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- Antibody Data
- Antigen structure
- References [3]
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- Product number
- 12-9878-42 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD371 (Clec12A) Monoclonal Antibody (HB3), PE, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: This HB3 monoclonal antibody reacts with human CD371, which is also known as Clec12A or Myeloid Inhibitory C-type Lectin-like receptor (MICL). CD371 is a highly glycosylated transmembrane receptor with a cytoplasmic ITIM that associates with SHP1 and SHP2. CD371 is expressed mainly on granulocytes, monocytes, macrophages, and dendritic cells, including plasmacytoid dendritic cells. Expression of CD371 on NK cells remains controversial. Although the function of CD371 is not fully understood, studies suggest that this receptor plays a role in inflammation and LPS activation.
- Conjugate
- Yellow dye
- Antibody clone number
- HB3
- Concentration
- 5 µL/Test
Submitted references The C-type lectin Clec12A present on mouse and human dendritic cells can serve as a target for antigen delivery and enhancement of antibody responses.
Human MICL (CLEC12A) is differentially glycosylated and is down-regulated following cellular activation.
Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes.
Lahoud MH, Proietto AI, Ahmet F, Kitsoulis S, Eidsmo L, Wu L, Sathe P, Pietersz S, Chang HW, Walker ID, Maraskovsky E, Braley H, Lew AM, Wright MD, Heath WR, Shortman K, Caminschi I
Journal of immunology (Baltimore, Md. : 1950) 2009 Jun 15;182(12):7587-94
Journal of immunology (Baltimore, Md. : 1950) 2009 Jun 15;182(12):7587-94
Human MICL (CLEC12A) is differentially glycosylated and is down-regulated following cellular activation.
Marshall AS, Willment JA, Pyz E, Dennehy KM, Reid DM, Dri P, Gordon S, Wong SY, Brown GD
European journal of immunology 2006 Aug;36(8):2159-69
European journal of immunology 2006 Aug;36(8):2159-69
Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes.
Marshall AS, Willment JA, Lin HH, Williams DL, Gordon S, Brown GD
The Journal of biological chemistry 2004 Apr 9;279(15):14792-802
The Journal of biological chemistry 2004 Apr 9;279(15):14792-802
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- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Staining of normal human peripheral blood cells with Anti-Human CD371 (Clec12A) PE. Cells in the lymphocyte (blue histogram), monocyte (orange histogram), and granulocyte (purple histogram) gates were used for analysis.
- Conjugate
- Yellow dye
