66636-1-Ig

antibody from Proteintech Group

Targeting: TGFBR2 MFS2, TBR-ii, TBRII

Provider product page for 66636-1-Ig

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Immunohistochemistry

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Antibody data

Antibody Data
Antigen structure
References [32]
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Product number: 66636-1-Ig - Provider product page
Provider: Proteintech Group
Product name: TGFBR2 antibody
Antibody type: Monoclonal
Description: TGFBR2 antibody (Cat. #66636-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, Mouse , Rat and has been validated for the following applications: FC, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 2D5H7
Vial size: 20ul, 150ul

TGFBR2 protein structure - 66636-1-Ig shown in red.

Submitted references Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFβ1- Smad1/5 signaling pathway.

Chen J, Zhang Z, Feng L, Liu W, Wang X, Chen H, Zou H
Archives of biochemistry and biophysics 2024 Mar;753:109892

Resistance exercise upregulates Irisin expression and suppresses myocardial fibrosis following myocardial infarction via activating AMPK-Sirt1 and inactivating TGFβ1-Smad2/3.

Li H, Qin S, Tang J, Wang T, Ren W, Di L, Bo W, Ma Y, Wu F, Xu Z, Song W, Cai M, Xi Y, Tian Z
Acta physiologica (Oxford, England) 2024 Jul;240(7):e14163

circGRHPR inhibits aberrant epithelial-mesenchymal transformation progression of lung epithelial cells associated with idiopathic pulmonary fibrosis.

Wu W, Wang Z, Zhang H, Zhang X, Tian H
Cell biology and toxicology 2024 Jan 25;40(1):7

Pirfenidone and nintedanib attenuate pulmonary fibrosis in mice by inhibiting the expression of JAK2.

Yang Y, Wang X, Zhang J
Journal of thoracic disease 2024 Feb 29;16(2):1128-1140

Irisin Ameliorates Renal Tubulointerstitial Fibrosis by Regulating the Smad4/β-Catenin Pathway in Diabetic Mice.

Yang Z, Wei J, Wang Y, Du Y, Song S, Li J, Su Z, Shi Y, Wu H
Diabetes, metabolic syndrome and obesity : targets and therapy 2023;16:1577-1593

Alkaline shear-thinning micro-nanocomposite hydrogels initiate endogenous TGFβ signaling for in situ bone regeneration.

Niu Y, Yang Z, Yang Y, Wang X, Zhang P, Lv L, Wang S, Liu Y, Liu Y, Zhou Y
NPJ Regenerative medicine 2023 Oct 13;8(1):56

C-X-C domain ligand 14-mediated stromal cell-macrophage interaction as a therapeutic target for hand dermal fibrosis.

Goto A, Komura S, Kato K, Maki R, Hirakawa A, Tomita H, Hirata A, Yamada Y, Akiyama H
Communications biology 2023 Nov 18;6(1):1173

Crosstalk between the JAK2 and TGF-β1 signaling pathways in scleroderma-related interstitial lung disease targeted by baricitinib.

Wang D, Wei Y, Xu L, Zhang J
Advances in rheumatology (London, England) 2023 May 16;63(1):22

Deubiquitinating enzyme USP11 promotes renal tubular cell senescence and fibrosis via inhibiting the ubiquitin degradation of TGF-β receptor II.

Ni JY, Wang X, Xie HY, Yang NH, Li JY, Sun XA, Guo HJ, Zhou L, Zhang W, Liu J, Lu LM
Acta pharmacologica Sinica 2023 Mar;44(3):584-595

Long non-coding RNA MFSD4A-AS1 promotes lymphangiogenesis and lymphatic metastasis of papillary thyroid cancer.

Liu X, Zhang C, Wang X, Cui C, Cui H, Zhu B, Chen A, Zhang L, Xin J, Fu Q, Dionigi G, Sun H
Endocrine-related cancer 2023 Mar 1;30(3)

GPR97 deficiency ameliorates renal interstitial fibrosis in mouse hypertensive nephropathy.

Wu JC, Wang XJ, Zhu JH, Huang XY, Liu M, Qiao Z, Zhang Y, Sun Y, Wang ZY, Zhan P, Zhang T, Hu HL, Liu H, Tang W, Yi F
Acta pharmacologica Sinica 2023 Jun;44(6):1206-1216

Hypoxia-Driven TGFβ Modulation of Side Population Cells in Breast Cancer: The Potential Role of ERα.

Mallini P, Chen M, Mahkamova K, Lennard TWJ, Pan Y, Wei D, Stemke-Hale K, Kirby JA, Lash GE, Meeson A
Cancers 2023 Feb 9;15(4)

Engineering irradiated tumor-derived microparticles as personalized vaccines to enhance anti-tumor immunity.

Sun Y, Tian Y, Wu S, Huang A, Hu Y, Liao Z, Swift M, Deng S, Yang X, Zhang B, Zhang Z, Wu B, Huang J, Jiang K, Huang F, Jin H, Wan C, Yang K
Cell reports. Medicine 2023 Dec 19;4(12):101303

Induced skin aging by blue-light irradiation in human skin fibroblasts via TGF-β, JNK and EGFR pathways.

Ge G, Wang Y, Xu Y, Pu W, Tan Y, Liu P, Ding H, Lu YM, Wang J, Liu W, Ma Y
Journal of dermatological science 2023 Aug;111(2):52-59

Baricitinib improves pulmonary fibrosis in mice with rheumatoid arthritis-associated interstitial lung disease by inhibiting the Jak2/Stat3 signaling pathway.

Liu H, Yang Y, Zhang J, Li X
Advances in rheumatology (London, England) 2023 Aug 28;63(1):45

NPRC deletion attenuates cardiac fibrosis in diabetic mice by activating PKA/PKG and inhibiting TGF-β1/Smad pathways.

Meng L, Lu Y, Wang X, Cheng C, Xue F, Xie L, Zhang Y, Sui W, Zhang M, Zhang Y, Zhang C
Science advances 2023 Aug 2;9(31):eadd4222

FUT1-mediated terminal fucosylation acts as a new target to attenuate renal fibrosis.

Luo J, Mao K, Zhu Z, Ye J, Li L, Wang D, Zhou J, Lin F, Li J, Ye J
Molecular medicine (Cambridge, Mass.) 2023 Apr 21;29(1):55

Direct conversion of human umbilical cord mesenchymal stem cells into retinal pigment epithelial cells for treatment of retinal degeneration.

Zhu X, Chen Z, Wang L, Ou Q, Feng Z, Xiao H, Shen Q, Li Y, Jin C, Xu JY, Gao F, Wang J, Zhang J, Zhang J, Xu Z, Xu GT, Lu L, Tian H
Cell death & disease 2022 Sep 12;13(9):785

Rab31 promotes activation of hepatic stellate cells by accelerating TGF-β receptor II complex endocytosis.

Qiu C, Liu Y, Huang S, Ning B, He S, Zhong L
The international journal of biochemistry & cell biology 2022 Mar;144:106170

Comparative analyses in transcriptome of human granulosa cells and follicular fluid micro-environment between poor ovarian responders with conventional controlled ovarian or mild ovarian stimulations.

Liu X, Mai H, Chen P, Zhang Z, Wu T, Chen J, Sun P, Zhou C, Liang X, Huang R
Reproductive biology and endocrinology : RB&E 2022 Mar 21;20(1):54

A novel ALG10/TGF-β positive regulatory loop contributes to the stemness of colorectal cancer.

Xu X, Wang H, Li X, Duan X, Wang Y
Aging 2022 Jun 9;14(11):4858-4873

N-n-Butyl haloperidol iodide ameliorates liver fibrosis and hepatic stellate cell activation in mice.

Shen DF, Cheng H, Cai BZ, Cai WF, Wang B, Zhu Q, Wu YB, Liu M, Chen RJ, Gao FF, Zhang YM, Niu YD, Shi GG
Acta pharmacologica Sinica 2022 Jan;43(1):133-145

Krill Oil Turns Off TGF-β1 Profibrotic Signaling in the Prevention of Diabetic Nephropathy.

Sun X, Yang Y, Sun X, Meng H, Hao W, Yin J, Ma F, Guo X, Du L, Sun L, Wu H
Journal of agricultural and food chemistry 2022 Aug 17;70(32):9865-9876

MiR-130a-3p Alleviates Liver Fibrosis by Suppressing HSCs Activation and Skewing Macrophage to Ly6C(lo) Phenotype.

Liu L, Wang P, Wang YS, Zhang YN, Li C, Yang ZY, Liu ZH, Zhan TZ, Xu J, Xia CM
Frontiers in immunology 2021;12:696069

Knockdown of ALDH1A3 reduces breast cancer stem cell marker CD44 via the miR-7-TGFBR2-Smad3-CD44 regulatory axis.

Pan M, Li M, Guo M, Zhou H, Xu H, Zhao F, Mei F, Xue R, Dou J
Experimental and therapeutic medicine 2021 Oct;22(4):1093

Astrocyte-Derived TGFβ1 Facilitates Blood-Brain Barrier Function via Non-Canonical Hedgehog Signaling in Brain Microvascular Endothelial Cells.

Fu J, Li L, Huo D, Zhi S, Yang R, Yang B, Xu B, Zhang T, Dai M, Tan C, Chen H, Wang X
Brain sciences 2021 Jan 8;11(1)

Inhibition of HSP90 S-nitrosylation alleviates cardiac fibrosis via TGFβ/SMAD3 signalling pathway.

Zhang X, Zhang Y, Miao Q, Shi Z, Hu L, Liu S, Gao J, Zhao S, Chen H, Huang Z, Han Y, Ji Y, Xie L
British journal of pharmacology 2021 Dec;178(23):4608-4625

Oridonin inhibits 4T1 tumor growth by suppressing Treg differentiation via TGF-β receptor.

Guo J, Chen T, Ma Z, Qiao C, Yuan F, Guo X, Liu J, Shen Y, Yu L, Xiang A
International immunopharmacology 2020 Nov;88:106831

miR-96-5p regulated TGF-β/SMAD signaling pathway and suppressed endometrial cell viability and migration via targeting TGFBR1.

Chen S, Luo Y, Cui L, Yang Q
Cell cycle (Georgetown, Tex.) 2020 Jul;19(14):1740-1753

Nagilactone D ameliorates experimental pulmonary fibrosis in vitro and in vivo via modulating TGF-β/Smad signaling pathway.

Li A, Xiao X, Feng ZL, Chen X, Liu LJ, Lin LG, Lu JJ, Zhang LL
Toxicology and applied pharmacology 2020 Jan 15;389:114882

Transactivation of miR-202-5p by Steroidogenic Factor 1 (SF1) Induces Apoptosis in Goat Granulosa Cells by Targeting TGFβR2.

Ding Q, Jin M, Wang Y, Liu J, Kalds P, Wang Y, Yang Y, Wang X, Chen Y
Cells 2020 Feb 14;9(2)

Lnc-SNHG1 Activates the TGFBR2/SMAD3 and RAB11A/Wnt/β-Catenin Pathway by Sponging MiR-302/372/373/520 in Invasive Pituitary Tumors.

Wang H, Wang G, Gao Y, Zhao C, Li X, Zhang F, Jiang C, Wu B
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(3):1291-1303

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