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- Product number
- 12543-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12543-1-AP, RRID:AB_10640897
- Product name
- TRIM31 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TRIM31 antibody (Cat. #12543-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references TRIM31 inhibits ferroptosis in LUAD through facilitating ubiquitination and degradation of P53.
The E3 ubiquitin ligase TRIM31 enhances the progression of esophageal cancer through the ubiquitination of BBOX1.
Modified Xiaoyao San ameliorates LPS-induced depression-like behavior by inhibiting NLRP3-mediated microglial pyroptosis.
Therapeutic potential of quercitrin in intervertebral disc degeneration: Targeting pyroptosis and inflammation.
Loss of Trim31 Worsens Cardiac Remodeling in a Mouse Model of Heart Failure by Enhancing the Activation of the NLRP3 Inflammasome.
TRIM31 triggers colorectal carcinogenesis and progression by maintaining YBX1 protein stability through ubiquitination modification.
E3 ubiquitin ligase TRIM31 alleviates dopaminergic neurodegeneration by promoting proteasomal degradation of VDAC1 in Parkinson's Disease model.
Modified Danzhi XiaoyaoSan inhibits neuroinflammation via regulating TRIM31/NLRP3 inflammasome in the treatment of CUMS depression.
An investigation of the molecular characterization of the tripartite motif (TRIM) family and primary validation of TRIM31 in gastric cancer.
NLRP10 promotes AGEs-induced NLRP1 and NLRP3 inflammasome activation via ROS/MAPK/NF-κB signaling in human periodontal ligament cells.
Inhibition of Immunoproteasome Attenuates NLRP3 Inflammasome Response by Regulating E3 Ubiquitin Ligase TRIM31.
Parthenolide alleviates microglia-mediated neuroinflammation via MAPK/TRIM31/NLRP3 signaling to ameliorate cognitive disorder.
The E3 ubiquitin ligase TRIM31 is involved in cerebral ischemic injury by promoting degradation of TIGAR.
Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.
USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS.
Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity.
AKT Regulates NLRP3 Inflammasome Activation by Phosphorylating NLRP3 Serine 5.
Nasopharyngeal carcinoma MHC region deep sequencing identifies HLA and novel non-HLA TRIM31 and TRIM39 loci.
TRIM31 enhances chemoresistance in glioblastoma through activation of the PI3K/Akt signaling pathway.
TRIM31 regulates chronic inflammation via NF-κB signal pathway to promote invasion and metastasis in colorectal cancer.
Tripartite motif 31 promotes resistance to anoikis of hepatocarcinoma cells through regulation of p53-AMPK axis.
TRIM31 promotes Atg5/Atg7-independent autophagy in intestinal cells.
TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity.
Dou T, Liu Y, Fang X, Yang L, Shu L, Chen T, Yang T, Yin Y, Wang H, Feng M, Li X
Scientific reports 2026 Mar 26;
Scientific reports 2026 Mar 26;
The E3 ubiquitin ligase TRIM31 enhances the progression of esophageal cancer through the ubiquitination of BBOX1.
Ge L, Sun M, Xu D, Sun G
Cellular signalling 2025 Nov;135:111975
Cellular signalling 2025 Nov;135:111975
Modified Xiaoyao San ameliorates LPS-induced depression-like behavior by inhibiting NLRP3-mediated microglial pyroptosis.
Tian L, Su P, Feng G, Peng S, Liu L, Yan X, Liu X, Li Y, Bai M, Wang B, Xu E
Metabolic brain disease 2025 Nov 22;40(8):324
Metabolic brain disease 2025 Nov 22;40(8):324
Therapeutic potential of quercitrin in intervertebral disc degeneration: Targeting pyroptosis and inflammation.
Wu X, Pan Q, Yao C, Gong Y, Li Z, Tang F, Fang Z, Bao Y, Chen Y, Yu M, Wang Z, Jiang C, Hong Z
International immunopharmacology 2025 May 27;156:114680
International immunopharmacology 2025 May 27;156:114680
Loss of Trim31 Worsens Cardiac Remodeling in a Mouse Model of Heart Failure by Enhancing the Activation of the NLRP3 Inflammasome.
Duan F, Li H, Lu B, Wang X, Xu X
Inflammation 2025 Aug;48(4):2650-2662
Inflammation 2025 Aug;48(4):2650-2662
TRIM31 triggers colorectal carcinogenesis and progression by maintaining YBX1 protein stability through ubiquitination modification.
Li X, Wu Y, Guo J, Huang P, Li Q, Gao Z, Hu Y, Gao A, Sun M, Min H, Zhou J
Cell death & disease 2025 Aug 16;16(1):621
Cell death & disease 2025 Aug 16;16(1):621
E3 ubiquitin ligase TRIM31 alleviates dopaminergic neurodegeneration by promoting proteasomal degradation of VDAC1 in Parkinson's Disease model.
Zhao Z, Song X, Wang Y, Yu L, Huang G, Li Y, Zong R, Liu T, Ji Q, Zheng Y, Liu B, Zhu Q, Chen L, Gao C, Liu H
Cell death and differentiation 2024 Nov;31(11):1410-1421
Cell death and differentiation 2024 Nov;31(11):1410-1421
Modified Danzhi XiaoyaoSan inhibits neuroinflammation via regulating TRIM31/NLRP3 inflammasome in the treatment of CUMS depression.
Wang B, Tian L, Wu M, Zhang D, Yan X, Bai M, Li Y, Su P, Xu E
Experimental gerontology 2024 Jul;192:112451
Experimental gerontology 2024 Jul;192:112451
An investigation of the molecular characterization of the tripartite motif (TRIM) family and primary validation of TRIM31 in gastric cancer.
Ding Y, Lu Y, Guo J, Chen S, Han X, Wang S, Zhang M, Wang R, Song J, Wang K, Qiu W, Qi W
Human genomics 2024 Jul 9;18(1):77
Human genomics 2024 Jul 9;18(1):77
NLRP10 promotes AGEs-induced NLRP1 and NLRP3 inflammasome activation via ROS/MAPK/NF-κB signaling in human periodontal ligament cells.
Yi X, Song Y, Xu J, Wang L, Liu L, Huang D, Zhang L
Odontology 2024 Jan;112(1):100-111
Odontology 2024 Jan;112(1):100-111
Inhibition of Immunoproteasome Attenuates NLRP3 Inflammasome Response by Regulating E3 Ubiquitin Ligase TRIM31.
Lee Y, Yoon B, Son S, Cho E, Kim KB, Choi EY, Kim DE
Cells 2024 Apr 13;13(8)
Cells 2024 Apr 13;13(8)
Parthenolide alleviates microglia-mediated neuroinflammation via MAPK/TRIM31/NLRP3 signaling to ameliorate cognitive disorder.
Fan M, Wang C, Zhao X, Jiang Y, Wang C
International immunopharmacology 2023 Jul;120:110287
International immunopharmacology 2023 Jul;120:110287
The E3 ubiquitin ligase TRIM31 is involved in cerebral ischemic injury by promoting degradation of TIGAR.
Zeng S, Zhao Z, Zheng S, Wu M, Song X, Li Y, Zheng Y, Liu B, Chen L, Gao C, Liu H
Redox biology 2021 Sep;45:102058
Redox biology 2021 Sep;45:102058
Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.
Guo Y, Li Q, Zhao G, Zhang J, Yuan H, Feng T, Ou D, Gu R, Li S, Li K, Lin P
Cell death & disease 2021 Oct 14;12(10):945
Cell death & disease 2021 Oct 14;12(10):945
USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS.
Hou J, Han L, Zhao Z, Liu H, Zhang L, Ma C, Yi F, Liu B, Zheng Y, Gao C
Nature communications 2021 May 20;12(1):2970
Nature communications 2021 May 20;12(1):2970
Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity.
Zhu J, Li X, Cai X, Zha H, Zhou Z, Sun X, Rong F, Tang J, Zhu C, Liu X, Fan S, Wang J, Liao Q, Ouyang G, Xiao W
Molecular cell 2021 Aug 5;81(15):3171-3186.e8
Molecular cell 2021 Aug 5;81(15):3171-3186.e8
AKT Regulates NLRP3 Inflammasome Activation by Phosphorylating NLRP3 Serine 5.
Zhao W, Shi CS, Harrison K, Hwang IY, Nabar NR, Wang M, Kehrl JH
Journal of immunology (Baltimore, Md. : 1950) 2020 Oct 15;205(8):2255-2264
Journal of immunology (Baltimore, Md. : 1950) 2020 Oct 15;205(8):2255-2264
Nasopharyngeal carcinoma MHC region deep sequencing identifies HLA and novel non-HLA TRIM31 and TRIM39 loci.
Ning L, Ko JM, Yu VZ, Ng HY, Chan CK, Tao L, Lam SY, Leong MM, Ngan RK, Kwong DL, Lee AW, Ng WT, Cheng A, Tung S, Lee VH, Lam KO, Kwan CK, Li WS, Yau S, Bei JX, Lung ML
Communications biology 2020 Dec 11;3(1):759
Communications biology 2020 Dec 11;3(1):759
TRIM31 enhances chemoresistance in glioblastoma through activation of the PI3K/Akt signaling pathway.
Fan MD, Zhao XY, Qi JN, Jiang Y, Liu BY, Dun ZP, Zhang R, Wang CW, Pang Q
Experimental and therapeutic medicine 2020 Aug;20(2):802-809
Experimental and therapeutic medicine 2020 Aug;20(2):802-809
TRIM31 regulates chronic inflammation via NF-κB signal pathway to promote invasion and metastasis in colorectal cancer.
Wang H, Yao L, Gong Y, Zhang B
American journal of translational research 2018;10(4):1247-1259
American journal of translational research 2018;10(4):1247-1259
Tripartite motif 31 promotes resistance to anoikis of hepatocarcinoma cells through regulation of p53-AMPK axis.
Guo P, Qiu Y, Ma X, Li T, Ma X, Zhu L, Lin Y, Han L
Experimental cell research 2018 Jul 1;368(1):59-66
Experimental cell research 2018 Jul 1;368(1):59-66
TRIM31 promotes Atg5/Atg7-independent autophagy in intestinal cells.
Ra EA, Lee TA, Won Kim S, Park A, Choi HJ, Jang I, Kang S, Hee Cheon J, Cho JW, Eun Lee J, Lee S, Park B
Nature communications 2016 May 24;7:11726
Nature communications 2016 May 24;7:11726
TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity.
Uchil PD, Hinz A, Siegel S, Coenen-Stass A, Pertel T, Luban J, Mothes W
Journal of virology 2013 Jan;87(1):257-72
Journal of virology 2013 Jan;87(1):257-72
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- COLO 320 cells were subjected to SDS PAGE followed by western blot with 12543-1-AP(TRIM31 antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TRIM31 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TRIM31. This antibody recognizes human antigen. The TRIM31 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
