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- References [11]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 12391-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12391-1-AP, RRID:AB_2066277
- Product name
- CA8 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CA8 antibody (Cat. #12391-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Cochlear nucleus spatial transcriptomes of normal and hearing loss mice reveal a critical role of Spp1 in bushy cells.
Effects of p53 on the Regulation of Carbonic Anhydrase 8 in Human Colorectal Cancer Cells: Interaction Between p53 and Sp1.
Consensus molecular subtyping of colorectal carcinoma brain metastases reveals a metabolic signature associated with poor patient survival.
Effects of down-regulated carbonic anhydrase 8 on cell survival and glucose metabolism in human colorectal cancer cell lines.
Glutamatergic cerebellar neurons differentially contribute to the acquisition of motor and social behaviors.
Disruption of the ATXN1-CIC complex reveals the role of additional nuclear ATXN1 interactors in spinocerebellar ataxia type 1.
Short DNA/RNA heteroduplex oligonucleotide interacting proteins are key regulators of target gene silencing.
Carbonic anhydrase 8 (CAR8) negatively regulates GLP-1 secretion from enteroendocrine cells in response to long-chain fatty acids.
Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation.
CA8 promotes RCC proliferation and migration though its expression level is lower in tumor compared to adjacent normal tissue.
Mechanisms that determine the internal environment of the developing brain: a transcriptomic, functional and ultrastructural approach.
Liu H, Liao S, Li X, Song L, Poo MM, Zhao J, Zhou W, Cai R, Wang M, Ma X, Lin S, Zhao X, Zhu N, Zhang Y, Mei J, Song L, Zhao L, Liu S, Chen Y, Wu H
Cell research 2026 Apr 6;
Cell research 2026 Apr 6;
Effects of p53 on the Regulation of Carbonic Anhydrase 8 in Human Colorectal Cancer Cells: Interaction Between p53 and Sp1.
Yu JY, Hsieh BY, Tsai SF, Hsieh M
Cell biochemistry and function 2025 May;43(5):e70081
Cell biochemistry and function 2025 May;43(5):e70081
Consensus molecular subtyping of colorectal carcinoma brain metastases reveals a metabolic signature associated with poor patient survival.
Irmer B, Wlochowitz D, Krekeler C, Richter KM, Chandrabalan S, Bayerlova M, Wolff A, Lenz G, Conradi LC, Schildhaus HU, Stadelmann C, Rohde V, Proescholdt M, Salinas G, Homayounfar K, Kuhlmann T, Hailfinger S, Pukrop T, Menck K, Beissbarth T, Bleckmann A
Molecular oncology 2025 Mar;19(3):614-634
Molecular oncology 2025 Mar;19(3):614-634
Effects of down-regulated carbonic anhydrase 8 on cell survival and glucose metabolism in human colorectal cancer cell lines.
Wu CY, Yu JY, Chen YS, Chang HP, Hsieh BY, Lin YH, Ma CY, Tsai SF, Hsieh M
Cell biochemistry and function 2024 Apr;42(3):e4001
Cell biochemistry and function 2024 Apr;42(3):e4001
Glutamatergic cerebellar neurons differentially contribute to the acquisition of motor and social behaviors.
van der Heijden ME, Rey Hipolito AG, Kim LH, Kizek DJ, Perez RM, Lin T, Sillitoe RV
Nature communications 2023 May 15;14(1):2771
Nature communications 2023 May 15;14(1):2771
Disruption of the ATXN1-CIC complex reveals the role of additional nuclear ATXN1 interactors in spinocerebellar ataxia type 1.
Coffin SL, Durham MA, Nitschke L, Xhako E, Brown AM, Revelli JP, Villavicencio Gonzalez E, Lin T, Handler HP, Dai Y, Trostle AJ, Wan YW, Liu Z, Sillitoe RV, Orr HT, Zoghbi HY
Neuron 2023 Feb 15;111(4):481-492.e8
Neuron 2023 Feb 15;111(4):481-492.e8
Short DNA/RNA heteroduplex oligonucleotide interacting proteins are key regulators of target gene silencing.
Asada K, Sakaue F, Nagata T, Zhang JC, Yoshida-Tanaka K, Abe A, Nawa M, Nishina K, Yokota T
Nucleic acids research 2021 May 21;49(9):4864-4876
Nucleic acids research 2021 May 21;49(9):4864-4876
Carbonic anhydrase 8 (CAR8) negatively regulates GLP-1 secretion from enteroendocrine cells in response to long-chain fatty acids.
Fujiwara Y, Yamane S, Harada N, Ikeguchi-Ogura E, Usui R, Nakamura T, Iwasaki K, Suzuki K, Yabe D, Hayashi Y, Inagaki N
American journal of physiology. Gastrointestinal and liver physiology 2021 Apr 1;320(4):G617-G626
American journal of physiology. Gastrointestinal and liver physiology 2021 Apr 1;320(4):G617-G626
Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation.
Dumas SJ, Meta E, Borri M, Goveia J, Rohlenova K, Conchinha NV, Falkenberg K, Teuwen LA, de Rooij L, Kalucka J, Chen R, Khan S, Taverna F, Lu W, Parys M, De Legher C, Vinckier S, Karakach TK, Schoonjans L, Lin L, Bolund L, Dewerchin M, Eelen G, Rabelink TJ, Li X, Luo Y, Carmeliet P
Journal of the American Society of Nephrology : JASN 2020 Jan;31(1):118-138
Journal of the American Society of Nephrology : JASN 2020 Jan;31(1):118-138
CA8 promotes RCC proliferation and migration though its expression level is lower in tumor compared to adjacent normal tissue.
Ma HL, Yu SJ, Chen J, Ding XF, Chen G, Liang Y, Pan JL
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jan;121:109578
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jan;121:109578
Mechanisms that determine the internal environment of the developing brain: a transcriptomic, functional and ultrastructural approach.
Liddelow SA, Dziegielewska KM, Ek CJ, Habgood MD, Bauer H, Bauer HC, Lindsay H, Wakefield MJ, Strazielle N, Kratzer I, Møllgård K, Ghersi-Egea JF, Saunders NR
PloS one 2013;8(7):e65629
PloS one 2013;8(7):e65629
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 12391-1-AP(CA8 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CA8 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CA8. This antibody recognizes human,mouse,rat antigen. The CA8 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
