BS7707

antibody from Bioworld Technology, Inc

Targeting: PTMA TMSA

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS7707

Provider

Bioworld Technology, Inc

Product name

PTMA polyclonal antibody

Antibody type

Polyclonal

Antigen

Recombinant full length Human PTMA.

Description

Prothymosin a (PTÏ«) is a nuclear protein that is widely expressed in mammalian tissues, including kidney, liver, spleen, normal lymphocytes, human T-cell leukemia virus-infected T cells and myeloma cells. The human PTÏ« gene maps to chromosome 2 and encodes a protein that exhibits punctuated nuclear distribution, which correlates to transcription sites. PTÏ« is a chromatin-remodeling protein that was initially thought to mediate T-lymphocyte maturation, but subsequently, has been shown to be involved in cell cycle progression, proliferation and cell differentiation. PTÏ« is thought to be transported into the nucleus by the karyopherin ÉÇ1-Rch-1 complex, where it associates with histones H2A, H2B, H3 and H4. Also, PTÏ« is phosphorylated on Thr 7 and Thr 12 or 13 by Prothymosin Ï«-phosphorylating kinase (PTÏ«K) in a mitogen-activating pathway. The amino terminus of PTÏ« is cleaved to produce a secreted, biologically active peptide thymosin Ï«1, which may be used as an immunomodulator in cancer patients and patients with chronic active hepatitis, or as an immunoenhancer of vaccines in immunocompromised individuals.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.