Antibody data
- Antibody Data
- Antigen structure
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- Product number
- CABT-BL8406 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Anti-Tox Monoclonal antibody, clone UYSY20
- Antibody type
- Monoclonal
- Description
- TOX (thymocyte selection-associated high mobility group (HMG) box protein) is a member of the HMG box family of DNA-binding proteins and likely plays a role in the regulation of T-cell development. It is a 526 amino acid nuclear protein and the expression of TOX is upregulated by pre-T cell receptor (pre-TCR) and TCR activation in immature thymocytes. TOX-mediated positive selection is associated with up-regulation of RUNX3 and is calcineurin dependent. TOX-dependent transition to the CD4+CD8 stage is required for development of class II major histocompatibility complex-specific T cells.
- Reactivity
- Human, Mouse
- Host
- Rat
- Conjugate
- Unconjugated
- Isotype
- IgG
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