14527-1-AP

antibody from Proteintech Group

Targeting: ACADVL ACAD6, LCACD, VLCAD

Provider product page for 14527-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [24]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

Submit

Product number: 14527-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14527-1-AP, RRID:AB_2288885
Product name: ACADVL antibody
Antibody type: Polyclonal
Description: KD/KO validated ACADVL antibody (Cat. #14527-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ACADVL protein structure - 14527-1-AP shown in red.

Submitted references Polydatin Targets ACADVL to Combat Obesity by Promoting Adipocyte Browning and Activating Fatty Acid Oxidation.

He W, Gu Y, Zhang F, Xiang Y, Fang Y, Cai J, Li W, Wang Z, Qin G, Li K, Gu X, Lin X, Ma L, Hou Y, Xiao X, Luo T
Phytotherapy research : PTR 2026 May;40(5):2417-2436

ACADVL upregulation is associated with placental ferroptosis in intrahepatic cholestasis of pregnancy.

Tang M, Cai J, Zhang L, Xiong L, Gong X, Fu J, Wang P, Luo M, Liu H, Ye Y, Yu M, Yu H, Xing S, Yang X
Biochimica et biophysica acta. Molecular and cell biology of lipids 2026 Mar;1871(2):159711

NAT10 regulates heart development and function by maintaining the expression of genes related to fatty acid β-oxidation and heart contraction.

Shi L, Zhang M, Yang H, Li X, He S, Chu Y, Gao M, Zhang Z, Zhang JZ, Li Z, Chen Z
Cell death and differentiation 2026 Feb;33(2):358-373

RNA binding protein HuD regulates fatty acid oxidation in pancreatic β-cells by modulating long-chain acyl-CoA dehydrogenase expression.

Seo J, Ryu S, Zhang W, Lee EK, Jeong SM
Animal cells and systems 2025;29(1):512-522

Artemether ameliorates type 1 diabetes mellitus by modulating glycolipid metabolism in skeletal muscle.

Dong Y, Fu Q, Zhang Y, Weng W, Han P, Cai Y, Sun H
American journal of translational research 2025;17(8):5871-5884

Subacute exposure to thallium disrupts renal energy metabolism by impairing the function of subcellular organelles in aged mice of both sexes.

Yao H, Li L, Dai Q, Li D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Nov;205:115700

PKM2 knockout facilitates the activation of the AMPK/KLF4/ACADVL pathway, leading to increased oxidative degradation of fatty acids in TNBC.

Zhang L, Cheng L, Ma Y, Li J, Zhong Y, Zhu X, Leng X, Xie F
Medical oncology (Northwood, London, England) 2025 Mar 12;42(4):102

Pemafibrate modulates peroxisome proliferator-activated receptor alpha and prevents alcohol-associated liver disease in rats.

Saito T, George J, Ozaki K, Tsuchishima M, Tsutsumi M
Molecular medicine (Cambridge, Mass.) 2025 Apr 22;31(1):145

Artemether regulates liver glycogen and lipid utilization through mitochondrial pyruvate oxidation in db/db mice.

Weng W, Shen L, Yu X, Yuan R, Shao M, Han P, Sun H
American journal of translational research 2024;16(1):27-38

Mitochondrial glycerol 3-phosphate dehydrogenase deficiency exacerbates lipotoxic cardiomyopathy.

Qu H, Liu X, Zhu J, He N, He Q, Zhang L, Wang Y, Gong X, Xiong X, Liu J, Wang C, Yang G, Yang Q, Luo G, Zhu Z, Zheng Y, Zheng H
iScience 2024 Jun 21;27(6):109796

Ginsenoside Rb1 regulates CPT1A deacetylation to inhibit intramuscular fat infiltration after rotator cuff tear.

Yin Y, Wang Z, Yang Y, Shen M, Hu H, Chen C, Zhou H, Li Z, Wu S
iScience 2024 Jul 19;27(7):110331

Comparison of the stage-dependent mitochondrial changes in response to pressure overload between the diseased right and left ventricle in the rat.

Li L, Niemann B, Knapp F, Werner S, Mühlfeld C, Schneider JP, Jurida LM, Molenda N, Schmitz ML, Yin X, Mayr M, Schulz R, Kracht M, Rohrbach S
Basic research in cardiology 2024 Aug;119(4):587-611

Proteomics Analysis Provides Insights into the Role of Lipid Metabolism in T2DM-Related Sarcopenia.

Wu J, Wang S, Zhuang H, Wang W, Wang Y, Chen Y, Huang Z, Chen C, Chen X
ACS omega 2024 Aug 6;9(31):34056-34069

Construction and validation of an oxidative-stress-related risk model for predicting the prognosis of osteosarcoma.

Wang H, Li J, Li X
Aging 2023 Jun 2;15(11):4820-4843

Stimulator of interferon genes promotes diabetic sarcopenia by targeting peroxisome proliferator activated receptors γ degradation and inhibiting fatty acid oxidation.

Yan SB, Liang H, Zhan P, Zheng H, Zhao QX, Zheng ZJ, Lu HX, Shang GK, Ji XP
Journal of cachexia, sarcopenia and muscle 2023 Dec;14(6):2623-2641

The serum acylcarnitines profile in epileptic children treated with valproic acid and the protective roles of peroxisome proliferator-activated receptor a activation in valproic acid-induced liver injury.

Ma Y, Wang M, Guo S, Li T, Liu X, Zhao L
Frontiers in pharmacology 2022;13:1048728

Multi-Omics Analysis of Fatty Acid Metabolism in Thyroid Carcinoma.

Lu J, Zhang Y, Sun M, Ding C, Zhang L, Kong Y, Cai M, Miccoli P, Ma C, Yue X
Frontiers in oncology 2021;11:737127

Very long chain fatty acid metabolism is required in acute myeloid leukemia.

Tcheng M, Roma A, Ahmed N, Smith RW, Jayanth P, Minden MD, Schimmer AD, Hess DA, Hope K, Rea KA, Akhtar TA, Bohrnsen E, D'Alessandro A, Mohsen AW, Vockley J, Spagnuolo PA
Blood 2021 Jun 24;137(25):3518-3532

Structure-activity relationship of avocadyne.

Tcheng M, Cunha VLS, Ahmed N, Liu X, Smith RW, Rea KA, Akhtar TA, D'Alessandro A, Minden MD, Vockley J, O'Doherty GA, Lowary TL, Spagnuolo PA
Food & function 2021 Jul 21;12(14):6323-6333

Mild Hypothermia Attenuates Hepatic Ischemia-Reperfusion Injury through Regulating the JAK2/STAT3-CPT1a-Dependent Fatty Acid β-Oxidation.

Wang W, Hu X, Xia Z, Liu Z, Zhong Z, Lu Z, Liu A, Ye S, Cao Q, Wang Y, Zhu F, Ye Q
Oxidative medicine and cellular longevity 2020;2020:5849794

Impaired Autophagy and Defective T Cell Homeostasis in Mice with T Cell-Specific Deletion of Receptor for Activated C Kinase 1.

Qiu G, Liu J, Cheng Q, Wang Q, Jing Z, Pei Y, Zhao M, Wang J, Guo JY, Zhang J
Frontiers in immunology 2017;8:575

Succinate accumulation impairs cardiac pyruvate dehydrogenase activity through GRP91-dependent and independent signaling pathways: Therapeutic effects of ginsenoside Rb1.

Li J, Yang YL, Li LZ, Zhang L, Liu Q, Liu K, Li P, Liu B, Qi LW
Biochimica et biophysica acta. Molecular basis of disease 2017 Nov;1863(11):2835-2847

Pharmacological inhibition of NOX4 ameliorates alcohol-induced liver injury in mice through improving oxidative stress and mitochondrial function.

Sun Q, Zhang W, Zhong W, Sun X, Zhou Z
Biochimica et biophysica acta. General subjects 2017 Jan;1861(1 Pt A):2912-2921

HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression.

Huang D, Li T, Li X, Zhang L, Sun L, He X, Zhong X, Jia D, Song L, Semenza GL, Gao P, Zhang H
Cell reports 2014 Sep 25;8(6):1930-1942

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse liver tissue were subjected to SDS PAGE followed by western blot with 14527-1-AP(ACADVL antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human liver cancer using 14527-1-AP(ACADVL antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The ACADVL antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ACADVL. This antibody recognizes human, mouse, rat antigen. The ACADVL antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 14527-1-AP.pdf

: Show more