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- Antigen structure
- References [18]
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- Product number
- 12251-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12251-1-AP, RRID:AB_2266259
- Product name
- MCM10 antibody
- Antibody type
- Polyclonal
- Description
- MCM10 antibody (Cat. #12251-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The E3 ubiquitin ligase UBR5 promotes ubiquitylation and degradation of the chromatin regulator ATAD2.
Topoisomerase I Inhibition in ETV4-overexpressed Non-Small Cell Lung Cancer Promotes Replication and Transcription Mediated R-Loop Accumulation and DNA Damage.
Distinct functions of EHMT1 and EHMT2 in cancer chemotherapy and immunotherapy.
Identification of Candidate Genes in Breast Cancer Induced by Estrogen Plus Progestogens Using Bioinformatic Analysis.
SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing.
Identification of Novel Hub Genes Associated with Psoriasis Using Integrated Bioinformatics Analysis.
BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage.
Constructing Auxin-Inducible Degron Mutants Using an All-in-One Vector.
Distinct MCM10 Proteasomal Degradation Profiles by Primate Lentiviruses Vpr Proteins.
DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain.
Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability.
The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis.
TIMELESS Suppresses the Accumulation of Aberrant CDC45·MCM2-7·GINS Replicative Helicase Complexes on Human Chromatin.
Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells.
Impaired p32 regulation caused by the lymphoma-prone RECQ4 mutation drives mitochondrial dysfunction.
Requirement of heterogeneous nuclear ribonucleoprotein C for BRCA gene expression and homologous recombination.
DDX5 regulates DNA replication and is required for cell proliferation in a subset of breast cancer cells.
MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication.
Honda R, Takao M, Akizuki Y, Ohtake F
FEBS letters 2026 May;600(9):1330-1339
FEBS letters 2026 May;600(9):1330-1339
Topoisomerase I Inhibition in ETV4-overexpressed Non-Small Cell Lung Cancer Promotes Replication and Transcription Mediated R-Loop Accumulation and DNA Damage.
Zhang J, Wang Y, Cao S, Xie SM, Liu B, Li Y, Hou Y, Meng X, Ruan M, Bu D, Kang J, Li R, Lou L, Wang J, Xing L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e09307
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e09307
Distinct functions of EHMT1 and EHMT2 in cancer chemotherapy and immunotherapy.
Kang Z, Fu P, Ma H, Li T, Lu K, Liu J, Ginjala V, Romanienko P, Feng Z, Guan M, Ganesan S, Xia B
bioRxiv : the preprint server for biology 2023 Oct 4;
bioRxiv : the preprint server for biology 2023 Oct 4;
Identification of Candidate Genes in Breast Cancer Induced by Estrogen Plus Progestogens Using Bioinformatic Analysis.
Deng Y, Huang H, Shi J, Jin H
International journal of molecular sciences 2022 Oct 6;23(19)
International journal of molecular sciences 2022 Oct 6;23(19)
SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing.
Liu W, Lu X, Zhao ZH, Su R, Li QL, Xue Y, Gao Z, Sun SS, Lei WL, Li L, An G, Liu H, Han Z, Ouyang YC, Hou Y, Wang ZB, Sun QY, Liu J
eLife 2022 Nov 10;11
eLife 2022 Nov 10;11
Identification of Novel Hub Genes Associated with Psoriasis Using Integrated Bioinformatics Analysis.
Yue Q, Li Z, Zhang Q, Jin Q, Zhang X, Jin G
International journal of molecular sciences 2022 Dec 4;23(23)
International journal of molecular sciences 2022 Dec 4;23(23)
BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage.
Kang Z, Fu P, Alcivar AL, Fu H, Redon C, Foo TK, Zuo Y, Ye C, Baxley R, Madireddy A, Buisson R, Bielinsky AK, Zou L, Shen Z, Aladjem MI, Xia B
Nature communications 2021 Oct 13;12(1):5966
Nature communications 2021 Oct 13;12(1):5966
Constructing Auxin-Inducible Degron Mutants Using an All-in-One Vector.
Yesbolatova A, Saito Y, Kanemaki MT
Pharmaceuticals (Basel, Switzerland) 2020 May 23;13(5)
Pharmaceuticals (Basel, Switzerland) 2020 May 23;13(5)
Distinct MCM10 Proteasomal Degradation Profiles by Primate Lentiviruses Vpr Proteins.
Chang H, Siarot L, Matsuura R, Lo CW, Sato H, Otsuki H, Aida Y
Viruses 2020 Jan 15;12(1)
Viruses 2020 Jan 15;12(1)
DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain.
Zhang J, Bellani MA, James RC, Pokharel D, Zhang Y, Reynolds JJ, McNee GS, Jackson AP, Stewart GS, Seidman MM
Nature communications 2020 Aug 7;11(1):3951
Nature communications 2020 Aug 7;11(1):3951
Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability.
Achuthankutty D, Thakur RS, Haahr P, Hoffmann S, Drainas AP, Bizard AH, Weischenfeldt J, Hickson ID, Mailand N
The Journal of cell biology 2019 Dec 2;218(12):3943-3953
The Journal of cell biology 2019 Dec 2;218(12):3943-3953
The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis.
Fan L, Cao X, Yan H, Wang Q, Tian X, Zhang L, He X, Borjihan G, Morigen
Oncotarget 2017 Jul 18;8(29):47250-47268
Oncotarget 2017 Jul 18;8(29):47250-47268
TIMELESS Suppresses the Accumulation of Aberrant CDC45·MCM2-7·GINS Replicative Helicase Complexes on Human Chromatin.
Xu X, Wang JT, Li M, Liu Y
The Journal of biological chemistry 2016 Oct 21;291(43):22544-22558
The Journal of biological chemistry 2016 Oct 21;291(43):22544-22558
Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells.
Kliszczak M, Sedlackova H, Pitchai GP, Streicher WW, Krejci L, Hickson ID
Oncotarget 2015 Dec 1;6(38):40464-79
Oncotarget 2015 Dec 1;6(38):40464-79
Impaired p32 regulation caused by the lymphoma-prone RECQ4 mutation drives mitochondrial dysfunction.
Wang JT, Xu X, Alontaga AY, Chen Y, Liu Y
Cell reports 2014 May 8;7(3):848-58
Cell reports 2014 May 8;7(3):848-58
Requirement of heterogeneous nuclear ribonucleoprotein C for BRCA gene expression and homologous recombination.
Anantha RW, Alcivar AL, Ma J, Cai H, Simhadri S, Ule J, König J, Xia B
PloS one 2013;8(4):e61368
PloS one 2013;8(4):e61368
DDX5 regulates DNA replication and is required for cell proliferation in a subset of breast cancer cells.
Mazurek A, Luo W, Krasnitz A, Hicks J, Powers RS, Stillman B
Cancer discovery 2012 Sep;2(9):812-25
Cancer discovery 2012 Sep;2(9):812-25
MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication.
Xu X, Rochette PJ, Feyissa EA, Su TV, Liu Y
The EMBO journal 2009 Oct 7;28(19):3005-14
The EMBO journal 2009 Oct 7;28(19):3005-14
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MCM10 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MCM10. This antibody recognizes human, mouse, rat antigen. The MCM10 antibody has been validated for the following applications: ELISA, WB analysis.
