ABIN196997

antibody from antibodies-online

Targeting: CDK1 CDC2, CDC28A

Western blot (Recommended by provider)

Antibody Data

Product number

ABIN196997

Provider

antibodies-online

Product name

anti-Cyclin-Dependent Kinase 1 (CDK1) (pTyr15) antibody

Antibody type

Polyclonal

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Reactivity

Human, Mouse

Host

Rabbit

Epitope

pTyr15

Vial size

50 μL

Storage

-20°C

Handling

Avoid repeated freezing and thawing.

References

Submitted references

Resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR-Chk1/2-Cdc25C pathway as a central mechanism for S phase arrest in human ovarian carcinoma Ovcar-3 cells.

Tyagi A, Singh RP, Agarwal C, Siriwardana S, Sclafani RA, Agarwal R
Carcinogenesis 2005 Nov;26(11):1978-87

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The G2/M DNA damage checkpoint inhibits mitosis through Tyr15 phosphorylation of p34cdc2 in Aspergillus nidulans.

Ye XS, Fincher RR, Tang A, Osmani SA
The EMBO journal 1997 Jan 2;16(1):182-92

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Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells.

Jin P, Gu Y, Morgan DO
The Journal of cell biology 1996 Aug;134(4):963-70

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Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15.

Gu Y, Rosenblatt J, Morgan DO
The EMBO journal 1992 Nov;11(11):3995-4005