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- References [21]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 21401-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21401-1-AP, RRID:AB_11232232
- Product name
- PAK1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PAK1 antibody (Cat. #21401-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The expression of congenital Shoc2 variants induces AKT-dependent crosstalk activation of the ERK1/2 pathway.
Estrogen inhibits TGF‑β1‑stimulated cardiac fibroblast differentiation and collagen synthesis by promoting Cdc42.
The extracellular matrix supports breast cancer cell growth under amino acid starvation by promoting tyrosine catabolism.
Targeting endothelial PDGFR-β facilitates angiogenesis-associated bone formation through the PAK1/NICD axis.
Rac is required for the survival of cortical neurons.
Multi-proteomic Analysis Revealed Distinct Protein Profiles in Cerebrospinal Fluid of Patients Between Anti-NMDAR Encephalitis NORSE and Cryptogenic NORSE.
Bacterial infection promotes tumorigenesis of colorectal cancer via regulating CDC42 acetylation.
Generating a Murine PTEN Null Cell Line to Discover the Key Role of p110β-PAK1 in Castration-Resistant Prostate Cancer Invasion.
SARS-CoV-2 hijacks macropinocytosis to facilitate its entry and promote viral spike-mediated cell-to-cell fusion.
LncRNA FAF attenuates hypoxia/ischaemia-induced pyroptosis via the miR-185-5p/PAK2 axis in cardiomyocytes.
Novel Thermosensitive Hydrogel Promotes Spinal Cord Repair by Regulating Mitochondrial Function.
Avian Hepatitis E Virus ORF2 Protein Interacts with Rap1b to Induce Cytoskeleton Rearrangement That Facilitates Virus Internalization.
Salvianolic acid A prevented cerebrovascular endothelial injury caused by acute ischemic stroke through inhibiting the Src signaling pathway.
DOCK7 protects against replication stress by promoting RPA stability on chromatin.
Bu-Shen-Huo-Xue Decoction Ameliorates Diabetic Nephropathy by Inhibiting Rac1/PAK1/p38MAPK Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Mice.
P-21-activated kinase 1 contributes to tumor angiogenesis upon photodynamic therapy via the HIF-1α/VEGF pathway.
Cdc42 Deficiency Leads To Epidermal Barrier Dysfunction by Regulating Intercellular Junctions and Keratinization of Epidermal Cells during Mouse Skin Development.
NCK1 promotes the angiogenesis of cervical squamous carcinoma via Rac1/PAK1/MMP2 signal pathway.
Adenoviral vector-induced silencing of RGMa attenuates blood-brain barrier dysfunction in a rat model of MCAO/reperfusion.
Nicotine facilitates VSMC dysfunction through a miR-200b/RhoGDIA/cytoskeleton module.
Identification of NCK1 as a novel downstream effector of STAT3 in colorectal cancer metastasis and angiogenesis.
Wilson PG, Abdelmoti L, Gao T, Galperin E
Human molecular genetics 2024 Sep 3;33(18):1592-1604
Human molecular genetics 2024 Sep 3;33(18):1592-1604
Estrogen inhibits TGF‑β1‑stimulated cardiac fibroblast differentiation and collagen synthesis by promoting Cdc42.
Xu J, Wang F, Li Y, Li P, Zhang Y, Xu G, Sun K, Huang Y
Molecular medicine reports 2024 Jul;30(1)
Molecular medicine reports 2024 Jul;30(1)
The extracellular matrix supports breast cancer cell growth under amino acid starvation by promoting tyrosine catabolism.
Nazemi M, Yanes B, Martinez ML, Walker HJ, Pham K, Collins MO, Bard F, Rainero E
PLoS biology 2024 Jan;22(1):e3002406
PLoS biology 2024 Jan;22(1):e3002406
Targeting endothelial PDGFR-β facilitates angiogenesis-associated bone formation through the PAK1/NICD axis.
Lin H, Lin R, Hou J, Zhu C, Liu G, Lin Y, Su J, Yang M, Yang B, Ma Y, Cheng C, Deng M, Yu B, Xu T, Wu H, Cui Z
Journal of cellular physiology 2024 Aug;239(8):e31291
Journal of cellular physiology 2024 Aug;239(8):e31291
Rac is required for the survival of cortical neurons.
Katayama KI, Zheng Y, Inoue N
Experimental neurology 2023 Mar;361:114316
Experimental neurology 2023 Mar;361:114316
Multi-proteomic Analysis Revealed Distinct Protein Profiles in Cerebrospinal Fluid of Patients Between Anti-NMDAR Encephalitis NORSE and Cryptogenic NORSE.
Wang D, Wu Y, Pan Y, Wang S, Liu G, Gao Y, Xu K
Molecular neurobiology 2023 Jan;60(1):98-115
Molecular neurobiology 2023 Jan;60(1):98-115
Bacterial infection promotes tumorigenesis of colorectal cancer via regulating CDC42 acetylation.
Wang DN, Ni JJ, Li JH, Gao YQ, Ni FJ, Zhang ZZ, Fang JY, Lu J, Yao YF
PLoS pathogens 2023 Feb;19(2):e1011189
PLoS pathogens 2023 Feb;19(2):e1011189
Generating a Murine PTEN Null Cell Line to Discover the Key Role of p110β-PAK1 in Castration-Resistant Prostate Cancer Invasion.
Wang H, Zhou Y, Chu C, Xiao J, Zheng S, Korpal M, Korn JM, Penaloza T, Drake RR, Gan W, Gao X
Molecular cancer research : MCR 2023 Dec 1;21(12):1317-1328
Molecular cancer research : MCR 2023 Dec 1;21(12):1317-1328
SARS-CoV-2 hijacks macropinocytosis to facilitate its entry and promote viral spike-mediated cell-to-cell fusion.
Zhang YY, Liang R, Wang SJ, Ye ZW, Wang TY, Chen M, Liu J, Na L, Yang YL, Yang YB, Yuan S, Yin X, Cai XH, Tang YD
The Journal of biological chemistry 2022 Nov;298(11):102511
The Journal of biological chemistry 2022 Nov;298(11):102511
LncRNA FAF attenuates hypoxia/ischaemia-induced pyroptosis via the miR-185-5p/PAK2 axis in cardiomyocytes.
Gu J, Shi JZ, Wang YX, Liu L, Wang SB, Sun JT, Shan TK, Wang H, Wang QM, Wang LS
Journal of cellular and molecular medicine 2022 May;26(10):2895-2907
Journal of cellular and molecular medicine 2022 May;26(10):2895-2907
Novel Thermosensitive Hydrogel Promotes Spinal Cord Repair by Regulating Mitochondrial Function.
Li Y, Yang L, Hu F, Xu J, Ye J, Liu S, Wang L, Zhuo M, Ran B, Zhang H, Ye J, Xiao J
ACS applied materials & interfaces 2022 Jun 8;14(22):25155-25172
ACS applied materials & interfaces 2022 Jun 8;14(22):25155-25172
Avian Hepatitis E Virus ORF2 Protein Interacts with Rap1b to Induce Cytoskeleton Rearrangement That Facilitates Virus Internalization.
Zhang B, Fan M, Fan J, Luo Y, Wang J, Wang Y, Liu B, Sun Y, Zhao Q, Hiscox JA, Nan Y, Zhou EM
Microbiology spectrum 2022 Feb 23;10(1):e0226521
Microbiology spectrum 2022 Feb 23;10(1):e0226521
Salvianolic acid A prevented cerebrovascular endothelial injury caused by acute ischemic stroke through inhibiting the Src signaling pathway.
Liu CD, Liu NN, Zhang S, Ma GD, Yang HG, Kong LL, Du GH
Acta pharmacologica Sinica 2021 Mar;42(3):370-381
Acta pharmacologica Sinica 2021 Mar;42(3):370-381
DOCK7 protects against replication stress by promoting RPA stability on chromatin.
Gao M, Guo G, Huang J, Hou X, Ham H, Kim W, Zhao F, Tu X, Zhou Q, Zhang C, Zhu Q, Liu J, Yan Y, Xu Z, Yin P, Luo K, Weroha J, Deng M, Billadeau DD, Lou Z
Nucleic acids research 2021 Apr 6;49(6):3322-3337
Nucleic acids research 2021 Apr 6;49(6):3322-3337
Bu-Shen-Huo-Xue Decoction Ameliorates Diabetic Nephropathy by Inhibiting Rac1/PAK1/p38MAPK Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Mice.
Wang W, Long H, Huang W, Zhang T, Xie L, Chen C, Liu J, Xiong D, Hu W
Frontiers in pharmacology 2020;11:587663
Frontiers in pharmacology 2020;11:587663
P-21-activated kinase 1 contributes to tumor angiogenesis upon photodynamic therapy via the HIF-1α/VEGF pathway.
Jiang S, Gao Y, Yu QH, Li M, Cheng X, Hu SB, Song ZF, Zheng QC
Biochemical and biophysical research communications 2020 May 21;526(1):98-104
Biochemical and biophysical research communications 2020 May 21;526(1):98-104
Cdc42 Deficiency Leads To Epidermal Barrier Dysfunction by Regulating Intercellular Junctions and Keratinization of Epidermal Cells during Mouse Skin Development.
Zhang M, Wang X, Guo F, Jia Q, Liu N, Chen Y, Yan Y, Huang M, Tang H, Deng Y, Huang S, Zhou Z, Zhang L, Zhang L
Theranostics 2019;9(17):5065-5084
Theranostics 2019;9(17):5065-5084
NCK1 promotes the angiogenesis of cervical squamous carcinoma via Rac1/PAK1/MMP2 signal pathway.
Xia P, Huang M, Zhang Y, Xiong X, Yan M, Xiong X, Yu W, Song E
Gynecologic oncology 2019 Feb;152(2):387-395
Gynecologic oncology 2019 Feb;152(2):387-395
Adenoviral vector-induced silencing of RGMa attenuates blood-brain barrier dysfunction in a rat model of MCAO/reperfusion.
Li M, Wen Y, Zhang R, Xie F, Zhang G, Qin X
Brain research bulletin 2018 Sep;142:54-62
Brain research bulletin 2018 Sep;142:54-62
Nicotine facilitates VSMC dysfunction through a miR-200b/RhoGDIA/cytoskeleton module.
Liang D, Wang Z, Yan Z, Hou S, Xu W, Wang L, Shang M, Qiao Z
Scientific reports 2017 Mar 2;7:43798
Scientific reports 2017 Mar 2;7:43798
Identification of NCK1 as a novel downstream effector of STAT3 in colorectal cancer metastasis and angiogenesis.
Zhang F, Lu YX, Chen Q, Zou HM, Zhang JM, Hu YH, Li XM, Zhang WJ, Zhang W, Lin C, Li XN
Cellular signalling 2017 Aug;36:67-78
Cellular signalling 2017 Aug;36:67-78
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 21401-1-AP(PAK1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PAK1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human PAK1. This antibody recognizes human,mouse,rat antigen. The PAK1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
