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Protein structure
PHOX2B
Paired like homeobox 2BNBPhox, PMX2B
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome. [provided by RefSeq, Jul 2016]
Top validated antibodies |
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| Proteintech Group |  25276-1-AP |
Polyclonal |
WB
EL
ICC
IHC
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| NovoPro Bioscience Inc. | 113862 |
Polyclonal |
WB
EL
ICC
IHC
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| Invitrogen Antibodies | 25276-1-AP |
Polyclonal |
WB
ICC
IHC
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| FineTest Biotech | FNab06408 |
Polyclonal |
WB
EL
ICC
IHC
|
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| Biorbyt | orb158147 |
Polyclonal |
WB
EL
ICC
IHC
|
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