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- Product number
- ABIN2841686 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Cullin 4A (CUL4A) (AA 102-131), (N-Term) antibody
- Antibody type
- Polyclonal
- Description
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- AA 102-131, N-Term
- Antibody clone number
- RB10557
- Vial size
- 80 μL
- Storage
- Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Submitted references VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation.
WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase.
The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor.
Huang J, Chen J
Oncogene 2008 Jul 3;27(29):4056-64
Oncogene 2008 Jul 3;27(29):4056-64
WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase.
Hu J, Zacharek S, He YJ, Lee H, Shumway S, Duronio RJ, Xiong Y
Genes & development 2008 Apr 1;22(7):866-71
Genes & development 2008 Apr 1;22(7):866-71
The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor.
Wen X, Duus KM, Friedrich TD, de Noronha CM
The Journal of biological chemistry 2007 Sep 14;282(37):27046-57
The Journal of biological chemistry 2007 Sep 14;282(37):27046-57
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