10762-1-AP

antibody from Proteintech Group

Targeting: CDK1 CDC2, CDC28A

Provider product page for 10762-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [63]
Comments [0]
Validations
Western blot [1]

Submit

Product number: 10762-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10762-1-AP, RRID:AB_2074898
Product name: CDK1 antibody
Antibody type: Polyclonal
Description: KD/KO validated CDK1 antibody (Cat. #10762-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CDK1 protein structure - 10762-1-AP shown in red.

Submitted references Dual targeting of wild-type p53 and gut microbiota by Magnolol represses key metabolic process and kills CRC cells.

Ji H, Qiao O, Zhang Y, Wang W, Han X, Zhang X, Liu C, Gao W
Phytotherapy research : PTR 2024 Oct;38(10):4982-4998

Crosstalk between ALK3(BMPR1A) deficiency and autophagy signaling mitigates pathological bone loss in osteoporosis.

Niu Z, Zhou Y, Liang M, Su F, Guo Q, Jing J, Xie J, Zhang D, Liu X
Bone 2024 May;182:117052

DMC-siERCC2 hybrid nanoparticle enhances TRAIL sensitivity by inducing cell cycle arrest for glioblastoma treatment.

Song M, Wang T, Liu T, Lei T, Teng X, Peng Q, Zhu Q, Chen F, Zhao G, Li K, Qi L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116470

Expression and Purification of Recombinant Bowman-Birk Trypsin Inhibitor from Foxtail Millet Bran and Its Anticolorectal Cancer Effect In Vitro and In Vivo.

Zhang H, Qiao Q, Zhao Y, Zhang L, Shi J, Wang N, Li Z, Shan S
Journal of agricultural and food chemistry 2024 May 8;72(18):10439-10450

Suppression of N-Glycosylation of Zinc Finger Protein 471 Affects Proliferation, Invasion, and Docetaxel Sensitivity of Tongue Squamous Cell Carcinoma via Regulation of c-Myc.

Liu Y, Cai X, Hu S, Wang Z, Tian H, Wang H
The American journal of pathology 2024 Jun;194(6):1106-1125

Nitidine chloride inhibits G2/M phase by regulating the p53/14-3-3 Sigma/CDK1 axis for hepatocellular carcinoma treatment.

Zhang B, Zhou B, Huang G, Huang J, Lin X, Li Z, Lian Y, Huang Q, Ye Y
Heliyon 2024 Jan 15;10(1):e24012

Combining transcriptomics and network pharmacology to reveal the mechanism of Zuojin capsule improving spasmolytic polypeptide-expressing metaplasia.

Xiong M, Chen X, Wang H, Tang X, Wang Q, Li X, Ma H, Ye X
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117075

A novel lncRNA-hidden polypeptide regulates malignant phenotypes and pemetrexed sensitivity in A549 pulmonary adenocarcinoma cells.

Han X, Chen L, Sun P, Wang X, Zhao Q, Liao L, Lou D, Zhou N, Wang Y
Amino acids 2024 Feb 13;56(1):15

Pyrogallol promotes growth arrest by activating the p53-mediated up-regulation of p21 and p62/SQSTM1-dependent degradation of β-catenin in nonsmall cell lung cancer cells.

Zhou B, Wang L, Ren Z, Liang Y, Yang S, Zhang Y, Che S, Fang W
Environmental toxicology 2024 Apr;39(4):2150-2165

ESCO2's oncogenic role in human tumors: a pan-cancer analysis and experimental validation.

Huang Y, Chen D, Bai Y, Zhang Y, Zheng Z, Fu Q, Yi B, Jiang Y, Zhang Z, Zhu J
BMC cancer 2024 Apr 11;24(1):452

Phosphofructokinase Platelet Overexpression Accelerated Colorectal Cancer Cell Growth and Motility.

Lu TJ, Yang YF, Cheng CF, Tu YT, Chen YR, Lee MC, Tsai KW
Journal of Cancer 2023;14(6):943-951

Artesunate, as an Hsp90 inhibitor, inhibits the proliferation of Burkitt's lymphoma cells by inhibiting AKT and ERK.

Yuan-Ce L, Qi Z, Hong-Yang Z, Yan-Wen W, Yu-Mei S, Bi-Juan Y, Jun-Lin Y
Frontiers in pharmacology 2023;14:1218467

Network pharmacology integrated with experimental validation revealed potential molecular mechanisms of Camellia nitidissima C. W. Chi in the treatment of lung cancer.

Zhou A, Zhou C, Wang D, Qian M, Huang L
Journal of ethnopharmacology 2023 Oct 5;314:116576

The HNF4A-CHPF pathway promotes proliferation and invasion through interactions with MAD1L1 in glioma.

Luo H, Huang K, Cheng M, Long X, Zhu X, Wu M
Aging 2023 Oct 17;15(20):11052-11066

A HER2-targeted Antibody-Drug Conjugate, RC48-ADC, Exerted Promising Antitumor Efficacy and Safety with Intravesical Instillation in Preclinical Models of Bladder Cancer.

Hong X, Chen X, Wang H, Xu Q, Xiao K, Zhang Y, Chi Z, Liu Y, Liu G, Li H, Fang J, Lin T, Zhang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Nov;10(32):e2302377

BPA induces placental trophoblast proliferation inhibition and fetal growth restriction by inhibiting the expression of SRB1.

Cao Y, Chen S, Lu J, Zhang M, Shi L, Qin J, Lv J, Li D, Ma L, Zhang Y
Environmental science and pollution research international 2023 May;30(21):60805-60819

Discovery of a potent inhibitor of chaperone-mediated autophagy that targets the HSC70-LAMP2A interaction in non-small cell lung cancer cells.

Dong RF, Qin CJ, Yin Y, Han LL, Xiao CM, Wang KD, Wei RY, Xia YZ, Kong LY
British journal of pharmacology 2023 Jun 13;

Periplocin inhibits hepatocellular carcinoma progression and reduces the recruitment of MDSCs through AKT/NF-κB pathway.

Lin JP, Huang MH, Sun ZT, Chen L, Lei YH, Huang YQ, Qi M, Fan SR, Chen SG, Chung CW, Chan MC, Liu JS, Hu M, Chen MF, Ye WC, Chen YY, Deng LJ
Life sciences 2023 Jul 1;324:121715

Revealing active components and action mechanism of Fritillariae Bulbus against non-small cell lung cancer through spectrum-effect relationship and proteomics.

Liu FJ, Chen XY, Yang J, Zhao Z, Wang QL, Li P, Jiang Y, Li HJ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154635

Hypoxia Inhibits Cell Cycle Progression and Cell Proliferation in Brain Microvascular Endothelial Cells via the miR-212-3p/MCM2 Axis.

Shi Q, Li S, Lyu Q, Zhang S, Bai Y, Ma J
International journal of molecular sciences 2023 Feb 1;24(3)

Isoliquiritigenin Inhibits the Growth of Colorectal Cancer Cells through the ESR2/PI3K/AKT Signalling Pathway.

Luo F, Tang Y, Zheng L, Yang Y, Gao H, Tian S, Chen H, Tang C, Tang S, Man Q, Wu Y
Pharmaceuticals (Basel, Switzerland) 2023 Dec 27;17(1)

UBP43 promotes epithelial ovarian carcinogenesis via activation of β-catenin signaling pathway.

Xie H, Chen J, Ma C, Zhao J, Cui M
Cell biology international 2023 Aug;47(8):1427-1440

A novel T-cell proliferation-associated gene predicts prognosis and reveals immune infiltration in patients with oral squamous cell carcinoma.

Cui Y, Cheng Y, Huang W, Liu J, Zhang X, Bu M, Li X
Archives of oral biology 2023 Aug;152:105719

The roles of METTL3 on autophagy and proliferation of vascular smooth muscle cells are mediated by mTOR rather than by CDK1.

Luo H, Wu X, Huo B, Liu L, Jiang DS, Yi X
Cell division 2023 Aug 9;18(1):13

Low-dose graphene oxide promotes tumor cells proliferation by activating PI3K-AKT-mTOR signaling via cellular membrane protein integrin αV.

Zheng Z, Halifu A, Ma J, Liu L, Fu Q, Yi B, Du E, Tian D, Xu Y, Zhang Z, Zhu J
Environmental pollution (Barking, Essex : 1987) 2023 Aug 1;330:121817

TUBA1C is a potential new prognostic biomarker and promotes bladder urothelial carcinoma progression by regulating the cell cycle.

Jiang Y, Zhu C, Huang H, Huang G, Fu B, Xi X
BMC cancer 2023 Aug 1;23(1):716

Molecular docking and in vitro experiments verified that kaempferol induced apoptosis and inhibited human HepG2 cell proliferation by targeting BAX, CDK1, and JUN.

Zhang Q, Chen L, Gao M, Wang S, Meng L, Guo L
Molecular and cellular biochemistry 2023 Apr;478(4):767-780

N(6)-methyladenosine reader IGF2BP3 as a prognostic Biomarker contribute to malignant progression of glioma.

Zheng X, Li S, Yu J, Dai C, Yan S, Chen G, Sun C
Translational cancer research 2023 Apr 28;12(4):992-1005

The Effective Analysis for Blue Honeysuckle Extract in the Treatment of Hepatocellular Carcinoma.

Zhang CP, Li WH, Liu JR, Li GD, Zhang HP, Wei JF, Chen HS, Zhao JL, Wang YF, Lv Q, Liu M
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9601020

Evodiamine as the Active Compound of Evodiae fructus to Inhibit Proliferation and Migration of Prostate Cancer through PI3K/AKT/NF-κB Signaling Pathway.

Lei Y, Chan M, Liu H, Lyu W, Chen L, Zhong Y, Gan H, Wang M, Qi M, Guo Y, Liu J, Zhang E
Disease markers 2022;2022:4399334

Design, synthesis, and biological evaluation of novel dual inhibitors of heat shock protein 90/mammalian target of rapamycin (Hsp90/mTOR) against bladder cancer cells.

Pan Z, Chen Y, Pang H, Wang X, Zhang Y, Xie X, He G
European journal of medicinal chemistry 2022 Nov 15;242:114674

MCTS1 promotes laryngeal squamous cell carcinoma cell growth via enhancing LARP7 stability.

Yang M, Ma B, Liu X
Clinical and experimental pharmacology & physiology 2022 Jun;49(6):652-660

Synthesis and structure-activity relationship study of a potent MHO7 analogue as potential anti-triple negative breast cancer agent.

Liang JJ, Yu WL, Yang L, Qin KM, Yin YP, Li D, Ni YH, Yan JJ, Zhong YX, Deng ZX, Hong K
European journal of medicinal chemistry 2022 Jun 5;236:114313

Inhibition of the lncRNA MIAT prevents podocyte injury and mitotic catastrophe in diabetic nephropathy.

Wang Z, Chang Y, Liu Y, Liu B, Zhen J, Li X, Lin J, Yu Q, Lv Z, Wang R
Molecular therapy. Nucleic acids 2022 Jun 14;28:136-153

N-glycosylation of GDF15 abolishes its inhibitory effect on EGFR in AR inhibitor-resistant prostate cancer cells.

Wang R, Wen P, Yang G, Feng Y, Mi Y, Wang X, Zhu S, Chen YQ
Cell death & disease 2022 Jul 19;13(7):626

Design, Synthesis and Anti-Tumor Activity Evaluation of Novel 3,4-(Methylenedioxy)cinnamic Acid Amide-Dithiocarbamate Derivatives.

Guo J, Cheng M, Liu P, Cao D, Luo J, Wan Y, Wang R, Fang Y, Jin Y, Zhang Z, Xie SS, Liu J
Chemistry & biodiversity 2022 Aug;19(8):e202200439

Inhibitory Effects of Periplocin on Lymphoma Cells: A Network Pharmacology Approach and Experimental Validation.

Zhao R, Han C, Dai S, Wei S, Xiang X, Wang Y, Zhao R, Zhao L, Shan B
Drug design, development and therapy 2021;15:1333-1344

Pinocembrin Inhibits the Proliferation and Metastasis of Breast Cancer via Suppression of the PI3K/AKT Signaling Pathway.

Zhu X, Li R, Wang C, Zhou S, Fan Y, Ma S, Gao D, Gai N, Yang J
Frontiers in oncology 2021;11:661184

Therapeutic Targeting PLK1 by ON-01910.Na Is Effective in Local Treatment of Retinoblastoma.

Ma H, Nie C, Chen Y, Li J, Xie Y, Tang Z, Gao Y, Ai S, Mao Y, Sun Q, Lu R
Oncology research 2021 Sep 7;28(7):745-761

JaponiconeA induces apoptosis of bortezomib-sensitive and -resistant myeloma cells in vitro and in vivo by targeting IKK.

Zhang Z, Ye C, Liu J, Xu W, Wu C, Yu Q, Xu X, Zeng X, Jin H, Wu Y, Yan H
Cancer biology & medicine 2021 Sep 28;19(5):651-68

Effects of Cynaroside on Cell Proliferation, Apoptosis, Migration and Invasion though the MET/AKT/mTOR Axis in Gastric Cancer.

Ji J, Wang Z, Sun W, Li Z, Cai H, Zhao E, Cui H
International journal of molecular sciences 2021 Nov 9;22(22)

VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, induces cell cycle arrest and apoptosis in breast cancer cells by inhibiting the Wnt/β-catenin pathway.

Li H, Dang C, Tai X, Xue L, Meng Y, Ma S, Zhang J
Scientific reports 2021 Jul 22;11(1):14985

Bioinformatics analysis combined with experiments predicts CENPK as a potential prognostic factor for lung adenocarcinoma.

Ma J, Chen X, Lin M, Wang Z, Wu Y, Li J
Cancer cell international 2021 Jan 21;21(1):65

Hsp90 is involved in pseudorabies virus virion assembly via stabilizing major capsid protein VP5.

Zhang WJ, Wang RQ, Li LT, Fu W, Chen HC, Liu ZF
Virology 2021 Jan 15;553:70-80

MicroRNA-520c-3p targeting of RelA/p65 suppresses atherosclerotic plaque formation.

Wang J, Hu X, Hu X, Gao F, Li M, Cui Y, Wei X, Qin Y, Zhang C, Zhao Y, Gao Y
The international journal of biochemistry & cell biology 2021 Feb;131:105873

The ATPase Pontin is a key cell cycle regulator by amplifying E2F1 transcription response in glioma.

Wang R, Li X, Sun C, Yu L, Hua D, Shi C, Wang Q, Rao C, Luo W, Jiang Z, Zhou X, Yu S
Cell death & disease 2021 Feb 1;12(2):141

Solasonine Suppresses the Proliferation of Acute Monocytic Leukemia Through the Activation of the AMPK/FOXO3A Axis.

Zhang H, Tian F, Jiang P, Qian S, Dai X, Ma B, Wang M, Dai H, Sha X, Yang Z, Zhu X, Sun X
Frontiers in oncology 2020;10:614067

Extracellular Vesicle Delivery of TRAIL Eradicates Resistant Tumor Growth in Combination with CDK Inhibition by Dinaciclib.

Ke C, Hou H, Li J, Su K, Huang C, Lin Y, Lu Z, Du Z, Tan W, Yuan Z
Cancers 2020 May 4;12(5)

Osthole induces cell cycle arrest and apoptosis in head and neck squamous cell carcinoma by suppressing the PI3K/AKT signaling pathway.

Yang J, Zhu XJ, Jin MZ, Cao ZW, Ren YY, Gu ZW
Chemico-biological interactions 2020 Jan 25;316:108934

Combined inhibition of sonic Hedgehog signaling and histone deacetylase is an effective treatment for liver cancer.

Li J, Cai H, Li H, Liu Y, Wang Y, Shi Y, Sun Y, Song H, Wang D
Oncology reports 2019 Mar;41(3):1991-1997

Nuciferine inhibits the progression of glioblastoma by suppressing the SOX2-AKT/STAT3-Slug signaling pathway.

Li Z, Chen Y, An T, Liu P, Zhu J, Yang H, Zhang W, Dong T, Jiang J, Zhang Y, Jiang M, Yang X
Journal of experimental & clinical cancer research : CR 2019 Mar 29;38(1):139

CtIP promotes G2/M arrest in etoposide-treated HCT116 cells in a p53-independent manner.

Chen H, Shan J, Chen D, Wang R, Qi W, Wang H, Ke Y, Liu W, Zeng X
Journal of cellular physiology 2019 Jul;234(7):11871-11881

Metformin Treatment Suppresses Melanoma Cell Growth and Motility Through Modulation of microRNA Expression.

Tseng HW, Li SC, Tsai KW
Cancers 2019 Feb 11;11(2)

EPB41L3 is a potential tumor suppressor gene and prognostic indicator in esophageal squamous cell carcinoma.

Zeng R, Liu Y, Jiang ZJ, Huang JP, Wang Y, Li XF, Xiong WB, Wu XC, Zhang JR, Wang QE, Zheng YF
International journal of oncology 2018 May;52(5):1443-1454

Osthole inhibits the PI3K/AKT signaling pathway via activation of PTEN and induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma.

Zhu X, Li Z, Li T, Long F, Lv Y, Liu L, Liu X, Zhan Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jun;102:502-509

Proteasome Inhibitor Carbobenzoxy-L-Leucyl-L-Leucyl-L-Leucinal (MG132) Enhances Therapeutic Effect of Paclitaxel on Breast Cancer by Inhibiting Nuclear Factor (NF)-κB Signaling.

Zhang Y, Yang B, Zhao J, Li X, Zhang L, Zhai Z
Medical science monitor : international medical journal of experimental and clinical research 2018 Jan 15;24:294-304

The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression.

Kueck T, Cassella E, Holler J, Kim B, Bieniasz PD
eLife 2018 Aug 22;7

PFKFB3 blockade inhibits hepatocellular carcinoma growth by impairing DNA repair through AKT.

Shi WK, Zhu XD, Wang CH, Zhang YY, Cai H, Li XL, Cao MQ, Zhang SZ, Li KS, Sun HC
Cell death & disease 2018 Apr 1;9(4):428

Whole exome-wide association study identifies a missense variant in SLC2A4RG associated with glioblastoma risk.

Zhao Y, Yun D, Zou X, Jiang T, Li G, Hu L, Chen J, Xu J, Mao Y, Chen H, Lu D
American journal of cancer research 2017;7(9):1937-1947

Synergistic antitumor effect of 3-bromopyruvate and 5-fluorouracil against human colorectal cancer through cell cycle arrest and induction of apoptosis.

Chong D, Ma L, Liu F, Zhang Z, Zhao S, Huo Q, Zhang P, Zheng H, Liu H
Anti-cancer drugs 2017 Sep;28(8):831-840

1, 25(OH)(2)D(3)-induced interaction of vitamin D receptor with p50 subunit of NF-κB suppresses the interaction between KLF5 and p50, contributing to inhibition of LPS-induced macrophage proliferation.

Ma D, Zhang RN, Wen Y, Yin WN, Bai D, Zheng GY, Li JS, Zheng B, Wen JK
Biochemical and biophysical research communications 2017 Jan 8;482(2):366-374

Elevated GAPDH expression is associated with the proliferation and invasion of lung and esophageal squamous cell carcinomas.

Hao L, Zhou X, Liu S, Sun M, Song Y, Du S, Sun B, Guo C, Gong L, Hu J, Guan H, Shao S
Proteomics 2015 Sep;15(17):3087-100

Novel taspine derivative 12k inhibits cell growth and induces apoptosis in lung cell carcinoma.

Dai B, Wang W, Liu R, Wang H, Zhang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2015 Mar;70:227-33

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The CDK1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CDK1. This antibody recognizes human antigen. The CDK1 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 10762-1-AP.pdf

: Show more