Antibody data
- Antibody Data
- Antigen structure
- References [121]
- Comments [0]
- Validations
- Western blot [3]
- Immunocytochemistry [2]
- Chromatin Immunoprecipitation [1]
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Validation data
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- Product number
- AF1924 - Provider product page
- Provider
- R&D Systems
- Product name
- Human SOX17 Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects human SOX17 in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) SOX18 is observed.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
Q9H6I2
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Efficient generation of human primordial germ cell-like cells from pluripotent stem cells in a methylcellulose-based 3D system at large scale.
Characterization of the first induced pluripotent stem cell line generated from a patient with autosomal dominant catecholaminergic polymorphic ventricular tachycardia due to a heterozygous mutation in cardiac calsequestrin-2.
Generation of a heterozygous COL1A1 (c.3969_3970insT) osteogenesis imperfecta mutation human iPSC line, MCRIi001-A-1, using CRISPR/Cas9 editing.
Generation of one iPSC line (IMEDEAi006-A) from an early-onset familial Alzheimer's Disease (fAD) patient carrying the E280A mutation in the PSEN1 gene.
Novel hybrid three-dimensional artificial liver using human induced pluripotent stem cells and a rat decellularized liver scaffold.
The use of simultaneous reprogramming and gene correction to generate an osteogenesis imperfecta patient COL1A1 c. 3936 G>T iPSC line and an isogenic control iPSC line.
Generation of a homozygous CRISPR/Cas9-mediated knockout human iPSC line for the STUB1 locus.
Generation of Spinocerebellar Ataxia Type 2 induced pluripotent stem cell lines, CHOPi002-A and CHOPi003-A, from patients with abnormal CAG repeats in the coding region of the ATXN2 gene.
Generation of human antral and fundic gastric organoids from pluripotent stem cells.
The BAF and PRC2 Complex Subunits Dpf2 and Eed Antagonistically Converge on Tbx3 to Control ESC Differentiation.
yylncT Defines a Class of Divergently Transcribed lncRNAs and Safeguards the T-mediated Mesodermal Commitment of Human PSCs.
Generation of a human induced pluripotent stem cell line, BRCi001-A, derived from a patient with mucopolysaccharidosis type I.
Histone H3K9 Methyltransferase G9a in Oocytes Is Essential for Preimplantation Development but Dispensable for CG Methylation Protection.
Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development.
Generation of two induced pluripotent stem cells lines from Mucopolysaccharydosis IIIA patient: IMEDEAi004-A and IMEDEAi004-B.
SOX17 regulates uterine epithelial-stromal cross-talk acting via a distal enhancer upstream of Ihh.
WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids.
A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival.
Derivation and characterization of the NIH registry human stem cell line NYSCF100 line under defined feeder-free conditions.
Establishment of STUB1/CHIP mutant induced pluripotent stem cells (iPSCs) from a patient with Gordon Holmes syndrome/SCAR16.
Generation of two induced pluripotent stem cell (iPSC) lines from p.F508del Cystic Fibrosis patients.
G9a regulates temporal preimplantation developmental program and lineage segregation in blastocyst.
Sox7 promotes high-grade glioma by increasing VEGFR2-mediated vascular abnormality.
Induced pluripotent stem cells derived from a schizophrenia patient with ASTN2 deletion.
Generation of gene-corrected iPSC line from Parkinson's disease patient iPSC line with alpha-SNCA A53T mutation.
Random Mutagenesis, Clonal Events, and Embryonic or Somatic Origin Determine the mtDNA Variant Type and Load in Human Pluripotent Stem Cells.
Lymphoblast-derived integration-free ISRM-CON9 iPS cell line from a 75year old female.
Generation of a PXR reporter human induced pluripotent stem cell line (PXR-mCherry hiPSC) using the CRISPR/Cas9 system.
Short-term retinoic acid treatment sustains pluripotency and suppresses differentiation of human induced pluripotent stem cells.
Generation of an induced pluripotent stem cell line from a hypertrophic cardiomyopathy patient with a pathogenic myosin binding protein C (MYBPC3) p.Arg502Trp mutation.
Generation of a human Ocular Albinism type 1 iPSC line, SEIi001-A, with a mutation in GPR143.
Generation of two induced pluripotent stem cells lines from a Mucopolysaccharydosis IIIB (MPSIIIB) patient.
Three lines of induced pluripotent stem cells derived from a 15q11.2-q13.1 duplication syndrome patient.
Generation of nine induced pluripotent stem cell lines as an ethnic diversity panel.
Generation of a human Juvenile myelomonocytic leukemia iPSC line, CHOPi001-A, with a mutation in CBL.
Esrrb Unlocks Silenced Enhancers for Reprogramming to Naive Pluripotency.
Derivation of induced pluripotent stem cells in Japanese macaque (Macaca fuscata).
Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation.
Functional Thyroid Follicular Cells Differentiation from Human-Induced Pluripotent Stem Cells in Suspension Culture.
ICM conversion to epiblast by FGF/ERK inhibition is limited in time and requires transcription and protein degradation.
Novel SOX17 frameshift mutations in endometrial cancer are functionally distinct from recurrent missense mutations.
The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency.
Plasticity of the inner cell mass in mouse blastocyst is restricted by the activity of FGF/MAPK pathway.
Rapid DNA replication origin licensing protects stem cell pluripotency.
Activation of the Aryl Hydrocarbon Receptor Interferes with Early Embryonic Development.
TALEN-mediated shift of mitochondrial DNA heteroplasmy in MELAS-iPSCs with m.13513G>A mutation.
Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders.
Embryonic cholecystitis and defective gallbladder contraction in the Sox17-haploinsufficient mouse model of biliary atresia.
Xist-dependent imprinted X inactivation and the early developmental consequences of its failure.
Distinct Requirements for FGFR1 and FGFR2 in Primitive Endoderm Development and Exit from Pluripotency.
Lineage Establishment and Progression within the Inner Cell Mass of the Mouse Blastocyst Requires FGFR1 and FGFR2.
Principles of early human development and germ cell program from conserved model systems.
Guided self-organization and cortical plate formation in human brain organoids.
Accreditation of Biosafe Clinical-Grade Human Embryonic Stem Cells According to Chinese Regulations.
Identification of a small molecule that facilitates the differentiation of human iPSCs/ESCs and mouse embryonic pancreatic explants into pancreatic endocrine cells.
Acellular Mouse Kidney ECM can be Used as a Three-Dimensional Substrate to Test the Differentiation Potential of Embryonic Stem Cell Derived Renal Progenitors.
Direct Reprogramming of Fibroblasts via a Chemically Induced XEN-like State.
Insulin-producing cells derived from 'induced pluripotent stem cells' of patients with fulminant type 1 diabetes: Vulnerability to cytokine insults and increased expression of apoptosis-related genes.
Generation of induced pluripotent stem cells (iPSCs) from a hypertrophic cardiomyopathy patient with the pathogenic variant p.Val698Ala in beta-myosin heavy chain (MYH7) gene.
Peripheral blood derived induced pluripotent stem cells (iPSCs) from a female with familial hypertrophic cardiomyopathy.
Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells.
Dynamics of 5-carboxylcytosine during hepatic differentiation: Potential general role for active demethylation by DNA repair in lineage specification.
The chromatin modifier Satb1 regulates cell fate through Fgf signalling in the early mouse embryo.
An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation.
Changes in Parthenogenetic Imprinting Patterns during Reprogramming by Cell Fusion.
Derivation of Patient Specific Pluripotent Stem Cells Using Clinically Discarded Cumulus Cells.
p38 (Mapk14/11) occupies a regulatory node governing entry into primitive endoderm differentiation during preimplantation mouse embryo development.
Generation of optic atrophy 1 patient-derived induced pluripotent stem cells (iPS-OPA1-BEHR) for disease modeling of complex optic atrophy syndromes (Behr syndrome).
Ductular reaction-on-a-chip: Microfluidic co-cultures to study stem cell fate selection during liver injury.
Anterior-Posterior Patterning of Definitive Endoderm Generated from Human Embryonic Stem Cells Depends on the Differential Signaling of Retinoic Acid, Wnt-, and BMP-Signaling.
Hepatic differentiation of human pluripotent stem cells in miniaturized format suitable for high-throughput screen.
Inappropriate cadherin switching in the mouse epiblast compromises proper signaling between the epiblast and the extraembryonic ectoderm during gastrulation.
Diverse Functions of Retinoic Acid in Brain Vascular Development.
Selection and dynamics of embryonic stem cell integration into early mouse embryos.
Capturing the biology of disease severity in a PSC-based model of familial dysautonomia.
Efficient derivation of extraembryonic endoderm stem cell lines from mouse postimplantation embryos.
Design of a Vitronectin-Based Recombinant Protein as a Defined Substrate for Differentiation of Human Pluripotent Stem Cells into Hepatocyte-Like Cells.
Activin-A and Bmp4 levels modulate cell type specification during CHIR-induced cardiomyogenesis.
Transcription activator-like effector nuclease (TALEN)-mediated CLYBL targeting enables enhanced transgene expression and one-step generation of dual reporter human induced pluripotent stem cell (iPSC) and neural stem cell (NSC) lines.
Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells.
Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis.
HEB associates with PRC2 and SMAD2/3 to regulate developmental fates.
Derivation of transgene-free human induced pluripotent stem cells from human peripheral T cells in defined culture conditions.
A modified EpiSC culture condition containing a GSK3 inhibitor can support germline-competent pluripotency in mice.
Generation and characterization of induced pluripotent stem cells from Aid-deficient mice.
Unfolded protein response is required for the definitive endodermal specification of mouse embryonic stem cells via Smad2 and β-catenin signaling.
GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst.
Citrullination regulates pluripotency and histone H1 binding to chromatin.
Efficient programming of human eye conjunctiva-derived induced pluripotent stem (ECiPS) cells into definitive endoderm-like cells.
Sox17-mediated maintenance of fetal intra-aortic hematopoietic cell clusters.
miR-373 is regulated by TGFβ signaling and promotes mesendoderm differentiation in human Embryonic Stem Cells.
Generation of functional insulin-producing cells from mouse embryonic stem cells through 804G cell-derived extracellular matrix and protein transduction of transcription factors.
Discovery of directional and nondirectional pioneer transcription factors by modeling DNase profile magnitude and shape.
BMP signalling regulates the pre-implantation development of extra-embryonic cell lineages in the mouse embryo.
High oxygen condition facilitates the differentiation of mouse and human pluripotent stem cells into pancreatic progenitors and insulin-producing cells.
Induction of pluripotency in human somatic cells via a transient state resembling primitive streak-like mesendoderm.
Identification of transcription factors for lineage-specific ESC differentiation.
Cell-cycle control of developmentally regulated transcription factors accounts for heterogeneity in human pluripotent cells.
Defined extracellular matrix components are necessary for definitive endoderm induction.
Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme.
CD166(pos) subpopulation from differentiated human ES and iPS cells support repair of acute lung injury.
The endothelial cell line bEnd.3 maintains human pluripotent stem cells.
A molecular signature for purified definitive endoderm guides differentiation and isolation of endoderm from mouse and human embryonic stem cells.
Early in vitro differentiation of mouse definitive endoderm is not correlated with progressive maturation of nuclear DNA methylation patterns.
A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3.
CD24: a novel surface marker for PDX1-positive pancreatic progenitors derived from human embryonic stem cells.
Induction of pluripotent stem cells from human third molar mesenchymal stromal cells.
A role for PDGF signaling in expansion of the extra-embryonic endoderm lineage of the mouse blastocyst.
Alginate microcapsule for propagation and directed differentiation of hESCs to definitive endoderm.
SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells.
The ROCK inhibitor Y-27632 improves recovery of human embryonic stem cells after fluorescence-activated cell sorting with multiple cell surface markers.
Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo.
Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells.
A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells.
Biphasic induction of Pdx1 in mouse and human embryonic stem cells can mimic development of pancreatic beta-cells.
Vitronectin promotes oligodendrocyte differentiation during neurogenesis of human embryonic stem cells.
Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells.
Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.
High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells.
Prospective isolation and global gene expression analysis of definitive and visceral endoderm.
Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions.
Wang X, Liao T, Wan C, Yang X, Zhao J, Fu R, Yao Z, Huang Y, Shi Y, Chang G, Zheng Y, Luo F, Liu Z, Wang Y, Mao X, Zhao XY
PeerJ 2019;6:e6143
PeerJ 2019;6:e6143
Characterization of the first induced pluripotent stem cell line generated from a patient with autosomal dominant catecholaminergic polymorphic ventricular tachycardia due to a heterozygous mutation in cardiac calsequestrin-2.
Ross S, Holliday M, Lim S, Semsarian C
Stem cell research 2019 May;37:101450
Stem cell research 2019 May;37:101450
Generation of a heterozygous COL1A1 (c.3969_3970insT) osteogenesis imperfecta mutation human iPSC line, MCRIi001-A-1, using CRISPR/Cas9 editing.
Hosseini Far H, Patria YN, Motazedian A, Elefanty AG, Stanley EG, Lamandé SR, Bateman JF
Stem cell research 2019 May;37:101449
Stem cell research 2019 May;37:101449
Generation of one iPSC line (IMEDEAi006-A) from an early-onset familial Alzheimer's Disease (fAD) patient carrying the E280A mutation in the PSEN1 gene.
Vallejo-Diez S, Fleischer A, Martín-Fernández JM, Sánchez-Gilabert A, Castresana M, Aguillón D, Villegas A, Mastronardi CA, Espinosa LG, Arcos-Burgos M, Del Pozo Á, Herrán E, Gainza E, Isaza-Ruget M, Lopera F, Bachiller D
Stem cell research 2019 May;37:101440
Stem cell research 2019 May;37:101440
Novel hybrid three-dimensional artificial liver using human induced pluripotent stem cells and a rat decellularized liver scaffold.
Minami T, Ishii T, Yasuchika K, Fukumitsu K, Ogiso S, Miyauchi Y, Kojima H, Kawai T, Yamaoka R, Oshima Y, Kawamoto H, Kotaka M, Yasuda K, Osafune K, Uemoto S
Regenerative therapy 2019 Jun;10:127-133
Regenerative therapy 2019 Jun;10:127-133
The use of simultaneous reprogramming and gene correction to generate an osteogenesis imperfecta patient COL1A1 c. 3936 G>T iPSC line and an isogenic control iPSC line.
Howden S, Hosseini Far H, Motazedian A, Elefanty AG, Stanley EG, Lamandé SR, Bateman JF
Stem cell research 2019 Jul;38:101453
Stem cell research 2019 Jul;38:101453
Generation of a homozygous CRISPR/Cas9-mediated knockout human iPSC line for the STUB1 locus.
Schuster S, Saravanakumar S, Schöls L, Hauser S
Stem cell research 2019 Jan;34:101378
Stem cell research 2019 Jan;34:101378
Generation of Spinocerebellar Ataxia Type 2 induced pluripotent stem cell lines, CHOPi002-A and CHOPi003-A, from patients with abnormal CAG repeats in the coding region of the ATXN2 gene.
Maguire JA, Gagne AL, Gonzalez-Alegre P, Davidson BL, Shakkottai V, Gadue P, French DL
Stem cell research 2019 Jan;34:101361
Stem cell research 2019 Jan;34:101361
Generation of human antral and fundic gastric organoids from pluripotent stem cells.
Broda TR, McCracken KW, Wells JM
Nature protocols 2019 Jan;14(1):28-50
Nature protocols 2019 Jan;14(1):28-50
The BAF and PRC2 Complex Subunits Dpf2 and Eed Antagonistically Converge on Tbx3 to Control ESC Differentiation.
Zhang W, Chronis C, Chen X, Zhang H, Spalinskas R, Pardo M, Chen L, Wu G, Zhu Z, Yu Y, Yu L, Choudhary J, Nichols J, Parast MM, Greber B, Sahlén P, Plath K
Cell stem cell 2019 Jan 3;24(1):138-152.e8
Cell stem cell 2019 Jan 3;24(1):138-152.e8
yylncT Defines a Class of Divergently Transcribed lncRNAs and Safeguards the T-mediated Mesodermal Commitment of Human PSCs.
Frank S, Ahuja G, Bartsch D, Russ N, Yao W, Kuo JC, Derks JP, Akhade VS, Kargapolova Y, Georgomanolis T, Messling JE, Gramm M, Brant L, Rehimi R, Vargas NE, Kuroczik A, Yang TP, Sahito RGA, Franzen J, Hescheler J, Sachinidis A, Peifer M, Rada-Iglesias A, Kanduri M, Costa IG, Kanduri C, Papantonis A, Kurian L
Cell stem cell 2019 Feb 7;24(2):318-327.e8
Cell stem cell 2019 Feb 7;24(2):318-327.e8
Generation of a human induced pluripotent stem cell line, BRCi001-A, derived from a patient with mucopolysaccharidosis type I.
Suga M, Kondo T, Imamura K, Shibukawa R, Okanishi Y, Sagara Y, Tsukita K, Enami T, Furujo M, Saijo K, Nakamura Y, Osawa M, Saito MK, Yamanaka S, Inoue H
Stem cell research 2019 Apr;36:101406
Stem cell research 2019 Apr;36:101406
Histone H3K9 Methyltransferase G9a in Oocytes Is Essential for Preimplantation Development but Dispensable for CG Methylation Protection.
Au Yeung WK, Brind'Amour J, Hatano Y, Yamagata K, Feil R, Lorincz MC, Tachibana M, Shinkai Y, Sasaki H
Cell reports 2019 Apr 2;27(1):282-293.e4
Cell reports 2019 Apr 2;27(1):282-293.e4
Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development.
Genga RMJ, Kernfeld EM, Parsi KM, Parsons TJ, Ziller MJ, Maehr R
Cell reports 2019 Apr 16;27(3):708-718.e10
Cell reports 2019 Apr 16;27(3):708-718.e10
Generation of two induced pluripotent stem cells lines from Mucopolysaccharydosis IIIA patient: IMEDEAi004-A and IMEDEAi004-B.
Vallejo S, Fleischer A, Martín JM, Sánchez A, Palomino E, Bachiller D
Stem cell research 2018 Oct;32:110-114
Stem cell research 2018 Oct;32:110-114
SOX17 regulates uterine epithelial-stromal cross-talk acting via a distal enhancer upstream of Ihh.
Wang X, Li X, Wang T, Wu SP, Jeong JW, Kim TH, Young SL, Lessey BA, Lanz RB, Lydon JP, DeMayo FJ
Nature communications 2018 Oct 24;9(1):4421
Nature communications 2018 Oct 24;9(1):4421
WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids.
Yoney A, Etoc F, Ruzo A, Carroll T, Metzger JJ, Martyn I, Li S, Kirst C, Siggia ED, Brivanlou AH
eLife 2018 Oct 12;7
eLife 2018 Oct 12;7
A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival.
Zhou T, Kim TW, Chong CN, Tan L, Amin S, Sadat Badieyan Z, Mukherjee S, Ghazizadeh Z, Zeng H, Guo M, Crespo M, Zhang T, Kenyon R, Robinson CL, Apostolou E, Wang H, Xiang JZ, Evans T, Studer L, Chen S
Nature communications 2018 Nov 16;9(1):4815
Nature communications 2018 Nov 16;9(1):4815
Derivation and characterization of the NIH registry human stem cell line NYSCF100 line under defined feeder-free conditions.
Sevilla A, Forero E, Zimmer M, Martinez H, Reggio K, Paull D, Egli D, Noggle S
Stem cell research 2018 May;29:99-102
Stem cell research 2018 May;29:99-102
Establishment of STUB1/CHIP mutant induced pluripotent stem cells (iPSCs) from a patient with Gordon Holmes syndrome/SCAR16.
Schuster S, Schelling Y, Synofzik M, Höflinger P, Schöls L, Hauser S
Stem cell research 2018 May;29:166-169
Stem cell research 2018 May;29:166-169
Generation of two induced pluripotent stem cell (iPSC) lines from p.F508del Cystic Fibrosis patients.
Fleischer A, Lorenzo IM, Palomino E, Aasen T, Gómez F, Servera M, Asensio VJ, Gálvez V, Izpisúa-Belmonte JC, Bachiller D
Stem cell research 2018 May;29:1-5
Stem cell research 2018 May;29:1-5
G9a regulates temporal preimplantation developmental program and lineage segregation in blastocyst.
Zylicz JJ, Borensztein M, Wong FC, Huang Y, Lee C, Dietmann S, Surani MA
eLife 2018 May 10;7
eLife 2018 May 10;7
Sox7 promotes high-grade glioma by increasing VEGFR2-mediated vascular abnormality.
Kim IK, Kim K, Lee E, Oh DS, Park CS, Park S, Yang JM, Kim JH, Kim HS, Shima DT, Kim JH, Hong SH, Cho YH, Kim YH, Park JB, Koh GY, Ju YS, Lee HK, Lee S, Kim I
The Journal of experimental medicine 2018 Mar 5;215(3):963-983
The Journal of experimental medicine 2018 Mar 5;215(3):963-983
Induced pluripotent stem cells derived from a schizophrenia patient with ASTN2 deletion.
Arioka Y, Kushima I, Kubo H, Mori D, Ozaki N
Stem cell research 2018 Jul;30:81-84
Stem cell research 2018 Jul;30:81-84
Generation of gene-corrected iPSC line from Parkinson's disease patient iPSC line with alpha-SNCA A53T mutation.
Lee SY, Jeong S, Kim J, Chung SK
Stem cell research 2018 Jul;30:145-149
Stem cell research 2018 Jul;30:145-149
Random Mutagenesis, Clonal Events, and Embryonic or Somatic Origin Determine the mtDNA Variant Type and Load in Human Pluripotent Stem Cells.
Zambelli F, Mertens J, Dziedzicka D, Sterckx J, Markouli C, Keller A, Tropel P, Jung L, Viville S, Van de Velde H, Geens M, Seneca S, Sermon K, Spits C
Stem cell reports 2018 Jul 10;11(1):102-114
Stem cell reports 2018 Jul 10;11(1):102-114
Lymphoblast-derived integration-free ISRM-CON9 iPS cell line from a 75year old female.
Martins S, Bohndorf M, Schröter F, Assar F, Wruck W, Sleegers K, Van Broeckhoven C, Adjaye J
Stem cell research 2018 Jan;26:76-79
Stem cell research 2018 Jan;26:76-79
Generation of a PXR reporter human induced pluripotent stem cell line (PXR-mCherry hiPSC) using the CRISPR/Cas9 system.
Kim H, Kim JW, Kim SJ, Choi YJ, Kim DS, Park HJ
Stem cell research 2018 Jan;26:72-75
Stem cell research 2018 Jan;26:72-75
Short-term retinoic acid treatment sustains pluripotency and suppresses differentiation of human induced pluripotent stem cells.
De Angelis MT, Parrotta EI, Santamaria G, Cuda G
Cell death & disease 2018 Jan 5;9(1):6
Cell death & disease 2018 Jan 5;9(1):6
Generation of an induced pluripotent stem cell line from a hypertrophic cardiomyopathy patient with a pathogenic myosin binding protein C (MYBPC3) p.Arg502Trp mutation.
Holliday M, Ross SB, Lim S, Semsarian C
Stem cell research 2018 Dec;33:56-59
Stem cell research 2018 Dec;33:56-59
Generation of a human Ocular Albinism type 1 iPSC line, SEIi001-A, with a mutation in GPR143.
Baulier E, Garcia Diaz A, Corneo B, Farber DB
Stem cell research 2018 Dec;33:274-277
Stem cell research 2018 Dec;33:274-277
Generation of two induced pluripotent stem cells lines from a Mucopolysaccharydosis IIIB (MPSIIIB) patient.
Vallejo-Diez S, Fleischer A, Martín-Fernández JM, Sánchez-Gilabert A, Bachiller D
Stem cell research 2018 Dec;33:180-184
Stem cell research 2018 Dec;33:180-184
Three lines of induced pluripotent stem cells derived from a 15q11.2-q13.1 duplication syndrome patient.
Arioka Y, Kushima I, Mori D, Ozaki N
Stem cell research 2018 Aug;31:240-243
Stem cell research 2018 Aug;31:240-243
Generation of nine induced pluripotent stem cell lines as an ethnic diversity panel.
Gao X, Yourick JJ, Sprando RL
Stem cell research 2018 Aug;31:193-196
Stem cell research 2018 Aug;31:193-196
Generation of a human Juvenile myelomonocytic leukemia iPSC line, CHOPi001-A, with a mutation in CBL.
Gagne AL, Maguire JA, Gandre-Babbe S, Chou ST, Tasian SK, Loh ML, Weiss MJ, Gadue P, French DL
Stem cell research 2018 Aug;31:157-160
Stem cell research 2018 Aug;31:157-160
Esrrb Unlocks Silenced Enhancers for Reprogramming to Naive Pluripotency.
Adachi K, Kopp W, Wu G, Heising S, Greber B, Stehling M, Araúzo-Bravo MJ, Boerno ST, Timmermann B, Vingron M, Schöler HR
Cell stem cell 2018 Aug 2;23(2):266-275.e6
Cell stem cell 2018 Aug 2;23(2):266-275.e6
Derivation of induced pluripotent stem cells in Japanese macaque (Macaca fuscata).
Nakai R, Ohnuki M, Kuroki K, Ito H, Hirai H, Kitajima R, Fujimoto T, Nakagawa M, Enard W, Imamura M
Scientific reports 2018 Aug 15;8(1):12187
Scientific reports 2018 Aug 15;8(1):12187
Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation.
Corsini NS, Peer AM, Moeseneder P, Roiuk M, Burkard TR, Theussl HC, Moll I, Knoblich JA
Cell stem cell 2018 Apr 5;22(4):543-558.e12
Cell stem cell 2018 Apr 5;22(4):543-558.e12
Functional Thyroid Follicular Cells Differentiation from Human-Induced Pluripotent Stem Cells in Suspension Culture.
Arauchi A, Matsuura K, Shimizu T, Okano T
Frontiers in endocrinology 2017;8:103
Frontiers in endocrinology 2017;8:103
ICM conversion to epiblast by FGF/ERK inhibition is limited in time and requires transcription and protein degradation.
Bessonnard S, Coqueran S, Vandormael-Pournin S, Dufour A, Artus J, Cohen-Tannoudji M
Scientific reports 2017 Sep 25;7(1):12285
Scientific reports 2017 Sep 25;7(1):12285
Novel SOX17 frameshift mutations in endometrial cancer are functionally distinct from recurrent missense mutations.
Walker CJ, O'Hern MJ, Serna VA, Kurita T, Miranda MA, Sapp CE, Mutch DG, Cohn DE, Goodfellow PJ
Oncotarget 2017 Sep 15;8(40):68758-68768
Oncotarget 2017 Sep 15;8(40):68758-68768
The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency.
Yu CY, Li TC, Wu YY, Yeh CH, Chiang W, Chuang CY, Kuo HC
Nature communications 2017 Oct 27;8(1):1149
Nature communications 2017 Oct 27;8(1):1149
Plasticity of the inner cell mass in mouse blastocyst is restricted by the activity of FGF/MAPK pathway.
Wigger M, Kisielewska K, Filimonow K, Plusa B, Maleszewski M, Suwińska A
Scientific reports 2017 Nov 9;7(1):15136
Scientific reports 2017 Nov 9;7(1):15136
Rapid DNA replication origin licensing protects stem cell pluripotency.
Matson JP, Dumitru R, Coryell P, Baxley RM, Chen W, Twaroski K, Webber BR, Tolar J, Bielinsky AK, Purvis JE, Cook JG
eLife 2017 Nov 17;6
eLife 2017 Nov 17;6
Activation of the Aryl Hydrocarbon Receptor Interferes with Early Embryonic Development.
Gialitakis M, Tolaini M, Li Y, Pardo M, Yu L, Toribio A, Choudhary JS, Niakan K, Papayannopoulos V, Stockinger B
Stem cell reports 2017 Nov 14;9(5):1377-1386
Stem cell reports 2017 Nov 14;9(5):1377-1386
TALEN-mediated shift of mitochondrial DNA heteroplasmy in MELAS-iPSCs with m.13513G>A mutation.
Yahata N, Matsumoto Y, Omi M, Yamamoto N, Hata R
Scientific reports 2017 Nov 14;7(1):15557
Scientific reports 2017 Nov 14;7(1):15557
Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders.
Lorenz C, Lesimple P, Bukowiecki R, Zink A, Inak G, Mlody B, Singh M, Semtner M, Mah N, Auré K, Leong M, Zabiegalov O, Lyras EM, Pfiffer V, Fauler B, Eichhorst J, Wiesner B, Huebner N, Priller J, Mielke T, Meierhofer D, Izsvák Z, Meier JC, Bouillaud F, Adjaye J, Schuelke M, Wanker EE, Lombès A, Prigione A
Cell stem cell 2017 May 4;20(5):659-674.e9
Cell stem cell 2017 May 4;20(5):659-674.e9
Embryonic cholecystitis and defective gallbladder contraction in the Sox17-haploinsufficient mouse model of biliary atresia.
Higashiyama H, Ozawa A, Sumitomo H, Uemura M, Fujino K, Igarashi H, Imaimatsu K, Tsunekawa N, Hirate Y, Kurohmaru M, Saijoh Y, Kanai-Azuma M, Kanai Y
Development (Cambridge, England) 2017 May 15;144(10):1906-1917
Development (Cambridge, England) 2017 May 15;144(10):1906-1917
Xist-dependent imprinted X inactivation and the early developmental consequences of its failure.
Borensztein M, Syx L, Ancelin K, Diabangouaya P, Picard C, Liu T, Liang JB, Vassilev I, Galupa R, Servant N, Barillot E, Surani A, Chen CJ, Heard E
Nature structural & molecular biology 2017 Mar;24(3):226-233
Nature structural & molecular biology 2017 Mar;24(3):226-233
Distinct Requirements for FGFR1 and FGFR2 in Primitive Endoderm Development and Exit from Pluripotency.
Molotkov A, Mazot P, Brewer JR, Cinalli RM, Soriano P
Developmental cell 2017 Jun 5;41(5):511-526.e4
Developmental cell 2017 Jun 5;41(5):511-526.e4
Lineage Establishment and Progression within the Inner Cell Mass of the Mouse Blastocyst Requires FGFR1 and FGFR2.
Kang M, Garg V, Hadjantonakis AK
Developmental cell 2017 Jun 5;41(5):496-510.e5
Developmental cell 2017 Jun 5;41(5):496-510.e5
Principles of early human development and germ cell program from conserved model systems.
Kobayashi T, Zhang H, Tang WWC, Irie N, Withey S, Klisch D, Sybirna A, Dietmann S, Contreras DA, Webb R, Allegrucci C, Alberio R, Surani MA
Nature 2017 Jun 15;546(7658):416-420
Nature 2017 Jun 15;546(7658):416-420
Guided self-organization and cortical plate formation in human brain organoids.
Lancaster MA, Corsini NS, Wolfinger S, Gustafson EH, Phillips AW, Burkard TR, Otani T, Livesey FJ, Knoblich JA
Nature biotechnology 2017 Jul;35(7):659-666
Nature biotechnology 2017 Jul;35(7):659-666
Accreditation of Biosafe Clinical-Grade Human Embryonic Stem Cells According to Chinese Regulations.
Gu Q, Wang J, Wang L, Liu ZX, Zhu WW, Tan YQ, Han WF, Wu J, Feng CJ, Fang JH, Liu L, Wang L, Li W, Zhao XY, Hu BY, Hao J, Zhou Q
Stem cell reports 2017 Jul 11;9(1):366-380
Stem cell reports 2017 Jul 11;9(1):366-380
Identification of a small molecule that facilitates the differentiation of human iPSCs/ESCs and mouse embryonic pancreatic explants into pancreatic endocrine cells.
Kondo Y, Toyoda T, Ito R, Funato M, Hosokawa Y, Matsui S, Sudo T, Nakamura M, Okada C, Zhuang X, Watanabe A, Ohta A, Inagaki N, Osafune K
Diabetologia 2017 Aug;60(8):1454-1466
Diabetologia 2017 Aug;60(8):1454-1466
Acellular Mouse Kidney ECM can be Used as a Three-Dimensional Substrate to Test the Differentiation Potential of Embryonic Stem Cell Derived Renal Progenitors.
Sambi M, Chow T, Whiteley J, Li M, Chua S, Raileanu V, Rogers IM
Stem cell reviews and reports 2017 Aug;13(4):513-531
Stem cell reviews and reports 2017 Aug;13(4):513-531
Direct Reprogramming of Fibroblasts via a Chemically Induced XEN-like State.
Li X, Liu D, Ma Y, Du X, Jing J, Wang L, Xie B, Sun D, Sun S, Jin X, Zhang X, Zhao T, Guan J, Yi Z, Lai W, Zheng P, Huang Z, Chang Y, Chai Z, Xu J, Deng H
Cell stem cell 2017 Aug 3;21(2):264-273.e7
Cell stem cell 2017 Aug 3;21(2):264-273.e7
Insulin-producing cells derived from 'induced pluripotent stem cells' of patients with fulminant type 1 diabetes: Vulnerability to cytokine insults and increased expression of apoptosis-related genes.
Hosokawa Y, Toyoda T, Fukui K, Baden MY, Funato M, Kondo Y, Sudo T, Iwahashi H, Kishida M, Okada C, Watanabe A, Asaka I, Osafune K, Imagawa A, Shimomura I
Journal of diabetes investigation 2017 Aug 10;
Journal of diabetes investigation 2017 Aug 10;
Generation of induced pluripotent stem cells (iPSCs) from a hypertrophic cardiomyopathy patient with the pathogenic variant p.Val698Ala in beta-myosin heavy chain (MYH7) gene.
Ross SB, Fraser ST, Nowak N, Semsarian C
Stem cell research 2017 Apr;20:88-90
Stem cell research 2017 Apr;20:88-90
Peripheral blood derived induced pluripotent stem cells (iPSCs) from a female with familial hypertrophic cardiomyopathy.
Ross SB, Fraser ST, Bagnall RD, Semsarian C
Stem cell research 2017 Apr;20:76-79
Stem cell research 2017 Apr;20:76-79
Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells.
Sampaziotis F, de Brito MC, Geti I, Bertero A, Hannan NR, Vallier L
Nature protocols 2017 Apr;12(4):814-827
Nature protocols 2017 Apr;12(4):814-827
Dynamics of 5-carboxylcytosine during hepatic differentiation: Potential general role for active demethylation by DNA repair in lineage specification.
Lewis LC, Lo PC, Foster JM, Dai N, Corrêa IR, Durczak PM, Duncan G, Ramsawhook A, Aithal GP, Denning C, Hannan NR, Ruzov A
Epigenetics 2017 Apr 3;12(4):277-286
Epigenetics 2017 Apr 3;12(4):277-286
The chromatin modifier Satb1 regulates cell fate through Fgf signalling in the early mouse embryo.
Goolam M, Zernicka-Goetz M
Development (Cambridge, England) 2017 Apr 15;144(8):1450-1461
Development (Cambridge, England) 2017 Apr 15;144(8):1450-1461
An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation.
Saarimäki-Vire J, Balboa D, Russell MA, Saarikettu J, Kinnunen M, Keskitalo S, Malhi A, Valensisi C, Andrus C, Eurola S, Grym H, Ustinov J, Wartiovaara K, Hawkins RD, Silvennoinen O, Varjosalo M, Morgan NG, Otonkoski T
Cell reports 2017 Apr 11;19(2):281-294
Cell reports 2017 Apr 11;19(2):281-294
Changes in Parthenogenetic Imprinting Patterns during Reprogramming by Cell Fusion.
Jang HS, Hong YJ, Choi HW, Song H, Byun SJ, Uhm SJ, Seo HG, Do JT
PloS one 2016;11(5):e0156491
PloS one 2016;11(5):e0156491
Derivation of Patient Specific Pluripotent Stem Cells Using Clinically Discarded Cumulus Cells.
Chang WF, Hwu YM, Xu J, Lin CJ, Wang SW, Cheng AS, Lu J, Lu CH, Sung LY
PloS one 2016;11(11):e0165715
PloS one 2016;11(11):e0165715
p38 (Mapk14/11) occupies a regulatory node governing entry into primitive endoderm differentiation during preimplantation mouse embryo development.
Thamodaran V, Bruce AW
Open biology 2016 Sep;6(9)
Open biology 2016 Sep;6(9)
Generation of optic atrophy 1 patient-derived induced pluripotent stem cells (iPS-OPA1-BEHR) for disease modeling of complex optic atrophy syndromes (Behr syndrome).
Hauser S, Schuster S, Theurer Y, Synofzik M, Schöls L
Stem cell research 2016 Sep;17(2):426-429
Stem cell research 2016 Sep;17(2):426-429
Ductular reaction-on-a-chip: Microfluidic co-cultures to study stem cell fate selection during liver injury.
Haque A, Gheibi P, Stybayeva G, Gao Y, Torok N, Revzin A
Scientific reports 2016 Oct 31;6:36077
Scientific reports 2016 Oct 31;6:36077
Anterior-Posterior Patterning of Definitive Endoderm Generated from Human Embryonic Stem Cells Depends on the Differential Signaling of Retinoic Acid, Wnt-, and BMP-Signaling.
Davenport C, Diekmann U, Budde I, Detering N, Naujok O
Stem cells (Dayton, Ohio) 2016 Nov;34(11):2635-2647
Stem cells (Dayton, Ohio) 2016 Nov;34(11):2635-2647
Hepatic differentiation of human pluripotent stem cells in miniaturized format suitable for high-throughput screen.
Carpentier A, Nimgaonkar I, Chu V, Xia Y, Hu Z, Liang TJ
Stem cell research 2016 May;16(3):640-50
Stem cell research 2016 May;16(3):640-50
Inappropriate cadherin switching in the mouse epiblast compromises proper signaling between the epiblast and the extraembryonic ectoderm during gastrulation.
Basilicata MF, Frank M, Solter D, Brabletz T, Stemmler MP
Scientific reports 2016 May 24;6:26562
Scientific reports 2016 May 24;6:26562
Diverse Functions of Retinoic Acid in Brain Vascular Development.
Bonney S, Harrison-Uy S, Mishra S, MacPherson AM, Choe Y, Li D, Jaminet SC, Fruttiger M, Pleasure SJ, Siegenthaler JA
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Jul 20;36(29):7786-801
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Jul 20;36(29):7786-801
Selection and dynamics of embryonic stem cell integration into early mouse embryos.
Alexandrova S, Kalkan T, Humphreys P, Riddell A, Scognamiglio R, Trumpp A, Nichols J
Development (Cambridge, England) 2016 Jan 1;143(1):24-34
Development (Cambridge, England) 2016 Jan 1;143(1):24-34
Capturing the biology of disease severity in a PSC-based model of familial dysautonomia.
Zeltner N, Fattahi F, Dubois NC, Saurat N, Lafaille F, Shang L, Zimmer B, Tchieu J, Soliman MA, Lee G, Casanova JL, Studer L
Nature medicine 2016 Dec;22(12):1421-1427
Nature medicine 2016 Dec;22(12):1421-1427
Efficient derivation of extraembryonic endoderm stem cell lines from mouse postimplantation embryos.
Lin J, Khan M, Zapiec B, Mombaerts P
Scientific reports 2016 Dec 19;6:39457
Scientific reports 2016 Dec 19;6:39457
Design of a Vitronectin-Based Recombinant Protein as a Defined Substrate for Differentiation of Human Pluripotent Stem Cells into Hepatocyte-Like Cells.
Nagaoka M, Kobayashi M, Kawai C, Mallanna SK, Duncan SA
PloS one 2015;10(8):e0136350
PloS one 2015;10(8):e0136350
Activin-A and Bmp4 levels modulate cell type specification during CHIR-induced cardiomyogenesis.
Kim MS, Horst A, Blinka S, Stamm K, Mahnke D, Schuman J, Gundry R, Tomita-Mitchell A, Lough J
PloS one 2015;10(2):e0118670
PloS one 2015;10(2):e0118670
Transcription activator-like effector nuclease (TALEN)-mediated CLYBL targeting enables enhanced transgene expression and one-step generation of dual reporter human induced pluripotent stem cell (iPSC) and neural stem cell (NSC) lines.
Cerbini T, Funahashi R, Luo Y, Liu C, Park K, Rao M, Malik N, Zou J
PloS one 2015;10(1):e0116032
PloS one 2015;10(1):e0116032
Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells.
Paull D, Sevilla A, Zhou H, Hahn AK, Kim H, Napolitano C, Tsankov A, Shang L, Krumholz K, Jagadeesan P, Woodard CM, Sun B, Vilboux T, Zimmer M, Forero E, Moroziewicz DN, Martinez H, Malicdan MC, Weiss KA, Vensand LB, Dusenberry CR, Polus H, Sy KT, Kahler DJ, Gahl WA, Solomon SL, Chang S, Meissner A, Eggan K, Noggle SA
Nature methods 2015 Sep;12(9):885-92
Nature methods 2015 Sep;12(9):885-92
Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis.
Takasato M, Er PX, Chiu HS, Maier B, Baillie GJ, Ferguson C, Parton RG, Wolvetang EJ, Roost MS, Chuva de Sousa Lopes SM, Little MH
Nature 2015 Oct 22;526(7574):564-8
Nature 2015 Oct 22;526(7574):564-8
HEB associates with PRC2 and SMAD2/3 to regulate developmental fates.
Yoon SJ, Foley JW, Baker JC
Nature communications 2015 Mar 16;6:6546
Nature communications 2015 Mar 16;6:6546
Derivation of transgene-free human induced pluripotent stem cells from human peripheral T cells in defined culture conditions.
Kishino Y, Seki T, Fujita J, Yuasa S, Tohyama S, Kunitomi A, Tabei R, Nakajima K, Okada M, Hirano A, Kanazawa H, Fukuda K
PloS one 2014;9(5):e97397
PloS one 2014;9(5):e97397
A modified EpiSC culture condition containing a GSK3 inhibitor can support germline-competent pluripotency in mice.
Tsukiyama T, Ohinata Y
PloS one 2014;9(4):e95329
PloS one 2014;9(4):e95329
Generation and characterization of induced pluripotent stem cells from Aid-deficient mice.
Shimamoto R, Amano N, Ichisaka T, Watanabe A, Yamanaka S, Okita K
PloS one 2014;9(4):e94735
PloS one 2014;9(4):e94735
Unfolded protein response is required for the definitive endodermal specification of mouse embryonic stem cells via Smad2 and β-catenin signaling.
Xu H, Tsang KS, Wang Y, Chan JC, Xu G, Gao WQ
The Journal of biological chemistry 2014 Sep 19;289(38):26290-301
The Journal of biological chemistry 2014 Sep 19;289(38):26290-301
GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst.
Schrode N, Saiz N, Di Talia S, Hadjantonakis AK
Developmental cell 2014 May 27;29(4):454-67
Developmental cell 2014 May 27;29(4):454-67
Citrullination regulates pluripotency and histone H1 binding to chromatin.
Christophorou MA, Castelo-Branco G, Halley-Stott RP, Oliveira CS, Loos R, Radzisheuskaya A, Mowen KA, Bertone P, Silva JC, Zernicka-Goetz M, Nielsen ML, Gurdon JB, Kouzarides T
Nature 2014 Mar 6;507(7490):104-8
Nature 2014 Mar 6;507(7490):104-8
Efficient programming of human eye conjunctiva-derived induced pluripotent stem (ECiPS) cells into definitive endoderm-like cells.
Massumi M, Hoveizi E, Baktash P, Hooti A, Ghazizadeh L, Nadri S, Pourasgari F, Hajarizadeh A, Soleimani M, Nabiuni M, Khorramizadeh MR
Experimental cell research 2014 Mar 10;322(1):51-61
Experimental cell research 2014 Mar 10;322(1):51-61
Sox17-mediated maintenance of fetal intra-aortic hematopoietic cell clusters.
Nobuhisa I, Osawa M, Uemura M, Kishikawa Y, Anani M, Harada K, Takagi H, Saito K, Kanai-Azuma M, Kanai Y, Iwama A, Taga T
Molecular and cellular biology 2014 Jun;34(11):1976-90
Molecular and cellular biology 2014 Jun;34(11):1976-90
miR-373 is regulated by TGFβ signaling and promotes mesendoderm differentiation in human Embryonic Stem Cells.
Rosa A, Papaioannou MD, Krzyspiak JE, Brivanlou AH
Developmental biology 2014 Jul 1;391(1):81-8
Developmental biology 2014 Jul 1;391(1):81-8
Generation of functional insulin-producing cells from mouse embryonic stem cells through 804G cell-derived extracellular matrix and protein transduction of transcription factors.
Kaitsuka T, Noguchi H, Shiraki N, Kubo T, Wei FY, Hakim F, Kume S, Tomizawa K
Stem cells translational medicine 2014 Jan;3(1):114-27
Stem cells translational medicine 2014 Jan;3(1):114-27
Discovery of directional and nondirectional pioneer transcription factors by modeling DNase profile magnitude and shape.
Sherwood RI, Hashimoto T, O'Donnell CW, Lewis S, Barkal AA, van Hoff JP, Karun V, Jaakkola T, Gifford DK
Nature biotechnology 2014 Feb;32(2):171-178
Nature biotechnology 2014 Feb;32(2):171-178
BMP signalling regulates the pre-implantation development of extra-embryonic cell lineages in the mouse embryo.
Graham SJ, Wicher KB, Jedrusik A, Guo G, Herath W, Robson P, Zernicka-Goetz M
Nature communications 2014 Dec 16;5:5667
Nature communications 2014 Dec 16;5:5667
High oxygen condition facilitates the differentiation of mouse and human pluripotent stem cells into pancreatic progenitors and insulin-producing cells.
Hakim F, Kaitsuka T, Raeed JM, Wei FY, Shiraki N, Akagi T, Yokota T, Kume S, Tomizawa K
The Journal of biological chemistry 2014 Apr 4;289(14):9623-38
The Journal of biological chemistry 2014 Apr 4;289(14):9623-38
Induction of pluripotency in human somatic cells via a transient state resembling primitive streak-like mesendoderm.
Takahashi K, Tanabe K, Ohnuki M, Narita M, Sasaki A, Yamamoto M, Nakamura M, Sutou K, Osafune K, Yamanaka S
Nature communications 2014 Apr 24;5:3678
Nature communications 2014 Apr 24;5:3678
Identification of transcription factors for lineage-specific ESC differentiation.
Yamamizu K, Piao Y, Sharov AA, Zsiros V, Yu H, Nakazawa K, Schlessinger D, Ko MS
Stem cell reports 2013;1(6):545-59
Stem cell reports 2013;1(6):545-59
Cell-cycle control of developmentally regulated transcription factors accounts for heterogeneity in human pluripotent cells.
Singh AM, Chappell J, Trost R, Lin L, Wang T, Tang J, Matlock BK, Weller KP, Wu H, Zhao S, Jin P, Dalton S
Stem cell reports 2013;1(6):532-44
Stem cell reports 2013;1(6):532-44
Defined extracellular matrix components are necessary for definitive endoderm induction.
Taylor-Weiner H, Schwarzbauer JE, Engler AJ
Stem cells (Dayton, Ohio) 2013 Oct;31(10):2084-94
Stem cells (Dayton, Ohio) 2013 Oct;31(10):2084-94
Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme.
Sneddon JB, Borowiak M, Melton DA
Nature 2012 Nov 29;491(7426):765-8
Nature 2012 Nov 29;491(7426):765-8
CD166(pos) subpopulation from differentiated human ES and iPS cells support repair of acute lung injury.
Soh BS, Zheng D, Li Yeo JS, Yang HH, Ng SY, Wong LH, Zhang W, Li P, Nichane M, Asmat A, Wong PS, Wong PC, Su LL, Mantalaris SA, Lu J, Xian W, McKeon F, Chen J, Lim EH, Lim B
Molecular therapy : the journal of the American Society of Gene Therapy 2012 Dec;20(12):2335-46
Molecular therapy : the journal of the American Society of Gene Therapy 2012 Dec;20(12):2335-46
The endothelial cell line bEnd.3 maintains human pluripotent stem cells.
Joubin K, Richardson A, Novoa N, Tu E, Tomishima MJ
Stem cells and development 2012 Aug 10;21(12):2312-21
Stem cells and development 2012 Aug 10;21(12):2312-21
A molecular signature for purified definitive endoderm guides differentiation and isolation of endoderm from mouse and human embryonic stem cells.
Wang P, McKnight KD, Wong DJ, Rodriguez RT, Sugiyama T, Gu X, Ghodasara A, Qu K, Chang HY, Kim SK
Stem cells and development 2012 Aug 10;21(12):2273-87
Stem cells and development 2012 Aug 10;21(12):2273-87
Early in vitro differentiation of mouse definitive endoderm is not correlated with progressive maturation of nuclear DNA methylation patterns.
Tajbakhsh J, Gertych A, Fagg WS, Hatada S, Fair JH
PloS one 2011;6(7):e21861
PloS one 2011;6(7):e21861
A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3.
Bone HK, Nelson AS, Goldring CE, Tosh D, Welham MJ
Journal of cell science 2011 Jun 15;124(Pt 12):1992-2000
Journal of cell science 2011 Jun 15;124(Pt 12):1992-2000
CD24: a novel surface marker for PDX1-positive pancreatic progenitors derived from human embryonic stem cells.
Jiang W, Sui X, Zhang D, Liu M, Ding M, Shi Y, Deng H
Stem cells (Dayton, Ohio) 2011 Apr;29(4):609-17
Stem cells (Dayton, Ohio) 2011 Apr;29(4):609-17
Induction of pluripotent stem cells from human third molar mesenchymal stromal cells.
Oda Y, Yoshimura Y, Ohnishi H, Tadokoro M, Katsube Y, Sasao M, Kubo Y, Hattori K, Saito S, Horimoto K, Yuba S, Ohgushi H
The Journal of biological chemistry 2010 Sep 17;285(38):29270-8
The Journal of biological chemistry 2010 Sep 17;285(38):29270-8
A role for PDGF signaling in expansion of the extra-embryonic endoderm lineage of the mouse blastocyst.
Artus J, Panthier JJ, Hadjantonakis AK
Development (Cambridge, England) 2010 Oct;137(20):3361-72
Development (Cambridge, England) 2010 Oct;137(20):3361-72
Alginate microcapsule for propagation and directed differentiation of hESCs to definitive endoderm.
Chayosumrit M, Tuch B, Sidhu K
Biomaterials 2010 Jan;31(3):505-14
Biomaterials 2010 Jan;31(3):505-14
SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells.
Chng Z, Teo A, Pedersen RA, Vallier L
Cell stem cell 2010 Jan 8;6(1):59-70
Cell stem cell 2010 Jan 8;6(1):59-70
The ROCK inhibitor Y-27632 improves recovery of human embryonic stem cells after fluorescence-activated cell sorting with multiple cell surface markers.
Emre N, Vidal JG, Elia J, O'Connor ED, Paramban RI, Hefferan MP, Navarro R, Goldberg DS, Varki NM, Marsala M, Carson CT
PloS one 2010 Aug 13;5(8):e12148
PloS one 2010 Aug 13;5(8):e12148
Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo.
Morris SA, Teo RT, Li H, Robson P, Glover DM, Zernicka-Goetz M
Proceedings of the National Academy of Sciences of the United States of America 2010 Apr 6;107(14):6364-9
Proceedings of the National Academy of Sciences of the United States of America 2010 Apr 6;107(14):6364-9
Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells.
Sun N, Panetta NJ, Gupta DM, Wilson KD, Lee A, Jia F, Hu S, Cherry AM, Robbins RC, Longaker MT, Wu JC
Proceedings of the National Academy of Sciences of the United States of America 2009 Sep 15;106(37):15720-5
Proceedings of the National Academy of Sciences of the United States of America 2009 Sep 15;106(37):15720-5
A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells.
Hansson M, Olesen DR, Peterslund JM, Engberg N, Kahn M, Winzi M, Klein T, Maddox-Hyttel P, Serup P
Developmental biology 2009 Jun 15;330(2):286-304
Developmental biology 2009 Jun 15;330(2):286-304
Biphasic induction of Pdx1 in mouse and human embryonic stem cells can mimic development of pancreatic beta-cells.
Bernardo AS, Cho CH, Mason S, Docherty HM, Pedersen RA, Vallier L, Docherty K
Stem cells (Dayton, Ohio) 2009 Feb;27(2):341-51
Stem cells (Dayton, Ohio) 2009 Feb;27(2):341-51
Vitronectin promotes oligodendrocyte differentiation during neurogenesis of human embryonic stem cells.
Gil JE, Woo DH, Shim JH, Kim SE, You HJ, Park SH, Paek SH, Kim SK, Kim JH
FEBS letters 2009 Feb 4;583(3):561-7
FEBS letters 2009 Feb 4;583(3):561-7
Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells.
Zhang D, Jiang W, Liu M, Sui X, Yin X, Chen S, Shi Y, Deng H
Cell research 2009 Apr;19(4):429-38
Cell research 2009 Apr;19(4):429-38
Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.
Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA
Cell stem cell 2009 Apr 3;4(4):348-58
Cell stem cell 2009 Apr 3;4(4):348-58
High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells.
Desbordes SC, Placantonakis DG, Ciro A, Socci ND, Lee G, Djaballah H, Studer L
Cell stem cell 2008 Jun 5;2(6):602-12
Cell stem cell 2008 Jun 5;2(6):602-12
Prospective isolation and global gene expression analysis of definitive and visceral endoderm.
Sherwood RI, Jitianu C, Cleaver O, Shaywitz DA, Lamenzo JO, Chen AE, Golub TR, Melton DA
Developmental biology 2007 Apr 15;304(2):541-55
Developmental biology 2007 Apr 15;304(2):541-55
Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions.
Yao S, Chen S, Clark J, Hao E, Beattie GM, Hayek A, Ding S
Proceedings of the National Academy of Sciences of the United States of America 2006 May 2;103(18):6907-12
Proceedings of the National Academy of Sciences of the United States of America 2006 May 2;103(18):6907-12
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of Human SOX17 by Western Blot. Western blot shows lysates of BG01V human embryonic stem cells untreated (-) or endoderm differentiated (+). PVDF membrane was probed with 1 µg/mL of Goat Anti-Human SOX17 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1924) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). A specific band was detected for SOX17 at approximately 55 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of Human SOX17 by Simple WesternTM. Simple Western lane view shows lysates of BG01V human embryonic stem cells untreated (-) or endoderm differentiated (+), loaded at 0.2 mg/mL. A specific band was detected for SOX17 at approximately 59 kDa (as indicated) using 10 µg/mL of Goat Anti-Human SOX17 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1924) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of Human SOX17 by Simple WesternTM. Simple Western lane view shows lysates of iBJ6 human induced pluripotent stem cell line untreated (-) or endoderm differentiated (+), loaded at 0.2 mg/mL. A specific band was detected for SOX17 at approximately 58 kDa (as indicated) using 10 µg/mL of Goat Anti-Human SOX17 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1924) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.
Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- SOX17 in B16 Mouse Cell Line. SOX17 was detected in immersion fixed B16 mouse melanoma cell line using 10 µg/mL Goat Anti-Human SOX17 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1924) for 3 hours at room temperature. Cells were stained with the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counter-stained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- SOX17 in Human BG01V Cells. SOX17 was detected in immersion fixed endoderm differentiated BG01V human embryonic stem cells using 10 µg/mL Goat Anti-Human SOX17 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1924) for 3 hours at room temperature. Cells were stained with the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red, upper panel; Catalog # NL001) and counterstained with DAPI (blue, lower panel). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.
Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of SOX17-regulated Genes by Chromatin Immunoprecipitation. Endoderm-differentiated D3 mouse embryonic stem cell line was fixed using formaldehyde, resuspended in lysis buffer, and sonicated to shear chromatin. SOX17/DNA complexes were immunoprecipitated using 5 μg Goat Anti-Human SOX17 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1924) or control antibody (Catalog # AB-108-C) for 15 minutes in an ultrasonic bath, followed by Biotinylated Anti-Goat IgG Secondary Antibody (Catalog # BAF109). Immunocomplexes were captured using 50 μL of MagCellect Streptavidin Ferrofluid (Catalog # MAG999) and DNA was purified using chelating resin solution. The p21 promoter was detected by standard PCR.