Antibody data
- Antibody Data
- Antigen structure
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- Validations
- Western blot [1]
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- Product number
- BS60817 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- PTMA polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human PTMA.
- Description
- ProthymosinÏ«(PTÏ«) is a nuclear protein that iswidely expressed inmammalian tissues, including kidney, liver,spleen, normal lymphocytes, human T cell leukemia virus-infected T cells andmyeloma cells. The human PTÏ« genemaps to chromosome 2 and encodes a protein that exhibits punctuated nuclear distribution,which correlatesto transcription sites. PTÏ« is a chromatin-remodeling protein that wasinitiallythought to mediate T lymphocyte maturation, butsubsequently has been shown to be involved in cellcycle progression, proliferation and cell differentiation. PTÏ« isthought to be transported into the nucleus bythe karyopherin ÉÇ1-Rch-1 complex,where it associates with Histones H2A, H2B, H3 and H4. Also, PTÏ« is phosphorylated on Thr 7 and Thr 12 or 13 by Prothymosin Ï«-phosphorylating kinase (PTÏ«K) in amitogen activating pathway. The amino terminus of PTÏ« iscleaved to produce a secreted, biologically active peptide thymosin Ï«1,whichmay be used as an immunomodulatorin cancer patients and patients with chronic active hepatitis, or as an immunoen hancer of vaccinesin immunocompromised individuals.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot (WB) analysis of PTMA pAb at 1:500 dilutionLane1:Hela whole cell lysateLane2:Raw264.7 whole cell lysateLane3:PC12 whole cell lysate