UBE2J1

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system. [provided by RefSeq, Jul 2008]

Description

Ubiquitin conjugating enzyme E2 J1

Tissue specificity

Low tissue specificity

Predicted location

Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

6 (89326625 - 89352722)

Ensembl ID

ENSG00000198833  (ver. 103.38)

Orthologs

Mouse Ube2j1: ENSMUSG00000028277

UniProt

Q9Y385

neXtProt

NX_Q9Y385

Human splice variants
Mouse splice variants

Protein structure