Antibody data
- Antibody Data
- Antigen structure
- References [8]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- FAB1567F-025 - Provider product page
- Provider
- R&D Systems
- Product name
- Human/Rat CCR4 Fluorescein-conjugated Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Stains human CCR4-transfected cell lines but not the corresponding parent cell lines. Also detects human CCR4 on human PBLs and platelets and rat CCR4 on rat splenocytes.
- Reactivity
- Human, Rat
- Host
- Mouse
- Antigen sequence
P51679
- Isotype
- IgG
- Antibody clone number
- 205410
- Vial size
- 25 Tests
- Storage
- Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.
Submitted references Histone deacetylase inhibitors downregulate CCR4 expression and decrease mogamulizumab efficacy in CCR4-positive mature T-cell lymphomas.
Glatiramer Acetate, Dimethyl Fumarate, and Monomethyl Fumarate Upregulate the Expression of CCR10 on the Surface of Natural Killer Cells and Enhance Their Chemotaxis and Cytotoxicity.
Neuroinvasive West Nile Infection Elicits Elevated and Atypically Polarized T Cell Responses That Promote a Pathogenic Outcome.
Porcine Treg depletion with a novel diphtheria toxin-based anti-human CCR4 immunotoxin.
Identification of human NK17/NK1 cells.
Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.
Homeostatic regulation of T effector to Treg ratios in an area of seasonal malaria transmission.
CCR4-expressing T cell tumors can be specifically controlled via delivery of toxins to chemokine receptors.
Kitadate A, Ikeda S, Abe F, Takahashi N, Shimizu N, Matsue K, Tagawa H
Haematologica 2018 Jan;103(1):126-135
Haematologica 2018 Jan;103(1):126-135
Glatiramer Acetate, Dimethyl Fumarate, and Monomethyl Fumarate Upregulate the Expression of CCR10 on the Surface of Natural Killer Cells and Enhance Their Chemotaxis and Cytotoxicity.
Maghazachi AA, Sand KL, Al-Jaderi Z
Frontiers in immunology 2016;7:437
Frontiers in immunology 2016;7:437
Neuroinvasive West Nile Infection Elicits Elevated and Atypically Polarized T Cell Responses That Promote a Pathogenic Outcome.
James EA, Gates TJ, LaFond RE, Yamamoto S, Ni C, Mai D, Gersuk VH, O'Brien K, Nguyen QA, Zeitner B, Lanteri MC, Norris PJ, Chaussabel D, Malhotra U, Kwok WW
PLoS pathogens 2016 Jan;12(1):e1005375
PLoS pathogens 2016 Jan;12(1):e1005375
Porcine Treg depletion with a novel diphtheria toxin-based anti-human CCR4 immunotoxin.
Wang Z, Navarro-Alvarez N, Shah JA, Zhang H, Huang Q, Zheng Q, Madsen JC, Sachs DH, Huang CA, Wang Z
Veterinary immunology and immunopathology 2016 Dec;182:150-158
Veterinary immunology and immunopathology 2016 Dec;182:150-158
Identification of human NK17/NK1 cells.
Pandya AD, Al-Jaderi Z, Høglund RA, Holmøy T, Harbo HF, Norgauer J, Maghazachi AA
PloS one 2011;6(10):e26780
PloS one 2011;6(10):e26780
Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.
Oo YH, Weston CJ, Lalor PF, Curbishley SM, Withers DR, Reynolds GM, Shetty S, Harki J, Shaw JC, Eksteen B, Hubscher SG, Walker LS, Adams DH
Journal of immunology (Baltimore, Md. : 1950) 2010 Mar 15;184(6):2886-98
Journal of immunology (Baltimore, Md. : 1950) 2010 Mar 15;184(6):2886-98
Homeostatic regulation of T effector to Treg ratios in an area of seasonal malaria transmission.
Finney OC, Nwakanma D, Conway DJ, Walther M, Riley EM
European journal of immunology 2009 May;39(5):1288-300
European journal of immunology 2009 May;39(5):1288-300
CCR4-expressing T cell tumors can be specifically controlled via delivery of toxins to chemokine receptors.
Baatar D, Olkhanud P, Newton D, Sumitomo K, Biragyn A
Journal of immunology (Baltimore, Md. : 1950) 2007 Aug 1;179(3):1996-2004
Journal of immunology (Baltimore, Md. : 1950) 2007 Aug 1;179(3):1996-2004
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Supportive validation
- Submitted by
- R&D Systems (provider)
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- Experimental details
- Detection of CCR4 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human/Rat CCR4 Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB1567F) and Mouse Anti-Human CD3 epsilon APC-conjugated Monoclonal Antibody (Catalog # FAB100A). Quadrant markers were set based on control antibody staining (Catalog # IC0041F). View our protocol for Staining Membrane-associated Proteins.