Antibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
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Validation data
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- Product number
- 10424-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10424-1-AP, RRID:AB_513880
- Product name
- JTV1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated JTV1 antibody (Cat. #10424-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The NR_109/FUBP1/c-Myc axis regulates TAM polarization and remodels the tumor microenvironment to promote cancer development.
RNA-binding protein CCDC137 activates AKT signaling and promotes hepatocellular carcinoma through a novel non-canonical role of DGCR8 in mRNA localization.
Hexokinase 2 confers radio-resistance in hepatocellular carcinoma by promoting autophagy-dependent degradation of AIMP2.
Identification and evaluation of midbrain specific longevity-related genes in exceptionally long-lived but healthy mice.
Multimodal cotranslational interactions direct assembly of the human multi-tRNA synthetase complex.
Human lysyl-tRNA synthetase evolves a dynamic structure that can be stabilized by forming complex.
USP29 coordinates MYC and HIF1α stabilization to promote tumor metabolism and progression.
Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex.
Deubiquitinase USP29 Governs MYBBP1A in the Brains of Parkinson's Disease Patients.
Fluorescence-Based Analysis of Noncanonical Functions of Aminoacyl-tRNA Synthetase-Interacting Multifunctional Proteins (AIMPs) in Peripheral Nerves.
CRISPR-Cas9 Mediated Telomere Removal Leads to Mitochondrial Stress and Protein Aggregation.
VPS35 regulates parkin substrate AIMP2 toxicity by facilitating lysosomal clearance of AIMP2.
Hydrocortisone-induced parkin prevents dopaminergic cell death via CREB pathway in Parkinson's disease model.
Dysregulation of parkin in the substantia nigra of db/db and high-fat diet mice.
Selenoprotein S is involved in maintenance and transport of multiprotein complexes.
Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss.
Prostaglandin E2 promotes liver cancer cell growth by the upregulation of FUSE-binding protein 1 expression.
Role for the obesity-related FTO gene in the cellular sensing of amino acids.
Molecular determinants of selective clearance of protein inclusions by autophagy.
Critical role of PINK1 in regulating Parkin protein levels in vivo.
Global landscape of HIV-human protein complexes.
Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function.
Zhang C, Wei S, Dai S, Li X, Wang H, Zhang H, Sun G, Shan B, Zhao L
Journal for immunotherapy of cancer 2023 May;11(5)
Journal for immunotherapy of cancer 2023 May;11(5)
RNA-binding protein CCDC137 activates AKT signaling and promotes hepatocellular carcinoma through a novel non-canonical role of DGCR8 in mRNA localization.
Tao S, Xie SJ, Diao LT, Lv G, Hou YR, Hu YX, Xu WY, Du B, Xiao ZD
Journal of experimental & clinical cancer research : CR 2023 Aug 5;42(1):194
Journal of experimental & clinical cancer research : CR 2023 Aug 5;42(1):194
Hexokinase 2 confers radio-resistance in hepatocellular carcinoma by promoting autophagy-dependent degradation of AIMP2.
Zheng Y, Zhan Y, Zhang Y, Zhang Y, Liu Y, Xie Y, Sun Y, Qian J, Ding Y, Ding Y, Fang Y
Cell death & disease 2023 Aug 1;14(8):488
Cell death & disease 2023 Aug 1;14(8):488
Identification and evaluation of midbrain specific longevity-related genes in exceptionally long-lived but healthy mice.
Kim H, Huh YJ, Kim JH, Jo M, Shin JH, Park SC, Ahn JY, Lee YI, Lee Y
Frontiers in aging neuroscience 2022;14:1030807
Frontiers in aging neuroscience 2022;14:1030807
Multimodal cotranslational interactions direct assembly of the human multi-tRNA synthetase complex.
Khan K, Long B, Gogonea V, Deshpande GM, Vasu K, Fox PL
Proceedings of the National Academy of Sciences of the United States of America 2022 Sep 6;119(36):e2205669119
Proceedings of the National Academy of Sciences of the United States of America 2022 Sep 6;119(36):e2205669119
Human lysyl-tRNA synthetase evolves a dynamic structure that can be stabilized by forming complex.
Wu S, Zheng L, Hei Z, Zhou JB, Li G, Li P, Wang J, Ali H, Zhou XL, Wang J, Fang P
Cellular and molecular life sciences : CMLS 2022 Feb 8;79(2):128
Cellular and molecular life sciences : CMLS 2022 Feb 8;79(2):128
USP29 coordinates MYC and HIF1α stabilization to promote tumor metabolism and progression.
Tu R, Kang W, Yang M, Wang L, Bao Q, Chen Z, Dong Y, Wang J, Jiang J, Liu H, Qing G
Oncogene 2021 Nov;40(46):6417-6429
Oncogene 2021 Nov;40(46):6417-6429
Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex.
Hei Z, Wu S, Liu Z, Wang J, Fang P
The Journal of biological chemistry 2019 Mar 29;294(13):4775-4783
The Journal of biological chemistry 2019 Mar 29;294(13):4775-4783
Deubiquitinase USP29 Governs MYBBP1A in the Brains of Parkinson's Disease Patients.
Jo A, Lee Y, Park CH, Shin JH
Journal of clinical medicine 2019 Dec 24;9(1)
Journal of clinical medicine 2019 Dec 24;9(1)
Fluorescence-Based Analysis of Noncanonical Functions of Aminoacyl-tRNA Synthetase-Interacting Multifunctional Proteins (AIMPs) in Peripheral Nerves.
Kim M, Kim H, Kim D, Park C, Huh Y, Jung J, Chung HJ, Jeong NY
Materials (Basel, Switzerland) 2019 Apr 1;12(7)
Materials (Basel, Switzerland) 2019 Apr 1;12(7)
CRISPR-Cas9 Mediated Telomere Removal Leads to Mitochondrial Stress and Protein Aggregation.
Kim H, Ham S, Jo M, Lee GH, Lee YS, Shin JH, Lee Y
International journal of molecular sciences 2017 Oct 3;18(10)
International journal of molecular sciences 2017 Oct 3;18(10)
VPS35 regulates parkin substrate AIMP2 toxicity by facilitating lysosomal clearance of AIMP2.
Yun SP, Kim H, Ham S, Kwon SH, Lee GH, Shin JH, Lee SH, Ko HS, Lee Y
Cell death & disease 2017 Apr 6;8(4):e2741
Cell death & disease 2017 Apr 6;8(4):e2741
Hydrocortisone-induced parkin prevents dopaminergic cell death via CREB pathway in Parkinson's disease model.
Ham S, Lee YI, Jo M, Kim H, Kang H, Jo A, Lee GH, Mo YJ, Park SC, Lee YS, Shin JH, Lee Y
Scientific reports 2017 Apr 3;7(1):525
Scientific reports 2017 Apr 3;7(1):525
Dysregulation of parkin in the substantia nigra of db/db and high-fat diet mice.
Khang R, Park C, Shin JH
Neuroscience 2015 May 21;294:182-92
Neuroscience 2015 May 21;294:182-92
Selenoprotein S is involved in maintenance and transport of multiprotein complexes.
Turanov AA, Shchedrina VA, Everley RA, Lobanov AV, Yim SH, Marino SM, Gygi SP, Hatfield DL, Gladyshev VN
The Biochemical journal 2014 Sep 15;462(3):555-65
The Biochemical journal 2014 Sep 15;462(3):555-65
Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss.
Lee Y, Karuppagounder SS, Shin JH, Lee YI, Ko HS, Swing D, Jiang H, Kang SU, Lee BD, Kang HC, Kim D, Tessarollo L, Dawson VL, Dawson TM
Nature neuroscience 2013 Oct;16(10):1392-400
Nature neuroscience 2013 Oct;16(10):1392-400
Prostaglandin E2 promotes liver cancer cell growth by the upregulation of FUSE-binding protein 1 expression.
Ma J, Chen M, Xia SK, Shu W, Guo Y, Wang YH, Xu Y, Bai XM, Zhang L, Zhang H, Zhang M, Wang YP, Leng J
International journal of oncology 2013 Mar;42(3):1093-104
International journal of oncology 2013 Mar;42(3):1093-104
Role for the obesity-related FTO gene in the cellular sensing of amino acids.
Gulati P, Cheung MK, Antrobus R, Church CD, Harding HP, Tung YC, Rimmington D, Ma M, Ron D, Lehner PJ, Ashcroft FM, Cox RD, Coll AP, O'Rahilly S, Yeo GS
Proceedings of the National Academy of Sciences of the United States of America 2013 Feb 12;110(7):2557-62
Proceedings of the National Academy of Sciences of the United States of America 2013 Feb 12;110(7):2557-62
Molecular determinants of selective clearance of protein inclusions by autophagy.
Wong E, Bejarano E, Rakshit M, Lee K, Hanson HH, Zaarur N, Phillips GR, Sherman MY, Cuervo AM
Nature communications 2012;3:1240
Nature communications 2012;3:1240
Critical role of PINK1 in regulating Parkin protein levels in vivo.
Choo YS, Tang C, Zhang Z
Archives of neurology 2011 May;68(5):684-5
Archives of neurology 2011 May;68(5):684-5
Global landscape of HIV-human protein complexes.
Jäger S, Cimermancic P, Gulbahce N, Johnson JR, McGovern KE, Clarke SC, Shales M, Mercenne G, Pache L, Li K, Hernandez H, Jang GM, Roth SL, Akiva E, Marlett J, Stephens M, D'Orso I, Fernandes J, Fahey M, Mahon C, O'Donoghue AJ, Todorovic A, Morris JH, Maltby DA, Alber T, Cagney G, Bushman FD, Young JA, Chanda SK, Sundquist WI, Kortemme T, Hernandez RD, Craik CS, Burlingame A, Sali A, Frankel AD, Krogan NJ
Nature 2011 Dec 21;481(7381):365-70
Nature 2011 Dec 21;481(7381):365-70
Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function.
Ko HS, Lee Y, Shin JH, Karuppagounder SS, Gadad BS, Koleske AJ, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM
Proceedings of the National Academy of Sciences of the United States of America 2010 Sep 21;107(38):16691-6
Proceedings of the National Academy of Sciences of the United States of America 2010 Sep 21;107(38):16691-6
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 10424-1-AP(JTV1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using JTV1 antibody 10424-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line