BS6279

antibody from Bioworld Technology, Inc
Targeting: TNFSF13 APRIL, CD256
Provider product page for BS6279
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS6279 - Provider product page
Provider
Bioworld Technology, Inc
Product name
APRIL polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human APRIL.
Description
A proliferation-inducing ligand (APRIL), also designated TNFSF13, is a Type II membrane protein that shares characteristics with other members of the tumor necrosis factor (TNF) cytokine family. APRIL is expressed in high levels in transformed cell lines and in human colon, thyroid, and lymphoid tumor tissues. APRIL is critically involved in the regulation of infections, inflammation, autoimmune diseases, and tissue homeostasis. APRIL is implicated in the regulation of tumor cell growth. The C-terminal extracellular domain has b jelly roll topography and is important in ligand trimerization. The binding of the ligand to its respective receptor induces oligomerization, initiating downstream signaling events. Intrinsic to oligomerization is the formation of the receptor binding site at the junction between neighboring subunits, creating a multivalent ligand.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
TNFSF13 protein structure - BS6279 shown in red.