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- References [144]
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- Product number
- 11577-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11577-1-AP, RRID:AB_2135972
- Product name
- LIAS antibody
- Antibody type
- Polyclonal
- Description
- LIAS antibody (Cat. #11577-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Injectable Cu(2+) loaded rhein hydrogel for cross-amplifying osteosarcoma apoptosis and cuproptosis epitranscriptomically.
Cuproptosis in atrazine-induced hepatotoxicity: ATOX1 as a therapeutic target for lycopene-mediated protection.
OTUB1/CDYL axis-mediated epigenetic repression of SOX18 facilitates lung cancer progression by inhibiting FDX1-dependent cuproptosis.
Hyaluronic acid-coated Cu/Mn Prussian blue nanocubes amplify cuproptosis and cGAS-STING signaling for synergistic prostate cancer therapy.
Programmable bacteria-driven biohybrid triggers spatiotemporal-controlled STING activation to potentiate cuproptosis-based cancer therapy.
Cuproptosis and Disulfidptosis Converge to Empower PD-L1 Checkpoint Therapy via Cadict-Induced PD-L1 Translation.
PD-L1 nanobody-engineered bacterial outer membrane vesicles delivering cuproptosis micelles for potentiated cancer immunotherapy.
Redox cycling nitroxide limits cellular iron availability and selectively inhibits iron-sulfur cluster metabolism.
A degradable multi-metal-chelating stealth nanoplatform for dual ferroptosis/cuproptosis-enhanced metalloimmunotherapy in leukemia.
A Dual-Responsive Versatile Nanohybrid Orchestrating Tumor Elimination and Tumor-Associated Osteolysis Restoration via Sequential Release.
Tumor-Directed Disulfidptosis via Spatiotemporally Controlled Copper Bioorthogonal Activation.
Glutathione-depleting mitochondria-targeting nanodrugs for stress amplification and immune activation via synergistic photodynamic therapy and cuproptosis.
Copper depletion ameliorates neuronal damage after intracerebral hemorrhage.
Copper potentiates PUFA-mediated antitumor activity by activating Lipophagy.
Role of copper ion overload triggered by CD44 endocytosis on STAT3-mediated cuproptosis in septic myocardial injury.
Ginsenoside Rh1 sensitizes gastric cancer to cuproptosis and represses immune evasion.
Omeprazole-mediated nanodelivery of copper for synchronous remodeling of copper influx and efflux in cuproptotic glioblastoma therapy.
COA6 deficiency inhibits hepatocellular carcinoma progression by regulating cuproptosis through the JAK/STAT signaling pathway.
Targeting SH3GL1 for prognosis and immune response in breast cancer.
Xinfeng Capsule ameliorates RA joint injury by inhibiting cuproptosis via the METTL3/miR-221/222-3p/ATP7A Axis.
Rational design of copper ionophores for efficient induction of cuproptosis via simple n-alkyl modification.
Cuproptosis of bronchial epithelial cells triggers airway remodeling in chronic asthma.
WTAP-mediated m6A modification of PRMT1 regulates cuproptosis to promote anaplastic thyroid carcinoma progression.
SERPINE1-Driven MAPK Activation Enhances Cuproptosis Resistance and Angiogenic Potential in Colorectal Cancer.
The EZH2-NEAT1 epigenetic axis promotes cuproptosis sensitivity and modulates cancer cell migration in colorectal cancer.
PDHA1-acetylation signaling suppresses cuproptosis to attenuate anti-androgen effect in prostate cancer.
Mitochondrial uncoupling sensitizes gastric cancer cells to elesclomol-induced cuproptosis via FDX1/DLAT upregulation.
Hepatocyte cuproptosis promotes the progression of hepatic fibrosis: Emerging a potential therapeutic target.
Unraveling the role of cuproptosis in pulmonary fibrosis pathogenesis and prognosis: an integrative single-cell transcriptomics and microarray analysis.
Transdermal siRNA delivery via biomineralized nanoparticle-incorporated microneedles modulates cuproptosis-ferroptosis interaction for psoriasis therapy.
Copper-based nanozymes synergistically enhance Cuproptosis for psoriasis treatment.
Nucleolin-Targeted DNA Nanoflowers Enable Multimodal Synergistic Cancer Therapy.
Yttrium Oxide Nanoparticles Affect Both Cognitive and Memory Function by Disrupting Copper Output in Neuronal Cells in a Rat Model.
Machine Learning-Based Identification and Experimental Validation of Hub Ferroptosis-Related Cuproptosis Genes in Lupus Nephritis.
Dexmedetomidine alleviates lung ischemia-reperfusion injury by inhibiting cuproptosis: an in vivo study.
Lnc-CNNM3-DT as a protective factor in cervical cancer: regulation of LIAS expression and intracellular copper levels.
Hypoxia, cuproptosis, and osteoarthritis: Unraveling the molecular crosstalk.
LncRNA PVT1 promotes cuproptosis through transcriptional activation of FDX1 in colorectal cancer.
CIAO1 as a crucial signature gene of cuproptosis in gastric cancer.
Cuproptosis involvement in neonatal ischemic-hypoxic encephalopathy through the COMMD1/ATP7A signaling axis.
Phillygenin ameliorates myocardial ischemia-reperfusion injury by inhibiting cuproptosis via the autophagy-lysosome degradation of CTR1.
Human cytomegalovirus protein UL13 targets to mitochondria to induce cuproptosis.
Iron overload exaggerates renal ischemia-reperfusion injury by promoting tubular cuproptosis via interrupting function of LIAS.
Magnesium hexacyanoferrate mitigates sepsis-associated encephalopathy through inhibiting microglial activation and neuronal cuproptosis.
Lithium Exposure Causes Trophoblast Cuproptosis by Upregulating FOXO1/STEAP4 Axis in Unexplained Miscarriage.
A CRISPR-Customizable Copper-Coordinated DNA Nanoplatform Potentiates Cuproptosis Through Circadian and Metabolic Pathway Manipulation.
Modulation of inflammatory and cuproptotic crosstalk by Ethyl and propyl gallate: a multi-targeted strategy against experimental colitis.
CDC26 facilitates ferroptosis through SLC7A11 degradation and cell cycle arrest.
A Tumor Microenvironment-Responsive Self-Oxygenating Nanoplatform for Dual-Enhanced Cuproptosis and Sonodynamic Synergistic Immunotherapy.
One-Step Symbiosis of Bimetallic Peroxides Nanoparticles to Induce Ferroptosis/Cuproptosis and Activate cGAS-STING Pathway for Enhanced Tumor Immunotherapy.
Targeting copper homeostasis: Akkermansia-derived OMVs co-deliver Atox1 siRNA and elesclomol for cancer therapy.
Polystyrene nanoplastics exposure induces cognitive impairment in mice via induction of oxidative stress and ERK/MAPK-mediated neuronal cuproptosis.
Novel Pt@PCN-Cu-induced cuproptosis amplifies αPD-L1 immunotherapy in pancreatic ductal adenocarcinoma through mitochondrial HK2-mediated PD-L1 upregulation.
A Copper-Manganese Based Nanocomposite Induces Cuproptosis and Potentiates Anti-Tumor Immune Responses.
Role of DLAT in cuproptosis and autophagy in hippocampal tissue of PTSD rats with high-voltage electrical burns.
Diallyl Trisulfide From Garlic Regulates RAB18 Phase Separation to Inhibit Lipophagy and Induce Cuproptosis in Hepatic Stellate Cells for Antifibrotic Effects.
Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance.
C5a/C5aR pathway blocking promoted CuS-mediated cancer therapy effect by inhibiting cuproptosis resistance.
A Novel Copper Ionophore Nanoshuttle (Winged Cu) for Inducing Cuproptosis in B16 Melanoma Cells.
Increased CDKN2A expression correlates with resistance to platinum-based therapy and decreased infiltration of B lymphocytes in colon adenocarcinoma.
LPS mediates cuproptosis and inflammation in THP-1 macrophages through HKDC1.
Copper/calcium co-doped carbon dots for targeted cancer therapy with dual-mode imaging and synergistic induction of cuproptosis and calcium-mediated apoptosis.
Lipoic acid functions in Paneth cells to prevent human intestinal stem cell aging.
Exploiting mitochondrial dysfunction to overcome BRAF inhibitor resistance in advanced melanoma: the role of disulfiram as a copper ionophore.
Endothelial Cu Uptake Transporter CTR1 Senses Disturbed Flow to Promote Atherosclerosis through Cuproptosis.
A metal-organic framework functionalized CaO(2)-based cascade nanoreactor induces synergistic cuproptosis/ferroptosis and Ca(2+) overload-mediated mitochondrial damage for enhanced sono-chemodynamic immunotherapy.
Unc5b prevents macrophage-derived foam cell migration and promotes atherosclerotic development via the P53-cuproptosis signaling pathway.
Elesclomol rescues mitochondrial copper deficiency in disease models without triggering cuproptosis.
Cuproptosis and Serine Metabolism Blockade Triggered by Copper-Based Prussian Blue Nanomedicine for Enhanced Tumor Therapy.
Glutathione Induced In Situ Activation of Dual-Locked Cuproptosis Nanoamplifier with Glycolysis Metabolism Inhibition to Boost Cancer Immunotherapy.
UiO-66 MOFs-Based "Epi-Nano-Sonosensitizer" for Ultrasound-Driven Cascade Immunotherapy against B-Cell Lymphoma.
Regulating SLC7A11/GSH/GPX4 axis by glucose dyshomeostasis to simultaneously promote disulfidptosis, cuproptosis and ferroptosis.
Unraveling the miR-144-3p/PUMA pathway: a novel regulator of FDX1-mediated cuproptosis in colorectal cancer.
Cu-doped dendritic biodegradable nanoplatforms for augmenting cuproptosis and tumor-starvation therapy through mitochondrial metabolic cascade modulation.
Biodegradable Cu-based sonozymes for tumor-specific cuproptosis-enhanced sono-immunotherapy through activating cGAS-STING pathway and sensitizing immune checkpoint blockade.
Clinically friendly smart hydrogel boosts cuproptosis and PD-L1 upregulation to enhance anti-tumor immunotherapy.
HMC ameliorates myocardial ischaemia-reperfusion injury through suppressing cuproptosis via the de-ubiquitination and stabilization of ATP7A.
Targeting multiple genetic defects of mitochondrial diseases with a single bacterial lipoate protein ligase.
Lycopene Alleviates Atrazine-Induced Mitochondrial Tricarboxylic Acid Cycle Disorder and Associated Cardiac Cell Senescence and Cuproptosis.
Elesclomol-copper combination synergistically targets mitochondrial metabolism in cancer stem cells to overcome chemoresistance in PDAC.
Deep Mutational Scanning of FDX1 Identifies Key Structural Determinants of Lipoylation and Cuproptosis.
TRIM21 promotes K63-linked ubiquitination of ALKBH5 and suppresses cuproptosis via down-regulation of LIAS in esophageal squamous cell carcinoma.
Melanoma MHC-I-membrane-encapsulated Cu@ferrihydrite induces ferroptosis/cuproptosis and systematic immunity against tumor.
Immunogenic cuproptosis in cancer immunotherapy via an in situ cuproptosis-inducing system.
Multi-pathway copper metabolisms regulation based on an engineered copper/ferrous nanoplatform for enhanced tumor cuproptosis therapy.
Multifunctional Bioactive Dual-Layered Nanofibrous Matrix for Effective Breast Cancer Therapy and Enhanced Wound Healing.
Ligand supplementation restores the cancer therapy efficacy of the antirheumatic drug auranofin from serum inactivation.
Copper-overload promotes ferroptosis in cervical cancer cells by upregulating HMOX1 expression.
Engineering M2 macrophage-derived exosomes modulate activated T cell cuproptosis to promote immune tolerance in rheumatoid arthritis.
Nano Copper-chelate Triggers Cuproptosis-like Death in Fungi and Synergizes with Microneedles for Enhanced Biofilm Removal.
Modulation of Bacterial Iron Homeostasis to Enhance Cuproptosis-like Death for the Treatment of Infected Diabetic Wound.
o8G-modified circKIAA1797 promotes lung cancer development by inhibiting cuproptosis.
CuO Nanozymes Catalyze Cysteine and Glutathione Depletion Induced Ferroptosis and Cuproptosis for Synergistic Tumor Therapy.
Multifunctional Copper-Phenolic Nanopills Achieve Comprehensive Polyamines Depletion to Provoke Enhanced Pyroptosis and Cuproptosis for Cancer Immunotherapy.
Bovine serum albumin-bound homologous targeted nanoparticles for breast cancer combinatorial therapy.
CircSpna2 attenuates cuproptosis by mediating ubiquitin ligase Keap1 to regulate the Nrf2-Atp7b signalling axis in depression after traumatic brain injury in a mouse model.
Three Birds with One Stone: Copper Ions Assisted Synergistic Cuproptosis/Chemodynamic/Photothermal Therapy by a Three-Pronged Approach.
Copper-Based Composites Nanoparticles Improve Triple-Negative Breast Cancer Treatment with Induction of Apoptosis-Cuproptosis and Immune Activation.
Rhomboid-like 2 correlated with TME infiltration inhibits cuproptosis-related genes and drives malignant phenotype in clear cell renal cell carcinoma.
Inhibition of CTR1 expression improves hypoxia/reoxygenation-induced myoblast injury by blocking cuproptosis.
Mitochondrial respiratory function is preserved under cysteine starvation via glutathione catabolism in NSCLC.
Retinoic acid mitigates the NSC319726-induced spermatogenesis dysfunction through cuproptosis-independent mechanisms.
MUC20 regulated by extrachromosomal circular DNA attenuates proteasome inhibitor resistance of multiple myeloma by modulating cuproptosis.
Clinical features and molecular landscape of cuproptosis signature-related molecular subtype in gastric cancer.
Molecular characterization and clinical relevance of metabolic signature subtypes in gastric cancer.
Tumor microenvironment-activated, immunomodulatory nanosheets loaded with copper(II) and 5-FU for synergistic chemodynamic therapy and chemotherapy.
Identification of cuproptosis-related molecular classification and characteristic genes in ulcerative colitis.
METTL17 is an Fe-S cluster checkpoint for mitochondrial translation.
Bioinformatics reveals diagnostic potential of cuproptosis-related genes in the pathogenesis of sepsis.
Deep learning enables the discovery of a novel cuproptosis-inducing molecule for the inhibition of hepatocellular carcinoma.
Changes in cuproptosis-related gene expression in periodontitis: An integrated bioinformatic analysis.
Engineered bacterial lipoate protein ligase A (lplA) restores lipoylation in cell models of lipoylation deficiency.
Synergistic enhancement of low-dose radiation therapy via cuproptosis and metabolic reprogramming for radiosensitization in in situ hepatocellular carcinoma.
Low Expression of Lipoic Acid Synthase Aggravates Silica-Induced Pulmonary Fibrosis by Inhibiting the Differentiation of Tregs in Mice.
Copper exposure induces trophoblast cell cuproptosis by up-regulating lnc-HZ11.
Enzalutamide Sensitizes Castration-Resistant Prostate Cancer to Copper-Mediated Cell Death.
A singular plasmonic-thermoelectric hollow nanostructure inducing apoptosis and cuproptosis for catalytic cancer therapy.
Triptolide-induced cuproptosis is a novel antitumor strategy for the treatment of cervical cancer.
Injectable Hydrogel-Encapsulating Pickering Emulsion for Overcoming Lenvatinib-Resistant Hepatocellular Carcinoma via Cuproptosis Induction and Stemness Inhibition.
Eupalinolide B suppresses pancreatic cancer by ROS generation and potential cuproptosis.
Cuproptosis associated cytoskeletal destruction contributes to podocyte injury in chronic kidney disease.
Bioinformatics-based dynamics of cuproptosis -related indicators in experimental silicosis.
Cellular Trojan Horse initiates bimetallic Fe-Cu MOF-mediated synergistic cuproptosis and ferroptosis against malignancies.
Impact of Cuproptosis-related markers on clinical status, tumor immune microenvironment and immunotherapy in colorectal cancer: A multi-omic analysis.
ITGB1-mediated molecular landscape and cuproptosis phenotype induced the worse prognosis in diffuse gastric cancer.
Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells.
FDX1 regulates cellular protein lipoylation through direct binding to LIAS.
Evaluation the role of cuproptosis-related genes in the pathogenesis, diagnosis and molecular subtypes identification of atherosclerosis.
Ferroptosis inducers enhanced cuproptosis induced by copper ionophores in primary liver cancer.
A mitochondrial iron-responsive pathway regulated by DELE1.
ATF3/SPI1/SLC31A1 Signaling Promotes Cuproptosis Induced by Advanced Glycosylation End Products in Diabetic Myocardial Injury.
FDX1 regulates cellular protein lipoylation through direct binding to LIAS.
Dexmedetomidine enables copper homeostasis in cerebral ischemia/reperfusion via ferredoxin 1.
Integrated bioinformatics and experiment revealed that cuproptosis is the potential common pathogenesis of three kinds of primary cardiomyopathy.
Lias overexpression alleviates pulmonary injury induced by fine particulate matter in mice.
Cuproptosis-Inducible Chemotherapeutic/Cascade Catalytic Reactor System for Combating with Breast Cancer.
Comprehensive analysis of cuproptosis-related genes in immune infiltration and diagnosis in ulcerative colitis.
Establishment and experimental validation of a novel cuproptosis-related gene signature for prognostic implication in cholangiocarcinoma.
Copper induces cell death by targeting lipoylated TCA cycle proteins.
Adaptation of the heart to Frataxin depletion: Evidence that integrated stress response can predominate over mTORC1 activation.
SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells.
Overexpression of lipoic acid synthase gene alleviates diabetic nephropathy of Lepr(db/db) mice.
Overexpression of endogenous lipoic acid synthase attenuates pulmonary fibrosis induced by crystalline silica in mice.
Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation.
Zhu J, Zhou T, Tang X, Gao Y, Teng Q, Zhang Y, Lv Z, Chen X, Zou J, Shi H
Biomaterials 2026 Sep;332:124170
Biomaterials 2026 Sep;332:124170
Cuproptosis in atrazine-induced hepatotoxicity: ATOX1 as a therapeutic target for lycopene-mediated protection.
Li NW, Yao X, Lu WH, Zhang YQ, Liu YY, Zhang TT, Zhao Y, Li JL
Journal of advanced research 2026 May;83:823-836
Journal of advanced research 2026 May;83:823-836
OTUB1/CDYL axis-mediated epigenetic repression of SOX18 facilitates lung cancer progression by inhibiting FDX1-dependent cuproptosis.
Zhang R, Li Y, Lu H, Wang X, Zhu Y, Zhao X, Jin K, Meng L, Xu Z, Liu H, Gu H, Wan J
Oncogene 2026 May;45(16):1453-1470
Oncogene 2026 May;45(16):1453-1470
Hyaluronic acid-coated Cu/Mn Prussian blue nanocubes amplify cuproptosis and cGAS-STING signaling for synergistic prostate cancer therapy.
Yao X, Ruan Y, Rao T, Lin F, Zhang W
International journal of biological macromolecules 2026 May;362:152036
International journal of biological macromolecules 2026 May;362:152036
Programmable bacteria-driven biohybrid triggers spatiotemporal-controlled STING activation to potentiate cuproptosis-based cancer therapy.
Kang R, Pan X, Zhou X, Pang Y, Shen Z, Luo L, Liu F, Yu S, Shen Q
Biomaterials 2026 May;328:123893
Biomaterials 2026 May;328:123893
Cuproptosis and Disulfidptosis Converge to Empower PD-L1 Checkpoint Therapy via Cadict-Induced PD-L1 Translation.
Huang S, Song S, Zhang X, Gao J, Pu R, Dai J, Wu X, Chen L, Li Q, Liu X, Zhou Q, Song M, He W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(25):e15367
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(25):e15367
PD-L1 nanobody-engineered bacterial outer membrane vesicles delivering cuproptosis micelles for potentiated cancer immunotherapy.
Li Z, Liang D, Huo M, Guan L, Liu Z, Gu F, Guan X, Chen L
Biomaterials advances 2026 Mar;180:214552
Biomaterials advances 2026 Mar;180:214552
Redox cycling nitroxide limits cellular iron availability and selectively inhibits iron-sulfur cluster metabolism.
Terzi EM, Fujihara KM, Molenaars M, Biancur DE, Possemato R
Cell death discovery 2026 Mar 24;12(1)
Cell death discovery 2026 Mar 24;12(1)
A degradable multi-metal-chelating stealth nanoplatform for dual ferroptosis/cuproptosis-enhanced metalloimmunotherapy in leukemia.
Wang Y, Xu J, Bai W, Zhang Z, Ma C, Tan Y, Zhang Z, Liu W, Wu Y, Liu J, Lei H, Xu H, Weng W, Huang M, Feng X, Zhu L, Yang L, Zhu Q, Wu YL
Journal of nanobiotechnology 2026 Mar 21;24(1)
Journal of nanobiotechnology 2026 Mar 21;24(1)
A Dual-Responsive Versatile Nanohybrid Orchestrating Tumor Elimination and Tumor-Associated Osteolysis Restoration via Sequential Release.
Liu L, Liu HZ, Liu ZN, Wang T, Yu LL, Li QJ, Chen ZY, Luo GF, Shang ZJ
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 18;:e18962
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 18;:e18962
Tumor-Directed Disulfidptosis via Spatiotemporally Controlled Copper Bioorthogonal Activation.
Yin Y, Yu W, Shen Z, Yuan S, Cao K, Liu HK, Liu Y
ACS nano 2026 Mar 10;20(9):7569-7588
ACS nano 2026 Mar 10;20(9):7569-7588
Glutathione-depleting mitochondria-targeting nanodrugs for stress amplification and immune activation via synergistic photodynamic therapy and cuproptosis.
Zhang P, Lin H, Guan Q, Xiong S, Tian Z, Wu W, Dai T, Wang X, Ruan J, Yang S, Dou H
Acta biomaterialia 2026 Jun;216:389-402
Acta biomaterialia 2026 Jun;216:389-402
Copper depletion ameliorates neuronal damage after intracerebral hemorrhage.
Zhang W, Wu G, Wang L, Ren S
Neurochemistry international 2026 Jun;196:106150
Neurochemistry international 2026 Jun;196:106150
Copper potentiates PUFA-mediated antitumor activity by activating Lipophagy.
He X, Yang Q, Lin X, Chen Z, Ren K, Yang J, An X, Yang S, Yang L, Xue Q, Chen X, Wang Y, Yu G, Yan D, Chen X
Cellular signalling 2026 Jun;142:112454
Cellular signalling 2026 Jun;142:112454
Role of copper ion overload triggered by CD44 endocytosis on STAT3-mediated cuproptosis in septic myocardial injury.
Zhang M, Fu D, Zhang Q, Liang T, Guo H
International immunopharmacology 2026 Jun 15;179:116648
International immunopharmacology 2026 Jun 15;179:116648
Ginsenoside Rh1 sensitizes gastric cancer to cuproptosis and represses immune evasion.
Zhao D, Yuan Q, Wang H, Yang H, Yang L
Free radical biology & medicine 2026 Jul;250:399-410
Free radical biology & medicine 2026 Jul;250:399-410
Omeprazole-mediated nanodelivery of copper for synchronous remodeling of copper influx and efflux in cuproptotic glioblastoma therapy.
Feng W, Weng C, Li C, Yang R, Shi W, Liu Y, Ge P, Zhang H
Acta biomaterialia 2026 Jan;210:499-515
Acta biomaterialia 2026 Jan;210:499-515
COA6 deficiency inhibits hepatocellular carcinoma progression by regulating cuproptosis through the JAK/STAT signaling pathway.
Tian K, Yang Y, Niu X, Wei X, Zhang M, Zhou Y, Yang M, Sun H, Zhu L, Liu F
Biochimica et biophysica acta. Molecular cell research 2026 Jan;1873(1):120065
Biochimica et biophysica acta. Molecular cell research 2026 Jan;1873(1):120065
Targeting SH3GL1 for prognosis and immune response in breast cancer.
Si S, Yu H, Zhang H, Yin J, Li Z, Wang N, Yu X
Journal of pharmaceutical analysis 2026 Jan;16(1):101377
Journal of pharmaceutical analysis 2026 Jan;16(1):101377
Xinfeng Capsule ameliorates RA joint injury by inhibiting cuproptosis via the METTL3/miR-221/222-3p/ATP7A Axis.
Wang H, Wang A, Liu J, Zhu NF, Cao Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157644
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157644
Rational design of copper ionophores for efficient induction of cuproptosis via simple n-alkyl modification.
Yu L, Shen Q, Xie X, Ai M, Li Z, Wang P, Zhu Z, Tan C
European journal of medicinal chemistry 2026 Jan 5;301:118257
European journal of medicinal chemistry 2026 Jan 5;301:118257
Cuproptosis of bronchial epithelial cells triggers airway remodeling in chronic asthma.
Wang M, Liu C, Li Z, Wang Y, Li Y, Pei F
Scientific reports 2026 Jan 13;16(1):4621
Scientific reports 2026 Jan 13;16(1):4621
WTAP-mediated m6A modification of PRMT1 regulates cuproptosis to promote anaplastic thyroid carcinoma progression.
Feng G, Chen C, Luo Y, Chen R, Tang X, Li T
Tissue & cell 2026 Feb;98:103221
Tissue & cell 2026 Feb;98:103221
SERPINE1-Driven MAPK Activation Enhances Cuproptosis Resistance and Angiogenic Potential in Colorectal Cancer.
Gao P, Li H, Luo J, Zhang C, Wei J, Li X, Ma H
Digestive diseases and sciences 2026 Feb 9;
Digestive diseases and sciences 2026 Feb 9;
The EZH2-NEAT1 epigenetic axis promotes cuproptosis sensitivity and modulates cancer cell migration in colorectal cancer.
Li R, Tao Q, Chen X, Liu C, Zhan H, Wang C, Wang X, Lin Y
Journal of gastrointestinal oncology 2026 Feb 28;17(1):18
Journal of gastrointestinal oncology 2026 Feb 28;17(1):18
PDHA1-acetylation signaling suppresses cuproptosis to attenuate anti-androgen effect in prostate cancer.
Zhuang R, Zhou Q, Cheng B, Peng S, Xiong Z, Xie Z, Lin W, Su T, Li Z, Yao K, Wu Z, Huang H, Li K
Cell death & disease 2026 Feb 23;17(1)
Cell death & disease 2026 Feb 23;17(1)
Mitochondrial uncoupling sensitizes gastric cancer cells to elesclomol-induced cuproptosis via FDX1/DLAT upregulation.
Lu Y, Li Y, Sun X, Li X, Zhao S, Fang Y, Qiu W, Luo C, Qi W
Free radical biology & medicine 2026 Feb 16;244:284-295
Free radical biology & medicine 2026 Feb 16;244:284-295
Hepatocyte cuproptosis promotes the progression of hepatic fibrosis: Emerging a potential therapeutic target.
Zhu C, Liu Z, Liu H, Qin L, Zhao X
International immunopharmacology 2026 Feb 1;170:116092
International immunopharmacology 2026 Feb 1;170:116092
Unraveling the role of cuproptosis in pulmonary fibrosis pathogenesis and prognosis: an integrative single-cell transcriptomics and microarray analysis.
Chen M, Chen J, Zhang J, Zhu Y, Meng X, Yang Z, Wang R
Molecular and cellular biochemistry 2026 Apr;481(4):1857-1874
Molecular and cellular biochemistry 2026 Apr;481(4):1857-1874
Transdermal siRNA delivery via biomineralized nanoparticle-incorporated microneedles modulates cuproptosis-ferroptosis interaction for psoriasis therapy.
Hao L, Yu P, Yan R, Li K, Luo Z, Xiang S, Wang Y, Fang C, Wang G, Ma S, Peng C, Hu S, Liu P
Materials today. Bio 2026 Apr;37:102991
Materials today. Bio 2026 Apr;37:102991
Copper-based nanozymes synergistically enhance Cuproptosis for psoriasis treatment.
Zhou J, Yu N, Yang X, Li S, Huang M, Pang T, Zhong D, Wen Y, Liu H
Materials today. Bio 2026 Apr;37:102855
Materials today. Bio 2026 Apr;37:102855
Nucleolin-Targeted DNA Nanoflowers Enable Multimodal Synergistic Cancer Therapy.
Ren A, Liu H, Tang Z, Zheng P, Hu Q, Huang T
Biomaterials research 2025;29:0254
Biomaterials research 2025;29:0254
Yttrium Oxide Nanoparticles Affect Both Cognitive and Memory Function by Disrupting Copper Output in Neuronal Cells in a Rat Model.
Zheng M, Chen Z, Xie J, Yang Q, Mo M, Chen L
International journal of nanomedicine 2025;20:5799-5815
International journal of nanomedicine 2025;20:5799-5815
Machine Learning-Based Identification and Experimental Validation of Hub Ferroptosis-Related Cuproptosis Genes in Lupus Nephritis.
Zhang S, Hu W, Zhang Y, Huang C, He Z, Xu J, Lin S, Yang B, Chen X
Journal of inflammation research 2025;18:11335-11353
Journal of inflammation research 2025;18:11335-11353
Dexmedetomidine alleviates lung ischemia-reperfusion injury by inhibiting cuproptosis: an in vivo study.
Liu H, Wang Z, Qiu T, Du W, Wu Z, Chen S, Jiao W
Frontiers in pharmacology 2025;16:1562535
Frontiers in pharmacology 2025;16:1562535
Lnc-CNNM3-DT as a protective factor in cervical cancer: regulation of LIAS expression and intracellular copper levels.
Yang Y, Zhu X, Sun D, Fan J
Frontiers in oncology 2025;15:1571788
Frontiers in oncology 2025;15:1571788
Hypoxia, cuproptosis, and osteoarthritis: Unraveling the molecular crosstalk.
Jiang Z, Li J, Shi M, Li Y, Sun N, Xi K, Li X, Zhao D, Leng X, Zhou Z, Dong H
Redox biology 2025 Sep;85:103757
Redox biology 2025 Sep;85:103757
LncRNA PVT1 promotes cuproptosis through transcriptional activation of FDX1 in colorectal cancer.
Ma J, Zhang Y, Sun Z, Guo H, Li X, Cai J, Zhang M, Chen M, Jiang J, Zhang L
Redox biology 2025 Sep;85:103722
Redox biology 2025 Sep;85:103722
CIAO1 as a crucial signature gene of cuproptosis in gastric cancer.
Qu J, Yang C, Zhou S, Zhao B, Tong Q, Zheng L
Oncology letters 2025 Sep;30(3):440
Oncology letters 2025 Sep;30(3):440
Cuproptosis involvement in neonatal ischemic-hypoxic encephalopathy through the COMMD1/ATP7A signaling axis.
Luo J, Zhang X, Bharati L, Hua Z, Chen S, Dong Z
Biochemical pharmacology 2025 Sep;239:117054
Biochemical pharmacology 2025 Sep;239:117054
Phillygenin ameliorates myocardial ischemia-reperfusion injury by inhibiting cuproptosis via the autophagy-lysosome degradation of CTR1.
Chen G, Wei M, Zhao CY, Zhang AY, Su JB, Ni ZR, Cai WW, Hou B, Du B, Liu MH, Xu GW, Yang L, Xu AJ, Wen YY, Wang J, Zou H, Zhuang YY, Xing HY, He T, Li YF, Lu QB, Zhu J, Zhu XX, Li KL, Sun HJ
Free radical biology & medicine 2025 Sep;237:542-557
Free radical biology & medicine 2025 Sep;237:542-557
Human cytomegalovirus protein UL13 targets to mitochondria to induce cuproptosis.
Yang XM, Lei YL, Zhang Y, Wang SH, Ren P, Li S, Yi XM
Biochemical and biophysical research communications 2025 Sep 1;777:152330
Biochemical and biophysical research communications 2025 Sep 1;777:152330
Iron overload exaggerates renal ischemia-reperfusion injury by promoting tubular cuproptosis via interrupting function of LIAS.
Chen S, Chen T, Xu C, Yu X, Shi J, Yang C, Zhu T
Redox biology 2025 Oct;86:103795
Redox biology 2025 Oct;86:103795
Magnesium hexacyanoferrate mitigates sepsis-associated encephalopathy through inhibiting microglial activation and neuronal cuproptosis.
Zhang Y, Xin J, Zhao D, Chen G, Ji P, Liu P, Wei H, Wang H, Xia Y, Wang Y, Wang Z, Ren X, Huo M, Yu H, Yang J
Biomaterials 2025 Oct;321:123279
Biomaterials 2025 Oct;321:123279
Lithium Exposure Causes Trophoblast Cuproptosis by Upregulating FOXO1/STEAP4 Axis in Unexplained Miscarriage.
Xing S, Lin Y, Sun Y, Yue X, Fan Q, Nie J, Zhang Z, Liu Y, Yang J, Kang Q, Wang Y, Yan H, Tian C, Chang Y, Zhang H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e02139
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e02139
A CRISPR-Customizable Copper-Coordinated DNA Nanoplatform Potentiates Cuproptosis Through Circadian and Metabolic Pathway Manipulation.
Zhang W, Feng ZY, Feng Z, Lian R, Liu Z, Zhang J
ACS nano 2025 Oct 21;19(41):36701-36717
ACS nano 2025 Oct 21;19(41):36701-36717
Modulation of inflammatory and cuproptotic crosstalk by Ethyl and propyl gallate: a multi-targeted strategy against experimental colitis.
Chougule PR, Sinha SN, Ghosh S, Rajendra S, Varma S, Challa S, Bhanoori M
Molecular biology reports 2025 Oct 14;52(1):1030
Molecular biology reports 2025 Oct 14;52(1):1030
CDC26 facilitates ferroptosis through SLC7A11 degradation and cell cycle arrest.
Lin J, Chen F, Tang H, Cai X, Huang M, Liang R, Kang R, Tang D, Liu J
Clinical and experimental medicine 2025 Nov 18;26(1):11
Clinical and experimental medicine 2025 Nov 18;26(1):11
A Tumor Microenvironment-Responsive Self-Oxygenating Nanoplatform for Dual-Enhanced Cuproptosis and Sonodynamic Synergistic Immunotherapy.
Tang Y, Ge L, Zhu D, Hu R, Chen W, Zhen X, Jiang X
ACS nano 2025 Nov 18;19(45):39228-39240
ACS nano 2025 Nov 18;19(45):39228-39240
One-Step Symbiosis of Bimetallic Peroxides Nanoparticles to Induce Ferroptosis/Cuproptosis and Activate cGAS-STING Pathway for Enhanced Tumor Immunotherapy.
Liu B, Chen X, Zhu Y, Chen H, Tan J, Yang Z, Li J, Zheng P, Feng L, Wang Q, Gai S, Zhong L, Yang P, Cheng Z, Lin J
Advanced materials (Deerfield Beach, Fla.) 2025 May;37(21):e2500337
Advanced materials (Deerfield Beach, Fla.) 2025 May;37(21):e2500337
Targeting copper homeostasis: Akkermansia-derived OMVs co-deliver Atox1 siRNA and elesclomol for cancer therapy.
Hamza M, Wang S, Wu H, Sun J, Du Y, Zeng C, Liu Y, Li K, Zhu X, Liu H, Chen L, Zhu M
Acta pharmaceutica Sinica. B 2025 May;15(5):2640-2654
Acta pharmaceutica Sinica. B 2025 May;15(5):2640-2654
Polystyrene nanoplastics exposure induces cognitive impairment in mice via induction of oxidative stress and ERK/MAPK-mediated neuronal cuproptosis.
Chen Y, Nan Y, Xu L, Dai A, Orteg RMM, Ma M, Zeng Y, Li J
Particle and fibre toxicology 2025 May 20;22(1):13
Particle and fibre toxicology 2025 May 20;22(1):13
Novel Pt@PCN-Cu-induced cuproptosis amplifies αPD-L1 immunotherapy in pancreatic ductal adenocarcinoma through mitochondrial HK2-mediated PD-L1 upregulation.
Wang P, Guo W, Liu S, Li S, Li J, Ding B, Yin F, Yang Y, Li X, Cao P, Ma C, Zhang W, Song Y, Geng Y, Liu L, Hu J, Hao J, Feng Y
Journal of experimental & clinical cancer research : CR 2025 May 17;44(1):149
Journal of experimental & clinical cancer research : CR 2025 May 17;44(1):149
A Copper-Manganese Based Nanocomposite Induces Cuproptosis and Potentiates Anti-Tumor Immune Responses.
Xie L, Gong J, He Z, Zhang W, Wang H, Wu S, Wang X, Sun P, Cai L, Wu Z, Wang H
Small (Weinheim an der Bergstrasse, Germany) 2025 Mar;21(12):e2412174
Small (Weinheim an der Bergstrasse, Germany) 2025 Mar;21(12):e2412174
Role of DLAT in cuproptosis and autophagy in hippocampal tissue of PTSD rats with high-voltage electrical burns.
Ge C, Zhao X, Zhang J, Li P, Hao J, Lu M, Li C, Ge L, Tu L, Zhang Q
Burns : journal of the International Society for Burn Injuries 2025 Jun;51(5):107519
Burns : journal of the International Society for Burn Injuries 2025 Jun;51(5):107519
Diallyl Trisulfide From Garlic Regulates RAB18 Phase Separation to Inhibit Lipophagy and Induce Cuproptosis in Hepatic Stellate Cells for Antifibrotic Effects.
Tian H, Sun S, Qiu X, Wang J, Gao Y, Chen J, Han X, Bao Z, Guo X, Sun Y, Lin Y, Hu M, Zhang F, Zhang Z, Wang F, Zheng S, Shao J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2415325
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2415325
Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance.
Lei G, Sun M, Cheng J, Ye R, Lu Z, Horbath A, Huo D, Wu S, Alapati A, Aggarwal S, Xu Z, Mao C, Yan Y, Yao J, Li Q, Chen X, Lee H, Zhuang L, Jiang D, Pataer A, Roth JA, Navin N, Koong AC, You MJ, Lin SH, Gan B
Cancer cell 2025 Jun 9;43(6):1076-1092.e5
Cancer cell 2025 Jun 9;43(6):1076-1092.e5
C5a/C5aR pathway blocking promoted CuS-mediated cancer therapy effect by inhibiting cuproptosis resistance.
Yang H, Deng B, Han X, Wang L, Zhao J, Zhao Y, Sun Z, Wang S, Liu G, Wu Y, Chen J
Journal for immunotherapy of cancer 2025 Jun 8;13(6)
Journal for immunotherapy of cancer 2025 Jun 8;13(6)
A Novel Copper Ionophore Nanoshuttle (Winged Cu) for Inducing Cuproptosis in B16 Melanoma Cells.
Wu Y, Chang Z, Wang W, Wu C, Pan X, Huang Z
Biomolecules 2025 Jun 18;15(6)
Biomolecules 2025 Jun 18;15(6)
Increased CDKN2A expression correlates with resistance to platinum-based therapy and decreased infiltration of B lymphocytes in colon adenocarcinoma.
Gu R, Li S, Yu B, Gu J, Guan B, Wu H
Functional & integrative genomics 2025 Jul 3;25(1):144
Functional & integrative genomics 2025 Jul 3;25(1):144
LPS mediates cuproptosis and inflammation in THP-1 macrophages through HKDC1.
Ou L, Meng Z, Mei J, Yuan H, Zhu X, Wang X, Shen A, Wang Z, Zhang L, Wang S, Chen Y, Pang X, Liu Y, Xu Y, Ma C
Acta biochimica et biophysica Sinica 2025 Jul 22;57(12):1953-68
Acta biochimica et biophysica Sinica 2025 Jul 22;57(12):1953-68
Copper/calcium co-doped carbon dots for targeted cancer therapy with dual-mode imaging and synergistic induction of cuproptosis and calcium-mediated apoptosis.
Zheng W, Liu Y, Liu J, Zhao Y, Wang P, Wang Y, Wang Y, Lu Z, Liu X, Shi Y, Zhou N, González FE, Sun H, Zhou D, Xu X
Journal of colloid and interface science 2025 Jul 15;690:137337
Journal of colloid and interface science 2025 Jul 15;690:137337
Lipoic acid functions in Paneth cells to prevent human intestinal stem cell aging.
Zhang Z, Wan Q, Zhu Y, Ye J, Fu F, Fan X, Chen H, Ren G, Jiang W, Guo X, Zhou J, Yan L, Yan J, Liu X, Yuan Y, Chen Y, Chen H
Nature communications 2025 Jul 1;16(1):6016
Nature communications 2025 Jul 1;16(1):6016
Exploiting mitochondrial dysfunction to overcome BRAF inhibitor resistance in advanced melanoma: the role of disulfiram as a copper ionophore.
Zhao B, Ban F, Li Y, Shi Q, Guo S, Yi X, Wang H, Gao T, Li C, Zhu G
Cell death & disease 2025 Jul 1;16(1):482
Cell death & disease 2025 Jul 1;16(1):482
Endothelial Cu Uptake Transporter CTR1 Senses Disturbed Flow to Promote Atherosclerosis through Cuproptosis.
Sudhahar V, Xiao Z, Das A, Ash D, Yadav S, Matier CD, Pezacki AT, Chatterjee B, Antipova OA, Vogt S, McMenamin M, Kelley S, Csanyi G, Lee J, Jo H, Chang CJ, Rao J, Kaplan JH, Ushio-Fukai M, Fukai T
bioRxiv : the preprint server for biology 2025 Jan 28;
bioRxiv : the preprint server for biology 2025 Jan 28;
A metal-organic framework functionalized CaO(2)-based cascade nanoreactor induces synergistic cuproptosis/ferroptosis and Ca(2+) overload-mediated mitochondrial damage for enhanced sono-chemodynamic immunotherapy.
Tang C, Liu K, Gao X, Kang H, Xie W, Chang J, Yin L, Kang J
Acta biomaterialia 2025 Jan 24;193:455-473
Acta biomaterialia 2025 Jan 24;193:455-473
Unc5b prevents macrophage-derived foam cell migration and promotes atherosclerotic development via the P53-cuproptosis signaling pathway.
Wang X, Geng S, Dai L, Niu Y, Chen J, Dong C, Liu R, Shi Y, Zhang J, Zhao N, Gao Z, Gao S, Yang X
Life sciences 2025 Jan 15;361:123334
Life sciences 2025 Jan 15;361:123334
Elesclomol rescues mitochondrial copper deficiency in disease models without triggering cuproptosis.
Zulkifli M, Maremanda KP, Okonkwo AU, Farid I, Gohil VM
The Journal of pharmacology and experimental therapeutics 2025 Feb;392(2):100048
The Journal of pharmacology and experimental therapeutics 2025 Feb;392(2):100048
Cuproptosis and Serine Metabolism Blockade Triggered by Copper-Based Prussian Blue Nanomedicine for Enhanced Tumor Therapy.
Ma Q, Gao S, Li C, Yao J, Xie Y, Jiang C, Yuan J, Fei K, Zhang P, Wang H, Li X
Small (Weinheim an der Bergstrasse, Germany) 2025 Feb;21(5):e2406942
Small (Weinheim an der Bergstrasse, Germany) 2025 Feb;21(5):e2406942
Glutathione Induced In Situ Activation of Dual-Locked Cuproptosis Nanoamplifier with Glycolysis Metabolism Inhibition to Boost Cancer Immunotherapy.
Wu X, Zhang S, Feng M, Sun H, Lan X, Liang W, Liu C, Li Y
Advanced healthcare materials 2025 Feb;14(4):e2403380
Advanced healthcare materials 2025 Feb;14(4):e2403380
UiO-66 MOFs-Based "Epi-Nano-Sonosensitizer" for Ultrasound-Driven Cascade Immunotherapy against B-Cell Lymphoma.
Wang Z, Han M, Wang Y, Wang N, Yang Y, Shao B, Miao Q, Shi Z, Yan F, Feng S
ACS nano 2025 Feb 18;19(6):6282-6298
ACS nano 2025 Feb 18;19(6):6282-6298
Regulating SLC7A11/GSH/GPX4 axis by glucose dyshomeostasis to simultaneously promote disulfidptosis, cuproptosis and ferroptosis.
Zhang M, Zheng H, Jin H, Zhu X, Liu S, Chen Y, Zhang H, Zhang S
Bioactive materials 2025 Dec;54:744-758
Bioactive materials 2025 Dec;54:744-758
Unraveling the miR-144-3p/PUMA pathway: a novel regulator of FDX1-mediated cuproptosis in colorectal cancer.
Jia G, Li J, Jiang M, Liu N, Ding N, Jiang X, Zhang G, Tan X, Kang Y, Zhang L, Wang F, Zhang Y
Cellular oncology (Dordrecht, Netherlands) 2025 Dec;48(6):1693-1710
Cellular oncology (Dordrecht, Netherlands) 2025 Dec;48(6):1693-1710
Cu-doped dendritic biodegradable nanoplatforms for augmenting cuproptosis and tumor-starvation therapy through mitochondrial metabolic cascade modulation.
Shi H, Xie Z, Zhang J, Lu F, Luo H, Guo P, Jiang M, Weng Z, Luo X, Chen B, Huang H, Teng T
Materials today. Bio 2025 Dec;35:102477
Materials today. Bio 2025 Dec;35:102477
Biodegradable Cu-based sonozymes for tumor-specific cuproptosis-enhanced sono-immunotherapy through activating cGAS-STING pathway and sensitizing immune checkpoint blockade.
Wu Y, Xu S, Cai J, Hu J, Pan D, Geng B, Gao W, Wu Y
Materials today. Bio 2025 Dec;35:102397
Materials today. Bio 2025 Dec;35:102397
Clinically friendly smart hydrogel boosts cuproptosis and PD-L1 upregulation to enhance anti-tumor immunotherapy.
Fu B, Li G, Yao Y, Zhang M, Zhong Y, Wang X, Chen Y, Liang W, Wang Y, Lin H, Zhang Y, Du Q, Xu Z, Cui H, Shi L, Chen X, Zhang J
Materials today. Bio 2025 Dec;35:102268
Materials today. Bio 2025 Dec;35:102268
HMC ameliorates myocardial ischaemia-reperfusion injury through suppressing cuproptosis via the de-ubiquitination and stabilization of ATP7A.
Su JB, Zhuang YY, Liu MH, Chen G, Wei M, Chen BX, Yang L, Ji YF, Zhu C, Zhu XX, Zhang JR, Sun HJ
British journal of pharmacology 2025 Dec;182(24):6007-6027
British journal of pharmacology 2025 Dec;182(24):6007-6027
Targeting multiple genetic defects of mitochondrial diseases with a single bacterial lipoate protein ligase.
Hu Z, Yu J, Liu Z, Jiang M, Zeng AP
Science advances 2025 Dec 5;11(49):eaea8481
Science advances 2025 Dec 5;11(49):eaea8481
Lycopene Alleviates Atrazine-Induced Mitochondrial Tricarboxylic Acid Cycle Disorder and Associated Cardiac Cell Senescence and Cuproptosis.
Li NW, Wang QQ, Zhao Y, Zhang TT, Liu YY, Malhi KK, Yao X, Li JL
Journal of agricultural and food chemistry 2025 Dec 31;73(52):33204-33214
Journal of agricultural and food chemistry 2025 Dec 31;73(52):33204-33214
Elesclomol-copper combination synergistically targets mitochondrial metabolism in cancer stem cells to overcome chemoresistance in PDAC.
Yu Q, Jiang K, Ma S, Zheng Q, Tondi S, Reina C, Šabanović B, Wen C, Shen B, Aicher A, Song H, Ma Y, Heeschen C
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Dec 3;33(12):6160-6177
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Dec 3;33(12):6160-6177
Deep Mutational Scanning of FDX1 Identifies Key Structural Determinants of Lipoylation and Cuproptosis.
Hsiao JC, Warui DM, Kwon JJ, Dreishpoon MB, Bick NR, Blue-Lahom T, Root DE, Booker SJ, Tsvetkov P
Nature communications 2025 Dec 21;17(1):1112
Nature communications 2025 Dec 21;17(1):1112
TRIM21 promotes K63-linked ubiquitination of ALKBH5 and suppresses cuproptosis via down-regulation of LIAS in esophageal squamous cell carcinoma.
Feng A, He L, Li Z, Wang Z, Sun M, Zhao Z, Zhang Z, Fang K, Wu H, Wang X, Zhang S, Chen Z, Zhang L, Chen T, Xu M
Communications biology 2025 Dec 18;8(1):1783
Communications biology 2025 Dec 18;8(1):1783
Melanoma MHC-I-membrane-encapsulated Cu@ferrihydrite induces ferroptosis/cuproptosis and systematic immunity against tumor.
Yang R, Deng F, Gao Z, Li X, Huangfu S, Tian Q, Wang H, Liu H, Wang X, Chen Y, Yang Y, Cheng G, Zhang L
Journal of controlled release : official journal of the Controlled Release Society 2025 Dec 10;388(Pt 1):114281
Journal of controlled release : official journal of the Controlled Release Society 2025 Dec 10;388(Pt 1):114281
Immunogenic cuproptosis in cancer immunotherapy via an in situ cuproptosis-inducing system.
Li J, Zhang G, Sun Z, Jiang M, Jia G, Liu H, Liu N, Shi L, Zhang L, Nie L, Zhang Y, Fu Y
Biomaterials 2025 Aug;319:123201
Biomaterials 2025 Aug;319:123201
Multi-pathway copper metabolisms regulation based on an engineered copper/ferrous nanoplatform for enhanced tumor cuproptosis therapy.
Gao Y, Han R, Guo Z, Zhuang Z, Fu J, Hou Y, Yu J, Tang K
Colloids and surfaces. B, Biointerfaces 2025 Aug;252:114682
Colloids and surfaces. B, Biointerfaces 2025 Aug;252:114682
Multifunctional Bioactive Dual-Layered Nanofibrous Matrix for Effective Breast Cancer Therapy and Enhanced Wound Healing.
Kim S, Jeong DI, Karmakar M, Huh JW, Hong EH, Kim DJ, Ko HJ, Cho HJ, Lee KB
Small (Weinheim an der Bergstrasse, Germany) 2025 Aug;21(31):e2500717
Small (Weinheim an der Bergstrasse, Germany) 2025 Aug;21(31):e2500717
Ligand supplementation restores the cancer therapy efficacy of the antirheumatic drug auranofin from serum inactivation.
Wang Y, Cao B, Wang Q, Zhong S, Fang X, Wang J, Chan ASC, Xiong X, Zou T
Nature communications 2025 Aug 9;16(1):7347
Nature communications 2025 Aug 9;16(1):7347
Copper-overload promotes ferroptosis in cervical cancer cells by upregulating HMOX1 expression.
Zhao C, Wang T, Lu Y, Zhou Y, Chen J, Ju R
Discover oncology 2025 Aug 14;16(1):1549
Discover oncology 2025 Aug 14;16(1):1549
Engineering M2 macrophage-derived exosomes modulate activated T cell cuproptosis to promote immune tolerance in rheumatoid arthritis.
Wu G, Su T, Zhou P, Tang R, Zhu X, Wang J, Chao M, Fan L, Yan H, Ye P, Yu D, Gao F, Chen H
Biomaterials 2025 Apr;315:122943
Biomaterials 2025 Apr;315:122943
Nano Copper-chelate Triggers Cuproptosis-like Death in Fungi and Synergizes with Microneedles for Enhanced Biofilm Removal.
Ge X, Deng S, Chen L, Feng F, Fang T, Ding Y, Jiang H, Yang J, Liu X, Dai J, Yang L, Ju Y
Advanced healthcare materials 2025 Apr;14(10):e2404464
Advanced healthcare materials 2025 Apr;14(10):e2404464
Modulation of Bacterial Iron Homeostasis to Enhance Cuproptosis-like Death for the Treatment of Infected Diabetic Wound.
Fang G, Dong Q, Shen X, Ye R, Chang Y, Pu K, Tao Y, Gao X, Zhou R, Ge C
ACS nano 2025 Apr 29;19(16):15578-15595
ACS nano 2025 Apr 29;19(16):15578-15595
o8G-modified circKIAA1797 promotes lung cancer development by inhibiting cuproptosis.
Xu H, Zhao Q, Cai D, Chen X, Zhou X, Gao Y, Wu J, Yuan S, Li D, Zhang R, Peng W, Li G, Nan A
Journal of experimental & clinical cancer research : CR 2025 Apr 2;44(1):110
Journal of experimental & clinical cancer research : CR 2025 Apr 2;44(1):110
CuO Nanozymes Catalyze Cysteine and Glutathione Depletion Induced Ferroptosis and Cuproptosis for Synergistic Tumor Therapy.
Bai J, Zhang X, Zhao Z, Sun S, Cheng W, Yu H, Chang X, Wang B
Small (Weinheim an der Bergstrasse, Germany) 2024 Oct;20(40):e2400326
Small (Weinheim an der Bergstrasse, Germany) 2024 Oct;20(40):e2400326
Multifunctional Copper-Phenolic Nanopills Achieve Comprehensive Polyamines Depletion to Provoke Enhanced Pyroptosis and Cuproptosis for Cancer Immunotherapy.
Zhu G, Xie Y, Wang J, Wang M, Qian Y, Sun Q, Dai Y, Li C
Advanced materials (Deerfield Beach, Fla.) 2024 Nov;36(45):e2409066
Advanced materials (Deerfield Beach, Fla.) 2024 Nov;36(45):e2409066
Bovine serum albumin-bound homologous targeted nanoparticles for breast cancer combinatorial therapy.
Chen C, Xie B, Sun S, Guo S, Yang Z, Yang L, Zhang Y, Li SA, Sun W, Wang Z, Qin S, Ji Y
International journal of biological macromolecules 2024 Nov;281(Pt 1):136090
International journal of biological macromolecules 2024 Nov;281(Pt 1):136090
CircSpna2 attenuates cuproptosis by mediating ubiquitin ligase Keap1 to regulate the Nrf2-Atp7b signalling axis in depression after traumatic brain injury in a mouse model.
Du M, Fu J, Zhang J, Zhu Z, Huang X, Tan W, Liu L, Huang Z, Liu X, Tan Q, Liao Z, Cheng Y
Clinical and translational medicine 2024 Nov;14(11):e70100
Clinical and translational medicine 2024 Nov;14(11):e70100
Three Birds with One Stone: Copper Ions Assisted Synergistic Cuproptosis/Chemodynamic/Photothermal Therapy by a Three-Pronged Approach.
Chen M, Xu C, Wang C, Huang N, Bian Z, Xiao Y, Ruan J, Sun F, Shi S
Advanced healthcare materials 2024 Nov;13(29):e2401567
Advanced healthcare materials 2024 Nov;13(29):e2401567
Copper-Based Composites Nanoparticles Improve Triple-Negative Breast Cancer Treatment with Induction of Apoptosis-Cuproptosis and Immune Activation.
Wang N, Liu Y, Peng D, Zhang Q, Zhang Z, Xu L, Yin L, Zhao X, Lu Z, Peng J
Advanced healthcare materials 2024 Nov;13(28):e2401646
Advanced healthcare materials 2024 Nov;13(28):e2401646
Rhomboid-like 2 correlated with TME infiltration inhibits cuproptosis-related genes and drives malignant phenotype in clear cell renal cell carcinoma.
Che Z, Jin W, Wu Y, Li H, Liang P
Scientific reports 2024 Nov 7;14(1):27053
Scientific reports 2024 Nov 7;14(1):27053
Inhibition of CTR1 expression improves hypoxia/reoxygenation-induced myoblast injury by blocking cuproptosis.
Fu DG, He JZ, Mu QC, Huo YF, Zhang NM, Zhang L, Hua S, Gao BQ
Biochemical and biophysical research communications 2024 Nov 26;735:150804
Biochemical and biophysical research communications 2024 Nov 26;735:150804
Mitochondrial respiratory function is preserved under cysteine starvation via glutathione catabolism in NSCLC.
Ward NP, Yoon SJ, Flynn T, Sherwood AM, Olley MA, Madej J, DeNicola GM
Nature communications 2024 May 18;15(1):4244
Nature communications 2024 May 18;15(1):4244
Retinoic acid mitigates the NSC319726-induced spermatogenesis dysfunction through cuproptosis-independent mechanisms.
Yi H, Chen T, He G, Liu L, Zhao J, Guo K, Cao Y, Sun P, Zhou X, Zhang B, Li C, Wang H
Cell biology and toxicology 2024 May 1;40(1):26
Cell biology and toxicology 2024 May 1;40(1):26
MUC20 regulated by extrachromosomal circular DNA attenuates proteasome inhibitor resistance of multiple myeloma by modulating cuproptosis.
Wang X, Shi Y, Shi H, Liu X, Liao A, Liu Z, Orlowski RZ, Zhang R, Wang H
Journal of experimental & clinical cancer research : CR 2024 Mar 5;43(1):68
Journal of experimental & clinical cancer research : CR 2024 Mar 5;43(1):68
Clinical features and molecular landscape of cuproptosis signature-related molecular subtype in gastric cancer.
Chong W, Ren H, Chen H, Xu K, Zhu X, Liu Y, Sang Y, Li H, Liu J, Ye C, Shang L, Jing C, Li L
iMeta 2024 Jun;3(3):e190
iMeta 2024 Jun;3(3):e190
Molecular characterization and clinical relevance of metabolic signature subtypes in gastric cancer.
Chen H, Jing C, Shang L, Zhu X, Zhang R, Liu Y, Wang M, Xu K, Ma T, Jing H, Wang Z, Li X, Chong W, Li L
Cell reports 2024 Jul 23;43(7):114424
Cell reports 2024 Jul 23;43(7):114424
Tumor microenvironment-activated, immunomodulatory nanosheets loaded with copper(II) and 5-FU for synergistic chemodynamic therapy and chemotherapy.
Xia Y, Gu M, Wang J, Zhang X, Shen T, Shi X, Yuan WE
Journal of colloid and interface science 2024 Jan;653(Pt A):137-147
Journal of colloid and interface science 2024 Jan;653(Pt A):137-147
Identification of cuproptosis-related molecular classification and characteristic genes in ulcerative colitis.
Bai X, Zhang F, Zhou C, Yan J, Liang H, Zhu R, Gong M, Song H, Niu J, Miao Y
Heliyon 2024 Jan 30;10(2):e24875
Heliyon 2024 Jan 30;10(2):e24875
METTL17 is an Fe-S cluster checkpoint for mitochondrial translation.
Ast T, Itoh Y, Sadre S, McCoy JG, Namkoong G, Wengrod JC, Chicherin I, Joshi PR, Kamenski P, Suess DLM, Amunts A, Mootha VK
Molecular cell 2024 Jan 18;84(2):359-374.e8
Molecular cell 2024 Jan 18;84(2):359-374.e8
Bioinformatics reveals diagnostic potential of cuproptosis-related genes in the pathogenesis of sepsis.
Sun Z, Zhao Q, Zhang J, Hu Y, Qu J, Gao H, Peng Z
Heliyon 2024 Jan 15;10(1):e22664
Heliyon 2024 Jan 15;10(1):e22664
Deep learning enables the discovery of a novel cuproptosis-inducing molecule for the inhibition of hepatocellular carcinoma.
Yang F, Jia L, Zhou HC, Huang JN, Hou MY, Liu FT, Prabhu N, Li ZJ, Yang CB, Zou C, Nordlund P, Wang JG, Dai LY
Acta pharmacologica Sinica 2024 Feb;45(2):391-404
Acta pharmacologica Sinica 2024 Feb;45(2):391-404
Changes in cuproptosis-related gene expression in periodontitis: An integrated bioinformatic analysis.
Liu N, He Y, Chen X, Qiu G, Wu Y, Shen Y
Life sciences 2024 Feb 1;338:122388
Life sciences 2024 Feb 1;338:122388
Engineered bacterial lipoate protein ligase A (lplA) restores lipoylation in cell models of lipoylation deficiency.
Bick NR, Dreishpoon MB, Perry A, Rogachevskaya A, Bottomley SS, Fleming MD, Ducamp S, Tsvetkov P
The Journal of biological chemistry 2024 Dec;300(12):107995
The Journal of biological chemistry 2024 Dec;300(12):107995
Synergistic enhancement of low-dose radiation therapy via cuproptosis and metabolic reprogramming for radiosensitization in in situ hepatocellular carcinoma.
Shao N, Yang Y, Hu G, Luo Q, Cheng N, Chen J, Huang Y, Zhang H, Luo L, Xiao Z
Journal of nanobiotechnology 2024 Dec 19;22(1):772
Journal of nanobiotechnology 2024 Dec 19;22(1):772
Low Expression of Lipoic Acid Synthase Aggravates Silica-Induced Pulmonary Fibrosis by Inhibiting the Differentiation of Tregs in Mice.
Yan S, Zhao Y, Yan J, Guan Y, Lyu M, Xu G, Yang X, Bai Y, Yao S
Antioxidants & redox signaling 2024 Aug;41(4-6):216-232
Antioxidants & redox signaling 2024 Aug;41(4-6):216-232
Copper exposure induces trophoblast cell cuproptosis by up-regulating lnc-HZ11.
Zheng Z, Fang J, Shen Y, Mi C, Xu Z, Zhao J, Chen W, Han R, Lei Q, Zhang H
Ecotoxicology and environmental safety 2024 Aug;281:116641
Ecotoxicology and environmental safety 2024 Aug;281:116641
Enzalutamide Sensitizes Castration-Resistant Prostate Cancer to Copper-Mediated Cell Death.
Gao X, Zhao H, Liu J, Wang M, Dai Z, Hao W, Wang Y, Wang X, Zhang M, Liu P, Cheng H, Liu Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2401396
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2401396
A singular plasmonic-thermoelectric hollow nanostructure inducing apoptosis and cuproptosis for catalytic cancer therapy.
Yang L, Zhao Z, Tian B, Yang M, Dong Y, Zhou B, Gai S, Xie Y, Lin J
Nature communications 2024 Aug 29;15(1):7499
Nature communications 2024 Aug 29;15(1):7499
Triptolide-induced cuproptosis is a novel antitumor strategy for the treatment of cervical cancer.
Xiao Y, Yin J, Liu P, Zhang X, Lin Y, Guo J
Cellular & molecular biology letters 2024 Aug 28;29(1):113
Cellular & molecular biology letters 2024 Aug 28;29(1):113
Injectable Hydrogel-Encapsulating Pickering Emulsion for Overcoming Lenvatinib-Resistant Hepatocellular Carcinoma via Cuproptosis Induction and Stemness Inhibition.
Li X, Tang C, Ye H, Fang C
Polymers 2024 Aug 26;16(17)
Polymers 2024 Aug 26;16(17)
Eupalinolide B suppresses pancreatic cancer by ROS generation and potential cuproptosis.
Huang Q, Yang J, Zhang J, Yao L, Jiang B, Du S, Li F, Peng Q, Qin L, Wang Y, Qi L
iScience 2024 Aug 16;27(8):110496
iScience 2024 Aug 16;27(8):110496
Cuproptosis associated cytoskeletal destruction contributes to podocyte injury in chronic kidney disease.
Li H, Fu Y, Xu Y, Miao H, Wang H, Zhang T, Mei X, He Y, Zhang A, Ge X
American journal of physiology. Cell physiology 2024 Aug 1;327(2):C254-C269
American journal of physiology. Cell physiology 2024 Aug 1;327(2):C254-C269
Bioinformatics-based dynamics of cuproptosis -related indicators in experimental silicosis.
Xia J, Wu C, Jin X, Ding M, Zhang C, Hou G, Hao C, Yao W
Ecotoxicology and environmental safety 2024 Apr 15;275:116286
Ecotoxicology and environmental safety 2024 Apr 15;275:116286
Cellular Trojan Horse initiates bimetallic Fe-Cu MOF-mediated synergistic cuproptosis and ferroptosis against malignancies.
Chen K, Zhou A, Zhou X, He J, Xu Y, Ning X
Science advances 2024 Apr 12;10(15):eadk3201
Science advances 2024 Apr 12;10(15):eadk3201
Impact of Cuproptosis-related markers on clinical status, tumor immune microenvironment and immunotherapy in colorectal cancer: A multi-omic analysis.
Shao Y, Fan X, Yang X, Li S, Huang L, Zhou X, Zhang S, Zheng M, Sun J
Computational and structural biotechnology journal 2023;21:3383-3403
Computational and structural biotechnology journal 2023;21:3383-3403
ITGB1-mediated molecular landscape and cuproptosis phenotype induced the worse prognosis in diffuse gastric cancer.
Zhu X, Chen H, Li H, Ren H, Ye C, Xu K, Liu J, Du F, Zhang Z, Liu Y, Xie X, Wang M, Ma T, Chong W, Shang L, Li L
Frontiers in oncology 2023;13:1115510
Frontiers in oncology 2023;13:1115510
Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells.
Joshi PR, Sadre S, Guo XA, McCoy JG, Mootha VK
The Journal of biological chemistry 2023 Sep;299(9):105075
The Journal of biological chemistry 2023 Sep;299(9):105075
FDX1 regulates cellular protein lipoylation through direct binding to LIAS.
Dreishpoon MB, Bick NR, Petrova B, Warui DM, Cameron A, Booker SJ, Kanarek N, Golub TR, Tsvetkov P
The Journal of biological chemistry 2023 Sep;299(9):105046
The Journal of biological chemistry 2023 Sep;299(9):105046
Evaluation the role of cuproptosis-related genes in the pathogenesis, diagnosis and molecular subtypes identification of atherosclerosis.
Wang M, Cheng L, Xiang Q, Gao Z, Ding Y, Xie H, Chen X, Yu P, Shen L
Heliyon 2023 Oct;9(10):e21158
Heliyon 2023 Oct;9(10):e21158
Ferroptosis inducers enhanced cuproptosis induced by copper ionophores in primary liver cancer.
Wang W, Lu K, Jiang X, Wei Q, Zhu L, Wang X, Jin H, Feng L
Journal of experimental & clinical cancer research : CR 2023 Jun 6;42(1):142
Journal of experimental & clinical cancer research : CR 2023 Jun 6;42(1):142
A mitochondrial iron-responsive pathway regulated by DELE1.
Sekine Y, Houston R, Eckl EM, Fessler E, Narendra DP, Jae LT, Sekine S
Molecular cell 2023 Jun 15;83(12):2059-2076.e6
Molecular cell 2023 Jun 15;83(12):2059-2076.e6
ATF3/SPI1/SLC31A1 Signaling Promotes Cuproptosis Induced by Advanced Glycosylation End Products in Diabetic Myocardial Injury.
Huo S, Wang Q, Shi W, Peng L, Jiang Y, Zhu M, Guo J, Peng D, Wang M, Men L, Huang B, Lv J, Lin L
International journal of molecular sciences 2023 Jan 14;24(2)
International journal of molecular sciences 2023 Jan 14;24(2)
FDX1 regulates cellular protein lipoylation through direct binding to LIAS.
Dreishpoon MB, Bick NR, Petrova B, Warui DM, Cameron A, Booker SJ, Kanarek N, Golub TR, Tsvetkov P
bioRxiv : the preprint server for biology 2023 Feb 4;
bioRxiv : the preprint server for biology 2023 Feb 4;
Dexmedetomidine enables copper homeostasis in cerebral ischemia/reperfusion via ferredoxin 1.
Guo Q, Ma M, Yu H, Han Y, Zhang D
Annals of medicine 2023 Dec;55(1):2209735
Annals of medicine 2023 Dec;55(1):2209735
Integrated bioinformatics and experiment revealed that cuproptosis is the potential common pathogenesis of three kinds of primary cardiomyopathy.
Wang M, Xu X, Li J, Gao Z, Ding Y, Chen X, Xiang Q, Shen L
Aging 2023 Dec 11;15(23):14210-14241
Aging 2023 Dec 11;15(23):14210-14241
Lias overexpression alleviates pulmonary injury induced by fine particulate matter in mice.
Xu G, Zhao Y, Tao Y, Xiong C, Lv M, Gao Q, Zhang F, An Z, Wu W
Environmental geochemistry and health 2023 Aug;45(8):6585-6603
Environmental geochemistry and health 2023 Aug;45(8):6585-6603
Cuproptosis-Inducible Chemotherapeutic/Cascade Catalytic Reactor System for Combating with Breast Cancer.
Lee SY, Seo JH, Kim S, Hwang C, Jeong DI, Park J, Yang M, Huh JW, Cho HJ
Small (Weinheim an der Bergstrasse, Germany) 2023 Aug;19(35):e2301402
Small (Weinheim an der Bergstrasse, Germany) 2023 Aug;19(35):e2301402
Comprehensive analysis of cuproptosis-related genes in immune infiltration and diagnosis in ulcerative colitis.
Huang J, Zhang J, Wang F, Zhang B, Tang X
Frontiers in immunology 2022;13:1008146
Frontiers in immunology 2022;13:1008146
Establishment and experimental validation of a novel cuproptosis-related gene signature for prognostic implication in cholangiocarcinoma.
Chen J, Yu X, Tong H, Tang C, Tang Z
Frontiers in oncology 2022;12:1054063
Frontiers in oncology 2022;12:1054063
Copper induces cell death by targeting lipoylated TCA cycle proteins.
Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M, Rossen J, Joesch-Cohen L, Humeidi R, Spangler RD, Eaton JK, Frenkel E, Kocak M, Corsello SM, Lutsenko S, Kanarek N, Santagata S, Golub TR
Science (New York, N.Y.) 2022 Mar 18;375(6586):1254-1261
Science (New York, N.Y.) 2022 Mar 18;375(6586):1254-1261
Adaptation of the heart to Frataxin depletion: Evidence that integrated stress response can predominate over mTORC1 activation.
Vásquez-Trincado C, Patel M, Sivaramakrishnan A, Bekeová C, Anderson-Pullinger L, Wang N, Tang HY, Seifert EL
Human molecular genetics 2021 Sep 22;33(8):637-54
Human molecular genetics 2021 Sep 22;33(8):637-54
SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells.
Wang Y, Yen FS, Zhu XG, Timson RC, Weber R, Xing C, Liu Y, Allwein B, Luo H, Yeh HW, Heissel S, Unlu G, Gamazon ER, Kharas MG, Hite R, Birsoy K
Nature 2021 Nov;599(7883):136-140
Nature 2021 Nov;599(7883):136-140
Overexpression of lipoic acid synthase gene alleviates diabetic nephropathy of Lepr(db/db) mice.
Zhao Y, Yan T, Xiong C, Chang M, Gao Q, Yao S, Wu W, Yi X, Xu G
BMJ open diabetes research & care 2021 Jun;9(1)
BMJ open diabetes research & care 2021 Jun;9(1)
Overexpression of endogenous lipoic acid synthase attenuates pulmonary fibrosis induced by crystalline silica in mice.
Zhao Y, Xu G, Li H, Chang M, Guan Y, Li Y, Wu W, Yao S
Toxicology letters 2020 May 1;323:57-66
Toxicology letters 2020 May 1;323:57-66
Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation.
Weber RA, Yen FS, Nicholson SPV, Alwaseem H, Bayraktar EC, Alam M, Timson RC, La K, Abu-Remaileh M, Molina H, Birsoy K
Molecular cell 2020 Feb 6;77(3):645-655.e7
Molecular cell 2020 Feb 6;77(3):645-655.e7
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 11577-1-AP(LIAS antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The LIAS antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human LIAS. This antibody recognizes human,mouse,rat antigen. The LIAS antibody has been validated for the following applications: ELISA, WB, IHC analysis.
