11837-1-AP

antibody from Proteintech Group

Targeting: OLR1 CLEC8A, LOX-1, SCARE1

Provider product page for 11837-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [39]
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Validations
Western blot [1]

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Product number: 11837-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11837-1-AP, RRID:AB_2299037
Product name: OLR1 antibody
Antibody type: Polyclonal
Description: KD/KO validated OLR1 antibody (Cat. #11837-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IHC, IP, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

OLR1 protein structure - 11837-1-AP shown in red.

Submitted references A comprehensive analysis of the expression and the prognosis for LOX-1 in multiple cancer types.

Wang F, Li H, Zhang J, Fan J, Xu J
Biotechnology & genetic engineering reviews 2024 Nov;40(3):2346-2368

Downregulation of HMGB1 carried by macrophage-derived extracellular vesicles delays atherosclerotic plaque formation through Caspase-11-dependent macrophage pyroptosis.

Liang W, Wei R, Zhu X, Li J, Lin A, Chen J, Wu W, Jie Q
Molecular medicine (Cambridge, Mass.) 2024 Mar 16;30(1):38

Type 2 diabetes aggravates periodontitis-induced pathological changes in the dental pulp.

Yang T, Zhou B, Shan Z, Hu L
Oral diseases 2024 Jul;30(5):3250-3260

Expression of OLR1 gene on tumor-associated macrophages of head and neck squamous cell carcinoma, and its correlation with clinical outcome.

Zhang P, Zhao Y, Xia X, Mei S, Huang Y, Zhu Y, Yu S, Chen X
Oncoimmunology 2023;12(1):2203073

Circular RNA circARPC1B functions as a stabilisation enhancer of Vimentin to prevent high cholesterol-induced articular cartilage degeneration.

Li J, Li X, Zhou S, Wang Y, Ying T, Wang Q, Wu Y, Zhao F
Clinical and translational medicine 2023 Sep;13(9):e1415

Bridging the gap between clear cell renal cell carcinoma and cutaneous melanoma: the role of SCARB1 in dysregulated cholesterol metabolism.

Song L, Wang S, Zhang X, Song N, Lu Y, Qin C
Aging 2023 Oct 5;15(19):10370-10388

Klotho inhibits renal ox-LDL deposition via IGF-1R/RAC1/OLR1 signaling to ameliorate podocyte injury in diabetic kidney disease.

Jiang W, Gan C, Zhou X, Yang Q, Chen D, Xiao H, Dai L, Chen Y, Wang M, Yang H, Li Q
Cardiovascular diabetology 2023 Oct 27;22(1):293

Impact of oxidized LDL/LOX-1 system on ligamentum flavum hypertrophy.

Nagai S, Hachiya K, Takeda H, Ikeda D, Kawabata S, Watanabe K, Kaneko S, Fujita N
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2023 May;28(3):669-676

Identification of BST2 as a conjunctival epithelial stem/progenitor cell marker.

Kitao M, Hayashi R, Nomi K, Kobayashi R, Katayama T, Takayanagi H, Oguchi A, Murakawa Y, Nishida K
iScience 2023 Jul 21;26(7):107016

Liraglutide ameliorates oxidized LDL-induced endothelial dysfunction by GLP-1R-dependent downregulation of LOX-1-mediated oxidative stress and inflammation.

Ying W, Meiyan S, Wen C, Kaizu X, Meifang W, Liming L
Redox report : communications in free radical research 2023 Dec;28(1):2218684

The oxidized-LDL/LOX-1 axis in tumor endothelial cells enhances metastasis by recruiting neutrophils and cancer cells.

Tsumita T, Maishi N, Annan DA, Towfik MA, Matsuda A, Onodera Y, Nam JM, Hida Y, Hida K
International journal of cancer 2022 Sep 15;151(6):944-956

Intramyocardial hemorrhage drives fatty degeneration of infarcted myocardium.

Cokic I, Chan SF, Guan X, Nair AR, Yang HJ, Liu T, Chen Y, Hernando D, Sykes J, Tang R, Butler J, Dohnalkova A, Kovarik L, Finney R, Kali A, Sharif B, Bouchard LS, Gupta R, Krishnam MS, Vora K, Tamarappoo B, Howarth AG, Kumar A, Francis J, Reeder SB, Wood JC, Prato FS, Dharmakumar R
Nature communications 2022 Oct 27;13(1):6394

The LOX-1 receptor ectopically expressed in the liver alleviates atherosclerosis by clearing Ox-LDL from the circulation.

Wang Z, Chen J, Zeng Z, Zhang Q, Du G, Guo X, Wei Y
Molecular medicine (Cambridge, Mass.) 2022 Mar 2;28(1):26

Inclisiran inhibits oxidized low-density lipoprotein-induced foam cell formation in Raw264.7 macrophages via activating the PPARγ pathway.

Wang Z, Chen X, Liu J, Wang Y, Zhang S
Autoimmunity 2022 Jun;55(4):223-232

Deacetylation of Caveolin-1 by Sirt6 induces autophagy and retards high glucose-stimulated LDL transcytosis and atherosclerosis formation.

Zhao Y, Jia X, Yang X, Bai X, Lu Y, Zhu L, Cheng W, Shu M, Zhu Y, Du X, Wang L, Shu Y, Song Y, Jin S
Metabolism: clinical and experimental 2022 Jun;131:155162

Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.

Li Z, Xu Q, Huangfu N, Chen X, Zhu J
Journal of clinical laboratory analysis 2022 Jan;36(1):e24019

Characterization of an Aging-Based Diagnostic Gene Signature and Molecular Subtypes With Diverse Immune Infiltrations in Atherosclerosis.

Zhao L, Lv F, Zheng Y, Yan L, Cao X
Frontiers in molecular biosciences 2021;8:792540

Celastrol Attenuates Lipid Accumulation and Stemness of Clear Cell Renal Cell Carcinoma via CAV-1/LOX-1 Pathway.

Zhang CJ, Zhu N, Wang YX, Liu LP, Zhao TJ, Wu HT, Liao DF, Qin L
Frontiers in pharmacology 2021;12:658092

Improvement of hyperlipidemia by aerobic exercise in mice through a regulatory effect of miR-21a-5p on its target genes.

Zhao J, Song Y, Zeng Y, Chen L, Yan F, Chen A, Wu B, Wang Y
Scientific reports 2021 Jun 7;11(1):11966

Up-regulation of thioredoxin system by puerarin inhibits lipid uptake in macrophages.

Li W, Xu X, Dong D, Lei T, Ou H
Free radical biology & medicine 2021 Jan;162:542-554

OLR1 is a prognostic factor and correlated with immune infiltration in breast cancer.

Sun X, Fu X, Xu S, Qiu P, Lv Z, Cui M, Zhang Q, Xu Y
International immunopharmacology 2021 Dec;101(Pt B):108275

Effect of Si-Miao-Yong-An decoction on the differentiation of monocytes, macrophages, and regulatory T cells in ApoE(-/-) mice.

Chen XN, Ge QH, Zhao YX, Guo XC, Zhang JP
Journal of ethnopharmacology 2021 Aug 10;276:114178

Matrix Metalloproteinase 9 is Regulated by LOX-1 and erk1/2 Pathway in Dental Peri-Implantitis.

Zhang Q, Xu H, Bai N, Tan F, Xu H, Liu J
Current pharmaceutical biotechnology 2020;21(9):862-871

OLR1 Promotes Pancreatic Cancer Metastasis via Increased c-Myc Expression and Transcription of HMGA2.

Yang G, Xiong G, Feng M, Zhao F, Qiu J, Liu Y, Cao Z, Wang H, Yang J, You L, Zheng L, Zhang T, Zhao Y
Molecular cancer research : MCR 2020 May;18(5):685-697

Nerolidol inhibits the LOX-1 / IL-1β signaling to protect against the Aspergillus fumigatus keratitis inflammation damage to the cornea.

Yang H, Wang Q, Han L, Yang X, Zhao W, Lyu L, Wang L, Yan H, Che C
International immunopharmacology 2020 Mar;80:106118

Serum LOX-1 is a novel prognostic biomarker of colorectal cancer.

Nakashima-Nakasuga C, Hazama S, Suzuki N, Nakagami Y, Xu M, Yoshida S, Tomochika S, Fujiwara N, Matsukuma S, Matsui H, Tokumitsu Y, Kanekiyo S, Shindo Y, Maeda N, Tsunedomi R, Iida M, Takeda S, Yoshino S, Ueno T, Hamamoto Y, Ogihara H, Hoshii Y, Nagano H
International journal of clinical oncology 2020 Jul;25(7):1308-1317

PP2A alleviates oxidized LDL-induced endothelial dysfunction by regulating LOX-1/ROS/MAPK axis.

Xu K, Liu X, Yin D, Ren G, Zhao Y
Life sciences 2020 Feb 15;243:117270

Increased Tissue Expression of Lectin-Like Oxidized LDL Receptor-1 (LOX-1) Is Associated with Disease Severity in Chronic Rhinosinusitis with Nasal Polyps.

Nishida M, Takeno S, Takemoto K, Takahara D, Hamamoto T, Ishino T, Kawasumi T
Diagnostics (Basel, Switzerland) 2020 Apr 23;10(4)

An in vitro model of foam cell formation induced by a stretchable microfluidic device.

Gu X, Xie S, Hong D, Ding Y
Scientific reports 2019 May 16;9(1):7461

LOX-1 is involved in TLR2 induced RANKL regulation in peri-implantitis.

Zhang Q, Liu J, Ma L, Bai N, Xu H
International immunopharmacology 2019 Dec;77:105956

Wedelolactone suppresses IL-1β maturation and neutrophil infiltration in Aspergillus fumigatus keratitis.

Cheng M, Lin J, Li C, Zhao W, Yang H, Lv L, Che C
International immunopharmacology 2019 Aug;73:17-22

ALDH2 deficiency inhibits Ox-LDL induced foam cell formation via suppressing CD36 expression.

Wei S, Zhang L, Bailu Wang, Zhao Y, Dong Q, Pan C, Li C, He D, Yuan Q, Xu F, Chen Y
Biochemical and biophysical research communications 2019 Apr 23;512(1):41-48

LOX-1 is a poor prognostic indicator and induces epithelial-mesenchymal transition and metastasis in pancreatic cancer patients.

Zhang J, Zhang L, Li C, Yang C, Li L, Song S, Wu H, Liu F, Wang L, Gu J
Cellular oncology (Dordrecht, Netherlands) 2018 Feb;41(1):73-84

Fenretinide Inhibits Neutrophil Recruitment and IL-1β Production in Aspergillus fumigatus Keratitis.

Zhao W, Che C, Liu K, Zhang J, Jiang N, Yuan K, Zhao G
Cornea 2018 Dec;37(12):1579-1585

Chronic administration of mitochondrion-targeted peptide SS-31 prevents atherosclerotic development in ApoE knockout mice fed Western diet.

Zhang M, Zhao H, Cai J, Li H, Wu Q, Qiao T, Li K
PloS one 2017;12(9):e0185688

LOX-1 is involved in IL-1β production and extracellular matrix breakdown in dental peri-implantitis.

Che C, Liu J, Ma L, Xu H, Bai N, Zhang Q
International immunopharmacology 2017 Nov;52:127-135

Up-regulation of OLR1 expression by TBC1D3 through activation of TNFα/NF-κB pathway promotes the migration of human breast cancer cells.

Wang B, Zhao H, Zhao L, Zhang Y, Wan Q, Shen Y, Bu X, Wan M, Shen C
Cancer letters 2017 Nov 1;408:60-70

Lectin-like oxidized low-density lipoprotein receptor-1 facilitates metastasis of gastric cancer through driving epithelial-mesenchymal transition and PI3K/Akt/GSK3β activation.

Li C, Zhang J, Wu H, Li L, Yang C, Song S, Peng P, Shao M, Zhang M, Zhao J, Zhao R, Wu W, Ruan Y, Wang L, Gu J
Scientific reports 2017 Mar 27;7:45275

Mitochondrion-Targeted Peptide SS-31 Inhibited Oxidized Low-Density Lipoproteins-Induced Foam Cell Formation through both ROS Scavenging and Inhibition of Cholesterol Influx in RAW264.7 Cells.

Hao S, Ji J, Zhao H, Shang L, Wu J, Li H, Qiao T, Li K
Molecules (Basel, Switzerland) 2015 Dec 1;20(12):21287-97

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The OLR1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human OLR1. This antibody recognizes human antigen. The OLR1 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 11837-1-AP.pdf

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