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GPS2
G protein pathway suppressor 2This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| GeneTex |  GTX117560 |
1 references | Polyclonal |
WB
ICC
IHC
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| Proteintech Group | 12177-1-AP |
1 references | Polyclonal |
WB
EL
IHC
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| NovoPro Bioscience Inc. | 111143 |
Polyclonal |
WB
EL
ICC
IHC
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| antibodies-online | ABIN561119 |
1 references | Monoclonal |
WB
EL
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| FineTest Biotech | FNab03617 |
Polyclonal |
WB
EL
ICC
IHC
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