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- Antibody Data
- Antigen structure
- References [182]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 19532-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19532-1-AP, RRID:AB_10638617
- Product name
- CDK1-Specific antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CDK1-Specific antibody (Cat. #19532-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references MK8722 initiates early-stage autophagy while inhibiting late-stage autophagy via FASN-dependent reprogramming of lipid metabolism.
Identification of PRDX5 as A Target for The Treatment of Castration-Resistant Prostate Cancer.
RRM2 promotes the proliferation of chicken myoblasts, inhibits their differentiation and muscle regeneration.
MTCH2 stimulates cellular proliferation and cycles via PI3K/Akt pathway in breast cancer.
Periplcymarin targets glycolysis and mitochondrial oxidative phosphorylation of esophageal squamous cell carcinoma: Implication in anti-cancer therapy.
The anti-non-small cell lung cancer effect of Diosbulbin B: Targeting YY1 induced cell cycle arrest and apoptosis.
Transcriptomics and molecular docking reveal the potential mechanism of lycorine against pancreatic cancer.
Pan-cancer analysis of the tumorigenic role of Fanconi anemia complementation group D2 (FANCD2) in human tumors.
SNRPB promotes the progression of hepatocellular carcinoma via regulating cell cycle, oxidative stress, and ferroptosis.
Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells.
Patulin induces ROS-dependent cardiac cell toxicity by inducing DNA damage and activating endoplasmic reticulum stress apoptotic pathway.
Proteolysis Targeting Chimeras (PROTACs) based on celastrol induce multiple protein degradation for triple-negative breast cancer treatment.
Aurora kinase A-mediated phosphorylation triggers structural alteration of Rab1A to enhance ER complexity during mitosis.
Comprehensive analysis of PSMD family members and validation of PSMD9 as a potential therapeutic target in human glioblastoma.
Aurora kinase B disruption suppresses pathological retinal angiogenesis by affecting cell cycle progression.
Molecular mechanism of human ISG20L2 for the ITS1 cleavage in the processing of 18S precursor ribosomal RNA.
Kinesin Family Member-18A (KIF18A) Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma.
Liensinine inhibits progression of intrahepatic cholangiocarcinoma by regulating TGF-β1 /P-smad3 signaling through HIF-1a.
Corynoxine triggers cell death via activating PP2A and regulating AKT-mTOR/GSK3β axes in NSCLC.
Targeting histone demethylases JMJD3 and UTX: selenium as a potential therapeutic agent for cervical cancer.
GTPBP8 modulates mitochondrial fission through a Drp1-dependent process.
CGRP Released by Corneal Sensory Nerve Maintains Tear Secretion of the Lacrimal Gland.
CDKs Functional Analysis in Low Proliferating Early-Stage Pancreatic Ductal Adenocarcinoma.
Nanoengineered Gallium Ion Incorporated Formulation for Safe and Efficient Reversal of PARP Inhibition and Platinum Resistance in Ovarian Cancer.
Down-regulation of histone deacetylase 7 reduces biological activities of retinal microvascular endothelial cells under high glucose condition and related mechanism.
AKIP1 accelerates glioblastoma progression through stabilizing EGFR expression.
Cooperation of long noncoding RNA LOC100909675 and transcriptional regulator CTCF modulates Cdk1 transcript to control astrocyte proliferation.
PUF60 promotes cell cycle and lung cancer progression by regulating alternative splicing of CDC25C.
Matrix stiffness induces Drp1-mediated mitochondrial fission through Piezo1 mechanotransduction in human intervertebral disc degeneration.
Rab11-FIP4 interacts with ARF5 to promote cancer stemness in hepatocellular carcinoma.
TRIM28 recruits E2F1 to regulate CBX8-mediated cell proliferation and tumor metastasis of ovarian cancer.
9-oxo-ODAs suppresses the proliferation of human cervical cancer cells through the inhibition of CDKs and HPV oncoproteins.
Modulation of cell cycle increases CRISPR-mediated homology-directed DNA repair.
Andrographolide inhibits the proliferation and migration of vascular smooth muscle cells via PI3K/AKT signaling pathway and amino acid metabolism to prevent intimal hyperplasia.
Exploring heterogeneity of tumor immune cells and adrenal cells in aldosterone-producing adenomas using single-cell RNA-seq and investigating differences by sex.
Effect of mir-92a-3p on hydroquinone induced changes in human lymphoblastoid cell cycle and apoptosis.
A Potential Anti-Glioblastoma Compound LH20 Induces Apoptosis and Arrest of Human Glioblastoma Cells via CDK4/6 Inhibition.
The Natural Alkaloid (-)-N-Hydroxyapiosporamide Suppresses Colorectal Tumor Progression as an NF-κB Pathway Inhibitor by Targeting the TAK1-TRAF6 Complex.
Modified Podophyllotoxin Phenoxyacetamide Phenylacetate Derivatives: Tubulin/AKT1 Dual-Targeting and Potential Anticancer Agents for Human NSCLC.
FGF19 induces the cell cycle arrest at G2-phase in chondrocytes.
CFNC, a neocryptolepine derivative, inhibited the growth of gastric cancer AGS cells by inhibiting PI3K/AKT signaling pathway.
HDAC7/c-Myc signaling pathway promotes the proliferation and metastasis of choroidal melanoma cells.
Ganoderma lucidum polysaccharide inhibits HSC activation and liver fibrosis via targeting inflammation, apoptosis, cell cycle, and ECM-receptor interaction mediated by TGF-β/Smad signaling.
Dual network analysis of transcriptome data for discovery of new therapeutic targets in non-small cell lung cancer.
Histone demethylase KDM4B accelerates the progression of glioblastoma via the epigenetic regulation of MYC stability.
Mutations in CCNB3 affect its location thus causing a multiplicity of phenotypes in human oocytes maturation by aberrant CDK1 activity and APC/C activity at different stages.
Ubiquitin-specific protease 7 prevents recurrent spontaneous abortion by targeting enhancer of zeste homolog 2 to regulate trophoblast proliferation, apoptosis, migration, and invasion through the Wnt/β-catenin pathway†.
Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions.
HJURP Promotes Malignant Progression and Mediates Sensitivity to Cisplatin and WEE1-inhibitor in Serous Ovarian Cancer.
Sinapine Thiocyanate Inhibits the Proliferation and Mobility of Pancreatic Cancer Cells by Up-Regulating GADD45A.
Identification and verification of hub genes associated with the progression of non-small cell lung cancer by integrated analysis.
The Natural Product Andrographolide Ameliorates Calcific Aortic Valve Disease by Regulating the Proliferation of Valve Interstitial Cells via the MAPK-ERK Pathway.
Theaflavin-3,3'-Digallate from Black Tea Inhibits Neointima Formation Through Suppression of the PDGFRβ Pathway in Vascular Smooth Muscle Cells.
Narciclasine inhibits phospholipase A2 and regulates phospholipid metabolism to ameliorate psoriasis-like dermatitis.
A four oxidative stress gene prognostic model and integrated immunity-analysis in pancreatic adenocarcinoma.
SMARCE1 promotes neuroblastoma tumorigenesis through assisting MYCN-mediated transcriptional activation.
Osteoblastic protein kinase D1 contributes to the prostate cancer cells dormancy via GAS6-circadian clock signaling.
Fibroblast growth factor 21, a stress regulator, inhibits Drp1 activation to alleviate skeletal muscle ischemia/reperfusion injury.
Activation of the Chemokine Receptor CCR1 and Preferential Recruitment of Gαi Suppress RSV Replication: Implications for Developing Novel Respiratory Syncytial Virus Treatment Strategies.
Cholecystectomy promotes colon carcinogenesis by activating the Wnt signaling pathway by increasing the deoxycholic acid level.
Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells.
An advanced network pharmacology study to explore the novel molecular mechanism of Compound Kushen Injection for treating hepatocellular carcinoma by bioinformatics and experimental verification.
HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathway.
Emodin-8-O-β-D-glucopyranoside, a natural hydroxyanthraquinone glycoside from plant, suppresses cancer cell proliferation via p21-CDKs-Rb axis.
ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination.
The Therapeutic Role of PNU-74654 in Hepatocellular Carcinoma May Involve Suppression of NF-κB Signaling.
Disruption of mitochondrial redox homeostasis as a mechanism of antimony-induced reactive oxygen species and cytotoxicity.
Inhibition of CDK1 attenuates neuronal apoptosis and autophagy and confers neuroprotection after chronic spinal cord injury in vivo.
SPOCK1 promotes metastasis in pancreatic cancer via NF-κB-dependent epithelial-mesenchymal transition by interacting with IκB-α.
Corynoxine suppresses pancreatic cancer growth primarily via ROS-p38 mediated cytostatic effects.
SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis.
Epithelial cells-enriched lncRNA SNHG8 regulates chromatin condensation by binding to Histone H1s.
Dematin inhibits glioblastoma malignancy through RhoA-mediated CDKs downregulation and cytoskeleton remodeling.
Bolbostemma paniculatum (Maxim.) Franquet extract suppresses the development of colorectal cancer through downregulation of PI3K/Akt pathway.
MCC Regulator of WNT Signaling Pathway (MCC) Is a Podocyte Essential Gene.
MiR-490-3p Silences CDK1 and Inhibits the Proliferation of Colon Cancer Through an LLPS-Dependent miRISC System.
Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways.
CircMETTL3, upregulated in a m6A-dependent manner, promotes breast cancer progression.
Magnesium-Assisted Cisplatin Inhibits Bladder Cancer Cell Survival by Modulating Wnt/β-Catenin Signaling Pathway.
Sempervirine Mediates Autophagy and Apoptosis via the Akt/mTOR Signaling Pathways in Glioma Cells.
Lycorine hydrochloride inhibits melanoma cell proliferation, migration and invasion via down-regulating p21(Cip1/WAF1).
PRCC-TFE3 fusion-mediated PRKN/parkin-dependent mitophagy promotes cell survival and proliferation in PRCC-TFE3 translocation renal cell carcinoma.
Methylation of TMEM176A, a key ERK signaling regulator, is a novel synthetic lethality marker of ATM inhibitors in human lung cancer.
Rubioncolin C, a natural naphthohydroquinone dimer isolated from Rubia yunnanensis, inhibits the proliferation and metastasis by inducing ROS-mediated apoptotic and autophagic cell death in triple-negative breast cancer cells.
Characteristics and clinical significance of polyploid giant cancer cells in laryngeal carcinoma.
Design, synthesis and antitumor evaluation of novel chiral diaryl substituted azetidin-2-one derivatives as tubulin polymerization inhibitors.
Inhibition of ubiquitin-specific protease 13-mediated degradation of Raf1 kinase by Spautin-1 has opposing effects in naïve and primed pluripotent stem cells.
The anti-neoplastic activities of aloperine in HeLa cervical cancer cells are associated with inhibition of the IL-6-JAK1-STAT3 feedback loop.
The Y14-p53 regulatory circuit in megakaryocyte differentiation and thrombocytopenia.
Long intergenic non-coding RNA 00473 promotes proliferation and migration of gastric cancer via the miR-16-5p/CCND2 axis and by regulating AQP3.
Overexpression of MYBL2 predicts poor prognosis and promotes oncogenesis in endometrial carcinoma.
Knockdown of SASS6 reduces growth of MDA‑MB‑231 triple‑negative breast cancer cells through arrest of the cell cycle at the G2/M phase.
DNA methylation mediated RSPO2 to promote follicular development in mammals.
NT5DC2 promotes leiomyosarcoma tumour cell growth via stabilizing unpalmitoylated TEAD4 and generating a positive feedback loop.
VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, induces cell cycle arrest and apoptosis in breast cancer cells by inhibiting the Wnt/β-catenin pathway.
miR-937-5p targets SOX17 to modulate breast cancer cell cycle and cell proliferation through the Wnt signaling pathway.
Avasimibe exerts anticancer effects on human glioblastoma cells via inducing cell apoptosis and cell cycle arrest.
Circ-NOLC1 promotes epithelial ovarian cancer tumorigenesis and progression by binding ESRP1 and modulating CDK1 and RhoA expression.
β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma.
Inhibition of bone morphogenetic protein receptor 2 suppresses pancreatic ductal adenocarcinoma growth by regulating GRB2/PI3K/AKT axis.
Glaucocalyxin A induces cell cycle arrest and apoptosis via inhibiting NF-κB/p65 signaling pathway in melanoma cells.
Oncogenic action of the exosome cofactor RBM7 by stabilization of CDK1 mRNA in breast cancer.
Ethanol extract of Ophiorrhiza pumila suppresses liver cancer cell proliferation and migration.
The Acetone Indigo Red Dehydrating Agent IF203 Induces HepG2 Cell Death Through Cell Cycle Arrest, Autophagy and Apoptosis.
Ursolic Acid Regulates Cell Cycle and Proliferation in Colon Adenocarcinoma by Suppressing Cyclin B1.
Grape Seed Proanthocyanidins Induce Apoptosis and Cell Cycle Arrest of HepG2 Cells Accompanied by Induction of the MAPK Pathway and NAG-1.
MicroRNA‑145‑5p inhibits osteosarcoma cell proliferation by targeting E2F transcription factor 3.
CDK1-PLK1/SGOL2/ANLN pathway mediating abnormal cell division in cell cycle may be a critical process in hepatocellular carcinoma.
Pulp stem cells with hepatocyte growth factor overexpression exhibit dual effects in rheumatoid arthritis.
Development and validation of a five-gene model to predict postoperative brain metastasis in operable lung adenocarcinoma.
HOTAIR-EZH2 inhibitor AC1Q3QWB upregulates CWF19L1 and enhances cell cycle inhibition of CDK4/6 inhibitor palbociclib in glioma.
SPOCK1/SIX1axis promotes breast cancer progression by activating AKT/mTOR signaling.
S119N Mutation of the E3 Ubiquitin Ligase SPOP Suppresses SLC7A1 Degradation to Regulate Hepatoblastoma Progression.
Apolipoprotein E2 modulates cell cycle function to promote proliferation in pancreatic cancer cells via regulation of the c-Myc-p21(Waf1) signalling pathway.
Potent USP10/13 antagonist spautin-1 suppresses melanoma growth via ROS-mediated DNA damage and exhibits synergy with cisplatin.
Effects of selenium on the proliferation and apoptosis of sheep spermatogonial stem cells in vitro.
Prognostic implications and oncogenic roles of MYBL2 protein expression in esophageal squamous-cell carcinoma.
Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma.
CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity.
Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis.
Characterization of Protein Profiling and mRNA Expression of LLC Exosomes.
CyclinB1 deubiquitination by USP14 regulates cell cycle progression in breast cancer.
Cyclin-dependent kinase 1 disruption inhibits angiogenesis by inducing cell cycle arrest and apoptosis.
O-GlcNAcylation of Thr(12)/Ser(56) in short-form O-GlcNAc transferase (sOGT) regulates its substrate selectivity.
A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer.
Lin28 promotes dental pulp cell proliferation via upregulation of cyclin-dependent proteins and interaction with let-7a/IGF2BP2 pathways.
RA-XII Suppresses the Development and Growth of Liver Cancer by Inhibition of Lipogenesis via SCAP-dependent SREBP Supression.
MiR-31-5p acts as a tumor suppressor in renal cell carcinoma by targeting cyclin-dependent kinase 1 (CDK1).
Inhibition of Wee1 sensitizes AML cells to ATR inhibitor VE-822-induced DNA damage and apoptosis.
Agenesis and Hypomyelination of Corpus Callosum in Mice Lacking Nsun5, an RNA Methyltransferase.
High expression of CDK1 and BUB1 predicts poor prognosis of pancreatic ductal adenocarcinoma.
Apoptosis induced by ursodeoxycholic acid in human melanoma cells through the mitochondrial pathway.
Effect of ingredients from Chinese herbs on enterovirus D68 production.
Shuttling SLC2A4RG is regulated by 14-3-3θ to modulate cell survival via caspase-3 and caspase-6 in human glioma.
BECN1 promotes the migration of NSCLC cells through regulating the ubiquitination of Vimentin.
Long non-coding RNA miR143HG predicts good prognosis and inhibits tumor multiplication and metastasis by suppressing mitogen-activated protein kinase and Wnt signaling pathways in hepatocellular carcinoma.
Cordycepin suppresses cell proliferation and migration by targeting CLEC2 in human gastric cancer cells via Akt signaling pathway.
Overexpression of Annexin A2 Receptor Inhibits Neovascularization via the Promotion of Krüppel-Like Transcription Factor 2.
Biocompatible PEGylated Gold nanorods function As cytokinesis inhibitors to suppress angiogenesis.
Co-culture with TM4 cells enhances the proliferation and migration of rat adipose-derived mesenchymal stem cells with high stemness.
Yes-associated protein promotes the abnormal proliferation of psoriatic keratinocytes via an amphiregulin dependent pathway.
Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells.
UBAP2L silencing inhibits cell proliferation and G2/M phase transition in breast cancer.
CDKN1C (P57): one of the determinants of human endometrial stromal cell decidualization.
3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase.
Involvement of mitochondrial fission in calcium sensing receptor-mediated vascular smooth muscle cells proliferation during hypertension.
LncRNA ABHD11-AS1 promotes the development of endometrial carcinoma by targeting cyclin D1.
Cancer-testis specific gene OIP5: a downstream gene of E2F1 that promotes tumorigenesis and metastasis in glioblastoma by stabilizing E2F1 signaling.
The enhancement of siPLK1 penetration across BBB and its anti glioblastoma activity in vivo by magnet and transferrin co-modified nanoparticle.
Silencing HOXD10 by promoter region hypermethylation activates ERK signaling in hepatocellular carcinoma.
Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-κB/COX-2 signaling pathways.
2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino) phenyl carbamoylsulfanyl] propionic acid, a glutathione reductase inhibitor, induces G(2)/M cell cycle arrest through generation of thiol oxidative stress in human esophageal cancer cells.
DLEU1 contributes to ovarian carcinoma tumourigenesis and development by interacting with miR-490-3p and altering CDK1 expression.
The transcription factor FOXA1 induces epithelial ovarian cancer tumorigenesis and progression.
Osthole inhibits the tumorigenesis of hepatocellular carcinoma cells.
Ginsenoside PPD's Antitumor Effect via Down-Regulation of mTOR Revealed by Super-Resolution Imaging.
SNORD47, a box C/D snoRNA, suppresses tumorigenesis in glioblastoma.
Anthocyanins from Black Chokeberry (Aroniamelanocarpa Elliot) Delayed Aging-Related Degenerative Changes of Brain.
The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD.
Knockdown of PYCR1 inhibits cell proliferation and colony formation via cell cycle arrest and apoptosis in prostate cancer.
ICT1 knockdown inhibits breast cancer cell growth via induction of cell cycle arrest and apoptosis.
Knockdown of ubiquitin-specific peptidase 39 inhibited the growth of osteosarcoma cells and induced apoptosis in vitro.
The Antitumor Effect of DYC-279 on Human Hepatocellular Carcinoma HepG2 Cells.
High Expression of PTGR1 Promotes NSCLC Cell Growth via Positive Regulation of Cyclin-Dependent Protein Kinase Complex.
Role of glycogen synthase kinase-3β inhibitor AZD1080 in ovarian cancer.
EIF3D silencing suppresses renal cell carcinoma tumorigenesis via inducing G2/M arrest through downregulation of Cyclin B1/CDK1 signaling.
Yes-Associated Protein Contributes to the Development of Human Cutaneous Squamous Cell Carcinoma via Activation of RAS.
Downregulation of vimentin expression increased drug resistance in ovarian cancer cells.
Carfilzomib induces G2/M cell cycle arrest in human endometrial cancer cells via upregulation of p21(Waf1/Cip1) and p27(Kip1).
Anti-tumor effects of osthole on ovarian cancer cells in vitro.
Methylation of DACT2 accelerates esophageal cancer development by activating Wnt signaling.
TRIM59 Promotes the Proliferation and Migration of Non-Small Cell Lung Cancer Cells by Upregulating Cell Cycle Related Proteins.
Immature Colon Carcinoma Transcript 1 Is Essential for Prostate Cancer Cell Viability and Proliferation.
Quercetin reverses experimental pulmonary arterial hypertension by modulating the TrkA pathway.
Phosphorylation of nucleophosmin at threonine 234/237 is associated with HCC metastasis.
Induction of S phase arrest and apoptosis by ethyl acetate extract from Tetrastigma hemsleyanum in human hepatoma HepG2 cells.
Trichostatin A targets the mitochondrial respiratory chain, increasing mitochondrial reactive oxygen species production to trigger apoptosis in human breast cancer cells.
The involvement of CXCR7 in modulating the progression of papillary thyroid carcinoma.
Eupolyphaga sinensis Walker inhibits human chronic myeloid leukemia cell K562 growth by inducing G2-M phase cell cycle arrest and targeting EGFR signaling pathway and in S180 tumor-bearing mice.
Eupolyphaga sinensis walker displays inhibition on hepatocellular carcinoma through regulating cell growth and metastasis signaling.
Brucine, an effective natural compound derived from nux-vomica, induces G1 phase arrest and apoptosis in LoVo cells.
Hepatitis E virus-induced neurological symptoms in a kidney-transplant patient with chronic hepatitis.
Wang L, Zhu H, Shi Z, Chen B, Huang H, Lin G, Li J, Yu H, Xu S, Chen G, Ou R, Dai C
Theranostics 2024;14(1):75-95
Theranostics 2024;14(1):75-95
Identification of PRDX5 as A Target for The Treatment of Castration-Resistant Prostate Cancer.
Wang R, Mi Y, Ni J, Wang Y, Ding L, Ran X, Sun Q, Tan SY, Koeffler HP, Feng N, Chen YQ
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(9):e2304939
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(9):e2304939
RRM2 promotes the proliferation of chicken myoblasts, inhibits their differentiation and muscle regeneration.
Chen B, Zhang Y, Niu Y, Wang Y, Liu Y, Ji H, Han R, Tian Y, Liu X, Kang X, Li Z
Poultry science 2024 Mar;103(3):103407
Poultry science 2024 Mar;103(3):103407
MTCH2 stimulates cellular proliferation and cycles via PI3K/Akt pathway in breast cancer.
Jiang W, Miao Y, Xing X, Liu S, Xing W, Qian F
Heliyon 2024 Mar 30;10(6):e28172
Heliyon 2024 Mar 30;10(6):e28172
Periplcymarin targets glycolysis and mitochondrial oxidative phosphorylation of esophageal squamous cell carcinoma: Implication in anti-cancer therapy.
Han L, Xiang X, Fu Y, Wei S, Zhang C, Li L, Liu Y, Lv H, Shan B, Zhao L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155539
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155539
The anti-non-small cell lung cancer effect of Diosbulbin B: Targeting YY1 induced cell cycle arrest and apoptosis.
Zhao JQ, Zhou QQ, Sun Y, Yu T, Jiang Y, Li HJ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155734
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155734
Transcriptomics and molecular docking reveal the potential mechanism of lycorine against pancreatic cancer.
Zhou X, Guo Z, Liu S, Chen Z, Wang Y, Yang R, Li X, Ma K
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;122:155128
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;122:155128
Pan-cancer analysis of the tumorigenic role of Fanconi anemia complementation group D2 (FANCD2) in human tumors.
Xie X, Zhao Y, Du F, Cai B, Fang Z, Liu Y, Sang Y, Ma C, Liu Z, Yu X, Zhang C, Jiang J, Gao Z, Liu Y, Lin X, Jing H, Zhong X, Cong L, Dai H, Sha D, Shao N, Feng H, Li L, Liu J, Shang L
Genomics 2024 Jan;116(1):110762
Genomics 2024 Jan;116(1):110762
SNRPB promotes the progression of hepatocellular carcinoma via regulating cell cycle, oxidative stress, and ferroptosis.
Wang X, Zhang H, Guo Z, Wang J, Lu C, Wang J, Jin R, Mo Z
Aging 2024 Jan 5;16(1):348-366
Aging 2024 Jan 5;16(1):348-366
Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells.
Zhu Q, Liang P, Meng H, Li F, Miao W, Chu C, Wang W, Li D, Chen C, Shi Y, Yu X, Ping Y, Niu C, Wu HB, Zhang A, Bian XW, Zhou W
Nature communications 2024 Jan 2;15(1):40
Nature communications 2024 Jan 2;15(1):40
Patulin induces ROS-dependent cardiac cell toxicity by inducing DNA damage and activating endoplasmic reticulum stress apoptotic pathway.
Zhang B, Huang C, Xu D, Huang K, Li Y, Jiao L, Fu B, Li S, Li Y
Ecotoxicology and environmental safety 2024 Jan 1;269:115784
Ecotoxicology and environmental safety 2024 Jan 1;269:115784
Proteolysis Targeting Chimeras (PROTACs) based on celastrol induce multiple protein degradation for triple-negative breast cancer treatment.
Gan X, Wang F, Luo J, Zhao Y, Wang Y, Yu C, Chen J
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2024 Jan 1;192:106624
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2024 Jan 1;192:106624
Aurora kinase A-mediated phosphorylation triggers structural alteration of Rab1A to enhance ER complexity during mitosis.
Zhang W, Zhang Z, Xiang Y, Gu DD, Chen J, Chen Y, Zhai S, Liu Y, Jiang T, Liu C, He B, Yan M, Wang Z, Xu J, Cao YL, Deng B, Zeng D, Lei J, Zhuo J, Lei X, Long Z, Jin B, Chen T, Li D, Shen Y, Hu J, Gao S, Liu Q
Nature structural & molecular biology 2024 Feb;31(2):219-231
Nature structural & molecular biology 2024 Feb;31(2):219-231
Comprehensive analysis of PSMD family members and validation of PSMD9 as a potential therapeutic target in human glioblastoma.
Li Y, Liu X, Zhao F, Zhao Z, Li X, Wang J, Huang B, Chen A
CNS neuroscience & therapeutics 2024 Feb;30(2):e14366
CNS neuroscience & therapeutics 2024 Feb;30(2):e14366
Aurora kinase B disruption suppresses pathological retinal angiogenesis by affecting cell cycle progression.
Zhu W, Gui X, Zhou Y, Gao X, Zhang R, Li Q, Zhang H, Zhao J, Cui X, Gao G, Tang H, Huan C, Pan D, Song H, Zhou Z, Shen W
Experimental eye research 2024 Feb;239:109753
Experimental eye research 2024 Feb;239:109753
Molecular mechanism of human ISG20L2 for the ITS1 cleavage in the processing of 18S precursor ribosomal RNA.
Ma Y, Wang J, He X, Liu Y, Zhen S, An L, Yang Q, Niu F, Wang H, An B, Tai X, Yan Z, Wu C, Yang X, Liu X
Nucleic acids research 2024 Feb 28;52(4):1878-1895
Nucleic acids research 2024 Feb 28;52(4):1878-1895
Kinesin Family Member-18A (KIF18A) Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma.
Ren J, Yao X, Yang M, Cheng S, Wu D, Xu K, Li R, Zhang H, Zhang D
Digestive diseases and sciences 2024 Apr;69(4):1274-1286
Digestive diseases and sciences 2024 Apr;69(4):1274-1286
Liensinine inhibits progression of intrahepatic cholangiocarcinoma by regulating TGF-β1 /P-smad3 signaling through HIF-1a.
Zhu X, Bao W, Xie X, Chen B, Li R, Zhao J, Wu L, Yu Z, Li S, Zhu Q, Chen G, Li J
Molecular carcinogenesis 2024 Apr;63(4):772-784
Molecular carcinogenesis 2024 Apr;63(4):772-784
Corynoxine triggers cell death via activating PP2A and regulating AKT-mTOR/GSK3β axes in NSCLC.
Hou G, Hu W, Sang Y, Gan X, Xu H, Hu Q, Cao X
Biochemical pharmacology 2024 Apr;222:116110
Biochemical pharmacology 2024 Apr;222:116110
Targeting histone demethylases JMJD3 and UTX: selenium as a potential therapeutic agent for cervical cancer.
Chen D, Cai B, Zhu Y, Ma Y, Yu X, Xiong J, Shen J, Tie W, Zhang Y, Guo F
Clinical epigenetics 2024 Apr 4;16(1):51
Clinical epigenetics 2024 Apr 4;16(1):51
GTPBP8 modulates mitochondrial fission through a Drp1-dependent process.
He X, Wang L, Tsang HY, Liu X, Yang X, Pu S, Guo Z, Yang C, Wu Q, Zhou Z, Cen X, Zhao H
Journal of cell science 2024 Apr 15;137(8)
Journal of cell science 2024 Apr 15;137(8)
CGRP Released by Corneal Sensory Nerve Maintains Tear Secretion of the Lacrimal Gland.
Ma L, Yang L, Wang X, Zhao L, Bai X, Qi X, Chen Q, Li Y, Zhou Q
Investigative ophthalmology & visual science 2024 Apr 1;65(4):30
Investigative ophthalmology & visual science 2024 Apr 1;65(4):30
CDKs Functional Analysis in Low Proliferating Early-Stage Pancreatic Ductal Adenocarcinoma.
Zhu S, Yang H, Liu L, Jiang Z, Ji J, Wang X, Zhong L, Liu F, Gao X, Wang H, Zhou Y
Journal of bioinformatics and systems biology : Open access 2023;6(3):187-200
Journal of bioinformatics and systems biology : Open access 2023;6(3):187-200
Nanoengineered Gallium Ion Incorporated Formulation for Safe and Efficient Reversal of PARP Inhibition and Platinum Resistance in Ovarian Cancer.
Li Y, Cen Y, Tu M, Xiang Z, Tang S, Lu W, Zhang H, Xu J
Research (Washington, D.C.) 2023;6:0070
Research (Washington, D.C.) 2023;6:0070
Down-regulation of histone deacetylase 7 reduces biological activities of retinal microvascular endothelial cells under high glucose condition and related mechanism.
Ning JY, Yang HY, Xie TK, Chen YX, Han J
International journal of ophthalmology 2023;16(8):1210-1217
International journal of ophthalmology 2023;16(8):1210-1217
AKIP1 accelerates glioblastoma progression through stabilizing EGFR expression.
Wan S, Liu C, Li C, Wang Z, Zhao G, Li J, Ran W, Zhong X, Li Y, Zhang L, Cui H
Oncogene 2023 Sep;42(39):2905-2918
Oncogene 2023 Sep;42(39):2905-2918
Cooperation of long noncoding RNA LOC100909675 and transcriptional regulator CTCF modulates Cdk1 transcript to control astrocyte proliferation.
Wu R, Lin H, Zhang W, Sun Y, Qian X, Lin G, Ma C, Dong Z, Yu B, Yang L, Liu Y, Liu M
The Journal of biological chemistry 2023 Sep;299(9):105153
The Journal of biological chemistry 2023 Sep;299(9):105153
PUF60 promotes cell cycle and lung cancer progression by regulating alternative splicing of CDC25C.
Xu N, Ren Y, Bao Y, Shen X, Kang J, Wang N, Wang Z, Han X, Li Z, Zuo J, Wei GH, Wang Z, Zong WX, Liu W, Xie G, Wang Y
Cell reports 2023 Sep 26;42(9):113041
Cell reports 2023 Sep 26;42(9):113041
Matrix stiffness induces Drp1-mediated mitochondrial fission through Piezo1 mechanotransduction in human intervertebral disc degeneration.
Ke W, Wang B, Liao Z, Song Y, Li G, Ma L, Wang K, Li S, Hua W, Yang C
Journal of translational medicine 2023 Oct 10;21(1):711
Journal of translational medicine 2023 Oct 10;21(1):711
Rab11-FIP4 interacts with ARF5 to promote cancer stemness in hepatocellular carcinoma.
Song F, Zhang Q, Lu X, Xu T, Hu Q, Hu X, Fan W, Zhang Y, Huang P
Journal of physiology and biochemistry 2023 Nov;79(4):757-770
Journal of physiology and biochemistry 2023 Nov;79(4):757-770
TRIM28 recruits E2F1 to regulate CBX8-mediated cell proliferation and tumor metastasis of ovarian cancer.
Zhang F, Zhu T, Wu C, Shen D, Liu L, Chen X, Guan Y, Ding H, Tong X
Human cell 2023 Nov;36(6):2113-2128
Human cell 2023 Nov;36(6):2113-2128
9-oxo-ODAs suppresses the proliferation of human cervical cancer cells through the inhibition of CDKs and HPV oncoproteins.
Mogi K, Koya Y, Yoshihara M, Sugiyama M, Miki R, Miyamoto E, Fujimoto H, Kitami K, Iyoshi S, Tano S, Uno K, Tamauchi S, Yokoi A, Shimizu Y, Ikeda Y, Yoshikawa N, Niimi K, Yamakita Y, Tomita H, Shibata K, Nawa A, Tomoda Y, Kajiyama H
Scientific reports 2023 Nov 6;13(1):19208
Scientific reports 2023 Nov 6;13(1):19208
Modulation of cell cycle increases CRISPR-mediated homology-directed DNA repair.
Li G, Yang X, Luo X, Wu Z, Yang H
Cell & bioscience 2023 Nov 25;13(1):215
Cell & bioscience 2023 Nov 25;13(1):215
Andrographolide inhibits the proliferation and migration of vascular smooth muscle cells via PI3K/AKT signaling pathway and amino acid metabolism to prevent intimal hyperplasia.
Han J, Tan C, Pan Y, Qu C, Wang Z, Wang S, Wang C, Xu K
European journal of pharmacology 2023 Nov 15;959:176082
European journal of pharmacology 2023 Nov 15;959:176082
Exploring heterogeneity of tumor immune cells and adrenal cells in aldosterone-producing adenomas using single-cell RNA-seq and investigating differences by sex.
Huang J, Qin F, Lai X, Yang T, Yu J, Wei C, Wei L, Li J
Heliyon 2023 Mar;9(3):e14357
Heliyon 2023 Mar;9(3):e14357
Effect of mir-92a-3p on hydroquinone induced changes in human lymphoblastoid cell cycle and apoptosis.
Xuan M, Wu Y, Wang H, Ye Z, Wu H, Chen Y, Yang H, Tang H
Environmental toxicology 2023 Jun;38(6):1420-1430
Environmental toxicology 2023 Jun;38(6):1420-1430
A Potential Anti-Glioblastoma Compound LH20 Induces Apoptosis and Arrest of Human Glioblastoma Cells via CDK4/6 Inhibition.
Wang Y, Li Y, Liu D, Zheng D, Li X, Li C, Huang C, Wang Y, Wang X, Li Q, Xu J
Molecules (Basel, Switzerland) 2023 Jun 28;28(13)
Molecules (Basel, Switzerland) 2023 Jun 28;28(13)
The Natural Alkaloid (-)-N-Hydroxyapiosporamide Suppresses Colorectal Tumor Progression as an NF-κB Pathway Inhibitor by Targeting the TAK1-TRAF6 Complex.
Feng L, Shang RR, Wang XJ, Li L, Li X, Gong YX, Shi LY, Wang JW, Qian ZY, Tan NH, Wang Z
Journal of natural products 2023 Jun 23;86(6):1449-1462
Journal of natural products 2023 Jun 23;86(6):1449-1462
Modified Podophyllotoxin Phenoxyacetamide Phenylacetate Derivatives: Tubulin/AKT1 Dual-Targeting and Potential Anticancer Agents for Human NSCLC.
Lin H, Ai D, Liu Q, Wang X, Gao J, Chen Q, Ruan L, Tao Y, Gao J, Wang L
Journal of natural products 2023 Jul 28;86(7):1844-1854
Journal of natural products 2023 Jul 28;86(7):1844-1854
FGF19 induces the cell cycle arrest at G2-phase in chondrocytes.
Chen H, Li J, Pi C, Guo D, Zhang D, Zhou X, Xie J
Cell death discovery 2023 Jul 15;9(1):250
Cell death discovery 2023 Jul 15;9(1):250
CFNC, a neocryptolepine derivative, inhibited the growth of gastric cancer AGS cells by inhibiting PI3K/AKT signaling pathway.
Ma Y, Xu H, Zhou Z, Tian Y, Du K, Zhang H, Jiang X, Lu J, Niu Y, Tu L, Liu H, Zhu H, Chen P, Liu Y
European journal of pharmacology 2023 Jan 5;938:175408
European journal of pharmacology 2023 Jan 5;938:175408
HDAC7/c-Myc signaling pathway promotes the proliferation and metastasis of choroidal melanoma cells.
Zhang Y, Ding P, Wang Y, Shao C, Guo K, Yang H, Feng Y, Ning J, Pan M, Wang P, Yan X, Ma Z, Han J
Cell death & disease 2023 Jan 18;14(1):38
Cell death & disease 2023 Jan 18;14(1):38
Ganoderma lucidum polysaccharide inhibits HSC activation and liver fibrosis via targeting inflammation, apoptosis, cell cycle, and ECM-receptor interaction mediated by TGF-β/Smad signaling.
Chen C, Chen J, Wang Y, Fang L, Guo C, Sang T, Peng H, Zhao Q, Chen S, Lin X, Wang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154626
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154626
Dual network analysis of transcriptome data for discovery of new therapeutic targets in non-small cell lung cancer.
Bai Y, Zhou L, Zhang C, Guo M, Xia L, Tang Z, Liu Y, Deng S
Oncogene 2023 Dec;42(49):3605-3618
Oncogene 2023 Dec;42(49):3605-3618
Histone demethylase KDM4B accelerates the progression of glioblastoma via the epigenetic regulation of MYC stability.
Wang Z, Cai H, Li Z, Sun W, Zhao E, Cui H
Clinical epigenetics 2023 Dec 13;15(1):192
Clinical epigenetics 2023 Dec 13;15(1):192
Mutations in CCNB3 affect its location thus causing a multiplicity of phenotypes in human oocytes maturation by aberrant CDK1 activity and APC/C activity at different stages.
Wang C, Chen MX, Zhang Y, Bai X, Cao Q, Han J, Zhang N, Zhao C, Ling X, Rui X, Guan Y, Zhang J, Huo R
Journal of ovarian research 2023 Aug 28;16(1):178
Journal of ovarian research 2023 Aug 28;16(1):178
Ubiquitin-specific protease 7 prevents recurrent spontaneous abortion by targeting enhancer of zeste homolog 2 to regulate trophoblast proliferation, apoptosis, migration, and invasion through the Wnt/β-catenin pathway†.
Zhou M, Gao Y, Wu S, Chen J, Ding J, Wang Y, Yang J
Biology of reproduction 2023 Aug 10;109(2):204-214
Biology of reproduction 2023 Aug 10;109(2):204-214
Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions.
Guan T, Li M, Song Y, Chen J, Tang J, Zhang C, Wen Y, Yang X, Huang L, Zhu Y, Wang H, Ding K, Zheng J, Zhang H, Liu T
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Apr;10(11):e2205873
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Apr;10(11):e2205873
HJURP Promotes Malignant Progression and Mediates Sensitivity to Cisplatin and WEE1-inhibitor in Serous Ovarian Cancer.
Dou Z, Qiu C, Zhang X, Yao S, Zhao C, Wang Z, Chu R, Chen J, Chen Z, Li R, Wang K, Liu P, Liu C, Song K, Kong B
International journal of biological sciences 2022;18(3):1188-1210
International journal of biological sciences 2022;18(3):1188-1210
Sinapine Thiocyanate Inhibits the Proliferation and Mobility of Pancreatic Cancer Cells by Up-Regulating GADD45A.
Wang J, Zeng Z, Lei S, Han J, Liao S, Zhang J, Wang L, Dong Y, Li H, Chen T
Journal of Cancer 2022;13(4):1229-1240
Journal of Cancer 2022;13(4):1229-1240
Identification and verification of hub genes associated with the progression of non-small cell lung cancer by integrated analysis.
Mengyan X, Kun D, Xinming J, Yutian W, Yongqian S
Frontiers in pharmacology 2022;13:997842
Frontiers in pharmacology 2022;13:997842
The Natural Product Andrographolide Ameliorates Calcific Aortic Valve Disease by Regulating the Proliferation of Valve Interstitial Cells via the MAPK-ERK Pathway.
Huang Y, Liu M, Liu C, Dong N, Chen L
Frontiers in pharmacology 2022;13:871748
Frontiers in pharmacology 2022;13:871748
Theaflavin-3,3'-Digallate from Black Tea Inhibits Neointima Formation Through Suppression of the PDGFRβ Pathway in Vascular Smooth Muscle Cells.
Wu Y, Chen M, Chen Z, Shu J, Zhang L, Hu J, Yu H, Huang K, Liang M
Frontiers in pharmacology 2022;13:861319
Frontiers in pharmacology 2022;13:861319
Narciclasine inhibits phospholipase A2 and regulates phospholipid metabolism to ameliorate psoriasis-like dermatitis.
Kong Y, Jiang J, Huang Y, Liu X, Jin Z, Li L, Wei F, Liu X, Yin J, Zhang Y, Tong Q, Chen H
Frontiers in immunology 2022;13:1094375
Frontiers in immunology 2022;13:1094375
A four oxidative stress gene prognostic model and integrated immunity-analysis in pancreatic adenocarcinoma.
Wang H, Tian RF, Liang X, Fan J, Duan ZC, Fan XY, Zhang JJ, Yao DS, Chen ZN, Li L
Frontiers in oncology 2022;12:1015042
Frontiers in oncology 2022;12:1015042
SMARCE1 promotes neuroblastoma tumorigenesis through assisting MYCN-mediated transcriptional activation.
Hu X, Liu R, Hou J, Peng W, Wan S, Xu M, Li Y, Zhang G, Zhai X, Liang P, Cui H
Oncogene 2022 Sep;41(37):4295-4306
Oncogene 2022 Sep;41(37):4295-4306
Osteoblastic protein kinase D1 contributes to the prostate cancer cells dormancy via GAS6-circadian clock signaling.
Li G, Fan M, Zheng Z, Zhang Y, Zhang Z, Huang Z, Luo W, Zhao W, Lai X, Chen H, Zeng F, Deng F
Biochimica et biophysica acta. Molecular cell research 2022 Sep;1869(9):119296
Biochimica et biophysica acta. Molecular cell research 2022 Sep;1869(9):119296
Fibroblast growth factor 21, a stress regulator, inhibits Drp1 activation to alleviate skeletal muscle ischemia/reperfusion injury.
Li B, Liu L
Laboratory investigation; a journal of technical methods and pathology 2022 Sep;102(9):979-988
Laboratory investigation; a journal of technical methods and pathology 2022 Sep;102(9):979-988
Activation of the Chemokine Receptor CCR1 and Preferential Recruitment of Gαi Suppress RSV Replication: Implications for Developing Novel Respiratory Syncytial Virus Treatment Strategies.
Li J, Xue L, Wang J, Meng A, Qiao J, Li M, Wang X, Meng L, Ning J, Gao X, Li W, Ma C, Wei L
Journal of virology 2022 Nov 23;96(22):e0130922
Journal of virology 2022 Nov 23;96(22):e0130922
Cholecystectomy promotes colon carcinogenesis by activating the Wnt signaling pathway by increasing the deoxycholic acid level.
Yao Y, Li X, Xu B, Luo L, Guo Q, Wang X, Sun L, Zhang Z, Li P
Cell communication and signaling : CCS 2022 May 25;20(1):71
Cell communication and signaling : CCS 2022 May 25;20(1):71
Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells.
Zhang J, Gan Y, Li H, Yin J, He X, Lin L, Xu S, Fang Z, Kim BW, Gao L, Ding L, Zhang E, Ma X, Li J, Li L, Xu Y, Horne D, Xu R, Yu H, Gu Y, Huang W
Nature communications 2022 May 20;13(1):2835
Nature communications 2022 May 20;13(1):2835
An advanced network pharmacology study to explore the novel molecular mechanism of Compound Kushen Injection for treating hepatocellular carcinoma by bioinformatics and experimental verification.
Lu S, Meng Z, Tan Y, Wu C, Huang Z, Huang J, Fu C, Stalin A, Guo S, Liu X, You L, Li X, Zhang J, Zhou W, Zhang X, Wang M, Wu J
BMC complementary medicine and therapies 2022 Mar 2;22(1):54
BMC complementary medicine and therapies 2022 Mar 2;22(1):54
HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathway.
Guo K, Ma Z, Zhang Y, Han L, Shao C, Feng Y, Gao F, Di S, Zhang Z, Zhang J, Tabbò F, Ekman S, Suda K, Cappuzzo F, Han J, Li X, Yan X
Journal of experimental & clinical cancer research : CR 2022 Mar 11;41(1):91
Journal of experimental & clinical cancer research : CR 2022 Mar 11;41(1):91
Emodin-8-O-β-D-glucopyranoside, a natural hydroxyanthraquinone glycoside from plant, suppresses cancer cell proliferation via p21-CDKs-Rb axis.
Li Y, Li K, Zhao Y, Li Y, Li D, Shen L, Wang Q, Yang HS, Sun Z
Toxicology and applied pharmacology 2022 Mar 1;438:115909
Toxicology and applied pharmacology 2022 Mar 1;438:115909
ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination.
Geng S, Peng W, Wang X, Hu X, Liang H, Hou J, Wang F, Zhao G, Lü M, Cui H
Cell death & disease 2022 Jun 22;13(6):564
Cell death & disease 2022 Jun 22;13(6):564
The Therapeutic Role of PNU-74654 in Hepatocellular Carcinoma May Involve Suppression of NF-κB Signaling.
Wu MY, Wang CC, Chang YC, Yu CY, Sung WW, Chen CJ, Tsai MC
Medicina (Kaunas, Lithuania) 2022 Jun 14;58(6)
Medicina (Kaunas, Lithuania) 2022 Jun 14;58(6)
Disruption of mitochondrial redox homeostasis as a mechanism of antimony-induced reactive oxygen species and cytotoxicity.
Su L, Fang W, Zhao X, Zhu L, Gao L, Chen G
Ecotoxicology and environmental safety 2022 Jun 1;237:113519
Ecotoxicology and environmental safety 2022 Jun 1;237:113519
Inhibition of CDK1 attenuates neuronal apoptosis and autophagy and confers neuroprotection after chronic spinal cord injury in vivo.
Nie BX, Zhao G, Yuan XF, Yu LX, Zhang J, Yuan Y, Liu Y, Hu J, Song E, Zhou YC, Shu J
Journal of chemical neuroanatomy 2022 Jan;119:102053
Journal of chemical neuroanatomy 2022 Jan;119:102053
SPOCK1 promotes metastasis in pancreatic cancer via NF-κB-dependent epithelial-mesenchymal transition by interacting with IκB-α.
Cui X, Wang Y, Lan W, Wang S, Cui Y, Zhang X, Lin Z, Piao J
Cellular oncology (Dordrecht, Netherlands) 2022 Feb;45(1):69-84
Cellular oncology (Dordrecht, Netherlands) 2022 Feb;45(1):69-84
Corynoxine suppresses pancreatic cancer growth primarily via ROS-p38 mediated cytostatic effects.
Wen C, Ruan Q, Li Z, Zhou X, Yang X, Xu P, Akuetteh PDP, Xu Z, Deng J
British journal of cancer 2022 Dec;127(12):2108-2117
British journal of cancer 2022 Dec;127(12):2108-2117
SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis.
Guo S, Lei X, Chang Y, Zhao J, Wang J, Dong X, Liu Q, Zhang Z, Wang L, Yi D, Ma L, Li Q, Zhang Y, Ding J, Liang C, Li X, Guo F, Wang J, Cen S
Signal transduction and targeted therapy 2022 Dec 27;7(1):400
Signal transduction and targeted therapy 2022 Dec 27;7(1):400
Epithelial cells-enriched lncRNA SNHG8 regulates chromatin condensation by binding to Histone H1s.
He P, Zhang C, Ji Y, Ge MK, Yu Y, Zhang N, Yang S, Yu JX, Shen SM, Chen GQ
Cell death and differentiation 2022 Aug;29(8):1569-1581
Cell death and differentiation 2022 Aug;29(8):1569-1581
Dematin inhibits glioblastoma malignancy through RhoA-mediated CDKs downregulation and cytoskeleton remodeling.
Wang M, Chen B, Zhang W, Zhang F, Qiu Y, Lin Y, Yang S
Experimental cell research 2022 Aug 1;417(1):113196
Experimental cell research 2022 Aug 1;417(1):113196
Bolbostemma paniculatum (Maxim.) Franquet extract suppresses the development of colorectal cancer through downregulation of PI3K/Akt pathway.
Li Y, Sun Y, Zhang Q, Liu Y, Niu Y, Li X, Cai D
Journal of ethnopharmacology 2022 Apr 6;287:114937
Journal of ethnopharmacology 2022 Apr 6;287:114937
MCC Regulator of WNT Signaling Pathway (MCC) Is a Podocyte Essential Gene.
Song H, Zhuang L, Xu X, Shi J, Hu W, Liu Z, Shi S
Frontiers in medicine 2021;8:777563
Frontiers in medicine 2021;8:777563
MiR-490-3p Silences CDK1 and Inhibits the Proliferation of Colon Cancer Through an LLPS-Dependent miRISC System.
Qin D, Wei R, Zhu S, Min L, Zhang S
Frontiers in molecular biosciences 2021;8:561678
Frontiers in molecular biosciences 2021;8:561678
Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways.
Hu Z, Wang H, Fu Y, Ma K, Ma X, Wang J
Nutrition and cancer 2021;73(8):1459-1470
Nutrition and cancer 2021;73(8):1459-1470
CircMETTL3, upregulated in a m6A-dependent manner, promotes breast cancer progression.
Li Z, Yang HY, Dai XY, Zhang X, Huang YZ, Shi L, Wei JF, Ding Q
International journal of biological sciences 2021;17(5):1178-1190
International journal of biological sciences 2021;17(5):1178-1190
Magnesium-Assisted Cisplatin Inhibits Bladder Cancer Cell Survival by Modulating Wnt/β-Catenin Signaling Pathway.
Li T, Tang Z, Li C, Liu X, Cheng L, Yang Z, Zhu X, Liu W, Huang Y
Frontiers in pharmacology 2021;12:804615
Frontiers in pharmacology 2021;12:804615
Sempervirine Mediates Autophagy and Apoptosis via the Akt/mTOR Signaling Pathways in Glioma Cells.
Li G, Zhong Y, Wang W, Jia X, Zhu H, Jiang W, Song Y, Xu W, Wu S
Frontiers in pharmacology 2021;12:770667
Frontiers in pharmacology 2021;12:770667
Lycorine hydrochloride inhibits melanoma cell proliferation, migration and invasion via down-regulating p21(Cip1/WAF1).
Shi S, Li C, Zhang Y, Deng C, Tan M, Pan G, Du J, Ji Y, Li Q, Liang H, Liu W, Guo L, Zhao G, Liu Y, Cui H
American journal of cancer research 2021;11(4):1391-1409
American journal of cancer research 2021;11(4):1391-1409
PRCC-TFE3 fusion-mediated PRKN/parkin-dependent mitophagy promotes cell survival and proliferation in PRCC-TFE3 translocation renal cell carcinoma.
Wang B, Yin X, Gan W, Pan F, Li S, Xiang Z, Han X, Li D
Autophagy 2021 Sep;17(9):2475-2493
Autophagy 2021 Sep;17(9):2475-2493
Methylation of TMEM176A, a key ERK signaling regulator, is a novel synthetic lethality marker of ATM inhibitors in human lung cancer.
Li H, Yang W, Zhang M, He T, Zhou F, G Herman J, Hu L, Guo M
Epigenomics 2021 Sep;13(17):1403-1419
Epigenomics 2021 Sep;13(17):1403-1419
Rubioncolin C, a natural naphthohydroquinone dimer isolated from Rubia yunnanensis, inhibits the proliferation and metastasis by inducing ROS-mediated apoptotic and autophagic cell death in triple-negative breast cancer cells.
Li L, Wang J, Feng L, Fan J, Wang J, Tan N, Wang Z
Journal of ethnopharmacology 2021 Sep 15;277:114184
Journal of ethnopharmacology 2021 Sep 15;277:114184
Characteristics and clinical significance of polyploid giant cancer cells in laryngeal carcinoma.
Liu HT, Xia T, You YW, Zhang QC, Ni HS, Liu YF, Liu YR, Xu YQ, You B, Zhang ZX
Laryngoscope investigative otolaryngology 2021 Oct;6(5):1228-1234
Laryngoscope investigative otolaryngology 2021 Oct;6(5):1228-1234
Design, synthesis and antitumor evaluation of novel chiral diaryl substituted azetidin-2-one derivatives as tubulin polymerization inhibitors.
Liang Y, Zhang M, Zhou P, Liu M, Li J, Wang Y
Bioorganic chemistry 2021 Oct;115:105239
Bioorganic chemistry 2021 Oct;115:105239
Inhibition of ubiquitin-specific protease 13-mediated degradation of Raf1 kinase by Spautin-1 has opposing effects in naïve and primed pluripotent stem cells.
Wang X, Wang X, Zhang X, Zhang Y, Zhu Z, Li Y, Zhang M, Ji J, Yu Y, Ye SD
The Journal of biological chemistry 2021 Nov;297(5):101332
The Journal of biological chemistry 2021 Nov;297(5):101332
The anti-neoplastic activities of aloperine in HeLa cervical cancer cells are associated with inhibition of the IL-6-JAK1-STAT3 feedback loop.
Chen YD, Cai FY, Mao YZ, Yang YS, Xu K, Liu XF, Fan WW, Chen W, Jiang FQ, Zhang H
Chinese journal of natural medicines 2021 Nov;19(11):815-824
Chinese journal of natural medicines 2021 Nov;19(11):815-824
The Y14-p53 regulatory circuit in megakaryocyte differentiation and thrombocytopenia.
Su CH, Liao WJ, Ke WC, Yang RB, Tarn WY
iScience 2021 Nov 19;24(11):103368
iScience 2021 Nov 19;24(11):103368
Long intergenic non-coding RNA 00473 promotes proliferation and migration of gastric cancer via the miR-16-5p/CCND2 axis and by regulating AQP3.
Zhuo S, Sun M, Bai R, Lu D, Di S, Ma T, Zou Z, Li H, Zhang Z
Cell death & disease 2021 May 15;12(5):496
Cell death & disease 2021 May 15;12(5):496
Overexpression of MYBL2 predicts poor prognosis and promotes oncogenesis in endometrial carcinoma.
Le L, Luo J, Wu H, Chen L, Tang X, Fu F
European journal of histochemistry : EJH 2021 Mar 30;65(2)
European journal of histochemistry : EJH 2021 Mar 30;65(2)
Knockdown of SASS6 reduces growth of MDA‑MB‑231 triple‑negative breast cancer cells through arrest of the cell cycle at the G2/M phase.
Du L, Jing J, Wang Y, Xu X, Sun T, Shi Y, Wang W, Tian B, Han C, Zhao X, Chang H
Oncology reports 2021 Jun;45(6)
Oncology reports 2021 Jun;45(6)
DNA methylation mediated RSPO2 to promote follicular development in mammals.
Zhou X, He Y, Li N, Bai G, Pan X, Zhang Z, Zhang H, Li J, Yuan X
Cell death & disease 2021 Jun 26;12(7):653
Cell death & disease 2021 Jun 26;12(7):653
NT5DC2 promotes leiomyosarcoma tumour cell growth via stabilizing unpalmitoylated TEAD4 and generating a positive feedback loop.
Hu B, Zhou S, Hu X, Zhang H, Lan X, Li M, Wang Y, Hu Q
Journal of cellular and molecular medicine 2021 Jul;25(13):5976-5987
Journal of cellular and molecular medicine 2021 Jul;25(13):5976-5987
VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, induces cell cycle arrest and apoptosis in breast cancer cells by inhibiting the Wnt/β-catenin pathway.
Li H, Dang C, Tai X, Xue L, Meng Y, Ma S, Zhang J
Scientific reports 2021 Jul 22;11(1):14985
Scientific reports 2021 Jul 22;11(1):14985
miR-937-5p targets SOX17 to modulate breast cancer cell cycle and cell proliferation through the Wnt signaling pathway.
Xiong X, Xu W, Gong J, Wang L, Dai M, Chen G, Yuan L
Cellular signalling 2021 Jan;77:109818
Cellular signalling 2021 Jan;77:109818
Avasimibe exerts anticancer effects on human glioblastoma cells via inducing cell apoptosis and cell cycle arrest.
Liu JY, Fu WQ, Zheng XJ, Li W, Ren LW, Wang JH, Yang C, Du GH
Acta pharmacologica Sinica 2021 Jan;42(1):97-107
Acta pharmacologica Sinica 2021 Jan;42(1):97-107
Circ-NOLC1 promotes epithelial ovarian cancer tumorigenesis and progression by binding ESRP1 and modulating CDK1 and RhoA expression.
Chen S, Wu W, Li QH, Xie BM, Shen F, Du YP, Zong ZH, Wang LL, Wei XQ, Zhao Y
Cell death discovery 2021 Jan 22;7(1):22
Cell death discovery 2021 Jan 22;7(1):22
β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma.
Lu Y, Li X, Liu H, Xue J, Zeng Z, Dong X, Zhang T, Wu G, Yang K, Xu S
Oncogene 2021 Feb;40(7):1269-1283
Oncogene 2021 Feb;40(7):1269-1283
Inhibition of bone morphogenetic protein receptor 2 suppresses pancreatic ductal adenocarcinoma growth by regulating GRB2/PI3K/AKT axis.
Wang Y, Guo H, Zhang Z, Wang Q, Tian X, Yang Y
Annals of translational medicine 2021 Apr;9(7):557
Annals of translational medicine 2021 Apr;9(7):557
Glaucocalyxin A induces cell cycle arrest and apoptosis via inhibiting NF-κB/p65 signaling pathway in melanoma cells.
Chen J, Zhang W, Pan C, Fan J, Zhong X, Tang S
Life sciences 2021 Apr 15;271:119185
Life sciences 2021 Apr 15;271:119185
Oncogenic action of the exosome cofactor RBM7 by stabilization of CDK1 mRNA in breast cancer.
Xi PW, Zhang X, Zhu L, Dai XY, Cheng L, Hu Y, Shi L, Wei JF, Ding Q
NPJ breast cancer 2020;6:58
NPJ breast cancer 2020;6:58
Ethanol extract of Ophiorrhiza pumila suppresses liver cancer cell proliferation and migration.
Liu H, Liao W, Fan L, Zheng Z, Liu D, Zhang QW, Yang A, Liu F
Chinese medicine 2020;15:11
Chinese medicine 2020;15:11
The Acetone Indigo Red Dehydrating Agent IF203 Induces HepG2 Cell Death Through Cell Cycle Arrest, Autophagy and Apoptosis.
Shang Y, Wang Q, Li J, Zhao Q, Huang X, Dong H, Liu H, Zhang Y, Zhang J, Gui R, Nie X
OncoTargets and therapy 2020;13:473-486
OncoTargets and therapy 2020;13:473-486
Ursolic Acid Regulates Cell Cycle and Proliferation in Colon Adenocarcinoma by Suppressing Cyclin B1.
Yang M, Hu C, Cao Y, Liang W, Yang X, Xiao T
Frontiers in pharmacology 2020;11:622212
Frontiers in pharmacology 2020;11:622212
Grape Seed Proanthocyanidins Induce Apoptosis and Cell Cycle Arrest of HepG2 Cells Accompanied by Induction of the MAPK Pathway and NAG-1.
Wang L, Zhan J, Huang W
Antioxidants (Basel, Switzerland) 2020 Nov 28;9(12)
Antioxidants (Basel, Switzerland) 2020 Nov 28;9(12)
MicroRNA‑145‑5p inhibits osteosarcoma cell proliferation by targeting E2F transcription factor 3.
Li H, Pan R, Lu Q, Ren C, Sun J, Wu H, Wen J, Chen H
International journal of molecular medicine 2020 May;45(5):1317-1326
International journal of molecular medicine 2020 May;45(5):1317-1326
CDK1-PLK1/SGOL2/ANLN pathway mediating abnormal cell division in cell cycle may be a critical process in hepatocellular carcinoma.
Li L, Huang K, Zhao H, Chen B, Ye Q, Yue J
Cell cycle (Georgetown, Tex.) 2020 May;19(10):1236-1252
Cell cycle (Georgetown, Tex.) 2020 May;19(10):1236-1252
Pulp stem cells with hepatocyte growth factor overexpression exhibit dual effects in rheumatoid arthritis.
Dong X, Kong F, Liu C, Dai S, Zhang Y, Xiao F, Zhang H, Wu CT, Wang H
Stem cell research & therapy 2020 Jun 10;11(1):229
Stem cell research & therapy 2020 Jun 10;11(1):229
Development and validation of a five-gene model to predict postoperative brain metastasis in operable lung adenocarcinoma.
Fu F, Zhang Y, Gao Z, Zhao Y, Wen Z, Han H, Li Y, Chen H
International journal of cancer 2020 Jul 15;147(2):584-592
International journal of cancer 2020 Jul 15;147(2):584-592
HOTAIR-EZH2 inhibitor AC1Q3QWB upregulates CWF19L1 and enhances cell cycle inhibition of CDK4/6 inhibitor palbociclib in glioma.
Shi J, Lv S, Wu M, Wang X, Deng Y, Li Y, Li K, Zhao H, Zhu X, Ye M
Clinical and translational medicine 2020 Jan;10(1):182-198
Clinical and translational medicine 2020 Jan;10(1):182-198
SPOCK1/SIX1axis promotes breast cancer progression by activating AKT/mTOR signaling.
Xu M, Zhang X, Zhang S, Piao J, Yang Y, Wang X, Lin Z
Aging 2020 Dec 3;13(1):1032-1050
Aging 2020 Dec 3;13(1):1032-1050
S119N Mutation of the E3 Ubiquitin Ligase SPOP Suppresses SLC7A1 Degradation to Regulate Hepatoblastoma Progression.
He W, Zhang J, Liu B, Liu X, Liu G, Xie L, He J, Wei M, Li K, Ma J, Dong R, Ma D, Dong K, Ye M
Molecular therapy oncolytics 2020 Dec 16;19:149-162
Molecular therapy oncolytics 2020 Dec 16;19:149-162
Apolipoprotein E2 modulates cell cycle function to promote proliferation in pancreatic cancer cells via regulation of the c-Myc-p21(Waf1) signalling pathway.
Du S, Wang H, Cai J, Ren R, Zhang W, Wei W, Shen X
Biochemistry and cell biology = Biochimie et biologie cellulaire 2020 Apr;98(2):191-202
Biochemistry and cell biology = Biochimie et biologie cellulaire 2020 Apr;98(2):191-202
Potent USP10/13 antagonist spautin-1 suppresses melanoma growth via ROS-mediated DNA damage and exhibits synergy with cisplatin.
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Journal of cellular and molecular medicine 2020 Apr;24(7):4324-4340
Journal of cellular and molecular medicine 2020 Apr;24(7):4324-4340
Effects of selenium on the proliferation and apoptosis of sheep spermatogonial stem cells in vitro.
Shi L, Duan Y, Yao X, Song R, Ren Y
Animal reproduction science 2020 Apr;215:106330
Animal reproduction science 2020 Apr;215:106330
Prognostic implications and oncogenic roles of MYBL2 protein expression in esophageal squamous-cell carcinoma.
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OncoTargets and therapy 2019;12:1917-1927
OncoTargets and therapy 2019;12:1917-1927
Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma.
Peng J, Sun BF, Chen CY, Zhou JY, Chen YS, Chen H, Liu L, Huang D, Jiang J, Cui GS, Yang Y, Wang W, Guo D, Dai M, Guo J, Zhang T, Liao Q, Liu Y, Zhao YL, Han DL, Zhao Y, Yang YG, Wu W
Cell research 2019 Sep;29(9):725-738
Cell research 2019 Sep;29(9):725-738
CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity.
Sang Y, Li Y, Zhang Y, Alvarez AA, Yu B, Zhang W, Hu B, Cheng SY, Feng H
Nature communications 2019 Sep 5;10(1):4013
Nature communications 2019 Sep 5;10(1):4013
Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis.
Li N, Piao J, Wang X, Kim KY, Bae JY, Ren X, Lin Z
Cancer research and treatment 2019 Oct;51(4):1653-1665
Cancer research and treatment 2019 Oct;51(4):1653-1665
Characterization of Protein Profiling and mRNA Expression of LLC Exosomes.
Zhang W, He P, Wang S, Adili A, Chen Z, Zhang CY, Jiang X, Li J, Zhang Y
The protein journal 2019 Oct;38(5):586-597
The protein journal 2019 Oct;38(5):586-597
CyclinB1 deubiquitination by USP14 regulates cell cycle progression in breast cancer.
Liu B, Liu Y, Wang Y, Xie C, Gan M, Han T, Cao J, Wang J
Pathology, research and practice 2019 Oct;215(10):152592
Pathology, research and practice 2019 Oct;215(10):152592
Cyclin-dependent kinase 1 disruption inhibits angiogenesis by inducing cell cycle arrest and apoptosis.
Gao X, Zhang Y, Zhang R, Zhao Z, Zhang H, Wu J, Shen W, Zhong M
Experimental and therapeutic medicine 2019 Oct;18(4):3062-3070
Experimental and therapeutic medicine 2019 Oct;18(4):3062-3070
O-GlcNAcylation of Thr(12)/Ser(56) in short-form O-GlcNAc transferase (sOGT) regulates its substrate selectivity.
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The Journal of biological chemistry 2019 Nov 8;294(45):16620-16633
The Journal of biological chemistry 2019 Nov 8;294(45):16620-16633
A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer.
Wang Y, Han T, Gan M, Guo M, Xie C, Jin J, Zhang S, Wang P, Cao J, Wang JB
Cell cycle (Georgetown, Tex.) 2019 May;18(9):1019-1032
Cell cycle (Georgetown, Tex.) 2019 May;18(9):1019-1032
Lin28 promotes dental pulp cell proliferation via upregulation of cyclin-dependent proteins and interaction with let-7a/IGF2BP2 pathways.
Liu Y, Dong N, Miao J, Li C, Wang X, Ruan J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 May;113:108742
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 May;113:108742
RA-XII Suppresses the Development and Growth of Liver Cancer by Inhibition of Lipogenesis via SCAP-dependent SREBP Supression.
Guo D, Wang Y, Wang J, Song L, Wang Z, Mao B, Tan N
Molecules (Basel, Switzerland) 2019 May 12;24(9)
Molecules (Basel, Switzerland) 2019 May 12;24(9)
MiR-31-5p acts as a tumor suppressor in renal cell carcinoma by targeting cyclin-dependent kinase 1 (CDK1).
Li Y, Quan J, Chen F, Pan X, Zhuang C, Xiong T, Zhuang C, Li J, Huang X, Ye J, Zhang F, Zhang Z, Gui Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Mar;111:517-526
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Mar;111:517-526
Inhibition of Wee1 sensitizes AML cells to ATR inhibitor VE-822-induced DNA damage and apoptosis.
Qi W, Xu X, Wang M, Li X, Wang C, Sun L, Zhao D, Sun L
Biochemical pharmacology 2019 Jun;164:273-282
Biochemical pharmacology 2019 Jun;164:273-282
Agenesis and Hypomyelination of Corpus Callosum in Mice Lacking Nsun5, an RNA Methyltransferase.
Yuan Z, Chen P, Zhang T, Shen B, Chen L
Cells 2019 Jun 6;8(6)
Cells 2019 Jun 6;8(6)
High expression of CDK1 and BUB1 predicts poor prognosis of pancreatic ductal adenocarcinoma.
Piao J, Zhu L, Sun J, Li N, Dong B, Yang Y, Chen L
Gene 2019 Jun 15;701:15-22
Gene 2019 Jun 15;701:15-22
Apoptosis induced by ursodeoxycholic acid in human melanoma cells through the mitochondrial pathway.
Yu H, Fu QR, Huang ZJ, Lin JY, Chen QX, Wang Q, Shen DY
Oncology reports 2019 Jan;41(1):213-223
Oncology reports 2019 Jan;41(1):213-223
Effect of ingredients from Chinese herbs on enterovirus D68 production.
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Phytotherapy research : PTR 2019 Jan;33(1):174-186
Shuttling SLC2A4RG is regulated by 14-3-3θ to modulate cell survival via caspase-3 and caspase-6 in human glioma.
Yun D, Wang H, Wang Y, Chen Y, Zhao Z, Ma J, Ji Y, Huang Q, Chen J, Chen H, Lu D
EBioMedicine 2019 Feb;40:163-175
EBioMedicine 2019 Feb;40:163-175
BECN1 promotes the migration of NSCLC cells through regulating the ubiquitination of Vimentin.
Cheng Z, Xin H, Han T
Cell adhesion & migration 2019 Dec;13(1):249-259
Cell adhesion & migration 2019 Dec;13(1):249-259
Long non-coding RNA miR143HG predicts good prognosis and inhibits tumor multiplication and metastasis by suppressing mitogen-activated protein kinase and Wnt signaling pathways in hepatocellular carcinoma.
Lin X, Xiaoqin H, Jiayu C, Li F, Yue L, Ximing X
Hepatology research : the official journal of the Japan Society of Hepatology 2019 Aug;49(8):902-918
Hepatology research : the official journal of the Japan Society of Hepatology 2019 Aug;49(8):902-918
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Wang Y, Lv Y, Liu TS, Yan WD, Chen LY, Li ZH, Piao YS, An RB, Lin ZH, Ren XS
Life sciences 2019 Apr 15;223:110-119
Life sciences 2019 Apr 15;223:110-119
Overexpression of Annexin A2 Receptor Inhibits Neovascularization via the Promotion of Krüppel-Like Transcription Factor 2.
Guo T, Song H, Zhao Z, Qi Z, Zhao S
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(4):1617-1627
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Biocompatible PEGylated Gold nanorods function As cytokinesis inhibitors to suppress angiogenesis.
Song H, Guo T, Zhao Z, Wei Y, Luo H, Weng W, Zhang R, Zhong M, Chen C, Su J, Shen W
Biomaterials 2018 Sep;178:23-35
Biomaterials 2018 Sep;178:23-35
Co-culture with TM4 cells enhances the proliferation and migration of rat adipose-derived mesenchymal stem cells with high stemness.
Luo Y, Mohsin A, Xu C, Wang Q, Hang H, Zhuang Y, Chu J, Guo M
Cytotechnology 2018 Oct;70(5):1409-1422
Cytotechnology 2018 Oct;70(5):1409-1422
Yes-associated protein promotes the abnormal proliferation of psoriatic keratinocytes via an amphiregulin dependent pathway.
Jia J, Li C, Yang J, Wang X, Li R, Luo S, Li Z, Liu J, Liu Z, Zheng Y
Scientific reports 2018 Oct 15;8(1):14513
Scientific reports 2018 Oct 15;8(1):14513
Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells.
Chen X, Liu C, Zhao R, Zhao P, Wu J, Zhou N, Ying M
Molecular pharmaceutics 2018 Nov 5;15(11):4974-4984
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UBAP2L silencing inhibits cell proliferation and G2/M phase transition in breast cancer.
He J, Chen Y, Cai L, Li Z, Guo X
Breast cancer (Tokyo, Japan) 2018 Mar;25(2):224-232
Breast cancer (Tokyo, Japan) 2018 Mar;25(2):224-232
CDKN1C (P57): one of the determinants of human endometrial stromal cell decidualization.
Wang L, Yang H, Hu L, Hu D, Ma S, Sun X, Jiang L, Song J, Ji L, Masau JF, Zhang H, Qian K
Biology of reproduction 2018 Mar 1;98(3):277-285
Biology of reproduction 2018 Mar 1;98(3):277-285
3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase.
Li W, Liu J, Fu W, Zheng X, Ren L, Liu S, Wang J, Ji T, Du G
Journal of experimental & clinical cancer research : CR 2018 Jul 3;37(1):132
Journal of experimental & clinical cancer research : CR 2018 Jul 3;37(1):132
Involvement of mitochondrial fission in calcium sensing receptor-mediated vascular smooth muscle cells proliferation during hypertension.
Zhang X, Chen W, Li J, Qi S, Hong S, Wang Y, Gao L, Shi Z, Liu Y, Liu W, Chi Y, Liu C, Fu Y, Yin X
Biochemical and biophysical research communications 2018 Jan 1;495(1):454-460
Biochemical and biophysical research communications 2018 Jan 1;495(1):454-460
LncRNA ABHD11-AS1 promotes the development of endometrial carcinoma by targeting cyclin D1.
Liu Y, Wang LL, Chen S, Zong ZH, Guan X, Zhao Y
Journal of cellular and molecular medicine 2018 Aug;22(8):3955-3964
Journal of cellular and molecular medicine 2018 Aug;22(8):3955-3964
Cancer-testis specific gene OIP5: a downstream gene of E2F1 that promotes tumorigenesis and metastasis in glioblastoma by stabilizing E2F1 signaling.
He J, Zhao Y, Zhao E, Wang X, Dong Z, Chen Y, Yang L, Cui H
Neuro-oncology 2018 Aug 2;20(9):1173-1184
Neuro-oncology 2018 Aug 2;20(9):1173-1184
The enhancement of siPLK1 penetration across BBB and its anti glioblastoma activity in vivo by magnet and transferrin co-modified nanoparticle.
Liu DZ, Cheng Y, Cai RQ, Wang Bd WW, Cui H, Liu M, Zhang BL, Mei QB, Zhou SY
Nanomedicine : nanotechnology, biology, and medicine 2018 Apr;14(3):991-1003
Nanomedicine : nanotechnology, biology, and medicine 2018 Apr;14(3):991-1003
Silencing HOXD10 by promoter region hypermethylation activates ERK signaling in hepatocellular carcinoma.
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Clinical epigenetics 2017;9:116
Clinical epigenetics 2017;9:116
Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-κB/COX-2 signaling pathways.
Zhao J, Zhu J, Lv X, Xing J, Liu S, Chen C, Xu Y
OncoTargets and therapy 2017;10:5471-5482
OncoTargets and therapy 2017;10:5471-5482
2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino) phenyl carbamoylsulfanyl] propionic acid, a glutathione reductase inhibitor, induces G(2)/M cell cycle arrest through generation of thiol oxidative stress in human esophageal cancer cells.
Li X, Jiang Z, Feng J, Zhang X, Wu J, Chen W
Oncotarget 2017 Sep 22;8(37):61846-61860
Oncotarget 2017 Sep 22;8(37):61846-61860
DLEU1 contributes to ovarian carcinoma tumourigenesis and development by interacting with miR-490-3p and altering CDK1 expression.
Wang LL, Sun KX, Wu DD, Xiu YL, Chen X, Chen S, Zong ZH, Sang XB, Liu Y, Zhao Y
Journal of cellular and molecular medicine 2017 Nov;21(11):3055-3065
Journal of cellular and molecular medicine 2017 Nov;21(11):3055-3065
The transcription factor FOXA1 induces epithelial ovarian cancer tumorigenesis and progression.
Wang LL, Xiu YL, Chen X, Sun KX, Chen S, Wu DD, Liu BL, Zhao Y
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 May;39(5):1010428317706210
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 May;39(5):1010428317706210
Osthole inhibits the tumorigenesis of hepatocellular carcinoma cells.
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Oncology reports 2017 Mar;37(3):1611-1618
Oncology reports 2017 Mar;37(3):1611-1618
Ginsenoside PPD's Antitumor Effect via Down-Regulation of mTOR Revealed by Super-Resolution Imaging.
Teng B, Jiang J, Zhao L, Gao J, Chen J, Liu Z, Wang H, Lu B
Molecules (Basel, Switzerland) 2017 Mar 19;22(3)
Molecules (Basel, Switzerland) 2017 Mar 19;22(3)
SNORD47, a box C/D snoRNA, suppresses tumorigenesis in glioblastoma.
Xu B, Ye MH, Lv SG, Wang QX, Wu MJ, Xiao B, Kang CS, Zhu XG
Oncotarget 2017 Jul 4;8(27):43953-43966
Oncotarget 2017 Jul 4;8(27):43953-43966
Anthocyanins from Black Chokeberry (Aroniamelanocarpa Elliot) Delayed Aging-Related Degenerative Changes of Brain.
Wei J, Zhang G, Zhang X, Xu D, Gao J, Fan J, Zhou Z
Journal of agricultural and food chemistry 2017 Jul 26;65(29):5973-5984
Journal of agricultural and food chemistry 2017 Jul 26;65(29):5973-5984
The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD.
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Toxicology letters 2017 Jan 4;265:131-139
Toxicology letters 2017 Jan 4;265:131-139
Knockdown of PYCR1 inhibits cell proliferation and colony formation via cell cycle arrest and apoptosis in prostate cancer.
Zeng T, Zhu L, Liao M, Zhuo W, Yang S, Wu W, Wang D
Medical oncology (Northwood, London, England) 2017 Feb;34(2):27
Medical oncology (Northwood, London, England) 2017 Feb;34(2):27
ICT1 knockdown inhibits breast cancer cell growth via induction of cell cycle arrest and apoptosis.
Wang C, Liang C, Feng W, Xia X, Chen F, Qiao E, Zhang X, Chen D, Ling Z, Yang H
International journal of molecular medicine 2017 Apr;39(4):1037-1045
International journal of molecular medicine 2017 Apr;39(4):1037-1045
Knockdown of ubiquitin-specific peptidase 39 inhibited the growth of osteosarcoma cells and induced apoptosis in vitro.
Gan Z, Han K, Lin S, Hu H, Shen Z, Min D
Biological research 2017 Apr 12;50(1):15
Biological research 2017 Apr 12;50(1):15
The Antitumor Effect of DYC-279 on Human Hepatocellular Carcinoma HepG2 Cells.
Junyan P, Shujuan Y, Shulin G, Yan C, Xia X
Pharmacology 2016;97(3-4):177-83
Pharmacology 2016;97(3-4):177-83
High Expression of PTGR1 Promotes NSCLC Cell Growth via Positive Regulation of Cyclin-Dependent Protein Kinase Complex.
Huang X, Zhou W, Zhang Y, Liu Y
BioMed research international 2016;2016:5230642
BioMed research international 2016;2016:5230642
Role of glycogen synthase kinase-3β inhibitor AZD1080 in ovarian cancer.
Chen S, Sun KX, Feng MX, Sang XB, Liu BL, Zhao Y
Drug design, development and therapy 2016;10:1225-32
Drug design, development and therapy 2016;10:1225-32
EIF3D silencing suppresses renal cell carcinoma tumorigenesis via inducing G2/M arrest through downregulation of Cyclin B1/CDK1 signaling.
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International journal of oncology 2016 Jun;48(6):2580-90
International journal of oncology 2016 Jun;48(6):2580-90
Yes-Associated Protein Contributes to the Development of Human Cutaneous Squamous Cell Carcinoma via Activation of RAS.
Jia J, Li C, Luo S, Liu-Smith F, Yang J, Wang X, Wang N, Lai B, Lei T, Wang Q, Xiao S, Shao Y, Zheng Y
The Journal of investigative dermatology 2016 Jun;136(6):1267-1277
The Journal of investigative dermatology 2016 Jun;136(6):1267-1277
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Huo Y, Zheng Z, Chen Y, Wang Q, Zhang Z, Deng H
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Oncotarget 2016 Jul 19;7(29):45876-45888
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Taiwanese journal of obstetrics & gynecology 2016 Dec;55(6):847-851
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Journal of ethnopharmacology 2016 Dec 4;193:368-376
Journal of ethnopharmacology 2016 Dec 4;193:368-376
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Zhang M, Linghu E, Zhan Q, He T, Cao B, Brock MV, Herman JG, Xiang R, Guo M
Oncotarget 2016 Apr 5;7(14):17957-69
Oncotarget 2016 Apr 5;7(14):17957-69
TRIM59 Promotes the Proliferation and Migration of Non-Small Cell Lung Cancer Cells by Upregulating Cell Cycle Related Proteins.
Zhan W, Han T, Zhang C, Xie C, Gan M, Deng K, Fu M, Wang JB
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Scientific reports 2014 Jul 1;4:5518
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American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010 May;10(5):1321-4
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 19532-1-AP(CDC2-Specific antibody) at dilution of 1:100
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human cervical cancer using 19532-1-AP(CDC2-Specific antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CDK1-Specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human CDK1-Specific. This antibody recognizes human,mouse,rat antigen. The CDK1-Specific antibody has been validated for the following applications: ELISA, WB, IHC analysis.
