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- Product number
- 13075-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13075-1-AP, RRID:AB_2093053
- Product name
- DFNA5/GSDME antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated DFNA5/GSDME antibody (Cat. #13075-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Curcumin enhances GSDME-mediated pyroptosis to potentiate PD-1/PD-L1 immune checkpoint blockade in colorectal cancer.
Reactive oxygen species/hypoxia dual-responsive polymers combined with melatonin inhibited PANoptosis of retinal ganglion cells for acute glaucoma treatment.
Targeting methionine-induced pyroptosis enhances anti-tumor immunity.
Statins targeting mevalonate-geranylgeranyl diphosphate pathway inhibit proliferation in NK/T lymphoma by promoting pyroptosis.
DEAF1 confers resistance to adriamycin-induced apoptosis and pyroptosis in multiple myeloma.
Caspase-3/7 deficiency results in enhanced intestinal inflammation and reduced tumorigenesis.
pH-Activatable engineered nanoparticle-based selective hexokinase 2 degrader provokes GSDME-dependent pyroptosis for cancer therapy.
5-HT reuptake blockade induces pyroptosis in BRAF(V600E)-mutated melanomas via remodeling histone serotonylation.
Engineered Akkermansia muciniphila vesicles for targeted pyroptosis and trained immunity to enhance immunotherapy in hepatocellular carcinoma.
Cell death modulation dictates tissue-specific tropism of lumpy skin disease virus.
Targeting G9a Exerts Pleiotropic Suppression in Triple-Negative Breast Cancer Cells: Cooperatively Inducing Pyroptosis and Apoptosis.
HIFU postoperative hypoxia-activated metal-organic frameworks modulate the tumor microenvironment to augment immunotherapy.
GSDME Deficiency Suppresses ER Stress-Induced Autophagic Cell Death via mTOR/S6K1 Activation in Hepatobiliary Carcinomas.
Saquinavir induces pyroptosis through the OTUD5-JAK1-GSDME axis in hepatocellular carcinoma.
Zinc-doped carbon dots from natural Isatis Indigotica folium and calamine: SOD/CAT-mimetic activity targets ROS-Ca²⁺-NLRP3 axis for psoriatic dermatitis therapy.
Inducible Nitric Oxide Deficiency Attenuates Necroptosis in Psoriasis-Like Dermatitis in Mice by Reducing Oxidative Stress.
IMRC-Exo mitigates Deinagkistrodon acutus venom-induced limb injury in rabbits by inhibiting GSDME-dependent pyroptosis.
Integrated metabolomic and transcriptomic analysis reveals the effects and mechanisms of Jingfang Baidu powder on acute lung injury.
β-elemene promotes ferroptosis to improve the sensitivity of imatinib in gastrointestinal stromal tumours by targeting N6AMT1.
Light-controlled pyroptosis via redox-responsive microneedles enhances photodynamic-epigenetic immunotherapy in breast cancer.
GSDME-dependent astrocyte pyroptosis promotes the progression of neuroinflammation in experimental cerebral malaria.
Nicotinamide riboside attenuates radiation-induced intestinal injury by suppressing gasdermin E-mediated pyroptosis in intestinal epithelial cells.
Inhibition of USP18 in the presence of IFN-α elevates apoptosis, autophagy, and chemosensitivity of oesophageal cancer cell lines.
Hydrogen Sulfide Attenuates Cisplatin-Induced Acute Kidney Injury via Dual Inhibition of Apoptosis and Pyroptosis.
Transcriptomic insights into GSDME-driven pyroptosis in head and neck cancer.
A novel sono-activatable nanoreactor induces precision intratumoral juglone generation and caspase 3/GSDME-mediated pyroptosis for treatment of bladder cancer.
Fosinopril mediates antitumor efficacy by inducing GSDME-dependent pyroptosis in NSCLC.
An epigenetic regulator synergizes with alphavirus-mediated gene therapy via biomimetic delivery for enhanced cancer therapy.
Pyroptosis was suppressed by 20-hydroxyecdysone through Lin28b-mediated let-7d in vascular endothelial cells.
Procyanidin B2 mitigates methotrexate-induced hepatic pyroptosis by suppressing TLR4/NF-κB and caspase-3/GSDME pathways.
Deoxynivalenol-induced pyroptosis and autophagy inhibition collectively promote inflammatory injury in the glandular stomach of chicken embryos.
Taletrectinib promotes pyroptosis in colorectal carcinoma via SRC/AKT/mTOR axis inhibition.
Glutamine transporter inhibitor enhances the sensitivity of NSCLC to trametinib through GSDME-dependent pyroptosis.
Oxaliplatin induces pyroptosis in hepatoma cells and enhances antitumor immunity against hepatocellular carcinoma.
Knockdown TNF family prognosis index crucial gene PDE4B promoted PANoptosis of ovarian carcinoma cell:Based in vitro and in vivo experiments.
Genetically engineered GSDME vesicle coated nanoparticle for immune activating and pyroptosis inducing synergetic therapy of fibrosarcoma.
Bufotalin loaded biomimetic nanodrug for combined chemo/photodynamic therapy of cancer.
In Situ Delivery of Gasdermin E mRNA Promotes Antitumor Immunity via Creatine-Elicited Type I Interferon Signaling in Monocytes.
Pyroptosis Mediated by ROS/Caspase-3/GSDME Pathway in Aspergillus fumigatus-Induced Fungal Keratitis.
Oxaliplatin accelerates immunogenic cell death by activating the cGAS/STING/TBK1/IRF5 pathway in gastric cancer.
The Role and Mechanism of GSDME-Dependent Pyroptosis in Cochlear Marginal Cells Injury by Cisplatin.
Berberine shaping the tumor immune landscape via pyroptosis.
Targeting pyroptosis reverses KIAA1199-mediated immunotherapy resistance in colorectal cancer.
Glucose starvation mimetic aldometanib removes immune barriers permitting mice with hepatocellular carcinoma to live to normal ages.
Lenvatinib promotes hepatocellular carcinoma pyroptosis by regulating GSDME palmitoylation.
Cucurbitacin B induces oral squamous cell carcinomapyroptosis via GSDME and inhibits tumour growth.
New Insights into Melatonin's Function on Thiacloprid-Induced Pyroptosis and Inflammatory Response in Head Kidney Lymphocytes of Cyprinus carpio: Implicating Mitochondrial Metabolic Imbalance and mtROS/cGAS-STING/NF-κB Axis.
Roles of PANoptosis and related genes in acute liver failure: neoteric insight from bioinformatics analysis and animal experiment verification.
Novel model of pyroptosis-related molecular signatures for prognosis prediction of clear cell renal cell carcinoma patients.
Role of miR-93-5p and Its Opposing Effect of Ionizing Radiation in Non-Small Cell Lung Cancer.
Impact of Caspase3/GSDME-Mediated Pyroptosis on Tumor Immune Microenvironment and Clinical Prognosis Across Multiple Cancers.
GEFT inhibits the GSDM-mediated proptosis signalling pathway, promoting the progression and drug resistance of rhabdomyosarcoma.
Enhancing cell pyroptosis with biomimetic nanoparticles for melanoma chemo-immunotherapy.
Lipocalin 2 (LCN2) confers acquired resistance to almonertinib in NSCLC through LCN2-MMP-9 signaling pathway.
G protein subunit Gγ13-mediated signaling pathway is critical to the inflammation resolution and functional recovery of severely injured lungs.
Enhanced Gasdermin-E-mediated Pyroptosis in Alzheimer's Disease.
TNFSF15 inhibits progression of diabetic retinopathy by blocking pyroptosis via interacting with GSDME.
The facilitating effects of KRT80 on chemoresistance, lipogenesis, and invasion of esophageal cancer.
Disturbance of mitochondrial dynamics led to spermatogenesis disorder in mice exposed to polystyrene micro- and nanoplastics.
Inhibiting caspase-3/GSDME-mediated pyroptosis ameliorates septic lung injury in mice model.
Tectorigenin improves metabolic dysfunction-associated steatohepatitis by down-regulating tRF-3040b and promoting mitophagy to inhibit pyroptosis pathway.
Synthetic lethality of combined ULK1 defection and p53 restoration induce pyroptosis by directly upregulating GSDME transcription and cleavage activation through ROS/NLRP3 signaling.
Miltirone induces GSDME-dependent pyroptosis in colorectal cancer by activating caspase 3.
Hydralazine loaded nanodroplets combined with ultrasound-targeted microbubble destruction to induce pyroptosis for tumor treatment.
Activation of STING by SAMHD1 Deficiency Promotes PANoptosis and Enhances Efficacy of PD-L1 Blockade in Diffuse Large B-cell Lymphoma.
Identification of molecular subtypes based on PANoptosis-related genes and construction of a signature for predicting the prognosis and response to immunotherapy response in hepatocellular carcinoma.
Exploring the molecular mechanisms of the involvement of GZMB-Caspase-3-GSDME pathway in the progression of rheumatoid arthritis.
Verbenalin alleviates acute lung injury induced by sepsis and IgG immune complex through GPR18 receptor.
A high-throughput Gaussia luciferase reporter assay for screening potential gasdermin E activators against pancreatic cancer.
Ferroptosis plays a crucial role in lung cell damage caused by ventilation stretch.
Single-cell sequencing reveals homogeneity and heterogeneity of the cytopathological mechanisms in different etiology-induced AKI.
Neobavaisoflavone induces pyroptosis of liver cancer cells via Tom20 sensing the activated ROS signal.
Triggering pyroptosis enhances the antitumor efficacy of PARP inhibitors in prostate cancer.
Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P.
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression.
GSDME Increases Chemotherapeutic Drug Sensitivity by Inducing Pyroptosis in Retinoblastoma Cells.
Pyroptosis relates to tumor microenvironment remodeling and prognosis: A pan-cancer perspective.
Expression levels of caspase-3 and gasdermin E and their involvement in the occurrence and prognosis of lung cancer.
JQ1 attenuates neuroinflammation by inhibiting the inflammasome-dependent canonical pyroptosis pathway in SAE.
Deoxynivalenol induces caspase-3/GSDME-dependent pyroptosis and inflammation in mouse liver and HepaRG cells.
Cadmium exposure induces pyroptosis in testicular tissue by increasing oxidative stress and activating the AIM2 inflammasome pathway.
HDAC11 promotes both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells.
Bexarotene-induced cell death in ovarian cancer cells through Caspase-4-gasdermin E mediated pyroptosis.
Coxsackievirus Group B3 Has Oncolytic Activity against Colon Cancer through Gasdermin E-Mediated Pyroptosis.
Gasdermin-E Mediated Pyroptosis-A Novel Mechanism Regulating Migration, Invasion and Release of Inflammatory Cytokines in Rheumatoid Arthritis Fibroblast-like Synoviocytes.
Role of Cytokines Released During Pyroptosis in Non-Small Cell Lung Cancer.
Gasdermin D Is a Novel Prognostic Biomarker and Relates to TMZ Response in Glioblastoma.
A hybrid membrane coating nanodrug system against gastric cancer via the VEGFR2/STAT3 signaling pathway.
GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy.
Exosome-Delivered LncHEIH Promotes Gastric Cancer Progression by Upregulating EZH2 and Stimulating Methylation of the GSDME Promoter.
Caspase-3 Promotes Diabetic Kidney Disease Through Gasdermin E-Mediated Progression to Secondary Necrosis During Apoptosis.
Methamphetamine induces GSDME-dependent cell death in hippocampal neuronal cells through the endoplasmic reticulum stress pathway.
Tan D, Li G, Li X, Zhai W, Jing L
Frontiers in pharmacology 2026;17:1734653
Frontiers in pharmacology 2026;17:1734653
Reactive oxygen species/hypoxia dual-responsive polymers combined with melatonin inhibited PANoptosis of retinal ganglion cells for acute glaucoma treatment.
Meng S, Fang W, Wu Y, Xia Z, Chou T, Xia Y, Ding L, Zhou X, Xia X
Theranostics 2026;16(2):830-851
Theranostics 2026;16(2):830-851
Targeting methionine-induced pyroptosis enhances anti-tumor immunity.
Lei M, Zhu W, Wang C, Zhang F, Li M, Zhang Y, Qu J, Luo Z, Li J, Li ZX, Yin M, Lei QY
Science China. Life sciences 2026 May;69(5):1604-1619
Science China. Life sciences 2026 May;69(5):1604-1619
Statins targeting mevalonate-geranylgeranyl diphosphate pathway inhibit proliferation in NK/T lymphoma by promoting pyroptosis.
Wang Y, Mei M, Wang J, Wei L, Zhang M, Zhang M
Translational oncology 2026 May;67:102747
Translational oncology 2026 May;67:102747
DEAF1 confers resistance to adriamycin-induced apoptosis and pyroptosis in multiple myeloma.
Deng Z, Wei Y, Liu S, Chen L, Wang X, Liu Z, Liu L, Wang Y, Lv X, Sun S, Ni H, Gu C, Yang Y
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2026 Mar;85:101344
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2026 Mar;85:101344
Caspase-3/7 deficiency results in enhanced intestinal inflammation and reduced tumorigenesis.
Xie W, Wyckaert L, Vadi M, Verstraeten B, Divert T, Haerinck J, De Rycke R, Baeke F, Lamkanfi M, Berx G, Wahida A, Vandenabeele P
Science advances 2026 Mar 20;12(12):eadz5906
Science advances 2026 Mar 20;12(12):eadz5906
pH-Activatable engineered nanoparticle-based selective hexokinase 2 degrader provokes GSDME-dependent pyroptosis for cancer therapy.
Gong L, Li S, Sun J, Liu K, Wang S, Ji M, Hou P, Yan L, Yang D, Liu D
Acta pharmaceutica Sinica. B 2026 Jan;16(1):539-554
Acta pharmaceutica Sinica. B 2026 Jan;16(1):539-554
5-HT reuptake blockade induces pyroptosis in BRAF(V600E)-mutated melanomas via remodeling histone serotonylation.
Li A, Xu S, Fan J, Liu J, Song X, Cao L, Gong Z, Lu X
Cell reports. Medicine 2026 Jan 20;7(1):102537
Cell reports. Medicine 2026 Jan 20;7(1):102537
Engineered Akkermansia muciniphila vesicles for targeted pyroptosis and trained immunity to enhance immunotherapy in hepatocellular carcinoma.
Huang L, Rong Y, Guo M, Liu M, Long F, Zhong W, Hu Y, He X, He J, Zheng D, Yuan C, Wang F
Cell reports. Medicine 2026 Jan 20;7(1):102524
Cell reports. Medicine 2026 Jan 20;7(1):102524
Cell death modulation dictates tissue-specific tropism of lumpy skin disease virus.
Wen Y, Wang T, Zhang S, Wang J, Li C, Liu C, Tang F, Dai J, Xue F
PLoS pathogens 2026 Feb;22(2):e1013982
PLoS pathogens 2026 Feb;22(2):e1013982
Targeting G9a Exerts Pleiotropic Suppression in Triple-Negative Breast Cancer Cells: Cooperatively Inducing Pyroptosis and Apoptosis.
Li J, Zhang G, Liu T, Yan X, Ma M
Biomolecules 2026 Feb 25;16(3)
Biomolecules 2026 Feb 25;16(3)
HIFU postoperative hypoxia-activated metal-organic frameworks modulate the tumor microenvironment to augment immunotherapy.
Luo C, Wu D, Peng S, Xu S, Zhang D, Huang X, Qin W, Li H, Li H
Journal of nanobiotechnology 2026 Feb 1;24(1)
Journal of nanobiotechnology 2026 Feb 1;24(1)
GSDME Deficiency Suppresses ER Stress-Induced Autophagic Cell Death via mTOR/S6K1 Activation in Hepatobiliary Carcinomas.
Sun L, Tang G, Zhang M, Zhou H, Liu Y, Cao X, Zhang J
Biochemical genetics 2026 Apr;64(2):2339-2352
Biochemical genetics 2026 Apr;64(2):2339-2352
Saquinavir induces pyroptosis through the OTUD5-JAK1-GSDME axis in hepatocellular carcinoma.
Yao L, Yao Y, He W, Xue Z, Zheng K, Lei Q, Deng Y, Liu Q, Shao Z, Liao Y
Free radical biology & medicine 2026 Apr;247:361-377
Free radical biology & medicine 2026 Apr;247:361-377
Zinc-doped carbon dots from natural Isatis Indigotica folium and calamine: SOD/CAT-mimetic activity targets ROS-Ca²⁺-NLRP3 axis for psoriatic dermatitis therapy.
Tian X, Huang Y, He C, Dai E, Zhang X, Zou P, Liu R, Xia M, Lu Z, Jin B, Wang S, Zhang Y, Kong H, Qu H, Zhao Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:158013
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:158013
Inducible Nitric Oxide Deficiency Attenuates Necroptosis in Psoriasis-Like Dermatitis in Mice by Reducing Oxidative Stress.
Sun M, Guo P, Guo Q, Li H, Huang J, Luo J, Zhu Q, Zhu Y, Yuan Q, Song S, He J, Su L, Xing W, Hu L
The Journal of investigative dermatology 2026 Apr;146(4):986-997.e12
The Journal of investigative dermatology 2026 Apr;146(4):986-997.e12
IMRC-Exo mitigates Deinagkistrodon acutus venom-induced limb injury in rabbits by inhibiting GSDME-dependent pyroptosis.
Wu H, Xie L, Du W, Lai L, Shangguan P, Wu X, Xu J, Lan P
The journal of venomous animals and toxins including tropical diseases 2025;31:e20230009
The journal of venomous animals and toxins including tropical diseases 2025;31:e20230009
Integrated metabolomic and transcriptomic analysis reveals the effects and mechanisms of Jingfang Baidu powder on acute lung injury.
Zhu Z, Cui B, Dai R, Hu G, Xu S, Zhao X, Wang W, Li X
Frontiers in pharmacology 2025;16:1649883
Frontiers in pharmacology 2025;16:1649883
β-elemene promotes ferroptosis to improve the sensitivity of imatinib in gastrointestinal stromal tumours by targeting N6AMT1.
Lan J, Zhang W, Zeng K, Li C, He J, Li X, Yang R, Chi J, Hong Z, Wang W, Zhou C, Xiao B, Fan W, Lin J, Ou Q, Fang Y, Pan Z, Peng J, Li W, Wu X
Clinical and translational medicine 2025 Sep;15(9):e70438
Clinical and translational medicine 2025 Sep;15(9):e70438
Light-controlled pyroptosis via redox-responsive microneedles enhances photodynamic-epigenetic immunotherapy in breast cancer.
Yu H, Chen Y, Yin J, Yuan Z, Feng S, Duan Y, Yan P, Liu S, Zhu W
Materials today. Bio 2025 Oct;34:102158
Materials today. Bio 2025 Oct;34:102158
GSDME-dependent astrocyte pyroptosis promotes the progression of neuroinflammation in experimental cerebral malaria.
Wang J, Zhu Q, Tong G, Yu K, Liang J, Huang Y, Wang Y, Yang C, Li T, Liang W, Li G, Liu X, Sun J, Li Y, Shen Y, Zhao Y
Apoptosis : an international journal on programmed cell death 2025 Oct;30(9-10):2385-2400
Apoptosis : an international journal on programmed cell death 2025 Oct;30(9-10):2385-2400
Nicotinamide riboside attenuates radiation-induced intestinal injury by suppressing gasdermin E-mediated pyroptosis in intestinal epithelial cells.
Zhou Q, Liu L, Lin X, Shen B, Huang W, Zhang Y, Li Y, Yang Y, Liu H, Zhang W, Zhao X, Qiao W, Liu Y, Tan G, Zhi F
Journal of translational medicine 2025 Oct 17;23(1):1126
Journal of translational medicine 2025 Oct 17;23(1):1126
Inhibition of USP18 in the presence of IFN-α elevates apoptosis, autophagy, and chemosensitivity of oesophageal cancer cell lines.
Carey MM, O'Donovan TR, Coveney CM, McKenna SL
Experimental cell research 2025 Oct 1;452(2):114768
Experimental cell research 2025 Oct 1;452(2):114768
Hydrogen Sulfide Attenuates Cisplatin-Induced Acute Kidney Injury via Dual Inhibition of Apoptosis and Pyroptosis.
Han Z, Jia Y, Yan D, Xue Y, Deng T, Wang P, Xiao L, Wang X
Biomedicines 2025 Nov 3;13(11)
Biomedicines 2025 Nov 3;13(11)
Transcriptomic insights into GSDME-driven pyroptosis in head and neck cancer.
Hao F, Qin D, Li R, Li X, Hou J, Zhao B
Scientific reports 2025 Nov 29;16(1):594
Scientific reports 2025 Nov 29;16(1):594
A novel sono-activatable nanoreactor induces precision intratumoral juglone generation and caspase 3/GSDME-mediated pyroptosis for treatment of bladder cancer.
Zhang Y, Yang E, Zhang X, Shi Y, Fan G, Wang Y, Tian J, Wang H, Dong Z, Wang Y, Cheng L, Zhao Z, Zhang Y, Wang B, Wang Z
Journal of nanobiotechnology 2025 Nov 22;23(1):795
Journal of nanobiotechnology 2025 Nov 22;23(1):795
Fosinopril mediates antitumor efficacy by inducing GSDME-dependent pyroptosis in NSCLC.
Gao Y, Zhai X, Zhang C, Zhao H, Ji B, Sun R, Du X, Du Y, Gao S, Zhang Y, Wang T
Cell death discovery 2025 Nov 21;11(1):540
Cell death discovery 2025 Nov 21;11(1):540
An epigenetic regulator synergizes with alphavirus-mediated gene therapy via biomimetic delivery for enhanced cancer therapy.
Xia Y, Su M, Ye Z, Du F, Wang X, Guan D, Zhang X, Rao Z, Ning P
Trends in biotechnology 2025 May;43(5):1196-1214
Trends in biotechnology 2025 May;43(5):1196-1214
Pyroptosis was suppressed by 20-hydroxyecdysone through Lin28b-mediated let-7d in vascular endothelial cells.
Chen D, Yang J, Ren L, Zheng Z, Jin Z, Wen J, He J, Ding R, Wang J, Lin R, Song Q
Naunyn-Schmiedeberg's archives of pharmacology 2025 May;398(5):6083-6097
Naunyn-Schmiedeberg's archives of pharmacology 2025 May;398(5):6083-6097
Procyanidin B2 mitigates methotrexate-induced hepatic pyroptosis by suppressing TLR4/NF-κB and caspase-3/GSDME pathways.
Alsaab J, Sarawi WS, Alhusaini AM, Hasan IH, Alturaif S, Ali RA, Alrasheed NM, Mohammad R, Algarzae NK
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 May;199:115341
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 May;199:115341
Deoxynivalenol-induced pyroptosis and autophagy inhibition collectively promote inflammatory injury in the glandular stomach of chicken embryos.
Chen F, Yang G, Qiu H, Gao S, Hou L, Dong J, Zhao P, Dong W
Poultry science 2025 May;104(5):105052
Poultry science 2025 May;104(5):105052
Taletrectinib promotes pyroptosis in colorectal carcinoma via SRC/AKT/mTOR axis inhibition.
Zhang T, Zou Y, Zhang SH, Wang YY, He S, Yuan W, Yang M, Liu T, Deng SH, Wu DM, Xu Y
Scientific reports 2025 May 24;15(1):18049
Scientific reports 2025 May 24;15(1):18049
Glutamine transporter inhibitor enhances the sensitivity of NSCLC to trametinib through GSDME-dependent pyroptosis.
Liu Q, Hu J, Li X, Gao H, Kong D, Jin M
Biochemical pharmacology 2025 Mar;233:116796
Biochemical pharmacology 2025 Mar;233:116796
Oxaliplatin induces pyroptosis in hepatoma cells and enhances antitumor immunity against hepatocellular carcinoma.
Deng M, Zhao R, Zou H, Guan R, Wang J, Lee C, He B, Zhou J, Li S, Wei W, Cai H, Guo R
British journal of cancer 2025 Mar;132(4):371-383
British journal of cancer 2025 Mar;132(4):371-383
Knockdown TNF family prognosis index crucial gene PDE4B promoted PANoptosis of ovarian carcinoma cell:Based in vitro and in vivo experiments.
Yu Q, Wang Y, Fu T, Han D, Wang L, Zhao L, Xu Y
Translational oncology 2025 Jun;56:102333
Translational oncology 2025 Jun;56:102333
Genetically engineered GSDME vesicle coated nanoparticle for immune activating and pyroptosis inducing synergetic therapy of fibrosarcoma.
Miao F, Wang Z, Wang Q, Zhou C, Zhou X, Zheng J, Ma Y, Lin Z, Gao Y, Wu T, Zhang Y, Gao J, Li W
Materials today. Bio 2025 Jun;32:101802
Materials today. Bio 2025 Jun;32:101802
Bufotalin loaded biomimetic nanodrug for combined chemo/photodynamic therapy of cancer.
Chen S, Fan J, Xie Q, Qin Y, Xie H, Xiao C, Wang W, Liu B
Materials today. Bio 2025 Jun;32:101684
Materials today. Bio 2025 Jun;32:101684
In Situ Delivery of Gasdermin E mRNA Promotes Antitumor Immunity via Creatine-Elicited Type I Interferon Signaling in Monocytes.
Li H, Lu J, Tan S, Jiang T, He X, Qiao W, Hu C, Dalangood S, Lin J, Gui J
Cancer immunology research 2025 Jun 4;13(6):939-956
Cancer immunology research 2025 Jun 4;13(6):939-956
Pyroptosis Mediated by ROS/Caspase-3/GSDME Pathway in Aspergillus fumigatus-Induced Fungal Keratitis.
Kan J, Song S, Liu M, Xu Q, Lee J, Sun J, Xue S, Sun X, Che C
Investigative ophthalmology & visual science 2025 Jun 2;66(6):52
Investigative ophthalmology & visual science 2025 Jun 2;66(6):52
Oxaliplatin accelerates immunogenic cell death by activating the cGAS/STING/TBK1/IRF5 pathway in gastric cancer.
Zhao S, Sun D, Yu H, Wang M, Xu B, Wang Y, Hu F, Wang X, Zhang J, Wang Y, Chai J
The FEBS journal 2025 Jul;292(14):3814-3828
The FEBS journal 2025 Jul;292(14):3814-3828
The Role and Mechanism of GSDME-Dependent Pyroptosis in Cochlear Marginal Cells Injury by Cisplatin.
Lei W, Yu W, Li T, Tang W, Zong S, Xiao H
Biomedicines 2025 Jul 9;13(7)
Biomedicines 2025 Jul 9;13(7)
Berberine shaping the tumor immune landscape via pyroptosis.
Xie J, Du X, Li Y, Wu C, Li R, Zhao M, Shi S
Cellular immunology 2025 Feb;408:104908
Cellular immunology 2025 Feb;408:104908
Targeting pyroptosis reverses KIAA1199-mediated immunotherapy resistance in colorectal cancer.
Li L, Zhao L, Zhou D, Yu Y, Zhang P, Zheng J, Lin Z, Yu D, Ren J, Zhang J, Zhou P, Zhang D, Zhang T
Journal for immunotherapy of cancer 2025 Feb 25;13(2)
Journal for immunotherapy of cancer 2025 Feb 25;13(2)
Glucose starvation mimetic aldometanib removes immune barriers permitting mice with hepatocellular carcinoma to live to normal ages.
Hu HH, Wang X, Lan B, Cheng H, Wen H, Chen F, Wu J, Li M, Chen J, Zhang J, Chen D, Lin S, Lin J, Yang M, Wu Z, Zheng ZZ, Chen F, Zhou J, Chen G, Chen Y, Deng X, Zhang CS, Liu J, Lin SC
Cell research 2025 Dec;35(12):934-953
Cell research 2025 Dec;35(12):934-953
Lenvatinib promotes hepatocellular carcinoma pyroptosis by regulating GSDME palmitoylation.
Yuan Y, Wang MR, Ding Y, Lin Y, Xu TT, He XX, Li PY
Cancer biology & therapy 2025 Dec;26(1):2532217
Cancer biology & therapy 2025 Dec;26(1):2532217
Cucurbitacin B induces oral squamous cell carcinomapyroptosis via GSDME and inhibits tumour growth.
Chen X, Yang M, Zhang H, Wang Y, Yan W, Cheng C, Guo R, Chai J, Zheng Y, Zhang F
Translational oncology 2025 Aug;58:102422
Translational oncology 2025 Aug;58:102422
New Insights into Melatonin's Function on Thiacloprid-Induced Pyroptosis and Inflammatory Response in Head Kidney Lymphocytes of Cyprinus carpio: Implicating Mitochondrial Metabolic Imbalance and mtROS/cGAS-STING/NF-κB Axis.
Diao L, Ma Y, Wang L, Li P, Zhang B, Meng W, Cai J, Meng Y, Zhou Y, Zhai J, Chen H
Journal of agricultural and food chemistry 2025 Apr 30;73(17):10574-10588
Journal of agricultural and food chemistry 2025 Apr 30;73(17):10574-10588
Roles of PANoptosis and related genes in acute liver failure: neoteric insight from bioinformatics analysis and animal experiment verification.
Ge T, Chen Y, Pang L, Shao J, Chen Z
Journal of Zhejiang University. Science. B 2025 Apr 23;26(4):353-370
Journal of Zhejiang University. Science. B 2025 Apr 23;26(4):353-370
Novel model of pyroptosis-related molecular signatures for prognosis prediction of clear cell renal cell carcinoma patients.
Chen J, Jiang R, Guan W, Cao Q, Tian Y, Dong K, Pan X, Cui X
International journal of medical sciences 2024;21(3):496-507
International journal of medical sciences 2024;21(3):496-507
Role of miR-93-5p and Its Opposing Effect of Ionizing Radiation in Non-Small Cell Lung Cancer.
Ni Q, Sang K, Zhou J, Pan C
Analytical cellular pathology (Amsterdam) 2024;2024:4218464
Analytical cellular pathology (Amsterdam) 2024;2024:4218464
Impact of Caspase3/GSDME-Mediated Pyroptosis on Tumor Immune Microenvironment and Clinical Prognosis Across Multiple Cancers.
Huang Y, Liu J, Lin C, Zhu Q, Wu L
Cancer management and research 2024;16:1663-1683
Cancer management and research 2024;16:1663-1683
GEFT inhibits the GSDM-mediated proptosis signalling pathway, promoting the progression and drug resistance of rhabdomyosarcoma.
Yang F, Xia T, Zhao Z, Lin J, Zhong L, Tang T, Liao D, Lai M, Ceng J, Meng L, Li F, Liu C
Cell death & disease 2024 Nov 30;15(11):867
Cell death & disease 2024 Nov 30;15(11):867
Enhancing cell pyroptosis with biomimetic nanoparticles for melanoma chemo-immunotherapy.
Sun S, He Y, Xu J, Leng S, Liu Y, Wan H, Yan L, Xu Y
Journal of controlled release : official journal of the Controlled Release Society 2024 Mar;367:470-485
Journal of controlled release : official journal of the Controlled Release Society 2024 Mar;367:470-485
Lipocalin 2 (LCN2) confers acquired resistance to almonertinib in NSCLC through LCN2-MMP-9 signaling pathway.
Shi C, Wang C, Fu Z, Liu J, Zhou Y, Cheng B, Zhang C, Li S, Zhang Y
Pharmacological research 2024 Mar;201:107088
Pharmacological research 2024 Mar;201:107088
G protein subunit Gγ13-mediated signaling pathway is critical to the inflammation resolution and functional recovery of severely injured lungs.
Li YH, Yang YS, Xue YB, Lei H, Zhang SS, Qian J, Yao Y, Zhou R, Huang L
eLife 2024 Jun 5;12
eLife 2024 Jun 5;12
Enhanced Gasdermin-E-mediated Pyroptosis in Alzheimer's Disease.
Wang Q, Guo S, Hu D, Dong X, Meng Z, Jiang Y, Feng Z, Zhou W, Song W
Neuroscience 2024 Jan 9;536:1-11
Neuroscience 2024 Jan 9;536:1-11
TNFSF15 inhibits progression of diabetic retinopathy by blocking pyroptosis via interacting with GSDME.
Zhao H, Dai Y, Li Y, Li J, Li H
Cell death & disease 2024 Feb 8;15(2):118
Cell death & disease 2024 Feb 8;15(2):118
The facilitating effects of KRT80 on chemoresistance, lipogenesis, and invasion of esophageal cancer.
Yun WJ, Li J, Yin NC, Zhang CY, Cui ZG, Zhang L, Zheng HC
Cancer biology & therapy 2024 Dec 31;25(1):2302162
Cancer biology & therapy 2024 Dec 31;25(1):2302162
Disturbance of mitochondrial dynamics led to spermatogenesis disorder in mice exposed to polystyrene micro- and nanoplastics.
Zhao M, Xie J, Zhang J, Zhao B, Zhang Y, Xue J, Zhang R, Zhang R, Wang H, Li Y, Ge W, Zhou X
Environmental pollution (Barking, Essex : 1987) 2024 Dec 1;362:124935
Environmental pollution (Barking, Essex : 1987) 2024 Dec 1;362:124935
Inhibiting caspase-3/GSDME-mediated pyroptosis ameliorates septic lung injury in mice model.
Qin H, Lu N, Chen K, Huang Y, Rui Y, Huang L, Gao Q, Hu J
Molecular immunology 2024 Aug;172:96-104
Molecular immunology 2024 Aug;172:96-104
Tectorigenin improves metabolic dysfunction-associated steatohepatitis by down-regulating tRF-3040b and promoting mitophagy to inhibit pyroptosis pathway.
Zhu J, Tang W, Wu X, Mu M, Zhang Q, Zhao X
Biochemical and biophysical research communications 2024 Aug 6;720:150118
Biochemical and biophysical research communications 2024 Aug 6;720:150118
Synthetic lethality of combined ULK1 defection and p53 restoration induce pyroptosis by directly upregulating GSDME transcription and cleavage activation through ROS/NLRP3 signaling.
Chen W, Yang KB, Zhang YZ, Lin ZS, Chen JW, Qi SF, Wu CF, Feng GK, Yang DJ, Chen M, Zhu XF, Li X
Journal of experimental & clinical cancer research : CR 2024 Aug 30;43(1):248
Journal of experimental & clinical cancer research : CR 2024 Aug 30;43(1):248
Miltirone induces GSDME-dependent pyroptosis in colorectal cancer by activating caspase 3.
Zheng G, Fang Z, Lin Z, Guan G
Heliyon 2024 Aug 30;10(16):e36603
Heliyon 2024 Aug 30;10(16):e36603
Hydralazine loaded nanodroplets combined with ultrasound-targeted microbubble destruction to induce pyroptosis for tumor treatment.
Huang S, Shang M, Guo L, Sun X, Xiao S, Shi D, Meng D, Zhao Y, Wang X, Liu R, Li J
Journal of nanobiotechnology 2024 Apr 20;22(1):193
Journal of nanobiotechnology 2024 Apr 20;22(1):193
Activation of STING by SAMHD1 Deficiency Promotes PANoptosis and Enhances Efficacy of PD-L1 Blockade in Diffuse Large B-cell Lymphoma.
Cai Y, Chen X, Lu T, Fang X, Ding M, Yu Z, Hu S, Liu J, Zhou X, Wang X
International journal of biological sciences 2023;19(14):4627-4643
International journal of biological sciences 2023;19(14):4627-4643
Identification of molecular subtypes based on PANoptosis-related genes and construction of a signature for predicting the prognosis and response to immunotherapy response in hepatocellular carcinoma.
Zhu J, Huang Q, Peng X, Luo C, Liu Z, Liu D, Yuan H, Yuan R, Cheng X
Frontiers in immunology 2023;14:1218661
Frontiers in immunology 2023;14:1218661
Exploring the molecular mechanisms of the involvement of GZMB-Caspase-3-GSDME pathway in the progression of rheumatoid arthritis.
Zhang Y, Cai X, Wang B, Zhang B, Xu Y
Molecular immunology 2023 Sep;161:82-90
Molecular immunology 2023 Sep;161:82-90
Verbenalin alleviates acute lung injury induced by sepsis and IgG immune complex through GPR18 receptor.
Yang L, Liu T, Zhuo Y, Li D, Li D, Liu J, Gao H, Zhang L, Lin J, Wang X
Cellular signalling 2023 Sep;109:110768
Cellular signalling 2023 Sep;109:110768
A high-throughput Gaussia luciferase reporter assay for screening potential gasdermin E activators against pancreatic cancer.
Liu Y, Zhang X, Zhang P, He T, Zhang W, Ma D, Li P, Chen J
Acta pharmaceutica Sinica. B 2023 Oct;13(10):4253-4272
Acta pharmaceutica Sinica. B 2023 Oct;13(10):4253-4272
Ferroptosis plays a crucial role in lung cell damage caused by ventilation stretch.
Jiang W, Liu J, Cui J, Su J, Xu W, Zhang F, Ding Y
Free radical biology & medicine 2023 Nov 20;209(Pt 1):84-95
Free radical biology & medicine 2023 Nov 20;209(Pt 1):84-95
Single-cell sequencing reveals homogeneity and heterogeneity of the cytopathological mechanisms in different etiology-induced AKI.
Chen Z, Li Y, Yuan Y, Lai K, Ye K, Lin Y, Lan R, Chen H, Xu Y
Cell death & disease 2023 May 11;14(5):318
Cell death & disease 2023 May 11;14(5):318
Neobavaisoflavone induces pyroptosis of liver cancer cells via Tom20 sensing the activated ROS signal.
Li Y, Zhao R, Xiu Z, Yang X, Zhu Y, Han J, Li S, Li Y, Sun L, Li X, Jin N, Li Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154869
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154869
Triggering pyroptosis enhances the antitumor efficacy of PARP inhibitors in prostate cancer.
Tian A, Wu T, Zhang Y, Chen J, Sha J, Xia W
Cellular oncology (Dordrecht, Netherlands) 2023 Dec;46(6):1855-1870
Cellular oncology (Dordrecht, Netherlands) 2023 Dec;46(6):1855-1870
Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P.
Ai YL, Wang WJ, Liu FJ, Fang W, Chen HZ, Wu LZ, Hong X, Zhu Y, Zhang CX, Liu LY, Hong WB, Zhou B, Chen QT, Wu Q
Cell research 2023 Dec;33(12):904-922
Cell research 2023 Dec;33(12):904-922
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression.
Cong L, Liu X, Bai Y, Qin Q, Zhao L, Shi Y, Bai Y, Guo Z
Biological research 2023 Dec 2;56(1):62
Biological research 2023 Dec 2;56(1):62
GSDME Increases Chemotherapeutic Drug Sensitivity by Inducing Pyroptosis in Retinoblastoma Cells.
Li F, Xia Q, Ren L, Nie Y, Ren H, Guo X, Yu J, Xing Y, Chen Z
Oxidative medicine and cellular longevity 2022;2022:2371807
Oxidative medicine and cellular longevity 2022;2022:2371807
Pyroptosis relates to tumor microenvironment remodeling and prognosis: A pan-cancer perspective.
Khan M, Ai M, Du K, Song J, Wang B, Lin J, Ren A, Chen C, Huang Z, Qiu W, Zhang J, Tian Y, Yuan Y
Frontiers in immunology 2022;13:1062225
Frontiers in immunology 2022;13:1062225
Expression levels of caspase-3 and gasdermin E and their involvement in the occurrence and prognosis of lung cancer.
Huang YL, Zhang GH, Zhu Q, Wu X, Wu LG
Cancer reports (Hoboken, N.J.) 2022 Sep;5(9):e1561
Cancer reports (Hoboken, N.J.) 2022 Sep;5(9):e1561
JQ1 attenuates neuroinflammation by inhibiting the inflammasome-dependent canonical pyroptosis pathway in SAE.
Zhong X, Chen Z, Wang Y, Mao M, Deng Y, Shi M, Xu Y, Chen L, Cao W
Brain research bulletin 2022 Oct 15;189:174-183
Brain research bulletin 2022 Oct 15;189:174-183
Deoxynivalenol induces caspase-3/GSDME-dependent pyroptosis and inflammation in mouse liver and HepaRG cells.
Mao X, Li J, Xie X, Chen S, Huang Q, Mu P, Jiang J, Deng Y
Archives of toxicology 2022 Nov;96(11):3091-3112
Archives of toxicology 2022 Nov;96(11):3091-3112
Cadmium exposure induces pyroptosis in testicular tissue by increasing oxidative stress and activating the AIM2 inflammasome pathway.
Zhou J, Zeng L, Zhang Y, Wang M, Li Y, Jia Y, Wu L, Su P
The Science of the total environment 2022 Nov 15;847:157500
The Science of the total environment 2022 Nov 15;847:157500
HDAC11 promotes both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells.
Yao F, Jin Z, Zheng Z, Lv X, Ren L, Yang J, Chen D, Wang B, Yang W, Chen L, Wang W, Gu J, Lin R
Cell death discovery 2022 Mar 12;8(1):112
Cell death discovery 2022 Mar 12;8(1):112
Bexarotene-induced cell death in ovarian cancer cells through Caspase-4-gasdermin E mediated pyroptosis.
Kobayashi T, Mitsuhashi A, Hongying P, Shioya M, Kojima K, Nishikimi K, Yahiro K, Shozu M
Scientific reports 2022 Jul 1;12(1):11123
Scientific reports 2022 Jul 1;12(1):11123
Coxsackievirus Group B3 Has Oncolytic Activity against Colon Cancer through Gasdermin E-Mediated Pyroptosis.
Zhang Y, Xu T, Tian H, Wu J, Yu X, Zeng L, Liu F, Liu Q, Huang X
Cancers 2022 Dec 15;14(24)
Cancers 2022 Dec 15;14(24)
Gasdermin-E Mediated Pyroptosis-A Novel Mechanism Regulating Migration, Invasion and Release of Inflammatory Cytokines in Rheumatoid Arthritis Fibroblast-like Synoviocytes.
Wu T, Zhang XP, Zhang Q, Zou YY, Ma JD, Chen LF, Zou YW, Xue JM, Ma RF, Chen Z, Dai L
Frontiers in cell and developmental biology 2021;9:810635
Frontiers in cell and developmental biology 2021;9:810635
Role of Cytokines Released During Pyroptosis in Non-Small Cell Lung Cancer.
Huang Y, Zhang G, Zhu Q, Wu X, Wu L
Cancer management and research 2021;13:7399-7409
Cancer management and research 2021;13:7399-7409
Gasdermin D Is a Novel Prognostic Biomarker and Relates to TMZ Response in Glioblastoma.
Liu J, Gao L, Zhu X, Geng R, Tao X, Xu H, Chen Z
Cancers 2021 Nov 10;13(22)
Cancers 2021 Nov 10;13(22)
A hybrid membrane coating nanodrug system against gastric cancer via the VEGFR2/STAT3 signaling pathway.
Long Y, Wang Z, Fan J, Yuan L, Tong C, Zhao Y, Liu B
Journal of materials chemistry. B 2021 May 12;9(18):3838-3855
Journal of materials chemistry. B 2021 May 12;9(18):3838-3855
GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy.
Li Y, Yuan Y, Huang ZX, Chen H, Lan R, Wang Z, Lai K, Chen H, Chen Z, Zou Z, Ma HB, Lan HY, Mak TW, Xu Y
Cell death and differentiation 2021 Aug;28(8):2333-2350
Cell death and differentiation 2021 Aug;28(8):2333-2350
Exosome-Delivered LncHEIH Promotes Gastric Cancer Progression by Upregulating EZH2 and Stimulating Methylation of the GSDME Promoter.
Lu Y, Hou K, Li M, Wu X, Yuan S
Frontiers in cell and developmental biology 2020;8:571297
Frontiers in cell and developmental biology 2020;8:571297
Caspase-3 Promotes Diabetic Kidney Disease Through Gasdermin E-Mediated Progression to Secondary Necrosis During Apoptosis.
Wen S, Wang ZH, Zhang CX, Yang Y, Fan QL
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:313-323
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:313-323
Methamphetamine induces GSDME-dependent cell death in hippocampal neuronal cells through the endoplasmic reticulum stress pathway.
Liu Y, Wen D, Gao J, Xie B, Yu H, Shen Q, Zhang J, Jing W, Cong B, Ma C
Brain research bulletin 2020 Sep;162:73-83
Brain research bulletin 2020 Sep;162:73-83
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The DFNA5 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human DFNA5. This antibody recognizes human, mouse antigen. The DFNA5 antibody has been validated for the following applications: ELISA, WB analysis.
