Antibody data
- Antibody Data
- Antigen structure
- References [9]
- Comments [0]
- Validations
- Immunohistochemistry [1]
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- Product number
- AF980 - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse TIMP-1 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Detects mouse TIMP-1 in direct ELISAs and Western blots. In direct ELISAs, approximately 15% cross-reactivity with recombinant rat TIMP-1 is observed, less than 5% cross-reactivity with recombinant human (rh) TIMP-1 is observed, and less than 1% cross-reactivity with rhTIMP-2 is observed.
- Reactivity
- Mouse
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
P12032
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Deletion of ADAM-9 in HGF/CDK4 mice impairs melanoma development and metastasis.
Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from Lungs in Mice.
Low-density lipoprotein receptor-related protein-1 mediates endocytic clearance of tissue inhibitor of metalloproteinases-1 and promotes its cytokine-like activities.
TAp73 is essential for germ cell adhesion and maturation in testis.
The MMP-9/TIMP-1 axis controls the status of differentiation and function of myelin-forming Schwann cells in nerve regeneration.
Differential vesicular distribution and trafficking of MMP-2, MMP-9, and their inhibitors in astrocytes.
Amelioration of coxsackievirus B3-mediated myocarditis by inhibition of tissue inhibitors of matrix metalloproteinase-1.
Tissue inhibitor of metalloproteinase-1 deficiency amplifies acute lung injury in bleomycin-exposed mice.
Upregulation of MMP-9/TIMP-1 enzymatic system in eosinophilic meningitis caused by Angiostrongylus cantonensis.
Giebeler N, Schönefuß A, Landsberg J, Tüting T, Mauch C, Zigrino P
Oncogene 2017 Aug 31;36(35):5058-5067
Oncogene 2017 Aug 31;36(35):5058-5067
Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from Lungs in Mice.
Fan MH, Zhu Q, Li HH, Ra HJ, Majumdar S, Gulick DL, Jerome JA, Madsen DH, Christofidou-Solomidou M, Speicher DW, Bachovchin WW, Feghali-Bostwick C, Puré E
The Journal of biological chemistry 2016 Apr 8;291(15):8070-89
The Journal of biological chemistry 2016 Apr 8;291(15):8070-89
Low-density lipoprotein receptor-related protein-1 mediates endocytic clearance of tissue inhibitor of metalloproteinases-1 and promotes its cytokine-like activities.
Thevenard J, Verzeaux L, Devy J, Etique N, Jeanne A, Schneider C, Hachet C, Ferracci G, David M, Martiny L, Charpentier E, Khrestchatisky M, Rivera S, Dedieu S, Emonard H
PloS one 2014;9(7):e103839
PloS one 2014;9(7):e103839
TAp73 is essential for germ cell adhesion and maturation in testis.
Holembowski L, Kramer D, Riedel D, Sordella R, Nemajerova A, Dobbelstein M, Moll UM
The Journal of cell biology 2014 Mar 31;204(7):1173-90
The Journal of cell biology 2014 Mar 31;204(7):1173-90
The MMP-9/TIMP-1 axis controls the status of differentiation and function of myelin-forming Schwann cells in nerve regeneration.
Kim Y, Remacle AG, Chernov AV, Liu H, Shubayev I, Lai C, Dolkas J, Shiryaev SA, Golubkov VS, Mizisin AP, Strongin AY, Shubayev VI
PloS one 2012;7(3):e33664
PloS one 2012;7(3):e33664
Differential vesicular distribution and trafficking of MMP-2, MMP-9, and their inhibitors in astrocytes.
Sbai O, Ould-Yahoui A, Ferhat L, Gueye Y, Bernard A, Charrat E, Mehanna A, Risso JJ, Chauvin JP, Fenouillet E, Rivera S, Khrestchatisky M
Glia 2010 Feb;58(3):344-66
Glia 2010 Feb;58(3):344-66
Amelioration of coxsackievirus B3-mediated myocarditis by inhibition of tissue inhibitors of matrix metalloproteinase-1.
Crocker SJ, Frausto RF, Whitmire JK, Benning N, Milner R, Whitton JL
The American journal of pathology 2007 Dec;171(6):1762-73
The American journal of pathology 2007 Dec;171(6):1762-73
Tissue inhibitor of metalloproteinase-1 deficiency amplifies acute lung injury in bleomycin-exposed mice.
Kim KH, Burkhart K, Chen P, Frevert CW, Randolph-Habecker J, Hackman RC, Soloway PD, Madtes DK
American journal of respiratory cell and molecular biology 2005 Sep;33(3):271-9
American journal of respiratory cell and molecular biology 2005 Sep;33(3):271-9
Upregulation of MMP-9/TIMP-1 enzymatic system in eosinophilic meningitis caused by Angiostrongylus cantonensis.
Chen KM, Lee HH, Chou HL, Liu JY, Tsai BC, Lai SC
International journal of experimental pathology 2005 Apr;86(2):81-9
International journal of experimental pathology 2005 Apr;86(2):81-9
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- TIMP-1 in Mouse Ovary. TIMP-1 was detected in perfusion fixed frozen sections of mouse ovary using Goat Anti-Mouse TIMP-1 Antigen Affinity-purified Polyclonal Antibody (red; Catalog # AF980) at 15 µg/mL overnight at 4 °C.