10-4048-25
antibody from ABEOMICS Inc.
Targeting: KLRB1
CD161, CLEC5B, hNKR-P1A, NKR, NKR-P1, NKR-P1A
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
- Flow cytometry [1]
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Validation data
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- Product number
- 10-4048-25 - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-CD161 Antibody
- Antibody type
- Monoclonal
- Description
- CD161 is the human equivalent of mouse NK cell receptor P1A. It is a type II transmembrane glycoprotein with characteristics of the C-type lectin superfamily. The expression confines to lymphocytes found in human gut and liver, as well as blood, especially NK (natural killer) cells, Th17 (T helper 17) cells, and a population of unconventional T cells known as MAIT (mucosal-associated invariant T) cells. CD161 promotes T cell expansion and eventually has been identified as a marker of human IL-17-producing T cells. It plays a pivotal role in trans-endothelial migration and is also implicated in the pathogenesis of RA (rheumatoid arthritis) as well as graft-versus-host disease (GVHD).
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
A full length human CD161 protein w
as used as the immunogen for this a
ntibody.- Isotype
- IgG
- Antibody clone number
- ABM2D74
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
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Supportive validation
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Western blot analysis of CD161. Anti-CD161 antibody (Clone: ABM2D74) was tested at 2 µg/ml on Jurkat lysate.
- Protocol
- Protocol
Supportive validation
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Immunohistochemical analysis of CD161 in small cell carcinoma of esophagus using CD161 antibody (Clone: ABM2D74) at 5 µg/ml.
- Protocol
- Protocol
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Immunohistochemical analysis of CD161 in Transitional cell carcinoma of urinary bladder using CD161 antibody (Clone: ABM2D74) at 5 µg/ml.
- Protocol
- Protocol
Supportive validation
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Cell Surface flow analysis of hCD161 in PBMC (Lymphocytes) using 0.2µg/10^6 cells of CD161 clone ( ABM2D74). Green represents isotype control; red represents anti-hCD161 antibody. Goat anti-mouse PE conjugated secondary antibody (ABEOMICS) was used.
- Protocol
- Protocol