Antibody data
- Antibody Data
- Antigen structure
- References [67]
- Comments [0]
- Validations [0]
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- Product number
- 66636-1-Ig - Provider product page

- Provider
- Proteintech Group
- Product name
- TGFBR2 antibody
- Antibody type
- Monoclonal
- Description
- TGFBR2 antibody (Cat. #66636-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, Mouse , Rat and has been validated for the following applications: FC, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 2D5H7
- Vial size
- 20ul, 150ul
Submitted references The TPx protein of Taenia solium metacestode regulates Treg and Th17 cell differentiation via the TGF-β/Smad signaling pathway.
Decoding the spatiotemporal development of the blood-brain barrier in human cortex.
Membrane Tension Integrates Physical and Signaling Cues to Gate Cell Fate Transitions.
Cardiomyocyte-derived TGFB3 attenuates cardiac fibrosis and preserves cardiac function in heart failure.
Circular RNA circFNDC3B Modulates M2 Macrophage Activation and Intestinal Inflammation in Crohn's Disease.
CRYM suppresses glioblastoma progression by inhibiting the TGFβ1/Smad-EMT signaling pathway.
miR-3606-3p alleviates skin fibrosis by integratively suppressing the integrin/FAK, p-AKT/p-ERK, and TGF-β signaling cascades.
Colla Corii Asini regulate collagen regeneration in UV exposure-induced skin photoaging in mice.
Prostaglandin F2α exacerbated dry eye by promoting lacrimal gland fibrosis progression through the activation of the RhoA/ROCKs signaling pathway.
Autophagic degradation of SQSTM1 enables fibroblast activation to accelerate wound healing.
Immune checkpoint TIM-3 regulates microglia and Alzheimer's disease.
DYRK1A-TGF-β signaling axis determines sensitivity to OXPHOS inhibition in hepatocellular carcinoma.
Prkci promotes colorectal cancer metastasis by phosphorylating and stabilizing Tgfbr1 to activate TGF-β signaling.
Lnc PVT1 facilitates TGF-β1-induced human cardiac fibroblast activation in vitro and ISO-induced myocardial fibrosis in vivo through regulating MYC.
Targeting the E Prostanoid Receptor EP4 Mitigates Cardiac Fibrosis Induced by β-Adrenergic Activation.
miR-145-enriched BMSCs-derived exosomes ameliorate neurogenic erectile dysfunction in aged rats via TGFBR2 inhibition.
Inhibition of recurrence and metastasis in triple-negative breast cancer through nanoparticle-mediated silencing of LPCAT1 to remodel ATP energy metabolism.
Sang-Bai-Pi extract and its constituent regiafuran C ameliorate renal fibrosis through TGF-β/Smad and Wnt/β-catenin signaling pathways.
TGF-β1-mediated intercellular signaling fuels cooperative cellular invasion.
One Month of Brief Weekly Magnetic Field Therapy Enhances the Anticancer Potential of Female Human Sera: Randomized Double-Blind Pilot Study.
Epithelial WNT secretion drives niche escape of developing gastric cancer.
TGFβ limits proximal CD8+ TCR signaling via PTPN22 following strong and moderate agonism.
Identification of potential biomarkers for lung adenocarcinoma: a study based on bioinformatics analysis combined with validation experiments.
BV2 Microglial Cell Activation/Polarization Is Influenced by Extracellular Vesicles Released from Mutated SOD1 NSC-34 Motoneuron-like Cells.
GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression.
TGF-β and RAS jointly unmask primed enhancers to drive metastasis.
Deubiquitinase USP18 inhibits hepatic stellate cells activation and alleviates liver fibrosis via regulation of TAK1 activity.
Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFβ1- Smad1/5 signaling pathway.
Fibromodulin facilitates the osteogenic effect of Masquelet's induced membrane by inhibiting the TGF-β/SMAD signaling pathway.
Ultrastructural Characterization of PBMCs and Extracellular Vesicles in Multiple Sclerosis: A Pilot Study.
Resistance exercise upregulates Irisin expression and suppresses myocardial fibrosis following myocardial infarction via activating AMPK-Sirt1 and inactivating TGFβ1-Smad2/3.
circGRHPR inhibits aberrant epithelial-mesenchymal transformation progression of lung epithelial cells associated with idiopathic pulmonary fibrosis.
Pirfenidone and nintedanib attenuate pulmonary fibrosis in mice by inhibiting the expression of JAK2.
Neuropeptide Precursor VGF Promotes Liver Metastatic Colonization of Gαq Mutant Uveal Melanoma by Facilitating Tumor Microenvironment via Paracrine Loops.
Smooth muscle-specific deletion of cellular communication network factor 2 causes severe aorta malformation and atherosclerosis.
Exploring the therapeutic potential of sγPNA-141: Pharmacodynamics and mechanistic insights during ischemic stroke recovery.
Exosomal miR-130b-3p suppresses metastasis of non-small cell lung cancer cells by targeting DEPDC1 via TGF-β signaling pathway.
Deficiency of flavin-containing monooxygenase 3 protects kidney function after ischemia-reperfusion in mice.
Irisin Ameliorates Renal Tubulointerstitial Fibrosis by Regulating the Smad4/β-Catenin Pathway in Diabetic Mice.
Alkaline shear-thinning micro-nanocomposite hydrogels initiate endogenous TGFβ signaling for in situ bone regeneration.
C-X-C domain ligand 14-mediated stromal cell-macrophage interaction as a therapeutic target for hand dermal fibrosis.
Crosstalk between the JAK2 and TGF-β1 signaling pathways in scleroderma-related interstitial lung disease targeted by baricitinib.
Deubiquitinating enzyme USP11 promotes renal tubular cell senescence and fibrosis via inhibiting the ubiquitin degradation of TGF-β receptor II.
Long non-coding RNA MFSD4A-AS1 promotes lymphangiogenesis and lymphatic metastasis of papillary thyroid cancer.
GPR97 deficiency ameliorates renal interstitial fibrosis in mouse hypertensive nephropathy.
Hypoxia-Driven TGFβ Modulation of Side Population Cells in Breast Cancer: The Potential Role of ERα.
Engineering irradiated tumor-derived microparticles as personalized vaccines to enhance anti-tumor immunity.
Induced skin aging by blue-light irradiation in human skin fibroblasts via TGF-β, JNK and EGFR pathways.
Baricitinib improves pulmonary fibrosis in mice with rheumatoid arthritis-associated interstitial lung disease by inhibiting the Jak2/Stat3 signaling pathway.
NPRC deletion attenuates cardiac fibrosis in diabetic mice by activating PKA/PKG and inhibiting TGF-β1/Smad pathways.
FUT1-mediated terminal fucosylation acts as a new target to attenuate renal fibrosis.
Direct conversion of human umbilical cord mesenchymal stem cells into retinal pigment epithelial cells for treatment of retinal degeneration.
Rab31 promotes activation of hepatic stellate cells by accelerating TGF-β receptor II complex endocytosis.
Comparative analyses in transcriptome of human granulosa cells and follicular fluid micro-environment between poor ovarian responders with conventional controlled ovarian or mild ovarian stimulations.
A novel ALG10/TGF-β positive regulatory loop contributes to the stemness of colorectal cancer.
N-n-Butyl haloperidol iodide ameliorates liver fibrosis and hepatic stellate cell activation in mice.
A novel role for PRL in regulating epithelial cell density by inducing apoptosis at confluence.
Krill Oil Turns Off TGF-β1 Profibrotic Signaling in the Prevention of Diabetic Nephropathy.
MiR-130a-3p Alleviates Liver Fibrosis by Suppressing HSCs Activation and Skewing Macrophage to Ly6C(lo) Phenotype.
Knockdown of ALDH1A3 reduces breast cancer stem cell marker CD44 via the miR-7-TGFBR2-Smad3-CD44 regulatory axis.
Astrocyte-Derived TGFβ1 Facilitates Blood-Brain Barrier Function via Non-Canonical Hedgehog Signaling in Brain Microvascular Endothelial Cells.
Inhibition of HSP90 S-nitrosylation alleviates cardiac fibrosis via TGFβ/SMAD3 signalling pathway.
Oridonin inhibits 4T1 tumor growth by suppressing Treg differentiation via TGF-β receptor.
miR-96-5p regulated TGF-β/SMAD signaling pathway and suppressed endometrial cell viability and migration via targeting TGFBR1.
Nagilactone D ameliorates experimental pulmonary fibrosis in vitro and in vivo via modulating TGF-β/Smad signaling pathway.
Transactivation of miR-202-5p by Steroidogenic Factor 1 (SF1) Induces Apoptosis in Goat Granulosa Cells by Targeting TGFβR2.
Lnc-SNHG1 Activates the TGFBR2/SMAD3 and RAB11A/Wnt/β-Catenin Pathway by Sponging MiR-302/372/373/520 in Invasive Pituitary Tumors.
Sun X, Mu Q, Zhou B
Frontiers in immunology 2026;17:1612077
Frontiers in immunology 2026;17:1612077
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bioRxiv : the preprint server for biology 2026 Mar 5;
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Cardiomyocyte-derived TGFB3 attenuates cardiac fibrosis and preserves cardiac function in heart failure.
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miR-3606-3p alleviates skin fibrosis by integratively suppressing the integrin/FAK, p-AKT/p-ERK, and TGF-β signaling cascades.
Chen Y, Gong Y, Shi M, Zhu H, Tang Y, Huang D, Wang W, Shi C, Xia X, Zhang Y, Liu J, Huang J, Liu M, Chen H, Ma Y, Wang Z, Wang L, Tu W, Zhao Y, Lin J, Jin L, Distler JH, Wu W, Wang J, Shi X
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Prostaglandin F2α exacerbated dry eye by promoting lacrimal gland fibrosis progression through the activation of the RhoA/ROCKs signaling pathway.
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Autophagy 2025 Nov;21(11):2401-2421
Autophagy 2025 Nov;21(11):2401-2421
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Nature 2025 May;641(8063):718-731
Nature 2025 May;641(8063):718-731
DYRK1A-TGF-β signaling axis determines sensitivity to OXPHOS inhibition in hepatocellular carcinoma.
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miR-145-enriched BMSCs-derived exosomes ameliorate neurogenic erectile dysfunction in aged rats via TGFBR2 inhibition.
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Regenerative therapy 2025 Jun;29:455-465
Regenerative therapy 2025 Jun;29:455-465
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Sang-Bai-Pi extract and its constituent regiafuran C ameliorate renal fibrosis through TGF-β/Smad and Wnt/β-catenin signaling pathways.
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Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156351
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Molecular cancer 2025 Dec 16;25(1):1
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TGFβ limits proximal CD8+ TCR signaling via PTPN22 following strong and moderate agonism.
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Frontiers in oncology 2024;14:1425895
BV2 Microglial Cell Activation/Polarization Is Influenced by Extracellular Vesicles Released from Mutated SOD1 NSC-34 Motoneuron-like Cells.
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Zhang Y, Gao J, Liu Y, Zhong L, He S, Qiu C
Experimental cell research 2024 Oct 1;442(2):114235
Experimental cell research 2024 Oct 1;442(2):114235
Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFβ1- Smad1/5 signaling pathway.
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Archives of biochemistry and biophysics 2024 Mar;753:109892
Fibromodulin facilitates the osteogenic effect of Masquelet's induced membrane by inhibiting the TGF-β/SMAD signaling pathway.
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International journal of molecular sciences 2024 Jun 22;25(13)
International journal of molecular sciences 2024 Jun 22;25(13)
Resistance exercise upregulates Irisin expression and suppresses myocardial fibrosis following myocardial infarction via activating AMPK-Sirt1 and inactivating TGFβ1-Smad2/3.
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Acta physiologica (Oxford, England) 2024 Jul;240(7):e14163
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Cell biology and toxicology 2024 Jan 25;40(1):7
Pirfenidone and nintedanib attenuate pulmonary fibrosis in mice by inhibiting the expression of JAK2.
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Journal of thoracic disease 2024 Feb 29;16(2):1128-1140
Neuropeptide Precursor VGF Promotes Liver Metastatic Colonization of Gαq Mutant Uveal Melanoma by Facilitating Tumor Microenvironment via Paracrine Loops.
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Cardiovascular research 2024 Dec 4;120(15):1851-1868
Exploring the therapeutic potential of sγPNA-141: Pharmacodynamics and mechanistic insights during ischemic stroke recovery.
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Molecular therapy. Nucleic acids 2024 Dec 10;35(4):102355
Exosomal miR-130b-3p suppresses metastasis of non-small cell lung cancer cells by targeting DEPDC1 via TGF-β signaling pathway.
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International journal of biological macromolecules 2024 Aug;275(Pt 1):133594
Deficiency of flavin-containing monooxygenase 3 protects kidney function after ischemia-reperfusion in mice.
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Communications biology 2024 Aug 27;7(1):1054
Irisin Ameliorates Renal Tubulointerstitial Fibrosis by Regulating the Smad4/β-Catenin Pathway in Diabetic Mice.
Yang Z, Wei J, Wang Y, Du Y, Song S, Li J, Su Z, Shi Y, Wu H
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Diabetes, metabolic syndrome and obesity : targets and therapy 2023;16:1577-1593
Alkaline shear-thinning micro-nanocomposite hydrogels initiate endogenous TGFβ signaling for in situ bone regeneration.
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NPJ Regenerative medicine 2023 Oct 13;8(1):56
NPJ Regenerative medicine 2023 Oct 13;8(1):56
C-X-C domain ligand 14-mediated stromal cell-macrophage interaction as a therapeutic target for hand dermal fibrosis.
Goto A, Komura S, Kato K, Maki R, Hirakawa A, Tomita H, Hirata A, Yamada Y, Akiyama H
Communications biology 2023 Nov 18;6(1):1173
Communications biology 2023 Nov 18;6(1):1173
Crosstalk between the JAK2 and TGF-β1 signaling pathways in scleroderma-related interstitial lung disease targeted by baricitinib.
Wang D, Wei Y, Xu L, Zhang J
Advances in rheumatology (London, England) 2023 May 16;63(1):22
Advances in rheumatology (London, England) 2023 May 16;63(1):22
Deubiquitinating enzyme USP11 promotes renal tubular cell senescence and fibrosis via inhibiting the ubiquitin degradation of TGF-β receptor II.
Ni JY, Wang X, Xie HY, Yang NH, Li JY, Sun XA, Guo HJ, Zhou L, Zhang W, Liu J, Lu LM
Acta pharmacologica Sinica 2023 Mar;44(3):584-595
Acta pharmacologica Sinica 2023 Mar;44(3):584-595
Long non-coding RNA MFSD4A-AS1 promotes lymphangiogenesis and lymphatic metastasis of papillary thyroid cancer.
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Endocrine-related cancer 2023 Mar 1;30(3)
Endocrine-related cancer 2023 Mar 1;30(3)
GPR97 deficiency ameliorates renal interstitial fibrosis in mouse hypertensive nephropathy.
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Acta pharmacologica Sinica 2023 Jun;44(6):1206-1216
Acta pharmacologica Sinica 2023 Jun;44(6):1206-1216
Hypoxia-Driven TGFβ Modulation of Side Population Cells in Breast Cancer: The Potential Role of ERα.
Mallini P, Chen M, Mahkamova K, Lennard TWJ, Pan Y, Wei D, Stemke-Hale K, Kirby JA, Lash GE, Meeson A
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Cancers 2023 Feb 9;15(4)
Engineering irradiated tumor-derived microparticles as personalized vaccines to enhance anti-tumor immunity.
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Cell reports. Medicine 2023 Dec 19;4(12):101303
Cell reports. Medicine 2023 Dec 19;4(12):101303
Induced skin aging by blue-light irradiation in human skin fibroblasts via TGF-β, JNK and EGFR pathways.
Ge G, Wang Y, Xu Y, Pu W, Tan Y, Liu P, Ding H, Lu YM, Wang J, Liu W, Ma Y
Journal of dermatological science 2023 Aug;111(2):52-59
Journal of dermatological science 2023 Aug;111(2):52-59
Baricitinib improves pulmonary fibrosis in mice with rheumatoid arthritis-associated interstitial lung disease by inhibiting the Jak2/Stat3 signaling pathway.
Liu H, Yang Y, Zhang J, Li X
Advances in rheumatology (London, England) 2023 Aug 28;63(1):45
Advances in rheumatology (London, England) 2023 Aug 28;63(1):45
NPRC deletion attenuates cardiac fibrosis in diabetic mice by activating PKA/PKG and inhibiting TGF-β1/Smad pathways.
Meng L, Lu Y, Wang X, Cheng C, Xue F, Xie L, Zhang Y, Sui W, Zhang M, Zhang Y, Zhang C
Science advances 2023 Aug 2;9(31):eadd4222
Science advances 2023 Aug 2;9(31):eadd4222
FUT1-mediated terminal fucosylation acts as a new target to attenuate renal fibrosis.
Luo J, Mao K, Zhu Z, Ye J, Li L, Wang D, Zhou J, Lin F, Li J, Ye J
Molecular medicine (Cambridge, Mass.) 2023 Apr 21;29(1):55
Molecular medicine (Cambridge, Mass.) 2023 Apr 21;29(1):55
Direct conversion of human umbilical cord mesenchymal stem cells into retinal pigment epithelial cells for treatment of retinal degeneration.
Zhu X, Chen Z, Wang L, Ou Q, Feng Z, Xiao H, Shen Q, Li Y, Jin C, Xu JY, Gao F, Wang J, Zhang J, Zhang J, Xu Z, Xu GT, Lu L, Tian H
Cell death & disease 2022 Sep 12;13(9):785
Cell death & disease 2022 Sep 12;13(9):785
Rab31 promotes activation of hepatic stellate cells by accelerating TGF-β receptor II complex endocytosis.
Qiu C, Liu Y, Huang S, Ning B, He S, Zhong L
The international journal of biochemistry & cell biology 2022 Mar;144:106170
The international journal of biochemistry & cell biology 2022 Mar;144:106170
Comparative analyses in transcriptome of human granulosa cells and follicular fluid micro-environment between poor ovarian responders with conventional controlled ovarian or mild ovarian stimulations.
Liu X, Mai H, Chen P, Zhang Z, Wu T, Chen J, Sun P, Zhou C, Liang X, Huang R
Reproductive biology and endocrinology : RB&E 2022 Mar 21;20(1):54
Reproductive biology and endocrinology : RB&E 2022 Mar 21;20(1):54
A novel ALG10/TGF-β positive regulatory loop contributes to the stemness of colorectal cancer.
Xu X, Wang H, Li X, Duan X, Wang Y
Aging 2022 Jun 9;14(11):4858-4873
Aging 2022 Jun 9;14(11):4858-4873
N-n-Butyl haloperidol iodide ameliorates liver fibrosis and hepatic stellate cell activation in mice.
Shen DF, Cheng H, Cai BZ, Cai WF, Wang B, Zhu Q, Wu YB, Liu M, Chen RJ, Gao FF, Zhang YM, Niu YD, Shi GG
Acta pharmacologica Sinica 2022 Jan;43(1):133-145
Acta pharmacologica Sinica 2022 Jan;43(1):133-145
A novel role for PRL in regulating epithelial cell density by inducing apoptosis at confluence.
Lohani S, Funato Y, Akieda Y, Mizutani K, Takai Y, Ishitani T, Miki H
Journal of cell science 2022 Jan 15;135(2)
Journal of cell science 2022 Jan 15;135(2)
Krill Oil Turns Off TGF-β1 Profibrotic Signaling in the Prevention of Diabetic Nephropathy.
Sun X, Yang Y, Sun X, Meng H, Hao W, Yin J, Ma F, Guo X, Du L, Sun L, Wu H
Journal of agricultural and food chemistry 2022 Aug 17;70(32):9865-9876
Journal of agricultural and food chemistry 2022 Aug 17;70(32):9865-9876
MiR-130a-3p Alleviates Liver Fibrosis by Suppressing HSCs Activation and Skewing Macrophage to Ly6C(lo) Phenotype.
Liu L, Wang P, Wang YS, Zhang YN, Li C, Yang ZY, Liu ZH, Zhan TZ, Xu J, Xia CM
Frontiers in immunology 2021;12:696069
Frontiers in immunology 2021;12:696069
Knockdown of ALDH1A3 reduces breast cancer stem cell marker CD44 via the miR-7-TGFBR2-Smad3-CD44 regulatory axis.
Pan M, Li M, Guo M, Zhou H, Xu H, Zhao F, Mei F, Xue R, Dou J
Experimental and therapeutic medicine 2021 Oct;22(4):1093
Experimental and therapeutic medicine 2021 Oct;22(4):1093
Astrocyte-Derived TGFβ1 Facilitates Blood-Brain Barrier Function via Non-Canonical Hedgehog Signaling in Brain Microvascular Endothelial Cells.
Fu J, Li L, Huo D, Zhi S, Yang R, Yang B, Xu B, Zhang T, Dai M, Tan C, Chen H, Wang X
Brain sciences 2021 Jan 8;11(1)
Brain sciences 2021 Jan 8;11(1)
Inhibition of HSP90 S-nitrosylation alleviates cardiac fibrosis via TGFβ/SMAD3 signalling pathway.
Zhang X, Zhang Y, Miao Q, Shi Z, Hu L, Liu S, Gao J, Zhao S, Chen H, Huang Z, Han Y, Ji Y, Xie L
British journal of pharmacology 2021 Dec;178(23):4608-4625
British journal of pharmacology 2021 Dec;178(23):4608-4625
Oridonin inhibits 4T1 tumor growth by suppressing Treg differentiation via TGF-β receptor.
Guo J, Chen T, Ma Z, Qiao C, Yuan F, Guo X, Liu J, Shen Y, Yu L, Xiang A
International immunopharmacology 2020 Nov;88:106831
International immunopharmacology 2020 Nov;88:106831
miR-96-5p regulated TGF-β/SMAD signaling pathway and suppressed endometrial cell viability and migration via targeting TGFBR1.
Chen S, Luo Y, Cui L, Yang Q
Cell cycle (Georgetown, Tex.) 2020 Jul;19(14):1740-1753
Cell cycle (Georgetown, Tex.) 2020 Jul;19(14):1740-1753
Nagilactone D ameliorates experimental pulmonary fibrosis in vitro and in vivo via modulating TGF-β/Smad signaling pathway.
Li A, Xiao X, Feng ZL, Chen X, Liu LJ, Lin LG, Lu JJ, Zhang LL
Toxicology and applied pharmacology 2020 Jan 15;389:114882
Toxicology and applied pharmacology 2020 Jan 15;389:114882
Transactivation of miR-202-5p by Steroidogenic Factor 1 (SF1) Induces Apoptosis in Goat Granulosa Cells by Targeting TGFβR2.
Ding Q, Jin M, Wang Y, Liu J, Kalds P, Wang Y, Yang Y, Wang X, Chen Y
Cells 2020 Feb 14;9(2)
Cells 2020 Feb 14;9(2)
Lnc-SNHG1 Activates the TGFBR2/SMAD3 and RAB11A/Wnt/β-Catenin Pathway by Sponging MiR-302/372/373/520 in Invasive Pituitary Tumors.
Wang H, Wang G, Gao Y, Zhao C, Li X, Zhang F, Jiang C, Wu B
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(3):1291-1303
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(3):1291-1303
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