AF1564

antibody from R&D Systems

Targeting: OLR1 CLEC8A, LOX-1, SCARE1

Western blot (Data presented on provider website)

Blocking/Neutralizing (Data presented on provider website)

Antibody Data

Product number

AF1564

Provider

R&D Systems

Product name

Mouse LOX-1/OLR1 Antibody

Antibody type

Polyclonal

Description

Antigen Affinity-purified. Selected for its ability to block receptor-ligand interaction in a functional ELISA assay. In Western blots, approximately 5% cross-reactivity with recombinant human LOX-1 is observed.

Reactivity

Mouse

Host

Goat

Conjugate

Unconjugated

Antigen sequence

AAG44998


Isotype

IgG

Vial size

100 ug

Concentration

LYOPH

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

References

Submitted references

Highly electronegative low-density lipoprotein L5 evokes microglial activation and creates a neuroinflammatory stress via Toll-like receptor 4 signaling.

Yu LE, Lai CL, Lee CT, Wang JY
Journal of neurochemistry 2017 Jul;142(2):231-245

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LOX-1 is a novel therapeutic target in neonatal hypoxic-ischemic encephalopathy.

Akamatsu T, Dai H, Mizuguchi M, Goto Y, Oka A, Itoh M
The American journal of pathology 2014 Jun;184(6):1843-52

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The receptor of advanced glycation end products plays a central role in advanced oxidation protein products-induced podocyte apoptosis.

Zhou LL, Cao W, Xie C, Tian J, Zhou Z, Zhou Q, Zhu P, Li A, Liu Y, Miyata T, Hou FF, Nie J
Kidney international 2012 Oct;82(7):759-70

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Leptin-deficient (ob/ob) mouse ovaries show fatty degeneration, enhanced apoptosis and decreased expression of steroidogenic acute regulatory enzyme.

Serke H, Nowicki M, Kosacka J, Schröder T, Klöting N, Blüher M, Kallendrusch S, Spanel-Borowski K
International journal of obesity (2005) 2012 Aug;36(8):1047-53

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Heat shock protein 90 mediates efficient antigen cross presentation through the scavenger receptor expressed by endothelial cells-I.

Murshid A, Gong J, Calderwood SK
Journal of immunology (Baltimore, Md. : 1950) 2010 Sep 1;185(5):2903-17

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Cilostazol inhibits modified low-density lipoprotein uptake and foam cell formation in mouse peritoneal macrophages.

Okutsu R, Yoshikawa T, Nagasawa M, Hirose Y, Takase H, Mitani K, Okada K, Miyakoda G, Yabuuchi Y
Atherosclerosis 2009 Jun;204(2):405-11