Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS7707 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- PTMA polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human PTMA.
- Description
- Prothymosin a (PTÏ«) is a nuclear protein that is widely expressed in mammalian tissues, including kidney, liver, spleen, normal lymphocytes, human T-cell leukemia virus-infected T cells and myeloma cells. The human PTÏ« gene maps to chromosome 2 and encodes a protein that exhibits punctuated nuclear distribution, which correlates to transcription sites. PTÏ« is a chromatin-remodeling protein that was initially thought to mediate T-lymphocyte maturation, but subsequently, has been shown to be involved in cell cycle progression, proliferation and cell differentiation. PTÏ« is thought to be transported into the nucleus by the karyopherin ÉÇ1-Rch-1 complex, where it associates with histones H2A, H2B, H3 and H4. Also, PTÏ« is phosphorylated on Thr 7 and Thr 12 or 13 by Prothymosin Ï«-phosphorylating kinase (PTÏ«K) in a mitogen-activating pathway. The amino terminus of PTÏ« is cleaved to produce a secreted, biologically active peptide thymosin Ï«1, which may be used as an immunomodulator in cancer patients and patients with chronic active hepatitis, or as an immunoenhancer of vaccines in immunocompromised individuals.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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