Methyltransferase-like 3 suppresses phenotypic switching of vascular smooth muscle cells by activating autophagosome formation.
Trehalose Protects Keratinocytes against Ultraviolet B Radiation by Activating Autophagy via Regulating TIMP3 and ATG9A.
Tau Protein Modulates Perineuronal Extracellular Matrix Expression in the TauP301L-acan Mouse Model.
Protective role of Achyranthes bidentata polysaccharides against chondrocyte extracellular matrix degeneration through lncRNA GAS5 in osteoarthritis.
Investigating the mechanism of Xian-ling-lian-xia-fang for inhibiting vasculogenic mimicry in triple negative breast cancer via blocking VEGF/MMPs pathway.
The prognostic and diagnostic value of tissue inhibitor of metalloproteinases gene family and potential function in gastric cancer.
Prostaglandin-E2 receptor-4 stimulant rescues cardiac malfunction during myocarditis and protects the heart from adverse ventricular remodeling after myocarditis.
Effects of aging on the histology and biochemistry of rat tendon healing.
MicroRNA-221 promotes proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs) by targeting tissue inhibitor of metalloproteinases-3 (TIMP3).
Aspirin inhibits inflammation and scar formation in the injury tendon healing through regulating JNK/STAT-3 signalling pathway.
miR-222-3p promotes osteosarcoma cell migration and invasion through targeting TIMP3.
miR-17-3p Contributes to Exercise-Induced Cardiac Growth and Protects against Myocardial Ischemia-Reperfusion Injury.
Databases for technical aspects of immunohistochemistry.
AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice.
Lack of Correlation between Aberrant p16, RAR-β2, TIMP3, ERCC1, and BRCA1 Protein Expression and Promoter Methylation in Squamous Cell Carcinoma Accompanying Candida albicans-Induced Inflammation.
Elevated MiR-222-3p promotes proliferation and invasion of endometrial carcinoma via targeting ERα.
Involvement of calcium-sensing receptors in hypoxia-induced vascular remodeling and pulmonary hypertension by promoting phenotypic modulation of small pulmonary arteries.
EZH2 regulates cancer cell migration through repressing TIMP-3 in non-small cell lung cancer.
Timp-3 deficiency impairs cognitive function in mice.
Ren X, Wang X, Song H, Zhang C, Yuan J, He J, Li J, Wang Z
Heliyon 2024 Mar 30;10(6):e27319
Heliyon 2024 Mar 30;10(6):e27319
WNTA5-mediated miR-374a-5p regulates vascular smooth muscle cell phenotype transformation and M1 macrophage polarization impacting intracranial aneurysm progression.
Li Z, Huang J, Yang L, Li X, Li W
Scientific reports 2024 Jan 4;14(1):559
Scientific reports 2024 Jan 4;14(1):559
FERMT2 upregulation in CAFs enhances EMT of OSCC and M2 macrophage polarization.
Ma X, Zhao D, Liu S, Zuo J, Wang W, Wang F, Li Y, Ding Z, Wang J, Wang X
Oral diseases 2024 Apr;30(3):991-1003
Oral diseases 2024 Apr;30(3):991-1003
Pacenta polypeptide injection alleviates the fibrosis and inflammation in cigarette smoke extracts-induced BEAS-2B cells by modulating MMP-9/TIMP-1 signaling.
Xu W, Li F, Zhu L, Cheng M, Cheng Y
Journal of biochemical and molecular toxicology 2023 Nov;37(11):e23453
Journal of biochemical and molecular toxicology 2023 Nov;37(11):e23453
Sublytic C5b-9 induces TIMP3 expression by glomerular mesangial cells via TRAF6-dependent KLF5 K63-linked ubiquitination in rat Thy-1 nephritis.
Ying S, Liu L, Luo C, Liu Y, Zhao C, Ge W, Wu N, Ruan Y, Wang W, Zhang J, Qiu W, Wang Y
International immunopharmacology 2023 Nov;124(Pt B):110970
International immunopharmacology 2023 Nov;124(Pt B):110970
Methyltransferase-like 3 suppresses phenotypic switching of vascular smooth muscle cells by activating autophagosome formation.
Fang ZM, Zhang SM, Luo H, Jiang DS, Huo B, Zhong X, Feng X, Cheng W, Chen Y, Feng G, Wu X, Zhao F, Yi X
Cell proliferation 2023 Apr;56(4):e13386
Cell proliferation 2023 Apr;56(4):e13386
Trehalose Protects Keratinocytes against Ultraviolet B Radiation by Activating Autophagy via Regulating TIMP3 and ATG9A.
Li L, Chen H, Chen X, Chen S, Gu H
Oxidative medicine and cellular longevity 2022;2022:9366494
Oxidative medicine and cellular longevity 2022;2022:9366494
Tau Protein Modulates Perineuronal Extracellular Matrix Expression in the TauP301L-acan Mouse Model.
Schmidt S, Holzer M, Arendt T, Sonntag M, Morawski M
Biomolecules 2022 Mar 26;12(4)
Biomolecules 2022 Mar 26;12(4)
Protective role of Achyranthes bidentata polysaccharides against chondrocyte extracellular matrix degeneration through lncRNA GAS5 in osteoarthritis.
Fu C, Qiu Z, Huang Y, Mei Y, Lin Q, Zeng J, Zhong W, Ma D
Experimental and therapeutic medicine 2022 Aug;24(2):532
Experimental and therapeutic medicine 2022 Aug;24(2):532
Investigating the mechanism of Xian-ling-lian-xia-fang for inhibiting vasculogenic mimicry in triple negative breast cancer via blocking VEGF/MMPs pathway.
Li F, Shi Y, Zhang Y, Yang X, Wang Y, Jiang K, Hua C, Wu C, Sun C, Qin Y, Liu S
Chinese medicine 2022 Apr 4;17(1):44
Chinese medicine 2022 Apr 4;17(1):44
The prognostic and diagnostic value of tissue inhibitor of metalloproteinases gene family and potential function in gastric cancer.
Li Z, Jing Q, Wu L, Chen J, Huang M, Qin Y, Wang T
Journal of Cancer 2021;12(13):4086-4098
Journal of Cancer 2021;12(13):4086-4098
Prostaglandin-E2 receptor-4 stimulant rescues cardiac malfunction during myocarditis and protects the heart from adverse ventricular remodeling after myocarditis.
Takakuma A, Nishii M, Valaperti A, Hiraga H, Saji R, Sakai K, Matsumura R, Miyata Y, Oba N, Nunose F, Ogawa F, Tamura K, Takeuchi I
Scientific reports 2021 Oct 26;11(1):20961
Scientific reports 2021 Oct 26;11(1):20961
Effects of aging on the histology and biochemistry of rat tendon healing.
Lai F, Tang H, Wang J, Lu K, Bian X, Wang Y, Shi Y, Guo Y, He G, Zhou M, Zhang X, Zhou B, Zhang J, Chen W, Tang K
BMC musculoskeletal disorders 2021 Nov 15;22(1):949
BMC musculoskeletal disorders 2021 Nov 15;22(1):949
MicroRNA-221 promotes proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs) by targeting tissue inhibitor of metalloproteinases-3 (TIMP3).
Yan Y, Xu Y, Ni G, Wang S, Li X, Gao J, Zhang H
Cardiovascular diagnosis and therapy 2020 Aug;10(4):646-657
Cardiovascular diagnosis and therapy 2020 Aug;10(4):646-657
Aspirin inhibits inflammation and scar formation in the injury tendon healing through regulating JNK/STAT-3 signalling pathway.
Wang Y, He G, Tang H, Shi Y, Kang X, Lyu J, Zhu M, Zhou M, Yang M, Mu M, Chen W, Zhou B, Zhang J, Tang K
Cell proliferation 2019 Jul;52(4):e12650
Cell proliferation 2019 Jul;52(4):e12650
miR-222-3p promotes osteosarcoma cell migration and invasion through targeting TIMP3.
Guo J, Liu Q, Li Z, Guo H, Bai C, Wang F
OncoTargets and therapy 2018;11:8643-8653
OncoTargets and therapy 2018;11:8643-8653
miR-17-3p Contributes to Exercise-Induced Cardiac Growth and Protects against Myocardial Ischemia-Reperfusion Injury.
Shi J, Bei Y, Kong X, Liu X, Lei Z, Xu T, Wang H, Xuan Q, Chen P, Xu J, Che L, Liu H, Zhong J, Sluijter JP, Li X, Rosenzweig A, Xiao J
Theranostics 2017;7(3):664-676
Theranostics 2017;7(3):664-676
Databases for technical aspects of immunohistochemistry.
Furukawa S, Nagaike M, Ozaki K
Journal of toxicologic pathology 2017 Jan;30(1):79-107
Journal of toxicologic pathology 2017 Jan;30(1):79-107
AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice.
Zhou S, Lu W, Chen L, Ge Q, Chen D, Xu Z, Shi D, Dai J, Li J, Ju H, Cao Y, Qin J, Chen S, Teng H, Jiang Q
Scientific reports 2017 Feb 22;7:43245
Scientific reports 2017 Feb 22;7:43245
Lack of Correlation between Aberrant p16, RAR-β2, TIMP3, ERCC1, and BRCA1 Protein Expression and Promoter Methylation in Squamous Cell Carcinoma Accompanying Candida albicans-Induced Inflammation.
Terayama Y, Matsuura T, Ozaki K
PloS one 2016;11(7):e0159090
PloS one 2016;11(7):e0159090
Elevated MiR-222-3p promotes proliferation and invasion of endometrial carcinoma via targeting ERα.
Liu B, Che Q, Qiu H, Bao W, Chen X, Lu W, Li B, Wan X
PloS one 2014;9(1):e87563
PloS one 2014;9(1):e87563
Involvement of calcium-sensing receptors in hypoxia-induced vascular remodeling and pulmonary hypertension by promoting phenotypic modulation of small pulmonary arteries.
Peng X, Li HX, Shao HJ, Li GW, Sun J, Xi YH, Li HZ, Wang XY, Wang LN, Bai SZ, Zhang WH, Zhang L, Yang GD, Wu LY, Wang R, Xu CQ
Molecular and cellular biochemistry 2014 Nov;396(1-2):87-98
Molecular and cellular biochemistry 2014 Nov;396(1-2):87-98
EZH2 regulates cancer cell migration through repressing TIMP-3 in non-small cell lung cancer.
Xu C, Hou Z, Zhan P, Zhao W, Chang C, Zou J, Hu H, Zhang Y, Yao X, Yu L, Yan J
Medical oncology (Northwood, London, England) 2013 Dec;30(4):713
Medical oncology (Northwood, London, England) 2013 Dec;30(4):713
Timp-3 deficiency impairs cognitive function in mice.
Baba Y, Yasuda O, Takemura Y, Ishikawa Y, Ohishi M, Iwanami J, Mogi M, Doe N, Horiuchi M, Maeda N, Fukuo K, Rakugi H
Laboratory investigation; a journal of technical methods and pathology 2009 Dec;89(12):1340-7
Laboratory investigation; a journal of technical methods and pathology 2009 Dec;89(12):1340-7
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- PC-3 cells were subjected to SDS PAGE followed by western blot with 10858-1-AP(Timp-3 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Timp-3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Timp-3. This antibody recognizes human, mouse, rat antigen. The Timp-3 antibody has been validated for the following applications: ELISA, WB, IHC analysis.