10424-1-AP

antibody from Proteintech Group

Targeting: AIMP2 JTV-1, JTV1, p38, PRO0992

Provider product page for 10424-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [30]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 10424-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10424-1-AP, RRID:AB_513880
Product name: JTV1 antibody
Antibody type: Polyclonal
Description: KD/KO validated JTV1 antibody (Cat. #10424-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

AIMP2 protein structure - 10424-1-AP shown in red.

Submitted references Variant-specific interaction of kinectin 1 with the multi-tRNA synthetase complex regulates ER sheet organization.

Hosogane M, Siao SY, Hatano A, Huang X, Shichino Y, Watanabe Y, Iwasaki S, Matsumoto M, Nakayama K
iScience 2026 Jan 16;29(1):114303

A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation.

Ali RH, Orellana EA, Lee SH, Chae YC, Chen Y, Clauwaert J, Kennedy AL, Gutierrez AE, Papke DJ, Valenzuela M, Silverman B, Falzetta A, Ficarro SB, Marto JA, Fletcher CDM, Perez-Atayde A, Alcindor T, Shimamura A, Prensner JR, Gregory RI, Gutierrez A
Molecular cell 2025 Mar 6;85(5):948-961.e11

MTCH2 promotes the malignant progression of ovarian cancer through the upregulation of AIMP2 expression levels, mitochondrial dysfunction and by mediating energy metabolism.

Sun G, Song Y, Li C, Sun B, Li C, Sun J, Xiao P, Zhang Z
Oncology letters 2024 Oct;28(4):492

AIMP2 accumulation in brain leads to cognitive deficits and blood secretion in Parkinson's disease.

Kim H, Shin JY, Ham S, Kim JH, Lee GH, Lee NE, Kim HT, Cho SH, Kim S, Lee Y
Journal of translational medicine 2024 Oct 10;22(1):919

Dual inhibition of aminoacyl-tRNA synthetase interacting multifunctional protein-2 and α-synuclein by steroid derivative is neuroprotective in Parkinson's model.

Shin JY, Ha MW, Kim JH, Cheon J, Lee GH, Paek SM, Lee Y
iScience 2024 Nov 15;27(11):111165

Identification of the proteolytic signature in CVB3-infected cells.

Vlok M, Solis N, Sadasivan J, Mohamud Y, Warsaba R, Kizhakkedathu J, Luo H, Overall CM, Jan E
Journal of virology 2024 Jul 23;98(7):e0049824

AIMP2 restricts EV71 replication by recruiting SMURF2 to promote the degradation of 3D polymerase.

Ren J, Yu L, Zhang Q, Ren P, Cai Y, Wang X, Lan K, Wu S
Virologica Sinica 2024 Aug;39(4):632-644

The NR_109/FUBP1/c-Myc axis regulates TAM polarization and remodels the tumor microenvironment to promote cancer development.

Zhang C, Wei S, Dai S, Li X, Wang H, Zhang H, Sun G, Shan B, Zhao L
Journal for immunotherapy of cancer 2023 May;11(5)

Pan-cancer Analysis Identifies AIMP2 as a Potential Biomarker for Breast Cancer.

Qiu J, Zhou T, Wang D, Hong W, Qian D, Meng X, Liu X
Current genomics 2023 Dec 20;24(5):307-329

RNA-binding protein CCDC137 activates AKT signaling and promotes hepatocellular carcinoma through a novel non-canonical role of DGCR8 in mRNA localization.

Tao S, Xie SJ, Diao LT, Lv G, Hou YR, Hu YX, Xu WY, Du B, Xiao ZD
Journal of experimental & clinical cancer research : CR 2023 Aug 5;42(1):194

Hexokinase 2 confers radio-resistance in hepatocellular carcinoma by promoting autophagy-dependent degradation of AIMP2.

Zheng Y, Zhan Y, Zhang Y, Zhang Y, Liu Y, Xie Y, Sun Y, Qian J, Ding Y, Ding Y, Fang Y
Cell death & disease 2023 Aug 1;14(8):488

Identification and evaluation of midbrain specific longevity-related genes in exceptionally long-lived but healthy mice.

Kim H, Huh YJ, Kim JH, Jo M, Shin JH, Park SC, Ahn JY, Lee YI, Lee Y
Frontiers in aging neuroscience 2022;14:1030807

Multimodal cotranslational interactions direct assembly of the human multi-tRNA synthetase complex.

Khan K, Long B, Gogonea V, Deshpande GM, Vasu K, Fox PL
Proceedings of the National Academy of Sciences of the United States of America 2022 Sep 6;119(36):e2205669119

Human lysyl-tRNA synthetase evolves a dynamic structure that can be stabilized by forming complex.

Wu S, Zheng L, Hei Z, Zhou JB, Li G, Li P, Wang J, Ali H, Zhou XL, Wang J, Fang P
Cellular and molecular life sciences : CMLS 2022 Feb 8;79(2):128

USP29 coordinates MYC and HIF1α stabilization to promote tumor metabolism and progression.

Tu R, Kang W, Yang M, Wang L, Bao Q, Chen Z, Dong Y, Wang J, Jiang J, Liu H, Qing G
Oncogene 2021 Nov;40(46):6417-6429

Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex.

Hei Z, Wu S, Liu Z, Wang J, Fang P
The Journal of biological chemistry 2019 Mar 29;294(13):4775-4783

Deubiquitinase USP29 Governs MYBBP1A in the Brains of Parkinson's Disease Patients.

Jo A, Lee Y, Park CH, Shin JH
Journal of clinical medicine 2019 Dec 24;9(1)

Fluorescence-Based Analysis of Noncanonical Functions of Aminoacyl-tRNA Synthetase-Interacting Multifunctional Proteins (AIMPs) in Peripheral Nerves.

Kim M, Kim H, Kim D, Park C, Huh Y, Jung J, Chung HJ, Jeong NY
Materials (Basel, Switzerland) 2019 Apr 1;12(7)

CRISPR-Cas9 Mediated Telomere Removal Leads to Mitochondrial Stress and Protein Aggregation.

Kim H, Ham S, Jo M, Lee GH, Lee YS, Shin JH, Lee Y
International journal of molecular sciences 2017 Oct 3;18(10)

VPS35 regulates parkin substrate AIMP2 toxicity by facilitating lysosomal clearance of AIMP2.

Yun SP, Kim H, Ham S, Kwon SH, Lee GH, Shin JH, Lee SH, Ko HS, Lee Y
Cell death & disease 2017 Apr 6;8(4):e2741

Hydrocortisone-induced parkin prevents dopaminergic cell death via CREB pathway in Parkinson's disease model.

Ham S, Lee YI, Jo M, Kim H, Kang H, Jo A, Lee GH, Mo YJ, Park SC, Lee YS, Shin JH, Lee Y
Scientific reports 2017 Apr 3;7(1):525

Dysregulation of parkin in the substantia nigra of db/db and high-fat diet mice.

Khang R, Park C, Shin JH
Neuroscience 2015 May 21;294:182-92

Selenoprotein S is involved in maintenance and transport of multiprotein complexes.

Turanov AA, Shchedrina VA, Everley RA, Lobanov AV, Yim SH, Marino SM, Gygi SP, Hatfield DL, Gladyshev VN
The Biochemical journal 2014 Sep 15;462(3):555-65

Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss.

Lee Y, Karuppagounder SS, Shin JH, Lee YI, Ko HS, Swing D, Jiang H, Kang SU, Lee BD, Kang HC, Kim D, Tessarollo L, Dawson VL, Dawson TM
Nature neuroscience 2013 Oct;16(10):1392-400

Prostaglandin E2 promotes liver cancer cell growth by the upregulation of FUSE-binding protein 1 expression.

Ma J, Chen M, Xia SK, Shu W, Guo Y, Wang YH, Xu Y, Bai XM, Zhang L, Zhang H, Zhang M, Wang YP, Leng J
International journal of oncology 2013 Mar;42(3):1093-104

Role for the obesity-related FTO gene in the cellular sensing of amino acids.

Gulati P, Cheung MK, Antrobus R, Church CD, Harding HP, Tung YC, Rimmington D, Ma M, Ron D, Lehner PJ, Ashcroft FM, Cox RD, Coll AP, O'Rahilly S, Yeo GS
Proceedings of the National Academy of Sciences of the United States of America 2013 Feb 12;110(7):2557-62

Molecular determinants of selective clearance of protein inclusions by autophagy.

Wong E, Bejarano E, Rakshit M, Lee K, Hanson HH, Zaarur N, Phillips GR, Sherman MY, Cuervo AM
Nature communications 2012;3:1240

Critical role of PINK1 in regulating Parkin protein levels in vivo.

Choo YS, Tang C, Zhang Z
Archives of neurology 2011 May;68(5):684-5

Global landscape of HIV-human protein complexes.

Jäger S, Cimermancic P, Gulbahce N, Johnson JR, McGovern KE, Clarke SC, Shales M, Mercenne G, Pache L, Li K, Hernandez H, Jang GM, Roth SL, Akiva E, Marlett J, Stephens M, D'Orso I, Fernandes J, Fahey M, Mahon C, O'Donoghue AJ, Todorovic A, Morris JH, Maltby DA, Alber T, Cagney G, Bushman FD, Young JA, Chanda SK, Sundquist WI, Kortemme T, Hernandez RD, Craik CS, Burlingame A, Sali A, Frankel AD, Krogan NJ
Nature 2011 Dec 21;481(7381):365-70

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function.

Ko HS, Lee Y, Shin JH, Karuppagounder SS, Gadad BS, Koleske AJ, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM
Proceedings of the National Academy of Sciences of the United States of America 2010 Sep 21;107(38):16691-6

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 10424-1-AP(JTV1 antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of Hela cells, using JTV1 antibody 10424-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line