11577-1-AP

antibody from Proteintech Group

Targeting: LIAS LAS

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

11577-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#11577-1-AP, RRID:AB_2135972

Product name

LIAS antibody

Antibody type

Polyclonal

Description

LIAS antibody (Cat. #11577-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Retinoic acid mitigates the NSC319726-induced spermatogenesis dysfunction through cuproptosis-independent mechanisms.

Yi H, Chen T, He G, Liu L, Zhao J, Guo K, Cao Y, Sun P, Zhou X, Zhang B, Li C, Wang H
Cell biology and toxicology 2024 May 1;40(1):26

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MUC20 regulated by extrachromosomal circular DNA attenuates proteasome inhibitor resistance of multiple myeloma by modulating cuproptosis.

Wang X, Shi Y, Shi H, Liu X, Liao A, Liu Z, Orlowski RZ, Zhang R, Wang H
Journal of experimental & clinical cancer research : CR 2024 Mar 5;43(1):68

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Clinical features and molecular landscape of cuproptosis signature-related molecular subtype in gastric cancer.

Chong W, Ren H, Chen H, Xu K, Zhu X, Liu Y, Sang Y, Li H, Liu J, Ye C, Shang L, Jing C, Li L
iMeta 2024 Jun;3(3):e190

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Tumor microenvironment-activated, immunomodulatory nanosheets loaded with copper(II) and 5-FU for synergistic chemodynamic therapy and chemotherapy.

Xia Y, Gu M, Wang J, Zhang X, Shen T, Shi X, Yuan WE
Journal of colloid and interface science 2024 Jan;653(Pt A):137-147

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METTL17 is an Fe-S cluster checkpoint for mitochondrial translation.

Ast T, Itoh Y, Sadre S, McCoy JG, Namkoong G, Wengrod JC, Chicherin I, Joshi PR, Kamenski P, Suess DLM, Amunts A, Mootha VK
Molecular cell 2024 Jan 18;84(2):359-374.e8

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Bioinformatics reveals diagnostic potential of cuproptosis-related genes in the pathogenesis of sepsis.

Sun Z, Zhao Q, Zhang J, Hu Y, Qu J, Gao H, Peng Z
Heliyon 2024 Jan 15;10(1):e22664

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Deep learning enables the discovery of a novel cuproptosis-inducing molecule for the inhibition of hepatocellular carcinoma.

Yang F, Jia L, Zhou HC, Huang JN, Hou MY, Liu FT, Prabhu N, Li ZJ, Yang CB, Zou C, Nordlund P, Wang JG, Dai LY
Acta pharmacologica Sinica 2024 Feb;45(2):391-404

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Changes in cuproptosis-related gene expression in periodontitis: An integrated bioinformatic analysis.

Liu N, He Y, Chen X, Qiu G, Wu Y, Shen Y
Life sciences 2024 Feb 1;338:122388

---

Copper exposure induces trophoblast cell cuproptosis by up-regulating lnc-HZ11.

Zheng Z, Fang J, Shen Y, Mi C, Xu Z, Zhao J, Chen W, Han R, Lei Q, Zhang H
Ecotoxicology and environmental safety 2024 Aug;281:116641

---

Bioinformatics-based dynamics of cuproptosis -related indicators in experimental silicosis.

Xia J, Wu C, Jin X, Ding M, Zhang C, Hou G, Hao C, Yao W
Ecotoxicology and environmental safety 2024 Apr 15;275:116286

---

Cellular Trojan Horse initiates bimetallic Fe-Cu MOF-mediated synergistic cuproptosis and ferroptosis against malignancies.

Chen K, Zhou A, Zhou X, He J, Xu Y, Ning X
Science advances 2024 Apr 12;10(15):eadk3201

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Impact of Cuproptosis-related markers on clinical status, tumor immune microenvironment and immunotherapy in colorectal cancer: A multi-omic analysis.

Shao Y, Fan X, Yang X, Li S, Huang L, Zhou X, Zhang S, Zheng M, Sun J
Computational and structural biotechnology journal 2023;21:3383-3403

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ITGB1-mediated molecular landscape and cuproptosis phenotype induced the worse prognosis in diffuse gastric cancer.

Zhu X, Chen H, Li H, Ren H, Ye C, Xu K, Liu J, Du F, Zhang Z, Liu Y, Xie X, Wang M, Ma T, Chong W, Shang L, Li L
Frontiers in oncology 2023;13:1115510

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FDX1 regulates cellular protein lipoylation through direct binding to LIAS.

Dreishpoon MB, Bick NR, Petrova B, Warui DM, Cameron A, Booker SJ, Kanarek N, Golub TR, Tsvetkov P
The Journal of biological chemistry 2023 Sep;299(9):105046

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Evaluation the role of cuproptosis-related genes in the pathogenesis, diagnosis and molecular subtypes identification of atherosclerosis.

Wang M, Cheng L, Xiang Q, Gao Z, Ding Y, Xie H, Chen X, Yu P, Shen L
Heliyon 2023 Oct;9(10):e21158

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Ferroptosis inducers enhanced cuproptosis induced by copper ionophores in primary liver cancer.

Wang W, Lu K, Jiang X, Wei Q, Zhu L, Wang X, Jin H, Feng L
Journal of experimental & clinical cancer research : CR 2023 Jun 6;42(1):142

---

A mitochondrial iron-responsive pathway regulated by DELE1.

Sekine Y, Houston R, Eckl EM, Fessler E, Narendra DP, Jae LT, Sekine S
Molecular cell 2023 Jun 15;83(12):2059-2076.e6

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ATF3/SPI1/SLC31A1 Signaling Promotes Cuproptosis Induced by Advanced Glycosylation End Products in Diabetic Myocardial Injury.

Huo S, Wang Q, Shi W, Peng L, Jiang Y, Zhu M, Guo J, Peng D, Wang M, Men L, Huang B, Lv J, Lin L
International journal of molecular sciences 2023 Jan 14;24(2)

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FDX1 regulates cellular protein lipoylation through direct binding to LIAS.

Dreishpoon MB, Bick NR, Petrova B, Warui DM, Cameron A, Booker SJ, Kanarek N, Golub TR, Tsvetkov P
bioRxiv : the preprint server for biology 2023 Feb 4;

---

Dexmedetomidine enables copper homeostasis in cerebral ischemia/reperfusion via ferredoxin 1.

Guo Q, Ma M, Yu H, Han Y, Zhang D
Annals of medicine 2023 Dec;55(1):2209735

---

Integrated bioinformatics and experiment revealed that cuproptosis is the potential common pathogenesis of three kinds of primary cardiomyopathy.

Wang M, Xu X, Li J, Gao Z, Ding Y, Chen X, Xiang Q, Shen L
Aging 2023 Dec 11;15(23):14210-14241

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Lias overexpression alleviates pulmonary injury induced by fine particulate matter in mice.

Xu G, Zhao Y, Tao Y, Xiong C, Lv M, Gao Q, Zhang F, An Z, Wu W
Environmental geochemistry and health 2023 Aug;45(8):6585-6603

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Cuproptosis-Inducible Chemotherapeutic/Cascade Catalytic Reactor System for Combating with Breast Cancer.

Lee SY, Seo JH, Kim S, Hwang C, Jeong DI, Park J, Yang M, Huh JW, Cho HJ
Small (Weinheim an der Bergstrasse, Germany) 2023 Aug;19(35):e2301402

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Comprehensive analysis of cuproptosis-related genes in immune infiltration and diagnosis in ulcerative colitis.

Huang J, Zhang J, Wang F, Zhang B, Tang X
Frontiers in immunology 2022;13:1008146

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Establishment and experimental validation of a novel cuproptosis-related gene signature for prognostic implication in cholangiocarcinoma.

Chen J, Yu X, Tong H, Tang C, Tang Z
Frontiers in oncology 2022;12:1054063

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Copper induces cell death by targeting lipoylated TCA cycle proteins.

Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M, Rossen J, Joesch-Cohen L, Humeidi R, Spangler RD, Eaton JK, Frenkel E, Kocak M, Corsello SM, Lutsenko S, Kanarek N, Santagata S, Golub TR
Science (New York, N.Y.) 2022 Mar 18;375(6586):1254-1261

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Adaptation of the heart to Frataxin depletion: Evidence that integrated stress response can predominate over mTORC1 activation.

Vásquez-Trincado C, Patel M, Sivaramakrishnan A, Bekeová C, Anderson-Pullinger L, Wang N, Tang HY, Seifert EL
Human molecular genetics 2021 Sep 22;33(8):637-54

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SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells.

Wang Y, Yen FS, Zhu XG, Timson RC, Weber R, Xing C, Liu Y, Allwein B, Luo H, Yeh HW, Heissel S, Unlu G, Gamazon ER, Kharas MG, Hite R, Birsoy K
Nature 2021 Nov;599(7883):136-140

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Overexpression of lipoic acid synthase gene alleviates diabetic nephropathy of Lepr(db/db) mice.

Zhao Y, Yan T, Xiong C, Chang M, Gao Q, Yao S, Wu W, Yi X, Xu G
BMJ open diabetes research & care 2021 Jun;9(1)

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Overexpression of endogenous lipoic acid synthase attenuates pulmonary fibrosis induced by crystalline silica in mice.

Zhao Y, Xu G, Li H, Chang M, Guan Y, Li Y, Wu W, Yao S
Toxicology letters 2020 May 1;323:57-66

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Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation.

Weber RA, Yen FS, Nicholson SPV, Alwaseem H, Bayraktar EC, Alam M, Timson RC, La K, Abu-Remaileh M, Molina H, Birsoy K
Molecular cell 2020 Feb 6;77(3):645-655.e7

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

human brain tissue were subjected to SDS PAGE followed by western blot with 11577-1-AP(LIAS antibody) at dilution of 1:500

Sample type

tissue

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The LIAS antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human LIAS. This antibody recognizes human,mouse,rat antigen. The LIAS antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

11577-1-AP.pdf

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