318704

antibody from BioLegend
Targeting: TNFSF14 CD258, HVEM-L, LIGHT, LTg
Provider product page for 318704

Antibody data

Product number
318704 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#318704, RRID:AB_830862
Product name
Biotin anti-human CD258 (LIGHT)
Antibody type
Monoclonal
Antigen
recombinant human LIGHT (TL5) protein
Description
The T5-39 antibody recognizes human LIGHT (CD258) also known as ligand for herpesvirus entry mediator, tumor necrosis factor receptor-like-2 ligand, TR2 ligand, and tumor necrosis factor ligand superfamily member 14 (TNFSF14). LIGHT is a type 2 transmembrane protein, and a member of the tumor necrosis factor ligand superfamily. LIGHT can be proteolytically cleaved and two isofoms have been shown to be produced by alternative splicing. The apparent molecular weight of LIGHT us approximately 30 kD. LIGHT expression has been observed in spleen, brain and kidney; expression is upregulated on activated T cells (particularly CD8+ cells). LIGHT stimulates proliferation of T cells and inhibits growth of some tumor cells. This protein has been shown to play a role in intestinal inflammation and contribute to IgA nephropathy. LIGHT is a ligand for HVEM, and LTβR and has also been shown to bind DcR3 and modulate function. In addition, LIGHT has been shown to interact with other proteins including TRAF2, TRAF3, and DIABLO. The T5-39 antibody has been shown to be useful for flow cytometry and ELISA.
Reactivity
Human
Host
Mouse
Conjugate
Biotin
Isotype
IgG
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
The antibody solution should be stored undiluted at 4°C. Do not freeze.
TNFSF14 protein structure - 318704 shown in red.