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- Antigen structure
- References [12]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 15457-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15457-1-AP, RRID:AB_2120828
- Product name
- HOOK3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HOOK3 antibody (Cat. #15457-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Rab11 regulates autophagy at dendritic spines in an mTOR- and NMDA-dependent manner.
HOOK3 suppresses proliferation and metastasis in gastric cancer via the SP1/VEGFA axis.
The Circ_35953 induced by the NF-κB mediated the septic AKI via targeting miR-7219-5p/HOOK3 and IGFBP7 axis.
The mechanism of acentrosomal spindle assembly in human oocytes.
Stem cells from human exfoliated deciduous teeth affect mitochondria and reverse cognitive decline in a senescence-accelerated mouse prone 8 model.
Mitotic HOOK3 phosphorylation by ERK1c drives microtubule-dependent Golgi destabilization and fragmentation.
The Dynein Adaptor RILP Controls Neuronal Autophagosome Biogenesis, Transport, and Clearance.
Hook3 is a scaffold for the opposite-polarity microtubule-based motors cytoplasmic dynein-1 and KIF1C.
Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation.
PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport.
The NQO1/PKLR axis promotes lymph node metastasis and breast cancer progression by modulating glycolytic reprogramming.
Dynein activator Hook1 is required for trafficking of BDNF-signaling endosomes in neurons.
Janusz-Kaminska A, Brzozowska A, Tempes A, Urbanska M, Blazejczyk M, Miłek J, Kuzniewska B, Zeng J, Wesławski J, Kisielewska K, Bassell GJ, Jaworski J
Molecular biology of the cell 2024 Mar 1;35(3):ar43
Molecular biology of the cell 2024 Mar 1;35(3):ar43
HOOK3 suppresses proliferation and metastasis in gastric cancer via the SP1/VEGFA axis.
Yang K, Li J, Zhu J, Chen Y, He Y, Wang J, Shen K, Wang K, Shi T, Chen W
Cell death discovery 2024 Jan 16;10(1):33
Cell death discovery 2024 Jan 16;10(1):33
The Circ_35953 induced by the NF-κB mediated the septic AKI via targeting miR-7219-5p/HOOK3 and IGFBP7 axis.
Feng Y, Liu B, Chen J, Li H, Zhang D
Journal of cellular and molecular medicine 2023 May;27(9):1261-1276
Journal of cellular and molecular medicine 2023 May;27(9):1261-1276
The mechanism of acentrosomal spindle assembly in human oocytes.
Wu T, Dong J, Fu J, Kuang Y, Chen B, Gu H, Luo Y, Gu R, Zhang M, Li W, Dong X, Sun X, Sang Q, Wang L
Science (New York, N.Y.) 2022 Nov 18;378(6621):eabq7361
Science (New York, N.Y.) 2022 Nov 18;378(6621):eabq7361
Stem cells from human exfoliated deciduous teeth affect mitochondria and reverse cognitive decline in a senescence-accelerated mouse prone 8 model.
Guo W, Zeng Z, Xing C, Zhang J, Bi W, Yang J, Shah R, Wang D, Li Y, Zhang X, Bian Y, Du H
Cytotherapy 2022 Jan;24(1):59-71
Cytotherapy 2022 Jan;24(1):59-71
Mitotic HOOK3 phosphorylation by ERK1c drives microtubule-dependent Golgi destabilization and fragmentation.
Wortzel I, Maik-Rachline G, Yadav SS, Hanoch T, Seger R
iScience 2021 Jun 25;24(6):102670
iScience 2021 Jun 25;24(6):102670
The Dynein Adaptor RILP Controls Neuronal Autophagosome Biogenesis, Transport, and Clearance.
Khobrekar NV, Quintremil S, Dantas TJ, Vallee RB
Developmental cell 2020 Apr 20;53(2):141-153.e4
Developmental cell 2020 Apr 20;53(2):141-153.e4
Hook3 is a scaffold for the opposite-polarity microtubule-based motors cytoplasmic dynein-1 and KIF1C.
Kendrick AA, Dickey AM, Redwine WB, Tran PT, Vaites LP, Dzieciatkowska M, Harper JW, Reck-Peterson SL
The Journal of cell biology 2019 Sep 2;218(9):2982-3001
The Journal of cell biology 2019 Sep 2;218(9):2982-3001
Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation.
Pauwels AM, Härtlova A, Peltier J, Driege Y, Baudelet G, Brodin P, Trost M, Beyaert R, Hoffmann E
Molecular & cellular proteomics : MCP 2019 May;18(5):909-922
Molecular & cellular proteomics : MCP 2019 May;18(5):909-922
PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport.
Siddiqui N, Zwetsloot AJ, Bachmann A, Roth D, Hussain H, Brandt J, Kaverina I, Straube A
Nature communications 2019 Jun 19;10(1):2693
Nature communications 2019 Jun 19;10(1):2693
The NQO1/PKLR axis promotes lymph node metastasis and breast cancer progression by modulating glycolytic reprogramming.
Yang Y, Zhu G, Dong B, Piao J, Chen L, Lin Z
Cancer letters 2019 Jul 1;453:170-183
Cancer letters 2019 Jul 1;453:170-183
Dynein activator Hook1 is required for trafficking of BDNF-signaling endosomes in neurons.
Olenick MA, Dominguez R, Holzbaur ELF
The Journal of cell biology 2019 Jan 7;218(1):220-233
The Journal of cell biology 2019 Jan 7;218(1):220-233
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human liver tissue were subjected to SDS PAGE followed by western blot with 15457-1-AP(HOOK3 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using HOOK3 antibody 15457-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 15457-1-AP(HOOK3 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 15457-1-AP(HOOK3 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
