RA0787

antibody from Oursmab

Targeting: TNFSF13 APRIL, CD256

Western blot (Supportive data in Antibodypedia)

ELISA (Supportive data in Antibodypedia)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0787

Provider

Oursmab

Product name

Sibeprenlimab (Biosimilar Reference Antibody) (TNFSF13)

Antibody type

Monoclonal

Description

Sibeprenlimab (VIS649) is a humanized IgG2 kappa monoclonal antibody targeting a proliferation-inducing ligand (APRIL, TNFSF13). It binds to and neutralizes APRIL, reducing the production of IgA, particularly pathogenic galactose-deficient IgA1 (Gd-IgA1). It is being developed for the treatment of IgA nephropathy (IgAN), aiming to lower levels of nephritogenic antibodies and slow disease progression.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.

Western blot

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

Sibeprenlimab (Biosimilar Reference Antibody) (TNFSF13)-RA0787-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.

ELISA

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

ELISA plate pre-coated Antigen protein, can bind Sibeprenlimab (Biosimilar Reference Antibody) (TNFSF13)-RA0787 in a linear range of 15.63¨C125 ng/mL.