Antibody data
- Antibody Data
- Antigen structure
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- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 46-2589-42 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD258 (LIGHT) Monoclonal Antibody (7-3 (7)), PerCP-eFluor™ 710, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: This 7-3 (7) monoclonal antibody reacts with human CD258 (also known as LIGHT), a 29-kDa type II transmembrane protein that is a member of the TNF ligand superfamily related to lymphotoxin-β (LT-β). Expressed on activated T cells, particularly CD8+ T cells, LIGHT plays a role in cell survival, inflammation, and tumor eradication. Furthermore, upon binding its ligand, herpesvirus entry mediator (HVEM), LIGHT induces a costimulatory effect on T cells, enhancing T cell proliferation and cytokine production. LIGHT has also been shown to indirectly interact with the LT-β receptor.
- Antibody clone number
- 7-3 (7)
- Concentration
- 5 µL/Test
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Supportive validation
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- Invitrogen Antibodies (provider)
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- Experimental details
- Normal human peripheral blood cells were unstimulated (left) or stimulated for 24 hours with the Cell Stimulation Cocktail (500X) (Product # 00-4970-03) (right). Cells were stained with Anti-Human CD8a eFluor® 450 (Product # 48-0086-42) and Anti-Human LIGHT (CD258) PerCP-eFluor® 710 (right). Cells in the lymphocyte gate were used for analysis.