318502

antibody from BioLegend

Targeting: TNFSF13 APRIL, CD256

ELISA (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

318502

Provider

BioLegend

Product name

Purified anti-human CD256 (APRIL)

Antibody type

Monoclonal

Antigen

recombinant human APRIL protein

Description

The T3-6 antibody recognizes human APRIL (CD256) also known as A proliferation-inducing ligand, TNF- and APOL-related leukocyte expressed ligand 2 (TALL-2), TNF-related death ligand 1, and TNFSF13. APRIL is a member of the TNF superfamily, synthesized as a type II transmembrane protein, but cleaved by furin intracellularly to become secreted factor.. Several isoforms of APRIL can be produced by alternative splicing. APRIL, like other members of the TNF ligand superfamily, forms homodimers. The reported molecular weight of an APRIL monomer is approximately 27 kD. APRIL is highly expressed in transformed cell lines, cancers of colon, thyroid, and lymphoid tissues. Monocytes and macrophages also express APRIL; expression of APRIL is down-regulated following PMA/ionomycin treatment. APRIL has been implicated in B cell development and IgA class switching, T cell survival, and the stimulation of tumor cell growth. T3-6 antibody has been shown to be useful for flow cytometry and ELISA.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µg

Concentration

0.5 mg/ml

Storage

The antibody solution should be stored undiluted at 4°C.