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- Antibody Data
- Antigen structure
- References [3]
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- Validations
- Blocking/Neutralizing [1]
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- Product number
- AF387 - Provider product page
- Provider
- R&D Systems
- Product name
- Human Neurturin Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Detects human Neurturin in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant mouse Neurturin is observed.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
Q99748- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence.
Neurturin gene therapy improves motor function and prevents death of striatal neurons in a 3-nitropropionic acid rat model of Huntington's disease.
Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys.
Ibiza S, García-Cassani B, Ribeiro H, Carvalho T, Almeida L, Marques R, Misic AM, Bartow-McKenney C, Larson DM, Pavan WJ, Eberl G, Grice EA, Veiga-Fernandes H
Nature 2016 Jul 21;535(7612):440-443
Nature 2016 Jul 21;535(7612):440-443
Neurturin gene therapy improves motor function and prevents death of striatal neurons in a 3-nitropropionic acid rat model of Huntington's disease.
Ramaswamy S, McBride JL, Herzog CD, Brandon E, Gasmi M, Bartus RT, Kordower JH
Neurobiology of disease 2007 May;26(2):375-84
Neurobiology of disease 2007 May;26(2):375-84
Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys.
Kordower JH, Herzog CD, Dass B, Bakay RA, Stansell J 3rd, Gasmi M, Bartus RT
Annals of neurology 2006 Dec;60(6):706-15
Annals of neurology 2006 Dec;60(6):706-15
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Supportive validation
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- R&D Systems (provider)
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- Experimental details
- Neuron Survival in Response to Neurturin and Neutralization by Human Neurturin Antibody. Recombinant Human Neurturin (Catalog # 387-NE) supports the survival of dorsal root ganglion neurons from E10 chick embryos in a dose-dependent manner (orange line), as measured by MTT staining. Neuron survival elicited by Recombinant Human Neurturin (6 ng/mL) is neutralized (green line) by increasing concentrations of Human Neurturin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF387). The ND50 is typically 0.5-2.0 µg/mL.
