HPA018322

antibody from Atlas Antibodies

Targeting: TOX KIAA0808, TOX1

Western blot (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

HPA018322

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA018322, RRID:AB_1858199

Product name

Anti-TOX

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human TOX, Gene description: thymocyte selection-associated high mobility group box, Alternative Gene Names: KIAA0808, TOX1, Validated applications: IHC, WB, Uniprot ID: O94900, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.1 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

Cutaneous T cell lymphoma atlas reveals malignant T(H)2 cells supported by a B cell-rich tumor microenvironment.

Li R, Strobl J, Poyner EFM, Balbaa A, Torabi F, Mazin PV, Chipampe NJ, Stephenson E, Ramírez-Suástegi C, Shanmugiah VBM, Gardner L, Olabi B, Coulthard R, Botting RA, Zila N, Prigmore E, Gopee NH, Chroscik MA, Kritikaki E, Engelbert J, Goh I, Chan HM, Johnson HF, Ellis J, Rowe V, Tun W, Reynolds G, Yang D, Foster AR, Gambardella L, Winheim E, Admane C, Rumney B, Steele L, Jardine L, Nenonen J, Pickard K, Lumley J, Hampton P, Hu S, Liu F, Liu X, Horsfall D, Basurto-Lozada D, Grimble L, Bacon CM, Weatherhead SC, Brauner H, Wang Y, Bai F, Reynolds NJ, Allen JE, Jonak C, Brunner PM, Teichmann SA, Haniffa M
Nature immunology 2024 Dec;25(12):2320-2330

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Immune checkpoint receptor VISTA on immune cells is associated with expression of T-cell exhaustion marker TOX and worse prognosis in renal cell carcinoma with venous tumor thrombus

Zapała Ł, Kunc M, Sharma S, Pęksa R, Popęda M, Biernat W, Radziszewski P
Journal of Cancer Research and Clinical Oncology 2022;149(7):4131-4139

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Stage-dependent Increase in Expression of miR-155 and Ki-67 and Number of Tumour-associated Inflammatory Cells in Folliculotropic Mycosis Fungoides

Atzmony L, Moyal L, Feinmesser M, Gorovitz B, Hirshberg A, Amitay-Laish I, Prag-Naveh H, Barzilai A, Hodak E
Acta Dermato Venereologica 2020;100(15):adv00230

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Increased Expression of Delta-like Ligand 4 in Mycosis Fungoides.

Boki H, Miyagaki T, Shono Y, Kamijo H, Oka T, Suga H, Asano Y, Sugaya M, Sato S
Acta dermato-venereologica 2020 Feb 25;100(4):adv00059

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Molecular profiling of TOX-deficient neoplastic cells in cutaneous T cell lymphoma

Xu J, Huang H, Wang S, Chen Y, Yin X, Zhang X, Zhang Y
Archives of Dermatological Research 2019;312(7):513-525

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TOX expression in cutaneous B-cell lymphomas

Schrader A, Jansen P, Willemze R
Archives of Dermatological Research 2016;308(6):423-427

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TOX expression and role in CTCL

McGirt L, Degesys C, Johnson V, Zic J, Zwerner J, Eischen C
Journal of the European Academy of Dermatology and Venereology 2016;30(9):1497-1502

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miR-223 Regulates Cell Growth and Targets Proto-Oncogenes in Mycosis Fungoides/Cutaneous T-Cell Lymphoma

McGirt L, Adams C, Baerenwald D, Zwerner J, Zic J, Eischen C
Journal of Investigative Dermatology 2014;134(4):1101-1107

Immunohistochemistry

Supportive validation

Submitted by

Atlas Antibodies (provider)

Enhanced method

Orthogonal validation

Main image

Experimental details

Immunohistochemistry analysis in human tonsil and liver tissues using HPA018322 antibody. Corresponding TOX RNA-seq data are presented for the same tissues.

Sample type

Human

Protocol

Protocol

Orthogonal method

Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.

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