Antibody data
- Antibody Data
- Antigen structure
- References [34]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 13075-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13075-1-AP, RRID:AB_2093053
- Product name
- DFNA5/GSDME antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated DFNA5/GSDME antibody (Cat. #13075-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Novel model of pyroptosis-related molecular signatures for prognosis prediction of clear cell renal cell carcinoma patients.
Enhancing cell pyroptosis with biomimetic nanoparticles for melanoma chemo-immunotherapy.
Enhanced Gasdermin-E-mediated Pyroptosis in Alzheimer's Disease.
TNFSF15 inhibits progression of diabetic retinopathy by blocking pyroptosis via interacting with GSDME.
The facilitating effects of KRT80 on chemoresistance, lipogenesis, and invasion of esophageal cancer.
Hydralazine loaded nanodroplets combined with ultrasound-targeted microbubble destruction to induce pyroptosis for tumor treatment.
Activation of STING by SAMHD1 Deficiency Promotes PANoptosis and Enhances Efficacy of PD-L1 Blockade in Diffuse Large B-cell Lymphoma.
Identification of molecular subtypes based on PANoptosis-related genes and construction of a signature for predicting the prognosis and response to immunotherapy response in hepatocellular carcinoma.
Exploring the molecular mechanisms of the involvement of GZMB-Caspase-3-GSDME pathway in the progression of rheumatoid arthritis.
Verbenalin alleviates acute lung injury induced by sepsis and IgG immune complex through GPR18 receptor.
A high-throughput Gaussia luciferase reporter assay for screening potential gasdermin E activators against pancreatic cancer.
Ferroptosis plays a crucial role in lung cell damage caused by ventilation stretch.
Single-cell sequencing reveals homogeneity and heterogeneity of the cytopathological mechanisms in different etiology-induced AKI.
Neobavaisoflavone induces pyroptosis of liver cancer cells via Tom20 sensing the activated ROS signal.
Triggering pyroptosis enhances the antitumor efficacy of PARP inhibitors in prostate cancer.
Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P.
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression.
GSDME Increases Chemotherapeutic Drug Sensitivity by Inducing Pyroptosis in Retinoblastoma Cells.
Pyroptosis relates to tumor microenvironment remodeling and prognosis: A pan-cancer perspective.
Expression levels of caspase-3 and gasdermin E and their involvement in the occurrence and prognosis of lung cancer.
JQ1 attenuates neuroinflammation by inhibiting the inflammasome-dependent canonical pyroptosis pathway in SAE.
Deoxynivalenol induces caspase-3/GSDME-dependent pyroptosis and inflammation in mouse liver and HepaRG cells.
Cadmium exposure induces pyroptosis in testicular tissue by increasing oxidative stress and activating the AIM2 inflammasome pathway.
HDAC11 promotes both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells.
Bexarotene-induced cell death in ovarian cancer cells through Caspase-4-gasdermin E mediated pyroptosis.
Coxsackievirus Group B3 Has Oncolytic Activity against Colon Cancer through Gasdermin E-Mediated Pyroptosis.
Gasdermin-E Mediated Pyroptosis-A Novel Mechanism Regulating Migration, Invasion and Release of Inflammatory Cytokines in Rheumatoid Arthritis Fibroblast-like Synoviocytes.
Role of Cytokines Released During Pyroptosis in Non-Small Cell Lung Cancer.
Gasdermin D Is a Novel Prognostic Biomarker and Relates to TMZ Response in Glioblastoma.
A hybrid membrane coating nanodrug system against gastric cancer via the VEGFR2/STAT3 signaling pathway.
GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy.
Exosome-Delivered LncHEIH Promotes Gastric Cancer Progression by Upregulating EZH2 and Stimulating Methylation of the GSDME Promoter.
Caspase-3 Promotes Diabetic Kidney Disease Through Gasdermin E-Mediated Progression to Secondary Necrosis During Apoptosis.
Methamphetamine induces GSDME-dependent cell death in hippocampal neuronal cells through the endoplasmic reticulum stress pathway.
Chen J, Jiang R, Guan W, Cao Q, Tian Y, Dong K, Pan X, Cui X
International journal of medical sciences 2024;21(3):496-507
International journal of medical sciences 2024;21(3):496-507
Enhancing cell pyroptosis with biomimetic nanoparticles for melanoma chemo-immunotherapy.
Sun S, He Y, Xu J, Leng S, Liu Y, Wan H, Yan L, Xu Y
Journal of controlled release : official journal of the Controlled Release Society 2024 Mar;367:470-485
Journal of controlled release : official journal of the Controlled Release Society 2024 Mar;367:470-485
Enhanced Gasdermin-E-mediated Pyroptosis in Alzheimer's Disease.
Wang Q, Guo S, Hu D, Dong X, Meng Z, Jiang Y, Feng Z, Zhou W, Song W
Neuroscience 2024 Jan 9;536:1-11
Neuroscience 2024 Jan 9;536:1-11
TNFSF15 inhibits progression of diabetic retinopathy by blocking pyroptosis via interacting with GSDME.
Zhao H, Dai Y, Li Y, Li J, Li H
Cell death & disease 2024 Feb 8;15(2):118
Cell death & disease 2024 Feb 8;15(2):118
The facilitating effects of KRT80 on chemoresistance, lipogenesis, and invasion of esophageal cancer.
Yun WJ, Li J, Yin NC, Zhang CY, Cui ZG, Zhang L, Zheng HC
Cancer biology & therapy 2024 Dec 31;25(1):2302162
Cancer biology & therapy 2024 Dec 31;25(1):2302162
Hydralazine loaded nanodroplets combined with ultrasound-targeted microbubble destruction to induce pyroptosis for tumor treatment.
Huang S, Shang M, Guo L, Sun X, Xiao S, Shi D, Meng D, Zhao Y, Wang X, Liu R, Li J
Journal of nanobiotechnology 2024 Apr 20;22(1):193
Journal of nanobiotechnology 2024 Apr 20;22(1):193
Activation of STING by SAMHD1 Deficiency Promotes PANoptosis and Enhances Efficacy of PD-L1 Blockade in Diffuse Large B-cell Lymphoma.
Cai Y, Chen X, Lu T, Fang X, Ding M, Yu Z, Hu S, Liu J, Zhou X, Wang X
International journal of biological sciences 2023;19(14):4627-4643
International journal of biological sciences 2023;19(14):4627-4643
Identification of molecular subtypes based on PANoptosis-related genes and construction of a signature for predicting the prognosis and response to immunotherapy response in hepatocellular carcinoma.
Zhu J, Huang Q, Peng X, Luo C, Liu Z, Liu D, Yuan H, Yuan R, Cheng X
Frontiers in immunology 2023;14:1218661
Frontiers in immunology 2023;14:1218661
Exploring the molecular mechanisms of the involvement of GZMB-Caspase-3-GSDME pathway in the progression of rheumatoid arthritis.
Zhang Y, Cai X, Wang B, Zhang B, Xu Y
Molecular immunology 2023 Sep;161:82-90
Molecular immunology 2023 Sep;161:82-90
Verbenalin alleviates acute lung injury induced by sepsis and IgG immune complex through GPR18 receptor.
Yang L, Liu T, Zhuo Y, Li D, Li D, Liu J, Gao H, Zhang L, Lin J, Wang X
Cellular signalling 2023 Sep;109:110768
Cellular signalling 2023 Sep;109:110768
A high-throughput Gaussia luciferase reporter assay for screening potential gasdermin E activators against pancreatic cancer.
Liu Y, Zhang X, Zhang P, He T, Zhang W, Ma D, Li P, Chen J
Acta pharmaceutica Sinica. B 2023 Oct;13(10):4253-4272
Acta pharmaceutica Sinica. B 2023 Oct;13(10):4253-4272
Ferroptosis plays a crucial role in lung cell damage caused by ventilation stretch.
Jiang W, Liu J, Cui J, Su J, Xu W, Zhang F, Ding Y
Free radical biology & medicine 2023 Nov 20;209(Pt 1):84-95
Free radical biology & medicine 2023 Nov 20;209(Pt 1):84-95
Single-cell sequencing reveals homogeneity and heterogeneity of the cytopathological mechanisms in different etiology-induced AKI.
Chen Z, Li Y, Yuan Y, Lai K, Ye K, Lin Y, Lan R, Chen H, Xu Y
Cell death & disease 2023 May 11;14(5):318
Cell death & disease 2023 May 11;14(5):318
Neobavaisoflavone induces pyroptosis of liver cancer cells via Tom20 sensing the activated ROS signal.
Li Y, Zhao R, Xiu Z, Yang X, Zhu Y, Han J, Li S, Li Y, Sun L, Li X, Jin N, Li Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154869
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154869
Triggering pyroptosis enhances the antitumor efficacy of PARP inhibitors in prostate cancer.
Tian A, Wu T, Zhang Y, Chen J, Sha J, Xia W
Cellular oncology (Dordrecht, Netherlands) 2023 Dec;46(6):1855-1870
Cellular oncology (Dordrecht, Netherlands) 2023 Dec;46(6):1855-1870
Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P.
Ai YL, Wang WJ, Liu FJ, Fang W, Chen HZ, Wu LZ, Hong X, Zhu Y, Zhang CX, Liu LY, Hong WB, Zhou B, Chen QT, Wu Q
Cell research 2023 Dec;33(12):904-922
Cell research 2023 Dec;33(12):904-922
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression.
Cong L, Liu X, Bai Y, Qin Q, Zhao L, Shi Y, Bai Y, Guo Z
Biological research 2023 Dec 2;56(1):62
Biological research 2023 Dec 2;56(1):62
GSDME Increases Chemotherapeutic Drug Sensitivity by Inducing Pyroptosis in Retinoblastoma Cells.
Li F, Xia Q, Ren L, Nie Y, Ren H, Guo X, Yu J, Xing Y, Chen Z
Oxidative medicine and cellular longevity 2022;2022:2371807
Oxidative medicine and cellular longevity 2022;2022:2371807
Pyroptosis relates to tumor microenvironment remodeling and prognosis: A pan-cancer perspective.
Khan M, Ai M, Du K, Song J, Wang B, Lin J, Ren A, Chen C, Huang Z, Qiu W, Zhang J, Tian Y, Yuan Y
Frontiers in immunology 2022;13:1062225
Frontiers in immunology 2022;13:1062225
Expression levels of caspase-3 and gasdermin E and their involvement in the occurrence and prognosis of lung cancer.
Huang YL, Zhang GH, Zhu Q, Wu X, Wu LG
Cancer reports (Hoboken, N.J.) 2022 Sep;5(9):e1561
Cancer reports (Hoboken, N.J.) 2022 Sep;5(9):e1561
JQ1 attenuates neuroinflammation by inhibiting the inflammasome-dependent canonical pyroptosis pathway in SAE.
Zhong X, Chen Z, Wang Y, Mao M, Deng Y, Shi M, Xu Y, Chen L, Cao W
Brain research bulletin 2022 Oct 15;189:174-183
Brain research bulletin 2022 Oct 15;189:174-183
Deoxynivalenol induces caspase-3/GSDME-dependent pyroptosis and inflammation in mouse liver and HepaRG cells.
Mao X, Li J, Xie X, Chen S, Huang Q, Mu P, Jiang J, Deng Y
Archives of toxicology 2022 Nov;96(11):3091-3112
Archives of toxicology 2022 Nov;96(11):3091-3112
Cadmium exposure induces pyroptosis in testicular tissue by increasing oxidative stress and activating the AIM2 inflammasome pathway.
Zhou J, Zeng L, Zhang Y, Wang M, Li Y, Jia Y, Wu L, Su P
The Science of the total environment 2022 Nov 15;847:157500
The Science of the total environment 2022 Nov 15;847:157500
HDAC11 promotes both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells.
Yao F, Jin Z, Zheng Z, Lv X, Ren L, Yang J, Chen D, Wang B, Yang W, Chen L, Wang W, Gu J, Lin R
Cell death discovery 2022 Mar 12;8(1):112
Cell death discovery 2022 Mar 12;8(1):112
Bexarotene-induced cell death in ovarian cancer cells through Caspase-4-gasdermin E mediated pyroptosis.
Kobayashi T, Mitsuhashi A, Hongying P, Shioya M, Kojima K, Nishikimi K, Yahiro K, Shozu M
Scientific reports 2022 Jul 1;12(1):11123
Scientific reports 2022 Jul 1;12(1):11123
Coxsackievirus Group B3 Has Oncolytic Activity against Colon Cancer through Gasdermin E-Mediated Pyroptosis.
Zhang Y, Xu T, Tian H, Wu J, Yu X, Zeng L, Liu F, Liu Q, Huang X
Cancers 2022 Dec 15;14(24)
Cancers 2022 Dec 15;14(24)
Gasdermin-E Mediated Pyroptosis-A Novel Mechanism Regulating Migration, Invasion and Release of Inflammatory Cytokines in Rheumatoid Arthritis Fibroblast-like Synoviocytes.
Wu T, Zhang XP, Zhang Q, Zou YY, Ma JD, Chen LF, Zou YW, Xue JM, Ma RF, Chen Z, Dai L
Frontiers in cell and developmental biology 2021;9:810635
Frontiers in cell and developmental biology 2021;9:810635
Role of Cytokines Released During Pyroptosis in Non-Small Cell Lung Cancer.
Huang Y, Zhang G, Zhu Q, Wu X, Wu L
Cancer management and research 2021;13:7399-7409
Cancer management and research 2021;13:7399-7409
Gasdermin D Is a Novel Prognostic Biomarker and Relates to TMZ Response in Glioblastoma.
Liu J, Gao L, Zhu X, Geng R, Tao X, Xu H, Chen Z
Cancers 2021 Nov 10;13(22)
Cancers 2021 Nov 10;13(22)
A hybrid membrane coating nanodrug system against gastric cancer via the VEGFR2/STAT3 signaling pathway.
Long Y, Wang Z, Fan J, Yuan L, Tong C, Zhao Y, Liu B
Journal of materials chemistry. B 2021 May 12;9(18):3838-3855
Journal of materials chemistry. B 2021 May 12;9(18):3838-3855
GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy.
Li Y, Yuan Y, Huang ZX, Chen H, Lan R, Wang Z, Lai K, Chen H, Chen Z, Zou Z, Ma HB, Lan HY, Mak TW, Xu Y
Cell death and differentiation 2021 Aug;28(8):2333-2350
Cell death and differentiation 2021 Aug;28(8):2333-2350
Exosome-Delivered LncHEIH Promotes Gastric Cancer Progression by Upregulating EZH2 and Stimulating Methylation of the GSDME Promoter.
Lu Y, Hou K, Li M, Wu X, Yuan S
Frontiers in cell and developmental biology 2020;8:571297
Frontiers in cell and developmental biology 2020;8:571297
Caspase-3 Promotes Diabetic Kidney Disease Through Gasdermin E-Mediated Progression to Secondary Necrosis During Apoptosis.
Wen S, Wang ZH, Zhang CX, Yang Y, Fan QL
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:313-323
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:313-323
Methamphetamine induces GSDME-dependent cell death in hippocampal neuronal cells through the endoplasmic reticulum stress pathway.
Liu Y, Wen D, Gao J, Xie B, Yu H, Shen Q, Zhang J, Jing W, Cong B, Ma C
Brain research bulletin 2020 Sep;162:73-83
Brain research bulletin 2020 Sep;162:73-83
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The DFNA5 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human DFNA5. This antibody recognizes human, mouse antigen. The DFNA5 antibody has been validated for the following applications: ELISA, WB analysis.