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- References [15]
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- Immunohistochemistry [1]
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- Product number
- 18436-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18436-1-AP, RRID:AB_2171798
- Product name
- PRMT5 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PRMT5 antibody (Cat. #18436-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Deciphering alternative splicing events and their therapeutic implications in colorectal Cancer.
The PRMT5 inhibitor C9 mitigates hypoxia-induced carboplatin resistance in lung cancer by inducing autophagy.
PRMT5 mediates FoxO1 methylation and subcellular localization to regulate lipophagy in myogenic progenitors.
GSK3326595 is a promising drug to prevent SARS-CoV-2 Omicron and other variants infection by inhibiting ACE2-R671 di-methylation.
PRMT5-mediated regulatory arginine methylation of RIPK3.
MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression.
PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours.
Discovery of novel PRMT5 inhibitors bearing a methylpiperazinyl moiety.
ZEB2/TWIST1/PRMT5/NuRD Multicomplex Contributes to the Epigenetic Regulation of EMT and Metastasis in Colorectal Carcinoma.
MYBL1 induces transcriptional activation of ANGPT2 to promote tumor angiogenesis and confer sorafenib resistance in human hepatocellular carcinoma.
Protein arginine methyltransferase 5 mediates THP-1-derived macrophage activation dependent on NF-κB in endometriosis.
Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response.
High PRMT5 expression is associated with poor overall survival and tumor progression in bladder cancer.
The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma.
USP9X regulates centrosome duplication and promotes breast carcinogenesis.
Ding W, Xiao Q, Yue Y, Chen S, She X, Pan B, Zhou L, Yin Y, Li Y, Wang S, Xu M
Cellular signalling 2024 Jun;118:111134
Cellular signalling 2024 Jun;118:111134
The PRMT5 inhibitor C9 mitigates hypoxia-induced carboplatin resistance in lung cancer by inducing autophagy.
Fan J, Li H, Ruan Q, Zhu X, Jing P, Gu Z
Cell biology international 2023 Oct;47(10):1702-1715
Cell biology international 2023 Oct;47(10):1702-1715
PRMT5 mediates FoxO1 methylation and subcellular localization to regulate lipophagy in myogenic progenitors.
Kim KH, Oprescu SN, Snyder MM, Kim A, Jia Z, Yue F, Kuang S
Cell reports 2023 Nov 28;42(11):113329
Cell reports 2023 Nov 28;42(11):113329
GSK3326595 is a promising drug to prevent SARS-CoV-2 Omicron and other variants infection by inhibiting ACE2-R671 di-methylation.
Li Z, Yong H, Wang W, Gao Y, Wang P, Chen X, Lu J, Zheng J, Bai J
Journal of medical virology 2023 Jan;95(1):e28158
Journal of medical virology 2023 Jan;95(1):e28158
PRMT5-mediated regulatory arginine methylation of RIPK3.
Chauhan C, Martinez-Val A, Niedenthal R, Olsen JV, Kotlyarov A, Bekker-Jensen S, Gaestel M, Menon MB
Cell death discovery 2023 Jan 19;9(1):14
Cell death discovery 2023 Jan 19;9(1):14
MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression.
Sun Y, Jin X, Meng J, Guo F, Chen T, Zhao X, Wu H, Ren D
The EMBO journal 2023 Dec 1;42(23):e114558
The EMBO journal 2023 Dec 1;42(23):e114558
PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours.
Yuan HF, Zhao M, Zhao LN, Yun HL, Yang G, Geng Y, Wang YF, Zheng W, Yuan Y, Song TQ, Niu JQ, Zhang XD
Acta pharmacologica Sinica 2022 Sep;43(9):2373-2385
Acta pharmacologica Sinica 2022 Sep;43(9):2373-2385
Discovery of novel PRMT5 inhibitors bearing a methylpiperazinyl moiety.
Bai X, Zhai Z, Zhao X, Li R, Liang L, Jin Y, Yin Y
Future medicinal chemistry 2022 Jul;14(14):1071-1086
Future medicinal chemistry 2022 Jul;14(14):1071-1086
ZEB2/TWIST1/PRMT5/NuRD Multicomplex Contributes to the Epigenetic Regulation of EMT and Metastasis in Colorectal Carcinoma.
Zheng Y, Dai M, Dong Y, Yu H, Liu T, Feng X, Yu B, Zhang H, Wu J, Kong W, Yu X, Wu H
Cancers 2022 Jul 14;14(14)
Cancers 2022 Jul 14;14(14)
MYBL1 induces transcriptional activation of ANGPT2 to promote tumor angiogenesis and confer sorafenib resistance in human hepatocellular carcinoma.
Zhu J, Wu Y, Yu Y, Li Y, Shen J, Zhang R
Cell death & disease 2022 Aug 20;13(8):727
Cell death & disease 2022 Aug 20;13(8):727
Protein arginine methyltransferase 5 mediates THP-1-derived macrophage activation dependent on NF-κB in endometriosis.
Chai X, Wu X, He L, Ding H
Experimental and therapeutic medicine 2021 Sep;22(3):1003
Experimental and therapeutic medicine 2021 Sep;22(3):1003
Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response.
Ma D, Yang M, Wang Q, Sun C, Shi H, Jing W, Bi Y, Shen X, Ma X, Qin Z, Lin Y, Zhu L, Zhao Y, Cheng Y, Han L
Science advances 2021 Mar;7(13)
Science advances 2021 Mar;7(13)
High PRMT5 expression is associated with poor overall survival and tumor progression in bladder cancer.
Tan L, Xiao K, Ye Y, Liang H, Chen M, Luo J, Qin Z
Aging 2020 May 11;12(9):8728-8741
Aging 2020 May 11;12(9):8728-8741
The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma.
Li Z, Zhang J, Liu X, Li S, Wang Q, Di Chen, Hu Z, Yu T, Ding J, Li J, Yao M, Fan J, Huang S, Gao Q, Zhao Y, He X
Nature communications 2018 Apr 20;9(1):1572
Nature communications 2018 Apr 20;9(1):1572
USP9X regulates centrosome duplication and promotes breast carcinogenesis.
Li X, Song N, Liu L, Liu X, Ding X, Song X, Yang S, Shan L, Zhou X, Su D, Wang Y, Zhang Q, Cao C, Ma S, Yu N, Yang F, Wang Y, Yao Z, Shang Y, Shi L
Nature communications 2017 Mar 31;8:14866
Nature communications 2017 Mar 31;8:14866
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 18436-1-AP(PRMT5 antibody) at dilution of 1:800
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PRMT5 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PRMT5. This antibody recognizes human,mouse,rat antigen. The PRMT5 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
