NB100-2288

Cedernaes J, Huang W, Ramsey KM, Waldeck N, Cheng L, Marcheva B, Omura C, Kobayashi Y, Peek CB, Levine DC, Dhir R, Awatramani R, Bradfield CA, Wang XA, Takahashi JS, Mokadem M, Ahima RS, Bass J
Cell metabolism 2019 May 7;29(5):1078-1091.e5

The Diurnal Rhythm of Insulin Receptor Substrate-1 (IRS-1) and Kir4.1 in Diabetes: Implications for a Clock Gene Bmal1.

Luo Q, Xiao Y, Alex A, Cummins TR, Bhatwadekar AD
Investigative ophthalmology & visual science 2019 May 1;60(6):1928-1936

Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation.

Hasegawa S, Fukushima H, Hosoda H, Serita T, Ishikawa R, Rokukawa T, Kawahara-Miki R, Zhang Y, Ohta M, Okada S, Tanimizu T, Josselyn SA, Frankland PW, Kida S
Nature communications 2019 Dec 18;10(1):5766

BMAL1 suppresses ROS-induced endothelial-to-mesenchymal transition and atherosclerosis plaque progression via BMP signaling.

Zhu M, Tang H, Tang X, Ma X, Guo D, Chen F
American journal of translational research 2018;10(10):3150-3161

Pharmacological targeting of the mammalian clock reveals a novel analgesic for osteoarthritis-induced pain.

Das V, Kc R, Li X, Varma D, Qiu S, Kroin JS, Forsyth CB, Keshavarzian A, van Wijnen AJ, Park TJ, Stein GS, O-Sullivan I, Burris TP, Im HJ
Gene 2018 May 20;655:1-12

Haploinsufficiency of hnRNP U Changes Activity Pattern and Metabolic Rhythms.

Lai B, Zou J, Lin Z, Qu Z, Song A, Xu Y, Gao X
The American journal of pathology 2018 Jan;188(1):173-183

Regulation of amyloid-β dynamics and pathology by the circadian clock.

Kress GJ, Liao F, Dimitry J, Cedeno MR, FitzGerald GA, Holtzman DM, Musiek ES
The Journal of experimental medicine 2018 Apr 2;215(4):1059-1068

Mapping the co-localization of the circadian proteins PER2 and BMAL1 with enkephalin and substance P throughout the rodent forebrain.

Frederick A, Goldsmith J, de Zavalia N, Amir S
PloS one 2017;12(4):e0176279

Comparative cell cycle transcriptomics reveals synchronization of developmental transcription factor networks in cancer cells.

Boström J, Sramkova Z, Salašová A, Johard H, Mahdessian D, Fedr R, Marks C, Medalová J, Souček K, Lundberg E, Linnarsson S, Bryja V, Sekyrova P, Altun M, Andäng M
PloS one 2017;12(12):e0188772

Dissociation of Molecular and Endocrine Circadian Rhythms in Male Mice Lacking Bmal1 in the Adrenal Cortex.

Dumbell R, Leliavski A, Matveeva O, Blaum C, Tsang AH, Oster H
Endocrinology 2016 Nov;157(11):4222-4233

PI3K-PTEN dysregulation leads to mTOR-driven upregulation of the core clock gene BMAL1 in normal and malignant epithelial cells.

Matsumoto CS, Almeida LO, Guimarães DM, Martins MD, Papagerakis P, Papagerakis S, Leopoldino AM, Castilho RM, Squarize CH
Oncotarget 2016 Jul 5;7(27):42393-42407

Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion.

Perelis M, Marcheva B, Ramsey KM, Schipma MJ, Hutchison AL, Taguchi A, Peek CB, Hong H, Huang W, Omura C, Allred AL, Bradfield CA, Dinner AR, Barish GD, Bass J
Science (New York, N.Y.) 2015 Nov 6;350(6261):aac4250

Impaired glucocorticoid production and response to stress in Arntl-deficient male mice.

Leliavski A, Shostak A, Husse J, Oster H
Endocrinology 2014 Jan;155(1):133-42

Differential effects of light and feeding on circadian organization of peripheral clocks in a forebrain Bmal1 mutant.

Izumo M, Pejchal M, Schook AC, Lange RP, Walisser JA, Sato TR, Wang X, Bradfield CA, Takahashi JS
eLife 2014 Dec 19;3

Involvement of Wee1 in the circadian rhythm-dependent intestinal damage induced by docetaxel.

Obi-Ioka Y, Ushijima K, Kusama M, Ishikawa-Kobayashi E, Fujimura A
The Journal of pharmacology and experimental therapeutics 2013 Oct;347(1):242-8

Global but not gonadotrope-specific disruption of Bmal1 abolishes the luteinizing hormone surge without affecting ovulation.

Chu A, Zhu L, Blum ID, Mai O, Leliavski A, Fahrenkrug J, Oster H, Boehm U, Storch KF
Endocrinology 2013 Aug;154(8):2924-35

Formation of invadopodia-like structures by synovial cells promotes cartilage breakdown in collagen-induced arthritis: involvement of the protein tyrosine kinase Src.

Lauzier A, Charbonneau M, Harper K, Jilaveanu-Pelmus M, Dubois CM
Arthritis and rheumatism 2011 Jun;63(6):1591-602

Proxisome proliferator-activated receptor-α mediates high-fat, diet-enhanced daily oscillation of plasminogen activator inhibitor-1 activity in mice.

Hayashida S, Kuramoto Y, Koyanagi S, Oishi K, Fujiki J, Matsunaga N, Ikeda E, Ohdo S, Shimeno H, Soeda S
Chronobiology international 2010 Oct;27(9-10):1735-53

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Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Western Blot: BMAL1 Antibody [NB100-2288] - Analysis of BMAL1 in A) MCF7, B) NIH/3T3, C) PC12.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Western Blot: BMAL1 Antibody [NB100-2288] - Analysis of MOP3 on 3T3/L1 cell lysates.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Immunohistochemistry: BMAL1 Antibody [NB100-2288] - Analysis of BMAL1 in mouse brain using DAB with hematoxylin counterstain.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Immunohistochemistry-Paraffin: BMAL1 Antibody [NB100-2288] - Analysis of a FFPE tissue section of mouse brain using 1:200 dilution of rabbit anti-BMAL1 antibody. The staining was developed using HRP labeled anti-rabbit IgG secondary antibody and DAB reagent, and nuclei of cells were counter-stained with hematoxylin. This BMAL1 antibody generated a specific nuclear staining in most of the cells and a relatively weaker cytoplasmic signal was also observed.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Flow (Intracellular): BMAL1 Antibody [NB100-2288] - An intracellular stain was performed on HeLa cells with NB100-2288AF647(blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 5 ug/mL for 30 minutes at room temperature. Both antibodies were conjugated to Alexa Fluor 647.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Flow Cytometry: BMAL1 Antibody [NB100-2288] - An intracellular stain was performed on Jurkat cells with NB100-2288 and a matched isotype control. Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 2.5 ug/mL for 30 minutes at room temperature, followed by Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Chromatin Immunoprecipitation: BMAL1 Antibody [NB100-2288] - Analysis of BMAL1 in mouse cerebral cortex (left: wt, right: Bmal1 KO) using anti-BMAL1 antibody. Image from verified customer review.