Ab130656

antibody from Aladdin Scientific
Targeting: TEAD1 AA, TCF13, TEF-1
Provider product page for Ab130656

Antibody data

Product number
Ab130656 - Provider product page
Provider
Aladdin Scientific
Product name
Recombinant TEF1/TEAD-1 Antibody
Antibody type
Recombinant
Description
Rabbit anti Human TEF1/TEAD-1 Antibody, Recombinant, could be used for WB and so on.ApplicationWB: 1/500-1/1000Protein FunctionTranscription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.
Reactivity
Human, Rat, Hamster
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
AA 411-426
Vial size
100_l,10_l,1ml,50_l
Concentration
1 mg/ml
Storage
Store at 4_ short term (1-2 weeks). Store at -20_ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
TEAD1 protein structure - Ab130656 shown in red.