CABT-BL8400

antibody from Creative Diagnostics

Targeting: TNFSF14 CD258, HVEM-L, LIGHT, LTg

Flow cytometry (Recommended by provider)

Antibody Data

Product number

CABT-BL8400

Provider

Creative Diagnostics

Product name

Anti-TNFSF14 Monoclonal antibody, clone 8-4 [APC]

Antibody type

Monoclonal

Description

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF (tumor necrosis factor) and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 (tumor necrosis factor receptor 1) and Fas. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE (interleukin-1-beta converting enzyme)/CED-3 (C. elegans death receptor-3) protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx (death associated protein 6). Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.

Reactivity

Human

Host

Mouse

Isotype

IgG