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- Antibody Data
- Antigen structure
- References [30]
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- Product number
- NB120-13810 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB120-13810, RRID:AB_922373
- Product name
- Rabbit Polyclonal TRIF/TICAM1 Antibody
- Antibody type
- Polyclonal
- Description
- Unpurified.
- Reactivity
- Human, Mouse, Rat, Porcine
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.2 ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Anti-influenza A virus mechanism of three representative compounds from Flos Trollii via TLRs signaling pathways.
Atractylodes macrocephala polysaccharides regulate the innate immunity of colorectal cancer cells by modulating the TLR4 signaling pathway.
SjHSP60 induces CD4+ CD25+ Foxp3+ Tregs via TLR4-Mal-drived production of TGF-β in macrophages.
TLR3 contributes to persistent autophagy and heart failure in mice after myocardial infarction.
Biphalin, a Dimeric Enkephalin, Alleviates LPS-Induced Activation in Rat Primary Microglial Cultures in Opioid Receptor-Dependent and Receptor-Independent Manners.
Pinocembrin protects hemorrhagic brain primarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia.
Inositol polyphosphate multikinase promotes Toll-like receptor-induced inflammation by stabilizing TRAF6.
S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.
Interferon β (IFN-β) Production during the Double-stranded RNA (dsRNA) Response in Hepatocytes Involves Coordinated and Feedforward Signaling through Toll-like Receptor 3 (TLR3), RNA-dependent Protein Kinase (PKR), Inducible Nitric Oxide Synthase (iNOS), and Src Protein.
Synergy of TLR3 and 7 ligands significantly enhances function of DCs to present inactivated PRRSV antigen through TRIF/MyD88-NF-κB signaling pathway.
Toll-Like Receptors Promote Mitochondrial Translocation of Nuclear Transcription Factor Nuclear Factor of Activated T-Cells in Prolonged Microglial Activation.
Mouse pyrin and HIN domain family member 1 (pyhin1) protein positively regulates LPS-induced IFN-β and NO production in macrophages.
Recapitulation of the hepatitis C virus life-cycle in engineered murine cell lines.
Cbl-b is a critical regulator of macrophage activation associated with obesity-induced insulin resistance in mice.
Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes.
CD4(+) T cell vaccination overcomes defective cross-presentation of fungal antigens in a mouse model of chronic granulomatous disease.
Dysregulated TLR3-dependent signaling and innate immune activation in superoxide-deficient macrophages from nonobese diabetic mice.
DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells.
TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy.
NADPH oxidase-dependent reactive oxygen species mediate amplified TLR4 signaling and sepsis-induced mortality in Nrf2-deficient mice.
Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner.
The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1.
Pioglitazone inhibits Toll-like receptor expression and activity in human monocytes and db/db mice.
MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages.
Members of the Toll-like receptor family of innate immunity pattern-recognition receptors are abundant in the male rat reproductive tract.
Expression of Toll-like receptors in the human decidua.
Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts.
Renal collecting duct epithelial cells react to pyelonephritis-associated Escherichia coli by activating distinct TLR4-dependent and -independent inflammatory pathways.
Renal collecting duct epithelial cells react to pyelonephritis-associated Escherichia coli by activating distinct TLR4-dependent and -independent inflammatory pathways.
Transforming growth factor-beta differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide-induced TLR4 signaling.
Shi D, Chen M, Liu L, Wang Q, Liu S, Wang L, Wang R
Journal of ethnopharmacology 2020 May 10;253:112634
Journal of ethnopharmacology 2020 May 10;253:112634
Atractylodes macrocephala polysaccharides regulate the innate immunity of colorectal cancer cells by modulating the TLR4 signaling pathway.
Feng Z, Yang R, Wu L, Tang S, Wei B, Guo L, He L, Feng Y
OncoTargets and therapy 2019;12:7111-7121
OncoTargets and therapy 2019;12:7111-7121
SjHSP60 induces CD4+ CD25+ Foxp3+ Tregs via TLR4-Mal-drived production of TGF-β in macrophages.
Zhou S, Qi Q, Wang X, Zhang L, Xu L, Dong L, Zhu J, Li Y, Wang X, Xu Z, Liu F, Hu W, Zhou L, Chen X, Su C
Immunology and cell biology 2018 Oct;96(9):958-968
Immunology and cell biology 2018 Oct;96(9):958-968
TLR3 contributes to persistent autophagy and heart failure in mice after myocardial infarction.
Gao T, Zhang SP, Wang JF, Liu L, Wang Y, Cao ZY, Hu QK, Yuan WJ, Lin L
Journal of cellular and molecular medicine 2018 Jan;22(1):395-408
Journal of cellular and molecular medicine 2018 Jan;22(1):395-408
Biphalin, a Dimeric Enkephalin, Alleviates LPS-Induced Activation in Rat Primary Microglial Cultures in Opioid Receptor-Dependent and Receptor-Independent Manners.
Popiolek-Barczyk K, Piotrowska A, Makuch W, Mika J
Neural plasticity 2017;2017:3829472
Neural plasticity 2017;2017:3829472
Pinocembrin protects hemorrhagic brain primarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia.
Lan X, Han X, Li Q, Li Q, Gao Y, Cheng T, Wan J, Zhu W, Wang J
Brain, behavior, and immunity 2017 Mar;61:326-339
Brain, behavior, and immunity 2017 Mar;61:326-339
Inositol polyphosphate multikinase promotes Toll-like receptor-induced inflammation by stabilizing TRAF6.
Kim E, Beon J, Lee S, Park SJ, Ahn H, Kim MG, Park JE, Kim W, Yuk JM, Kang SJ, Lee SH, Jo EK, Seong RH, Kim S
Science advances 2017 Apr;3(4):e1602296
Science advances 2017 Apr;3(4):e1602296
S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.
Wang F, Alain T, Szretter KJ, Stephenson K, Pol JG, Atherton MJ, Hoang HD, Fonseca BD, Zakaria C, Chen L, Rangwala Z, Hesch A, Chan ESY, Tuinman C, Suthar MS, Jiang Z, Ashkar AA, Thomas G, Kozma SC, Gale M Jr, Fitzgerald KA, Diamond MS, Mossman K, Sonenberg N, Wan Y, Lichty BD
Nature immunology 2016 May;17(5):514-522
Nature immunology 2016 May;17(5):514-522
Interferon β (IFN-β) Production during the Double-stranded RNA (dsRNA) Response in Hepatocytes Involves Coordinated and Feedforward Signaling through Toll-like Receptor 3 (TLR3), RNA-dependent Protein Kinase (PKR), Inducible Nitric Oxide Synthase (iNOS), and Src Protein.
Zhang L, Xiang W, Wang G, Yan Z, Zhu Z, Guo Z, Sengupta R, Chen AF, Loughran PA, Lu B, Wang Q, Billiar TR
The Journal of biological chemistry 2016 Jul 15;291(29):15093-107
The Journal of biological chemistry 2016 Jul 15;291(29):15093-107
Synergy of TLR3 and 7 ligands significantly enhances function of DCs to present inactivated PRRSV antigen through TRIF/MyD88-NF-κB signaling pathway.
Hu Y, Cong X, Chen L, Qi J, Wu X, Zhou M, Yoo D, Li F, Sun W, Wu J, Zhao X, Chen Z, Yu J, Du Y, Wang J
Scientific reports 2016 Apr 5;6:23977
Scientific reports 2016 Apr 5;6:23977
Toll-Like Receptors Promote Mitochondrial Translocation of Nuclear Transcription Factor Nuclear Factor of Activated T-Cells in Prolonged Microglial Activation.
Ma B, Yu J, Xie C, Sun L, Lin S, Ding J, Luo J, Cai H
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Jul 29;35(30):10799-814
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Jul 29;35(30):10799-814
Mouse pyrin and HIN domain family member 1 (pyhin1) protein positively regulates LPS-induced IFN-β and NO production in macrophages.
Haque A, Koide N, Odkhuu E, Tsolmongyn B, Naiki Y, Komatsu T, Yoshida T, Yokochi T
Innate immunity 2014 Jan;20(1):40-8
Innate immunity 2014 Jan;20(1):40-8
Recapitulation of the hepatitis C virus life-cycle in engineered murine cell lines.
Vogt A, Scull MA, Friling T, Horwitz JA, Donovan BM, Dorner M, Gerold G, Labitt RN, Rice CM, Ploss A
Virology 2013 Sep;444(1-2):1-11
Virology 2013 Sep;444(1-2):1-11
Cbl-b is a critical regulator of macrophage activation associated with obesity-induced insulin resistance in mice.
Abe T, Hirasaka K, Kagawa S, Kohno S, Ochi A, Utsunomiya K, Sakai A, Ohno A, Teshima-Kondo S, Okumura Y, Oarada M, Maekawa Y, Terao J, Mills EM, Nikawa T
Diabetes 2013 Jun;62(6):1957-69
Diabetes 2013 Jun;62(6):1957-69
Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes.
Tian J, Guo X, Liu XM, Liu L, Weng QF, Dong SJ, Knowlton AA, Yuan WJ, Lin L
Cardiovascular research 2013 Jun 1;98(3):391-401
Cardiovascular research 2013 Jun 1;98(3):391-401
CD4(+) T cell vaccination overcomes defective cross-presentation of fungal antigens in a mouse model of chronic granulomatous disease.
De Luca A, Iannitti RG, Bozza S, Beau R, Casagrande A, D'Angelo C, Moretti S, Cunha C, Giovannini G, Massi-Benedetti C, Carvalho A, Boon L, Latgé JP, Romani L
The Journal of clinical investigation 2012 May;122(5):1816-31
The Journal of clinical investigation 2012 May;122(5):1816-31
Dysregulated TLR3-dependent signaling and innate immune activation in superoxide-deficient macrophages from nonobese diabetic mice.
Seleme MC, Lei W, Burg AR, Goh KY, Metz A, Steele C, Tse HM
Free radical biology & medicine 2012 May 1;52(9):2047-56
Free radical biology & medicine 2012 May 1;52(9):2047-56
DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells.
Zhang Z, Kim T, Bao M, Facchinetti V, Jung SY, Ghaffari AA, Qin J, Cheng G, Liu YJ
Immunity 2011 Jun 24;34(6):866-78
Immunity 2011 Jun 24;34(6):866-78
TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy.
Shi CS, Kehrl JH
Science signaling 2010 May 25;3(123):ra42
Science signaling 2010 May 25;3(123):ra42
NADPH oxidase-dependent reactive oxygen species mediate amplified TLR4 signaling and sepsis-induced mortality in Nrf2-deficient mice.
Kong X, Thimmulappa R, Kombairaju P, Biswal S
Journal of immunology (Baltimore, Md. : 1950) 2010 Jul 1;185(1):569-77
Journal of immunology (Baltimore, Md. : 1950) 2010 Jul 1;185(1):569-77
Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner.
Wong SW, Kwon MJ, Choi AM, Kim HP, Nakahira K, Hwang DH
The Journal of biological chemistry 2009 Oct 2;284(40):27384-92
The Journal of biological chemistry 2009 Oct 2;284(40):27384-92
The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1.
Wang XM, Kim HP, Nakahira K, Ryter SW, Choi AM
Journal of immunology (Baltimore, Md. : 1950) 2009 Mar 15;182(6):3809-18
Journal of immunology (Baltimore, Md. : 1950) 2009 Mar 15;182(6):3809-18
Pioglitazone inhibits Toll-like receptor expression and activity in human monocytes and db/db mice.
Dasu MR, Park S, Devaraj S, Jialal I
Endocrinology 2009 Aug;150(8):3457-64
Endocrinology 2009 Aug;150(8):3457-64
MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages.
Shi CS, Kehrl JH
The Journal of biological chemistry 2008 Nov 28;283(48):33175-82
The Journal of biological chemistry 2008 Nov 28;283(48):33175-82
Members of the Toll-like receptor family of innate immunity pattern-recognition receptors are abundant in the male rat reproductive tract.
Palladino MA, Johnson TA, Gupta R, Chapman JL, Ojha P
Biology of reproduction 2007 Jun;76(6):958-64
Biology of reproduction 2007 Jun;76(6):958-64
Expression of Toll-like receptors in the human decidua.
Krikun G, Lockwood CJ, Abrahams VM, Mor G, Paidas M, Guller S
Histology and histopathology 2007 Aug;22(8):847-54
Histology and histopathology 2007 Aug;22(8):847-54
Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts.
Nakahira K, Kim HP, Geng XH, Nakao A, Wang X, Murase N, Drain PF, Wang X, Sasidhar M, Nabel EG, Takahashi T, Lukacs NW, Ryter SW, Morita K, Choi AM
The Journal of experimental medicine 2006 Oct 2;203(10):2377-89
The Journal of experimental medicine 2006 Oct 2;203(10):2377-89
Renal collecting duct epithelial cells react to pyelonephritis-associated Escherichia coli by activating distinct TLR4-dependent and -independent inflammatory pathways.
Chassin C, Goujon JM, Darche S, du Merle L, Bens M, Cluzeaud F, Werts C, Ogier-Denis E, Le Bouguénec C, Buzoni-Gatel D, Vandewalle A
Journal of immunology (Baltimore, Md. : 1950) 2006 Oct 1;177(7):4773-84
Journal of immunology (Baltimore, Md. : 1950) 2006 Oct 1;177(7):4773-84
Renal collecting duct epithelial cells react to pyelonephritis-associated Escherichia coli by activating distinct TLR4-dependent and -independent inflammatory pathways.
Chassin C, Goujon JM, Darche S, du Merle L, Bens M, Cluzeaud F, Werts C, Ogier-Denis E, Le Bouguénec C, Buzoni-Gatel D, Vandewalle A
Journal of immunology (Baltimore, Md. : 1950) 2006 Oct 1;177(7):4773-84
Journal of immunology (Baltimore, Md. : 1950) 2006 Oct 1;177(7):4773-84
Transforming growth factor-beta differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide-induced TLR4 signaling.
Naiki Y, Michelsen KS, Zhang W, Chen S, Doherty TM, Arditi M
The Journal of biological chemistry 2005 Feb 18;280(7):5491-5
The Journal of biological chemistry 2005 Feb 18;280(7):5491-5
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Simple Western: TRIF/TICAM1 Antibody [NB120-13810] - Image shows a specific band for TRIF in 0.5 mg/mL of Raji lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: TRIF/TICAM1 Antibody [NB120-13810] - Analysis of TRIF in mouse spleen probed with TRIF antibody, in A: presence and B: absence of immunizing peptide, at 1:1000.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: TRIF/TICAM1 Antibody [NB120-13810] - Analysis of TRIF in mouse A: Intestine. B: Spleen. C: RAW lysate using TRIF antibody at 1:1000 dilution.
