12-1949-42

antibody from Invitrogen Antibodies
Targeting: CCR4 CC-CKR-4, CD194, ChemR13, CKR4, CMKBR4, k5-5
Provider product page for 12-1949-42

Antibody data

Product number
12-1949-42 - Provider product page
Provider
Invitrogen Antibodies
Product name
CD194 (CCR4) Monoclonal Antibody (D8SEE), PE, eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: This D8SEE monoclonal antibody reacts with human CD194 (CCR4). CD194, also known as C-C Chemokine Receptor 4 (CCR4) is a member of the G protein-coupled receptor family, a large family characterized by seven transmembrane alpha helical domains. The ligands for CCR4 are CCL17 (TARC) and CCL22 (MDC), which direct the migration of target cells. CCR4 and its ligands, along with the other receptors CCR10 and CLA, are particularly important for the recruitment of T cells into the skin, where they may also play a role in adhesion and extravasation. Although CCR4 expression was originally believed to be restricted to Th2 cells, it has since been observed in some subsets of Th17, Treg, and Th1 cells. It is not expressed by naive T cells, indicating a role in memory or effector function. Other cells that express CCR4 are activated NK cells, platelets, monocytes, and basophils.
Conjugate
Yellow dye
Antibody clone number
D8SEE
Concentration
5 µL/Test
CCR4 protein structure - 12-1949-42 shown in red.