359418

antibody from BioLegend
Targeting: CCR4 CC-CKR-4, CD194, ChemR13, CKR4, CMKBR4, k5-5
Provider product page for 359418

Antibody data

Product number
359418 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#359418, RRID:AB_2562483
Product name
Brilliant Violet 605™ anti-human CD194 (CCR4)
Antibody type
Monoclonal
Antigen
Human CC4 transfected cells
Description
CD194, also known as CCR4, is a CC chemokine receptor. It binds CCL17 and CCL22 and is expressed on a subset of T and B cells, basophils, monocytes, and NK cells. Human Th2 cells are characterized by the expression of CCR4 and CCR8, and these receptors are regulated differently during Th2 development. Human peripheral blood Tregs can be divided into two distinct populations based on the expression of CCR4. Freshly isolated Tregs express CCR4 and presumably represent memory-type Tregs, and CCR4(-) Tregs require CD3-mediated activation to acquire a regulatory activity. Depletion of CCR4(+) T cells leads to Th1-type polarization of CD4(+) T cells and augmentation of CD8(+) T cell responses to tumor antigens. CCR4 and its ligands are important for the recruitment of memory T cells into the skin in various cutaneous immune diseases.
Reactivity
Human
Host
Mouse
Conjugate
Red dye
Antibody clone number
L291H4
Vial size
100 tests
Storage
2°C-8°C
Handling
Ambient RT
CCR4 protein structure - 359418 shown in red.