10574-1-AP

antibody from Proteintech Group

Targeting: SUV39H1 KMT1A, SUV39H

Provider product page for 10574-1-AP

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Immunoprecipitation

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [23]
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Validations
Western blot [1]

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Product number: 10574-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10574-1-AP, RRID:AB_2196710
Product name: SUV39H1 antibody
Antibody type: Polyclonal
Description: KD/KO validated SUV39H1 antibody (Cat. #10574-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SUV39H1 protein structure - 10574-1-AP shown in red.

Submitted references NUSAP1 Recruits DAXX to Suppress HIF-Driven Triple-Negative Breast Cancer Progression.

Du Y, Wang J, Wang M, Zhang Y, Zheng M, Li H, Wang X, Sun H, Tang K, Shan C, Zhao Q, Meng X, Wang Y, Zhou J, Chen Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(5):e13380

Improving erectile function in diabetic male mice by rescuing depalmitoylated FBP1 to reduce cavernosal lactate.

Xiao M, Guo W, Zeng R, Wu S, Jin X
Nature communications 2026 Jan 16;17(1):1740

Comprehensive Bioinformatics Analysis and Validation of the Mechanism of Glutamic-pyruvic Transaminase 2 in Bladder Cancer.

Dong H, Li H, Chen S, Wang Q, Zhang Y, Shi H, Zuo J, Chen J, Wang J, Wang H
Journal of Cancer 2025;16(15):4357-4370

SUV39H1 facilitate the osteogenic differentiation of dental pulp stem cells by modulating lipid metabolism and mitochondrial dynamics through FASN via non-histone methylation and ubiquitination mechanism.

Wang N, Wang W, Han X, Cao Y, Yang H, Zhang C, Liu H, Zhu M, Xia D, Fan Z
Stem cell research & therapy 2025 Sep 25;16(1):498

The ZBTB24-CDCA7-HELLS axis suppresses the totipotent 2C-like reprogramming by maintaining Dux methylation and repression.

Guo D, Du Z, Liu Y, Lin M, Lu Y, Hardikar S, Xue Y, Zhang J, Chen T, Dan J
Nucleic acids research 2025 Apr 10;53(7)

Inhibition of SUV39H1 reduces tumor angiogenesis via Notch1 in oral squamous cell carcinoma.

Chen Y, Weng X, Zhang C, Wang S, Wu X, Cheng B
PeerJ 2024;12:e17222

Inhibition of protein kinase C increases Prdm14 level to promote self-renewal of embryonic stem cells through reducing Suv39h-induced H3K9 methylation.

Ji J, Cao J, Chen P, Huang R, Ye SD
The Journal of biological chemistry 2024 Mar;300(3):105714

Comprehensive gene set enrichment and variation analyses identify SUV39H1 as a potential prognostic biomarker for glioblastoma immunorelevance.

Liu J, Luo Q, Zhao H, Yang M, Yang J, Wang Y, Zhao M, Mao J, Chen J, Guo B, Zhang L
Computational and structural biotechnology journal 2024 Dec;23:4161-4176

ORC1 enhances repressive epigenetic modifications on HIV-1 LTR to promote HIV-1 latency.

Zhou M, Yang T, Yuan M, Li X, Deng J, Wu S, Zhong Z, Lin Y, Zhang W, Xia B, Wu Y, Wang L, Chen T, Liu R, Pan T, Ma X, Li L, Liu B, Zhang H
Journal of virology 2024 Aug 20;98(8):e0003524

ATM, KAP1 and the Epstein-Barr virus polymerase processivity factor direct traffic at the intersection of transcription and replication.

Xu H, Akinyemi IA, Haley J, McIntosh MT, Bhaduri-McIntosh S
Nucleic acids research 2023 Nov 10;51(20):11104-11122

SUV39H1 Inhibits Angiogenesis in Limb Ischemia of Mice.

Niu W, Cao W, Wu F, Liang C
Cell transplantation 2023 Jan-Dec;32:9636897231198167

Dependence of glucose transport on autophagy and GAPDH activity.

Craven RJ, Frazier HN, Thibault O
Brain research 2022 Feb 1;1776:147747

N(6) -Methyladenosine-Modified CBX1 Regulates Nasopharyngeal Carcinoma Progression Through Heterochromatin Formation and STAT1 Activation.

Zhao Y, Huang S, Tan X, Long L, He Q, Liang X, Bai J, Li Q, Lin J, Li Y, Liu N, Ma J, Chen Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Dec;9(36):e2205091

Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP-Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis.

Peng T, He Y, Wang T, Yu J, Ma X, Zhou Z, Sheng Y, Li L, Peng H, Li S, Zou J, Yuan Y, Zhao Y, Shi H, Li F, Liu W, Hu K, Lu X, Zhang G, Wang F
Journal of medicinal chemistry 2022 Aug 25;65(16):11010-11033

Linkage of methionine addiction, histone lysine hypermethylation, and malignancy.

Yamamoto J, Inubushi S, Han Q, Tashiro Y, Sugisawa N, Hamada K, Aoki Y, Miyake K, Matsuyama R, Bouvet M, Clarke SG, Endo I, Hoffman RM
iScience 2022 Apr 15;25(4):104162

MiR-520a-3p inhibits malignant progression of epithelial ovarian cancer by targeting SUV39H1 expression.

Li J, Shao W, Zhao J
Human cell 2021 Mar;34(2):570-578

CyclinD1 inhibits dicer and crucial miRNA expression by chromatin modification to promote the progression of intrahepatic cholangiocarcinoma.

Qi Y, Wang D, Huang W, Wang B, Huang D, Xiong F, Chen X, Chen Y
Journal of experimental & clinical cancer research : CR 2019 Oct 7;38(1):413

Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors.

Wang Y, Zhang J, Ren S, Sun D, Huang HY, Wang H, Jin Y, Li F, Zheng C, Yang L, Deng L, Jiang Z, Jiang T, Han X, Hou S, Guo C, Li F, Gao D, Qin J, Gao D, Chen L, Lin SH, Wong KK, Li C, Hu L, Zhou C, Ji H
Cell reports 2019 Jul 9;28(2):512-525.e6

Class II transactivator (CIITA) mediates IFN-γ induced eNOS repression by enlisting SUV39H1.

Weng X, Zhang Y, Li Z, Yu L, Xu F, Fang M, Hou L, Ge J, Xu Y
Biochimica et biophysica acta. Gene regulatory mechanisms 2019 Feb;1862(2):163-172

Triptolide Promotes Senescence of Prostate Cancer Cells Through Histone Methylation and Heterochromatin Formation.

Tamgue O, Lei M
Asian Pacific journal of cancer prevention : APJCP 2017 Sep 27;18(9):2519-2526

The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction.

Yang G, Weng X, Zhao Y, Zhang X, Hu Y, Dai X, Liang P, Wang P, Ma L, Sun X, Hou L, Xu H, Fang M, Li Y, Jenuwein T, Xu Y, Sun A
Nature communications 2017 Mar 31;8:14941

Dicer promotes tumorigenesis by translocating to nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells.

Cheng W, Qi Y, Tian L, Wang B, Huang W, Chen Y
Cell death & disease 2017 Feb 23;8(2):e2628

Downregulation of HP1α suppresses proliferation of cholangiocarcinoma by restoring SFRP1 expression.

Cheng W, Tian L, Wang B, Qi Y, Huang W, Li H, Chen YJ
Oncotarget 2016 Jul 26;7(30):48107-48119

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The SUV39H1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SUV39H1. This antibody recognizes human,mouse,rat antigen. The SUV39H1 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 10574-1-AP.pdf

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