ABIN196897

antibody from antibodies-online

Targeting: PAK1

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN196897

Provider

antibodies-online

Product name

anti-P21-Activated Kinase 1 (PAK1) (pThr402), (pThr421), (pThr423) antibody

Antibody type

Polyclonal

Description

Affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Epitope

pThr402, pThr421, pThr423

Vial size

50 μL

Storage

Store the antibody (in aliquots) at -20°C.

Handling

Avoid repeated freezing and thawing.

References

Submitted references

Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells.

Parsons M, Monypenny J, Ameer-Beg SM, Millard TH, Machesky LM, Peter M, Keppler MD, Schiavo G, Watson R, Chernoff J, Zicha D, Vojnovic B, Ng T
Molecular and cellular biology 2005 Mar;25(5):1680-95

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Regulation of the interaction of Pak2 with Cdc42 via autophosphorylation of serine 141.

Jung JH, Traugh JA
The Journal of biological chemistry 2005 Dec 2;280(48):40025-31

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P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium.

Wang RA, Mazumdar A, Vadlamudi RK, Kumar R
The EMBO journal 2002 Oct 15;21(20):5437-47

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VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam.

Lampugnani MG, Zanetti A, Breviario F, Balconi G, Orsenigo F, Corada M, Spagnuolo R, Betson M, Braga V, Dejana E
Molecular biology of the cell 2002 Apr;13(4):1175-89