DPABH-13411

antibody from Creative Diagnostics

Targeting: CWC27 NY-CO-10, SDCCAG-10, SDCCAG10

Western blot (Recommended by provider)

Antibody Data

Product number

DPABH-13411

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DPABH-13411, RRID:AB_2512449

Product name

Rabbit Anti-Human CWC27 Polyclonal Antibody

Antibody type

Polyclonal

Description

Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Concentration

Lot specific

Storage

2 - 8° C. 1 year from date of receipt