12801-1-AP

antibody from Proteintech Group

Targeting: GATM AGAT

Provider product page for 12801-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [16]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 12801-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12801-1-AP, RRID:AB_2109060
Product name: GATM antibody
Antibody type: Polyclonal
Description: GATM antibody (Cat. #12801-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

GATM protein structure - 12801-1-AP shown in red.

Submitted references Glioblastoma exploits ATP from leading-edge astrocytes to fuel its infiltrative growth revealed by spatially resolved chimeric analysis.

Yang G, Niu X, Gan J, Yu T, Li M, Xiao P, Zhang R, He P, Yang Y, Cui Y, Huang X, Wang Y, Mao Q, Zhou R
Science advances 2025 Sep 26;11(39):eadv5673

Guanidinylation of the cold shock protein YB-1: Molecular basis, structural changes and Notch-3 receptor binding.

Leitz A, Kav B, Liu X, Fatafta H, Jankowski V, Aggeler B, Gao Y, Martin IV, Vogt K, Kramann R, Ostendorf T, Rauen T, Strodel B, Raffetseder U
Protein science : a publication of the Protein Society 2025 Jul;34(7):e70188

Role of GATM/creatine as energy reserves in the poll gland and rutting activities in male Bactrian camel.

Tang Z, Li J, Zhou B, Zhang B, Zhang J, Cheng S, Dong W, Zhang Y, Zhao X, Zhang Q, Gao Y
International journal of biological macromolecules 2025 Jul;318(Pt 2):145042

Lighting up arginine metabolism reveals its functional diversity in physiology and pathology.

Li R, Li Y, Jiang K, Zhang L, Li T, Zhao A, Zhang Z, Xia Y, Ge K, Chen Y, Wang C, Tang W, Liu S, Lin X, Song Y, Mei J, Xiao C, Wang A, Zou Y, Li X, Chen X, Ju Z, Jia W, Loscalzo J, Sun Y, Fang W, Yang Y, Zhao Y
Cell metabolism 2025 Jan 7;37(1):291-304.e9

Reduced guanidinoacetate in plasma of patients with autosomal dominant Fanconi syndrome due to heterozygous P341L GATM variant and study of organoids towards treatment.

Portales-Castillo I, Singal R, Ambrose A, Song JH, Son M, Goo YA, Zhou W, Traum AZ, Coler-Reilly A, Humphreys BD, Civitelli R, Jüppner H, Lundquist AL, Seres P, Allegretti AS, Mercimek-Andrews S
JIMD reports 2024 Sep;65(5):341-353

A novel biomarker GATM suppresses proliferation and malignancy of cholangiocarcinoma cells by modulating the JNK/c-Jun signalling pathways.

Yu Y, Gan W, Xiong J, Li J
Heliyon 2024 Sep 15;10(17):e37344

Spatial metabolomics highlights metabolic reprogramming in acute myeloid leukemia mice through creatine pathway.

Bao Y, Qiao J, Gong W, Zhang R, Zhou Y, Xie Y, Xie Y, He J, Yin T
Acta pharmaceutica Sinica. B 2024 Oct;14(10):4461-4477

Functional metabolomics reveals arsenic-induced inhibition of linoleic acid metabolism in mice kidney in drinking water.

He T, Xiong L, Lin K, Yi J, Duan C, Zhang J
Environmental pollution (Barking, Essex : 1987) 2024 May 15;349:123949

Clinical and functional characterization of rare compound heterozygous mutations in the SERPINC1 gene causing severe thrombophilia.

Zhang K, Zhang H, Yu D, Pan J, Wang M, Xie H
Gene 2024 Mar 1;897:148085

Artesunate attenuates serum amyloid A-induced M1 macrophage differentiation through the promotion of PHGDH.

Lu X, Huang Y, Zhou M, Guo Y, Zhou Y, Wang R, Jin W, Wen C, Zhang Y, Tang Y
International immunopharmacology 2024 Jan 25;127:111462

Myeloid cell-derived creatine in the hypoxic niche promotes glioblastoma growth.

Rashidi A, Billingham LK, Zolp A, Chia TY, Silvers C, Katz JL, Park CH, Delay S, Boland L, Geng Y, Markwell SM, Dmello C, Arrieta VA, Zilinger K, Jacob IM, Lopez-Rosas A, Hou D, Castro B, Steffens AM, McCortney K, Walshon JP, Flowers MS, Lin H, Wang H, Zhao J, Sonabend A, Zhang P, Ahmed AU, Brat DJ, Heiland DH, Lee-Chang C, Lesniak MS, Chandel NS, Miska J
Cell metabolism 2024 Jan 2;36(1):62-77.e8

Influence of homoarginine on creatine accumulation and biosynthesis in the mouse.

Lygate CA, Lake HA, McAndrew DJ, Neubauer S, Zervou S
Frontiers in nutrition 2022;9:969702

Arginine:Glycine Amidinotransferase Is Essential for Creatine Supply in Mice During Chronic Hypoxia.

Hannemann J, Cordts K, Seniuk A, Choe CU, Schmidt-Hutten L, Duque Escobar J, Weinberger F, Böger R, Schwedhelm E
Frontiers in physiology 2021;12:703069

Muscle phenotype of AGAT- and GAMT-deficient mice after simvastatin exposure.

Sasani A, Hornig S, Grzybowski R, Cordts K, Hanff E, Tsikas D, Böger R, Gerloff C, Isbrandt D, Neu A, Schwedhelm E, Choe CU
Amino acids 2020 Jan;52(1):73-85

Artepillin C, a Key Component of Brazilian Propolis, Induces Thermogenesis in Inguinal White Adipose Tissue of Mice through a Creatine-Metabolism-Related Thermogenic Pathway.

Nishikawa S, Hydo T, Aoyama H, Miyata R, Kumazawa S, Tsuda T
Journal of agricultural and food chemistry 2020 Jan 29;68(4):1007-1014

Metabolomic profiling of metoprolol-induced cardioprotection in a murine model of acute myocardial ischemia.

Lai Q, Yuan G, Wang H, Liu Z, Kou J, Yu B, Li F
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Apr;124:109820

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse kidney tissue were subjected to SDS PAGE followed by western blot with 12801-1-AP(GATM antibody) at dilution of 1:300
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The GATM antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human GATM. This antibody recognizes human, mouse, rat antigen. The GATM antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 12801-1-AP.pdf

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