Antibody data
- Antibody Data
- Antigen structure
- References [11]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 10218-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10218-1-AP, RRID:AB_2077735
- Product name
- CDC37 antibody
- Antibody type
- Polyclonal
- Description
- CDC37 antibody (Cat. #10218-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, monkey, mouse and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Simian
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Identifying mitophagy-related genes as prognostic biomarkers and therapeutic targets of gastric carcinoma by integrated analysis of single-cell and bulk-RNA sequencing data.
HSP90/CDC37 inactivation promotes degradation of LKB1 protein to suppress AMPK signaling in bronchial epithelial cells exposed to sulfur mustard analog, 2-chloroethyl ethyl sulfide.
Inhibition of Cdc37 Ameliorates Arthritis in Collagen-Induced Arthritis Rats by Inhibiting Synoviocyte Proliferation and Migration Through the ERK Pathway.
Smad3-mediated lncRNA HSALR1 enhances the non-classic signalling pathway of TGF-β1 in human bronchial fibroblasts by binding to HSP90AB1.
Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells.
(20S) Ginsenoside Rh2 Exerts Its Anti-Tumor Effect by Disrupting the HSP90A-Cdc37 System in Human Liver Cancer Cells.
Tubocapsenolide A targets C-terminal cysteine residues of HSP90 to exert the anti-tumor effect.
Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways.
Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma.
KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex Assembly.
Non-canonical roles of PFKFB3 in regulation of cell cycle through binding to CDK4.
Wang Z, Chen C, Ai J, Shu J, Ding Y, Wang W, Gao Y, Jia Y, Qin Y
Computers in biology and medicine 2023 Sep;163:107227
Computers in biology and medicine 2023 Sep;163:107227
HSP90/CDC37 inactivation promotes degradation of LKB1 protein to suppress AMPK signaling in bronchial epithelial cells exposed to sulfur mustard analog, 2-chloroethyl ethyl sulfide.
Ye F, Wang X, Liu H, Dong X, Cheng J, Chen M, Dan G, Sai Y, Zou Z
Chemico-biological interactions 2023 Sep 1;382:110643
Chemico-biological interactions 2023 Sep 1;382:110643
Inhibition of Cdc37 Ameliorates Arthritis in Collagen-Induced Arthritis Rats by Inhibiting Synoviocyte Proliferation and Migration Through the ERK Pathway.
Sun W, Mao X, Wu W, Nan Y, Xu C, Wang Y, Xu H
Inflammation 2023 Jun;46(3):1022-1035
Inflammation 2023 Jun;46(3):1022-1035
Smad3-mediated lncRNA HSALR1 enhances the non-classic signalling pathway of TGF-β1 in human bronchial fibroblasts by binding to HSP90AB1.
Yi E, Lin B, Zhang Y, Wang X, Zhang J, Liu Y, Jin J, Hong W, Lin Z, Cao W, Mei X, Bai G, Li B, Zhou Y, Ran P
Clinical and translational medicine 2023 Jun;13(6):e1292
Clinical and translational medicine 2023 Jun;13(6):e1292
Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells.
Zhang J, Gan Y, Li H, Yin J, He X, Lin L, Xu S, Fang Z, Kim BW, Gao L, Ding L, Zhang E, Ma X, Li J, Li L, Xu Y, Horne D, Xu R, Yu H, Gu Y, Huang W
Nature communications 2022 May 20;13(1):2835
Nature communications 2022 May 20;13(1):2835
(20S) Ginsenoside Rh2 Exerts Its Anti-Tumor Effect by Disrupting the HSP90A-Cdc37 System in Human Liver Cancer Cells.
Chen C, Wang YS, Zhang ET, Li GA, Liu WY, Li Y, Jin YH
International journal of molecular sciences 2021 Dec 6;22(23)
International journal of molecular sciences 2021 Dec 6;22(23)
Tubocapsenolide A targets C-terminal cysteine residues of HSP90 to exert the anti-tumor effect.
Zhu D, Li S, Chen C, Wang S, Zhu J, Kong L, Luo J
Pharmacological research 2021 Apr;166:105523
Pharmacological research 2021 Apr;166:105523
Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways.
Zhao Q, Zhu HP, Xie X, Mao Q, Liu YQ, He XH, Peng C, Jiang QL, Huang W
International journal of molecular sciences 2020 Mar 7;21(5)
International journal of molecular sciences 2020 Mar 7;21(5)
Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma.
Qin F, Wang Y, Jiang X, Wang Y, Zhang N, Wen X, Wang L, Jiang Q, He G
Journal of enzyme inhibition and medicinal chemistry 2019 Dec;34(1):909-926
Journal of enzyme inhibition and medicinal chemistry 2019 Dec;34(1):909-926
KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex Assembly.
Liu Y, Yin W, Wang J, Lei Y, Sun G, Li W, Huang Z, Guo M
Cells 2019 Dec 10;8(12)
Cells 2019 Dec 10;8(12)
Non-canonical roles of PFKFB3 in regulation of cell cycle through binding to CDK4.
Jia W, Zhao X, Zhao L, Yan H, Li J, Yang H, Huang G, Liu J
Oncogene 2018 Mar;37(13):1685-1698
Oncogene 2018 Mar;37(13):1685-1698
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 10218-1-AP(CDC37 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of MCF-7 cells, using CDC37 antibody 10218-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 10218-1-AP(CDC37 antibody) at dilution of 1:100 (under 25x lens)
- Sample type
- tissue