RA0758

antibody from Oursmab

Targeting: TNFRSF17 BCM, BCMA, CD269, TNFRSF13A

Immunocytochemistry

Flow cytometry

Functional assay

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Validation data

Product number: RA0758 - Provider product page
Provider: Oursmab
Product name: Belantamab (Biosimilar Reference Antibody) (TNFRSF17)
Antibody type: Monoclonal
Description: Belantamab mafodotin is a first-in-class antibody-drug conjugate (ADC) approved for the treatment of relapsed or refractory multiple myeloma (RRMM). It consists of a humanized, afucosylated anti-BCMA (B-cell maturation antigen) monoclonal antibody conjugated to the potent microtubule-disrupting agent monomethyl auristatin F (MMAF) via a non-cleavable linker. The ADC binds to BCMA on myeloma cells, is internalized, and releases its payload, leading to targeted apoptosis. It was granted accelerated approval by the U.S. FDA and conditional approval by the EMA based on impressive single-agent response rates. However, it carries a notable ocular toxicity risk (keratopathy), requiring strict monitoring. Following confirmatory Phase III trial results that did not meet the prespecified criteria for superiority over standard care, its U.S. approval was withdrawn (though it remains available in other regions under specific conditions).
Reactivity: Human
Isotype: IgG
Vial size: 100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg
Concentration: Bottled at the concentration indicated on the vial.
Storage: Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.

TNFRSF17 protein structure - RA0758 shown in red.