Antibody data
- Antibody Data
- Antigen structure
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- Validations
- Western blot [1]
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- Product number
- BS8211 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- RNGTT polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human RNGTT.
- Description
- RNGTT (RNA guanylyltransferase and 5'-phosphatase), also known as HCE, HCE1, hCAP or CAP1A, is a 597 amino acid protein that localizes to the nucleus and exists as four alternatively spliced isoforms. Expressed in kidney, lung, heart, brain, liver, testis, skin and muscle, RNGTT acts as a bifunctional mRNA-capping enzyme that exhibits RNA 5'-triphosphatase activity at its N-terminus and mRNA guanylyltransferase activity at its C-terminus. Via its catalytic activity, RNGTT facilitates the first two steps of mRNA cap formation, naming the removal of a ÎÛ-phosphate from the end of nascent mRNA and the subsequent transfer of the phospho residue to the 5£ª-diphosphate terminus. The gene encoding RNGTT maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- WesternBlot (WB) analysis of RNGTT polyclonal antibody